36
Views
2
CrossRef citations to date
0
Altmetric
Original Article

The Chronic Lymphocytic Leukemia Antigen (cCLLa) as Immunotherapy Target: Assessment of LD50 and MTD of Four Ricin-Based Anti-cCLLa Immunotoxins (ITs) in Balb/c Mice

&
Pages 531-537 | Accepted 06 Jul 1996, Published online: 01 Jul 2009

References

  • Foon K. A., Schroff R. W., Bunn P. A., Mayer D., Abrams P. G., Fer M., Ochs J., Bottino G. C., Sherwin S. A., Carlo D. J., et al. Effects of monoclonal antibody therapy in patients with chronic lymphocytic leukemia. Blood 1984; 64: 1085
  • Meeker T. C., Lowder J., Maloney D. B., Miller R. A., Thielmans K., Wamke R., Levy R. A clinical trial of anti‐idiotype therapy for B‐cell malignancy. Blood 1985; 65: 1349
  • Janson D., Nissel‐Horowitz S., Sattler M., Rai K. R. Complete and partial response in treatment of advanced refractory B‐cell chronic lymphocytic leukemia using CAMPATH‐1H. Blood 1993; 82: 139a, abstract
  • Vitetta E. S., Fulton R. J., May D., Till M., Uhr J. W. Redesigning nature's poisons to create anti‐tumor reagents. Science 1987; 238: 1098
  • Pastan I., Willingham M. C., Fitzgerald D. J. Immunotoxins. Cell 1986; 47: 641
  • Faguet G. B., Agee J. F. Fourricin chain A‐based immunotoxins directed against the common chronic lymphocytic leukemia antigen: In vitro characterization. Blood 1993; 82: 536
  • Hertler A. A., Schlossman D. M., Borowitz M. J., Laurent G., Jansen F. K., Schmidt C., Frankel A. E. A phase I study of T10l‐ricin A chain immunotoxin in refractory chronic lymphocytic leukemia. J. Biol. Resp. Modif 1988; 7: 97
  • Dillman R. O., Beauregard D. L., Shawler J. B., Halpern S. E., Markman M., Ryan K. P., Baird S. M., Cluter M. Continuous infusion of T101 monoclonal antibody in chronic lymphocytic leukemia and cutaneous T‐cell lym‐phoma. J. Biol. Resp. Modif. 1986; 5: 394
  • Grossbard M. L., Freedman S. A., Ritz J., Coral F., Goldmacher V. S., Eliseo L., Spector N., Dear K., Lambert J. M., Blatter W. A., et al. Serotherapy of B‐CLL neoplasms with anti‐B4–blocked ricin: A phase I trial of daily bolus infusion. Blood 1992; 79: 576
  • Vitetta E. S., Stone M., Amlot P., Fay J., May R., Till M., Newman J., Clark P., Collins R., Cunningham D., Ghetie V., Uhr J. W., Thorpe P. E. Phase I immunotoxin trial in patients with B‐cell lymphoma. Cancer Res. 1991; 54: 4052
  • Derocq J. M., Casellas P., Laurent G., Ravel S., Vidal H., Jansen F. Comparison of the cytotoxic potency of T101 Fab, F(ab)2 and whole IgG immunotoxins. J. Immunol. 1988; 141: 2837
  • Faguet G. B., Agee J. F. Monoclonal antibodies against the chronic lymphocytic leukemia antigen cCLLa: characterization and reactivity. Blood 1987; 70: 437
  • Faguet G. B., Agee J. F., Marti G. E. CDS and cCLLa expression in chronic lymphocytic leukemia (CLL): Demonstration of their relative prevalence and that of other common B‐CLL markers. Leukemia & Lymphoma 1992; 6: 335
  • Faguet G. B., Agee J. F. The chronic lymphocytic leukemia antigen (cCLLa) as immunotherapy target: Pharmacokinetics and biodistribution of two divalent, ricin‐based immunotoxins in xenografted, athymic mice. Leukemia & Lymphoma, 25: 509–520
  • Faguet G. B., Agee J. F. Transplantation of human hairy cell leukemia in radiation‐preconditioned nude mice: Characterization of the model by histological, histo‐chemical, phenotypic and tumor kinetics studies. Blood 1988; 71: 1511–1517
