Wilms Tumor Gene Expression in Acute Myeloid Leukemias

References

• Call K. M., Glaser T., Ito C. Y., Buckler A. J., Pelletier J., Haber D. A., Rose E. A., Krai A., Yeger H., Lewis W. H., Jones C., Housman D. E. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990; 60: 509–520
   PubMed Web of Science ®Google Scholar
• Gessler M., Poustka A., Cavenee W., Neve R. L., Orkin S. H., Bruns G. A. P. Homozygous deletion in Wilms' tumors of a zinc‐finger gene identified by chromosome jumping. Nature 1990; 343: 774–778
   PubMed Web of Science ®Google Scholar
• Werner H., Re G., Drummond I., Sukathme V., Rauscher F. J., III, Sens D., Garvin A., LeRoith D., Roberts C. Increased expression of the insulin like growth factor I receptor gene, IGF 1R, in Wilms' tumors is correlated with modulation of the IGF 1 R promoter activity by the wt1 Wilms tumor gene product. Proc. Natl. Acad. Sci. USA 1993; 90: 5828–5832
   PubMed Web of Science ®Google Scholar
• Cashier A. L., Bonthron D. T., Madden S. L., Rauscher F. J., III, Collins T., Sukhatme V. P. Human platelet‐derived growth factor A chain is transcriptionally repressed by the Wilms' tumor suppressor WT1. Proc. Natl. Acad. Sci. USA 1992; 89: 10984–10988
   PubMed Web of Science ®Google Scholar
• Dey B. R., Sukhatme V. P., Roberts A. B., Sporn M. B., Rauscher F. J., III, Kim S. J. Repression of the transforming growth factor—beta 1 gene by the Wilms' tumor suppressor wt1 gene product. Mol. Endocrinol. 1994; 8: 595–602
   PubMed Web of Science ®Google Scholar
• Harrington M. A., Konicek B., Song A., Xia X., Fredericks W. J., Rauscher F., III. Inhibition of colony‐stimulating factor‐1 promotor activity by the product of the Wilms' tumor locus. J. Biol. Chem. 1993; 268: 21271–21275
   PubMed Web of Science ®Google Scholar
• Drummond I. A., Madden S. L., Rohwer‐Nutter P., Bell G. I., Sukhatme V. P., Rauscher F. J. Repression of the insulin‐like growth factor II gene by the Wilms' tumor suppressor wt 1. Science 1992; 257: 674–678
   PubMed Web of Science ®Google Scholar
• Wang Z. Y., Qiu Q. Q., Deuel T. F. The Wilms' tumor gene product wt‐1 activates or suppresses transcription through separate functional domains. J. Biol. Chem. 1993; 268: 9172–9175
   PubMed Web of Science ®Google Scholar
• Haber D. A., Sohn R. L., Buckler A. J., Pelletier J., Call K. M., Housman D. E. Alternative splicing and genomic strukture of the Wilms' tumor gene wt‐1. Proc. Natl. Acad. Sci. USA 1991; 88: 9618–9622
   PubMed Web of Science ®Google Scholar
• Pritchard‐Jones K., Fleming S., Davidson D., Bickmore W., Porteous D., Gosden C., Bard J., Buckler A., Pelletier J., Housman D., Heyningen W., Hastie N. The candidate Wilms' tumor gene is involved in genitourinary development. Nature 1990; 46: 194–197
   Web of Science ®Google Scholar
• Rackley R., Flenniken A., Kuryan N., Kessler P., Stolen M., Williams G. Expression of the Wilms' Tumor suppressor gene wtl during mouse embryogenesis. Cell Growth Differ. 1993; 4: 1023–1031
   PubMedGoogle Scholar
• Kreidberg J., Sariola H., Loring J., Maeda M., Pelletier J., Housman D., Jaenisch R. WT1 is required for early kidney development. Cell 1993; 74: 679–691
   PubMed Web of Science ®Google Scholar
