28
Views
39
CrossRef citations to date
0
Altmetric
Original Article

The Use of a Sequential High Dose Recombinant Interleukin 2 Regimen After Autologous Bone Marrow Transplantation Does Not Improve the Disease Free Survival of Patients with Acute Leukemia Transplanted in First Complete Remission

, , , , , , , , , , , , , , & show all
Pages 469-478 | Published online: 01 Jul 2009

References

  • Zittoun R. A., Mandelli F., Willemze R., De Witte T., Labar B., Resegotti L., Leoni F., Damasio E., Visani G., Papa G., Caronia F., Hayat M., Stryckmans P., Rotoli B., Leoni P., Peetermans M. E., Dardene M., Vegna M. L., Petti M. C., Solbu G., Suciu S. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N. Engl. J. Med. 1995; 332: 217–223
  • Copelan E. A., McGuire E. A. The biology and treatment of acute lymphoblastic leukemia in adults. Blood 1995; 85: 1151–1168
  • Horowitz M. M., Gale R. P., Sondel P. M., Goldman J. M., Kersey J., Kolb H. J., Rimm A. A., Ringden O., Rozman C., Speck B., Truitt R. L., Zwaan F. E., Bortin M. M. Graft‐versus‐leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555–562
  • Maraninchi D., Gluckman E., Blaise D., Guyotat D., Rio B., Pico J. L., Leblond V., Michallet M., Dreyfus F., Lfrah N. Impact of T‐cell depletion on outcome of allogeneic bone marrow transplantation for standard‐risk leukemias. Lancet 1987; 2: 175–178
  • Blaise D., Olive D., Michallet M., Marit G., Leblond V., Maraninchi D. Impairment of leukaemia‐free survival by addition of interleukin‐2 receptor antibody to standard graft‐versus‐host prophylaxis. Lancet 1995; 345: 1144–1146
  • Laporte J. P., Douay L., Lopez M., Labopin M., Jouet J. P., Lesage S., Stachowiak J., Fouillard L., Isnard F., Noel‐Walter M. P., Pene F., Deloux J., Van Den Akker J., Grande M., Bauters F., Najman A., Gorin N. C. One hundred twenty‐five adult patients with primary acute leukemia autografted with marrow purged by mafosfamide: a 10‐year single institution experience. Blood 1994; 84: 3810–3818
  • Reiffers J., Gaspard M. H., Maraninchi D., Michallet M., Marit G., Stoppa A. M., Corront B., David B., Gastaut J. A., Sotto J. J., Broustet A., Carcassonne Y., Hollard D. Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: a prospective controlled trial. Br. J. Haematol. 1989; 72: 57–63
  • Martin P. J., Hansen J. A., Storb R., Thomas E. D. Human marrow transplantation: An immunological perspective. Adv. Immunol. 1987; 40: 379–389
  • Robertson M. J., Ritz J. Biology and clinical relevance of human natural killer cells. Blood 1990; 76: 2421–2438
  • Hercend T., Takvorian T., Nowill A., Tantravahi R., Moingeon P., Anderson K. C., Murray C., Bohuon C., Ythier A., Ritz J. Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation. Blood 1986; 67: 722–728
  • Lotzova E. Role of interleukin‐2 activated MHC‐non restricted lymphocytes in antileukemia activity and therapy. Leukemia and Lymphoma 1992; 7: 15–28
  • Foa R., Guarini A., Tos A. G., Cardona S., Fierro M. T., Meloni G., Tosti S., Mandelli F., Gavosto F. Peripheral Blood and Bone Marrow immunophenotypic and functional modifications induced in acute leukemia patients treated with interleukin 2 evidence of in vivo lymphokine activated killer cell generation. Cancer Research 1991; 51: 964–968
  • Rosenberg A., Lotze M. T., Muul L. M., Chang A. E., Avis F. P., Leitman S., Linehan W. M., Robertson C. N., Lee R. E., Rubin J. T., Seipp C. A., Simpson C. G., White D. E. A progress report on the treatment of 157 patients with advanced cancer using lymphokine‐activated killer cells and interleukin‐2 or high dose interleukin‐2 alone. N. Engl. J. Med. 1987; 316: 889–897