  • Faguet G. B., Agee J. F. A simple technique for the rapid enrichment of class and subclass hybridoma switch variants: A 1000–fold enrichment in half the time for half the cost. J. Immunol. Methods 1993; 165: 217
  • Ghetie M. A., May R. D., Till M., Uhr J. W., Ghetie V., Knowles P. P., Relf M., Brown A., Wallace P. M., Janossy G., Amlot P., Vitetta E. S., Thorpe P. E. Evaluation of ricin‐A‐chain‐containing immunotoxins directed against CD 19 and CD22 antigens on normal and malignant human B‐cells as potential reagents for in vivo therapy. Cancer Res. 1988; 48: 2610
  • Weil C. S. Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics 1952; 8: 249–163
  • Thompson W. R. Approximation of chi‐square by “probits” and by “logits”. Am. Stat. Assoc. 1947; 41: 70–74
  • Mordenti J. Phamacokinetic scale‐up: Accurate prediction of human pharmacokinetic profiles from animal data. J. Pharmaceutical Sciences 1985; 74: 1097–1099
  • Mordenti J. Man versus Beast: Pharmacokinetic scaling in mammals. J. Pharmaceutical Sciences 1986; 75: 1028–1040
  • Faguet G. B., Agee J. F., Marti G. E. Clone emergence and evolution in chronic lymphocytic leukemia: Characterization of the clinical, laboratory and immunopheno‐typic profiles in 25 patients. Leuk. Lymphoma 1992; 6: 345
  • Faguet G. B., Agee J. F. Kinetics of the malignant clone during fludarabine treatment of chronic lymphocytic leukemia (CLL). Blood 1989; 74: 274A
  • Bourne B. J. P., Casellas P., Blythman H. E., Jansen J. K. Study of the plasma clearance of antibody ricin‐A chain immunotoxins. Evidence for specific recognition sites on the A chain that mediate rapid clearance of the immunotoxin. Eur. J. Biochem. 1986; 155: 1
  • Zhu Z., Ghose T., Iles S., Yang C., Lee S. H. Pharmacokinetics, biodistribution and tumor localization of two anti‐human B‐cell chronic lymphocytic leukemia monoclonal antibodies and their F(ab)′2 fragments in a xenograft model. Cancer Letters 1994; 76: 31
  • Fulton R. J., Tucker T. F., Vitetta E. S., Uhr J. W. Pharmacokinetics of tumor‐reactive immunotoxins in tumor‐bearing mice: Effect of antibody valency and deglyco‐sylation of the ricin A chain on clearance and tumor localization. Cancer Res. 1988; 48: 2618
  • Schlesinger P. H., Doebber T. W., Mandell B. F., White R., SeSchryver C., Rodman J. S., Miller M. J., Stahl P. Plasma clearance of glycoproteins with terminal mannose and N‐acetylglucosamine by liver non‐parenchy‐mal cells. Studies with ™D‐glucosaminidase ribonuclease B and galacto‐orosomucoid. Biochem. J. 1978; 176: 103
  • Ramakrishnan S., Houston L. L. Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide‐linked pokeweed antiviral protein‐antibody conjugates from blood. Cancer Res. 1985; 45: 2031–2036
  • Worrell N. R., Cumber A. J., Pamell G. D., Ross W. C. J., Forrester J. A. Fate of an antibody‐ricin A conjugate administered to normal rats. Biochem. Pharmacol. 1986; 35: 417
  • Blakey D. C., Watson G. J., Knowles P. P., Thorpe P. E. Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti‐Thy‐1.1 antibody. Cancer Res. 1987; 47: 947
  • Thorpe P. E., Detre S. I., Foxwell B. M., Brown A. N. F., Skilleter D. N., Wilson G., Forrester J. A., Stirpe F. Modifications of the carbohydrate in ricin with meta‐periodate‐cyanoborohydride mixtures, Effects on toxicity and in vivo distribution. Eur. J. Biochem. 1985; 147: 197
  • Collins J. M., Zaharko D. S., Dedrick R. L., Chabner B. A. Potential roles for preclinical pharmacology in phase I clinical trials. Cancer Treat. Rep. 1986; 70: 73–80

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.