• Jinno Y., Yun K., Nishiwaki K., Kubota T., Ogawa O., Reeve A., Niikawa N. Mosaic and polymorphic imprinting of the WT1 gene in humans. Nature Genet. 1994; 6: 305–309
   PubMed Web of Science ®Google Scholar
• Inoue K., Sugiyama H., Ogawa H., Nakagawa M., Yamagami T., Miwa H., Kita K., Hiraoka A., Nasu K., Kyo T., Dohy H., Nakauchi H., Ishidate T., Akiyama T., Kishimoto T. WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 1994; 84: 3071–3079
   PubMed Web of Science ®Google Scholar
• Fraizer G. C., Patmasiriwat P., Zhang X., Saunders G. F. Expression of the Wilms' tumor gene in both human and mouse bone marrow. Blood 1995; 86: 4704, letter
   PubMed Web of Science ®Google Scholar
• Maurer U., Weidmann E., Brieger J., Finkler S., Mitrou P. S., Hoelzer D., Bergmann L. The Wilms tumor gene is expressed in normal hematopoetic progenitors and downregulated during differentiation. Proc. Am. Ass. Cancer Res. 1996; 37: 529, Abstr. 3621
   Google Scholar
• Haber D. A., Buckler A. J. Wtl: A novel tumor suppressor gene inactivated in Wilms' tumor. The New Biologist 1992; 4: 97–106
   PubMedGoogle Scholar
• Brown K. W., Watson J. E., Poirier V., Mott M. G., Berry P. J., Maitland N. J. Inactivation of the remaining allele of the wt1 gene in a Wilms' tumour from a WAGR patient. Oncogene 1992; 1: 763–768
   Google Scholar
• Akasaka Y., Kikuchi H., Nagai T., Hiraoka N., Kato S., Hata J. A point mutation in a sporadic Wilms' Tumor without genitoury abnormalities is identical with the most frequent mutations in Denys‐Drash syndrome. FEBS 1993; 317: 39–43
   PubMed Web of Science ®Google Scholar
• Rodeck U., Bossier A., Kari C., Humphreys C. W., Gyorfi T., Maurer J., Thiel E., Menssen H. D. Expression of the Wilms' tumor gene by normal and malignant human melanocytes. Int. J. Cancer 1994; 59: 78–82
   PubMed Web of Science ®Google Scholar
• Viel A., Giannini F., Capozzi E., Canzonieri V., Scarabeli C., Gloghini A., Boiocci M. Molecular mechanisms possibly affecting WT1 functions in human ovarian tumors. Int. J. Cancer 1994; 57: 515–521
   PubMed Web of Science ®Google Scholar
• Miwa H., Beran M., Saunders G. F. Expression of the Wilms' tumor gene (wt‐1) in human leukemias. Leukemia 1992; 6: 405–409
   PubMed Web of Science ®Google Scholar
• Brieger J., Weidmann E., Fenchel K., Mitrou P. S., Hoelzer D., Bergmann L. The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia 1994; 8: 2138–2143
   PubMed Web of Science ®Google Scholar
• Menssen H. D., Renkl H. J., Maurer J., Notter M., Schwartz S., Reinhardt R., Thiel E. Presence of the Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995; 9: 1060–1067
   PubMed Web of Science ®Google Scholar
• Mohrbacher A., Nishida K., Douer D. Wt1 expression in clonogenic vs. circulating cells of normal and leukemic hematopoiesis. Blood 1995; 86(suppl. 1)147a, abstract
   PubMedGoogle Scholar
• Brown K., Wilmore H., Watson J., Mott M., Berry P., Maitland N. Low frequency of mutations in the WT1 coding region in Wilms' tumors. Gen. Chrom. Cancer 1993; 8: 74–79
   PubMed Web of Science ®Google Scholar
• King‐Underwood L., Renshaw J., Pritchard‐Jones K. Wilms' tumor gene mutations in acute myeloid leukemia. Proc. Am. Assoc. Cancer Res. 1995; 36: 605, abstract
   Google Scholar