  • Gisselbrecht C., Maraninchi D., Pico J. L., Milpied N., Coiffier B., Divine M., Tiberghien P., Bosly A., Tilly H., Boulat O., Brandely M. Interleukin‐2 treatment in lymphoma: a phase II multicenter study. Blood 1994; 83: 2081–2085
  • Blaise D., Viens P., Olive D., Stoppa A. M., Gabert J., Pourreau C. N., Attal M., Gaspard M. H., Mannoni P., Jasmin C., Palmer P., Franks C., Michel G., Mawas C., Baume D., Philip T., Maraninchi D. Recombinant interleukin‐2 after autologous bone marrow transplantation: a pilot study in 19 patients. Eur. Cytokine Net. 1991; 2: 121–129
  • Benyunes M. C., Massumoto C., York A., Higuchi C. M., Buckner C. D., Thompson J. A., Petersen F. B., Fefer A. Interleukin‐2 with or without lymphokine‐activated killer cells as consolidative immunotherapy after autologous bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplantation 1993; 12: 159–163
  • Gottlieb D. J., Prentice H. G., Heslop H. E. Effects of recombinant interleukine‐2 administration on cyto‐toxic function following high‐dose chemo‐radiotherapy for hematological malignancy. Blood 1989; 74: 2335–2342
  • Hamon M. D., Prentice H. G., Gottlieb D. J., Gottlieb D. J., Macdonald I. D., Cunningham J. M., Smith O. P., Gilmore M., Gandhi L., Collis C. Preliminary report. Immunotherapy with interleukin 2 after ABMT in AML. Bone Marrow Transplantation 1993; 11: 399–401
  • Bosly A., Guillaume T., Brice P., Humblet Y., Staquet P., Doyen C., Chatelain B., Franks C. R., Gisselbrecht C., Symann M. Effects of escalading doses of recombinant human interleukin‐2 in correcting functional T‐cell defects following autologous bone marrow transplantation for lymphomas and solid tumors. Exp. Hematol. 1992; 20: 962–968
  • Costello R., Blaise D., Jacquemier J., Monges G., Stoppa A. M., Viens P., Olive D., Bouabdallah R., Brandely M., Gastaut J. A., Maraninchi D. Induction of cutaneous graft versus host like reaction by recombinant IL‐2 after autologous bone marrow transplantation. Bone Marrow Transplantation 1995; 16: 199–200
  • Gaspari A. A., Lotze M. T., Rosenberg S. A., Stem J. B., Katz S. I. Dermatologic changes associated with interleukin 2 administration. J. Am. Med. Assoc. 1987; 258: 1624–1629
  • Ettinghausen S. E., Moore J. G., White D. E., Platanias L., Young N. S., Rosenberg S. A. Hematologic effects of immunotherapy with lymphokine‐activated killer cells and recombinant IL2 in cancer patients. Blood 1987; 6: 1654–1660
  • Schwartentruber D. J., White de Zweig M. H., Weintraub B. D., Rosenberg S. A. Thyroid dysfunction associated with immunotherapy for patients with cancer. Cancer 1991; 68: 2384–2390
  • Vialettes B., Guillerand M. A., Viens P., Stoppa A. M., Baume D., Sauvan R., Pasquier J., San Marco M., Olive D., Maraninchi D. Incidence rate risk and risk factors for thyroid dysfunction during recombinant interleukin‐2 therapy in advanced malignancies. Acta Endocrinol. 1993; 129: 31–38
  • Murphy P. M., Lane H. C., Gallin J. I., Fauci A. S. Marked disparity in incidence of bacterial infections in patients with the acquired immunodeficiency syndrome receiving interleukin‐2 or interferon gamma. Ann. Intern. Med. 1988; 108: 36–41
  • Blaise D., Stoppa A. M., Viens P., Sainty D., Fossat C., Miquel M., Olive D., Bouabdallah R., Gabert J., Baume D., Maraninchi D. Intensive immunotherapy with recombinant 1L2 after autologous bone marrow transplantation is associated with a high incidence of bacterial infections. Bone Marrow Transplantation 1992; 10: 193–195