• Brieger J., Weidmann E., Maurer U., Hoelzer D., Mitrou P. S., Bergmann L. The Wilms' tumor gene is frequently expressd in acute leukemias and may provide a marker for residual blast cells detectable by PCR. Ann. Oncol. 1995; 6: 811–816
   PubMed Web of Science ®Google Scholar
• Maheswaran S., Park S., Bernard A., Morris J. F., Rauscher F. J., III, Hill D. E., Haber D. A. Physical and functional interaction between WT‐1 and p53 proteins. Proc. Natl. Acad. Sci. USA 1993; 90: 5100–5104
   PubMed Web of Science ®Google Scholar
• Hewitt S. M., Hamada S., McDonnell T. J., Rauscher F. J., III, Saunders G. F. Regulation of the proto‐onco‐genes bcl‐2 and c‐myc by the Wilms' tumor suppressor gene wt1. Cancer Res. 1995; 55: 5386–5389
   PubMed Web of Science ®Google Scholar
• Gessler M., König A., Bruns G. A. P. The genomic organisation and expression of the wt1 gene. Genomics. 1992; 12: 807–813
   PubMed Web of Science ®Google Scholar
• Gerber H. P., Seipel K., Georgiev O., Hofferer M., Hug M., Rusconi S., Schaffner W. Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 1994; 263: 808–811
   PubMed Web of Science ®Google Scholar
• Haber D. A., Park S., Maheswaran S., Englert C., Re G. G., Hazen‐Martin D. J., Sens D., Garvin J. Wt1‐mediated growth suppression of Wilms' tumor cells expressing a wt1 splicing variant. Science 1993; 262: 2057–2059
   PubMed Web of Science ®Google Scholar
• Wang Z. Y., Qiu Q. Q., Gurrieri M., Huang J., Deuel T. F. Wt1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein. Oncogene 1995; 10: 1243–1247
   PubMed Web of Science ®Google Scholar
• Drummond I., Rupprecht H., Rohwer‐Nutter P., Lopez‐Guisa J., Madden S., Rauscher F., III, Suthkame V. DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1. Mol. Cell. Biol. 1994; 14: 3800–3809
   PubMed Web of Science ®Google Scholar
• Larsson S. H., Charlieu J. P., Miyagawa K., Engelkamp D., Rassoulzadegan M., Ross A., Cuzin F., Heyningen V., Hastie N. D. Subnuclear localistaion of wt1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 1995; 81: 391–401
   PubMed Web of Science ®Google Scholar
• Fraizer G. C., Wu Y. J., Hewitt S. M., Maity T., Ton C. C. T., Huff V., Saunders G. F. Transcriptional regulation of the human Wilms' tumor gene (wt1) cell type specific enhancer and promiscous promoter. J. Biol. Chem. 1994; 269: 8892–8900
   PubMed Web of Science ®Google Scholar
• Wu Y., Fraizer G., Saunders G. GATA‐1 trans‐activates the wt1 hematopoetic specific enhancer. J. Biol. Chem. 1995; 270: 5944–5949
   PubMed Web of Science ®Google Scholar
• Rupprecht H. D., Drummond I. A., Madden S. L., Rauscher F. J., Sukhatme V. The Wilms' tumor suppressor‐gene WT1 is negatively autoregulated. J. Biol. Chem. 1994; 269: 6198–6206
   PubMed Web of Science ®Google Scholar
• Malik K., Poirier V., Ivins S., Brown K. Autoregulation of the human WT1 gene promoter. FEBS Letters 1994; 349: 75–78
   PubMed Web of Science ®Google Scholar
• Maurer U., Weidmann E., Brieger J., Mitrou P. S., Hoelzer D., Bergmann L. Genomic imprinting of WT1 in blast cells of patients with acute myelocytic leukemia appears independent of WTI expression level. Exp. Hematol. 1995; 23: 782, Abstr. 147
   Web of Science ®Google Scholar
• Li E., Beard C., Jaenish R. Role for DNA methylation in genomic imprinting. Nature 1993; 366: 362–365
   PubMed Web of Science ®Google Scholar
• Rauscher F., III, Morris J., Tournay O., Cook D., Curran T. Binding of the Wilms' tumor locus zinc finger protein to the egr‐1 consensus sequence. Science 1990; 250: 1259–1262
   PubMed Web of Science ®Google Scholar
• Ryan G., Steele‐Perkins V., Morris J. F., Rauscher F. J., III, Dressler G. R. Repression of Pax‐2 by WT1 during normal kidney development. Development 1995; 121: 867–875
   PubMed Web of Science ®Google Scholar
• Goodyer P., Dehbi N., Torban E., Bruening W., Pelletier J. Repression of the retanoic acid receptor‐a gene by the wilms' tumor suppressor gene product, wt‐1. Oncogene 1995; 10: 1125–1129
   PubMed Web of Science ®Google Scholar
• Wang Z. Y., Qiu Q. Q., Enger K., Deuel T. F. A second transcriptionally active DNA binding site for the Wilms' tumor gene product, wt1. Proc. Natl. Acad. Sci. 1993; 90: 8896–8900
   PubMed Web of Science ®Google Scholar
• Madden S. L., Cook D. M., Morris J. F., Gershler A., Sukatme V. P., Rauscher F. J. Transcriptional repression mediated by the wt1 Wilms'tumor gene product. Science 1990; 253: 1550–1553
   Web of Science ®Google Scholar
• Reddy J. C., Morris J. C., Wang J., English M. ‐A., Haber D. A., Shi Y., Licht J. D. WT1‐mediated transcriptional activation is inhibited by dominant negative mutant proteins. J. Biol. Chem. 1995; 270: 10878–10884
   PubMed Web of Science ®Google Scholar
• Moffet P., Bruening W., Nakagama H., Bardeesy N., Housman D., Housman D. E., Pelletier J. Antagonism of wt1 activity by protein self association. Proc. Natl. Acad. Science 1995; 92: 11105–11109
   PubMed Web of Science ®Google Scholar
• Phelan S. A., Linberg C., Call K. M. Wilms' tumor gene. WTI, mRNA is down‐regulated during induction of erythroid and megakaryocytic differentiation of K562 cells. Cell Growth Differ 1993; 5: 677
   Google Scholar
• Sekya M., Adachi M., Hinoda Y., Imai K., Yachi A. Downregulation of Wilms' tumor gene, wt1, during myelomonocytic differentiation in HL60 cells. Blood 1994; 83: 1876–1882
   PubMed Web of Science ®Google Scholar
• Yamagami T., Sugiyama H., Inoue K., Ogawa H., Tatekawa T., Hirata M., Kudoh T., Akiyama T., Murakami A., Maekawa T., Kishimoto T. Growth inhibition of human Leukemic cells by wt‐1 antisence oligodeoxynucleotides: Implications for the involvement of WT‐1 in leukemogenesis. Blood 1996; 87: 2878–2884
   PubMed Web of Science ®Google Scholar
• Miyagi T., Ahuja H., Kubota T., Kubonishi I., Koeffler H. P., Miyoshi I. Expression of the candidate Wilms' tumor gene, WT1, in human leukemia cells. Leuk. 1993; 7: 970–977
   PubMed Web of Science ®Google Scholar
• Miething C. C., Brieger J., Weidmann E., Maurer U., Mitrou P. S., Hoelzer D., Bergmann L. Clinical evaluation of proposed molecular marker wt‐1 (Wilms'tumor gene) in acute myeloid leukemia. Proc. Am. Ass. Cancer Res. 1996; 37: 207, Abstr. 1419
   Google Scholar
• Karakas T., Miething C. C., Brieger J., Maurer U., Weidmann E., Mitrou P. S., Hoelzer D., Bergmann L. The expression of bcl‐2 in AML is associated with a poor outcome and correlated to the expression of wt‐1. Brit. J. Haematol. 1996; 93: 144, Abstr
   Google Scholar