  • Attal M., Blaise D., Marit G., Payen C., Michallet M., Vernant J. P., Sauvage C., Troussard X., Nedellec G., Pico J. L., Huguet F., Stoppa A. M., Broustet A., Sotto J. J., Pris J., Maraninchi D., Reiffers J. Consolidation treatment of adult acute lymphoblastic leukemia a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant Interleukin‐2 after autologous bone marrow transplantation. Blood 1980; 86(4)1619–1628
  • Blaise D., Olive D., Stoppa A. M., Viens P., Pourreau C., Lopez M., Attal M., Jasmin C., Monges G., Mawas C., Mannoni P., Palmer P., Franks C., Philip T., Maraninchi D. Hematologic and Immunologic effects of the systemic administration of recombinant interleukin‐2 after autologous bone marrow transplantation. Blood 1990; 76: 1092–1097
  • Sykes M., Abraham V. S., Harty N. W., Pearson D. A. IL2 reduces graft versus host disease and preserves a graft versus leukemia effect by selectively inhibiting CD4+ T cell activity. J. Immunol. 1993; 150: 197–205
  • Smith K. A. Lowest dose interleukin‐2 immunotherapy. Blood, 81: 1414–1423
  • Atzpodien J., Körfer A., Franks C. R., Poliwoda H., Kirchner H. Home therapy with recombinant interleukin‐2 and interferon α2b in advanced human malignancies. Lancet 1990; 335: 1509–1512
  • Soiffer R. J., Murray C., Gonin R., Ritz J. Effect of low dose interleukin‐2 on disease relapse after T‐cell depleted allogeneic bone marrow transplantation. Blood 1994; 84: 964–971
  • Weisdorf D. J., Anderson P. M., Blazar B. R., Uckun F. M., Kersey J. H., Ramsay N. K. Interleukin‐2 immediately after autologous bone marrow transplantation for acute lymphoblastic leukemia: a phase I study. Transplantation 1993; 55: 61–66
  • Brenner M. K., Heslop H. E. Immunotherapy of leukemia. Leukemia 1992; 6: 76–79
  • Lehmann F., Marchand M., Hainaut P., Pouillart P., Sastre X., Ikeda H., Boon T., Coulie P. G. Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection. Eur. J. Immunol. 1995; 25: 340
  • Foa R. Does interleukin‐2 have a role in the management of acute leukemia. J. Clin. Oncol. 1993; 11: 1817–1825
  • Maraninchi D., Blaise D., Viens P., Brandely M., Olive D., Lopez M., Sainty D., Marit G., Stoppa A. M., Reiffers J., Gratecos N., Bertau‐Perez P., Mannoni P., Mawas C., Hercend T., Sebahoun G., Carcassonne Y. High dose recombinant interleukin‐2 and acute myeloid leukemias in relapse. Blood 1991; 78: 2182–2187
  • Meloni G., Foa R., Vignetti M., Guarini A., Fenu S., Tosti A. G., Mandelli F. Interleukin‐2 may induce prolonged remissions in advanced acute myelogenous leukemia. Blood 1994; 84: 2158–2163
  • Reittie J. E., Gottlieb D., Heslop H. E., Leger O., Drexler H. G., Hazlehurst G., Hoffbrand A. V., Prentice H. G., Brenner M. K. Endogenously generated activated killer cells circulate after autologous and allogeneic marrow transplantation but not after chemotherapy. Blood 1989; 73: 1351–1358
  • Higuchi C. M., Thompson J. A., Cox T., Lindgren C. G., Buckner C. D., Fefer A. Lymphokine activated killer function following autologous bone marrow transplantation for refractory hematological malignancies. Cancer Research 1989; 49: 5509–5513
  • Fierro M. T., Liao X. S., Lusso P., Bonferroni M., Matera L., Cesano A., Lista P., Arione R., Forni G., Foa R. In vitro and in vivo susceptibility of human leukemic cells to lymphokine activated killer activity. Leukemia 1988; 2: 50–54
  • Brenner M. K., Rill D. R., Moen R. C., Krance C., Miro J., Anderson W. F., Ihle J. N. Gene marking to trace origin of relapse after autologous bone marrow transplantation. Lancet 1993; 341: 85–86
  • Fefer A., Einstein A. B., Thomas D., Buckner C. D., Clift R. A., Glucksberg H., Neiman P. E., Storb R. Bone marrow transplantation for hematologic neoplasia in 16 patients with identical twins. The New Engl. J. of Med., 290: 1389–1393

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.