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Original Article

Clinicopathological Impact of the Interaction Between Megakaryocytes and Myeloid Stroma in Chronic Myeloproliferative Disorders: A Concise Update

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Pages 463-481 | Received 27 May 1996, Published online: 01 Jul 2009

References

  • Bentley S. A. Bone marrow connective tissue and the haematopoietic microenvironment. Br. J. Haematol. 1982; 50: 1–6
  • McCarthy D. M. Fibrosis of the bone marrow: Content and causes. Br. J. Haematol. 1985; 59: 1–7
  • Lewis S. M. Myelofibrosis: Historical perspective. Myelofibrosis, Pathophysiology and Clinical Management, S. M. Lewis. Marcel Dekker, New York 1985; 1–13
  • Charron D., Robert L., Couty M. C., Binet J. L. Biochemical and histological analysis of bone marrow collagen in myelofibrosis. Br. J. Haematol. 1979; 41: 151–61
  • Gay S., Gay R. E., Prchal J. T. Immunohistological studies of bone marrow collagen. Myelofibrosis and the Biology of Connective Tissue, P. Berk, H. Castro-Malaspina, L. Wasserman. Alan R. Liss, New York 1984; 291–306
  • Apaja-Sarkkinen M., Autio-Harmainen H., Alavaikko M., Risteli J., Risteli L. Immunohistochemical study of basement membrane proteins and type III procollagen in myelofibrosis. Br. J. Haematol. 1986; 63: 571–580
  • Reilly J. T., Nash J. R. G., Mackie M. J., McVerry B. A. Endothelial cell proliferation in myelofibrosis. Br. J. Haematol. 1985; 60: 625–630
  • Lisse I., Hasselbach H., Junker P. Bone marrow stroma in idiopathic myelofibrosis and other haematological diseases. An immunohistological study. APMIS 1991; 99: 171–178
  • Reilly J. T., Nash J. R. G., Mackie M. J., McVerry B. A. Immuno-enzymatic detection of fibronectin in normal and pathological tissue. Br. J. Haematol. 1985; 59: 497–504
  • Roberts A. B., Sporn M. B., Assoian R. K., Smith J. M., Roche N. S., Wakefield L. M., Heine U. I., Liotta L. A., Falanga V., Kehrl J. H., Fauci A. S. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA 1986; 83: 4167–4171
  • Hasselbach H. On the pathogenesis of angiogenesis in idiopathic myelofibrosis. Am. J. Hematol. 1990; 33: 151
  • Thiele J., Rompcik V., Wagner S. T., Fischer R. Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: An immunomorphometric study on trephine biopsies of the bone marrow. Br. J. Haematol. 1992; 80: 227–234
  • Burkhardt R., Bartl R., Jaeger K., Frisch B., Kettner G., Mahl G., Sund M. Chronic myeloproliferative disorders (CMPD). Path. Res. Pract. 1984; 179: 131–186
  • Frisch B., Bartl R. Histology of myelofibrosis and osteomyelosclerosis. Myelofibrosis, Pathophysiology and Clinical Management, S. M. Lewis. Marcel Dekker, New York 1985; 51–86
  • Georgii A., Vykoupil K. F., Buhr T., Choritz H., Dohler U., Kaloutsi V., Werner M. Chronic myeloproliferative disorders in bone marrow biopsies. Path. Res. Pract. 1990; 186: 3–27
  • Buhr T., Georgii A., Choritz H. Myelofibrosis in chronic myeloproliferative disorders. Incidence among subtypes according to the Hannover Classification. Path. Res. Pract. 1993; 189: 121–132
  • Bartl R., Frisch B., Wilmanns W. Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD). Eur. J. Haematol. 1993; 50: 41–52
  • Dickstein J. I., Vardiman J. W. Issues in the pathology and diagnosis of the chronic myeloproliferative disorders and the myelodysplastic syndromes. Am. J. Clin. Pathol. 1993; 99: 513–525
  • Adamson J. W., Fialkow P. J. The pathogenesis of myeloproliferative disorders. Br. J. Haematol. 1978; 38: 299–303
  • Jacobson R. J., Salo A., Fialkow P. J. Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood 1978; 51: 189–94
  • Groopman J. E. The pathogenesis of myelofibrosis in myeloproliferative disorders. Ann. Intern. Med. 1980; 92: 857–858
  • Huang S., Terstappen L. W. Formation of hematopoietic microenviroment and haematopietic stem cells from single human bone marrow stem cells. Nature 1992; 360: 745–749
  • Greenberg B. R., Wilson F. D., Woo L., Jenks H. M. Cytogenetics of fibroblastic colonies in PH1-positive chronic myelogenous leukemia. Blood 1978; 51: 1039–1044
  • Golde D. W., Hocking W. G., Quan S. G., Sparkes R. S., Gale R. P. Origin of human bone marrow fibroblasts. Br. J. Haematol. 1980; 44: 183–187
  • Castro-Malaspina H., Gay R. E., Resnick G., Kapoor N., Meyers P., Chiarieri D., McKenzie S., Broxmeyer H. E., Moore M. A. S. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980; 56: 289–301
  • Greenberg B. R., Woo L., Veomett I. C., Payne C. M., Ahmann F. R. Cytogenetics of bone marrow fibroblastic cells in idiopathic chronic myelofibrosis. Br. J. Haematol. 1987; 66: 487–490
  • O'Brian S., Kantarjan H., Shtalrid M., Blick M., Beran M., Talpaz M. Lack of cluster region rearrangement in marrow fibroblasts of patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Hematol. Pathol. 1988; 2: 25–29
  • Wang J. C., Lang H. D., Lichter S., Weinstein M., Benn P. Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia. Br. J. Haematol. 1992; 80: 184–188
  • Waller E. K., Olweus J., Lund-Johansen F., Huang S., Nguyen M., Guo G. R., Terstappen L. The “common stem cell” hypothesis reevaluated: Human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood 1995; 85: 2422–2435
  • Bhatia R., McGlave P. M., Dewald G. W., Blazar B. R., Verfaillie C. M. Abnormal function of the bone marrow microenviroment in chronic myelogenous leukemia: Role of malignant stromal macrophages. Blood 1995; 85: 3636–3645
  • Castro-Malaspina H. Pathogenesis of myelofibrosis: Role of ineffective megakaryopoiesis and megakaryocyte components. Myelofibrosis and the Biology of Connective Tissue, P. Berk, H. Castro-Malaspina, L. Wasserman. Alan R Liss, New York 1984; 427–454
  • Reilly J. T. Pathogenesis of idiopathic myelofibrosis: Role of growth factors. J. Clin. Pathol. 1992; 45: 461–464
  • Kimura A., Katoh O., Hyodo H., Kuramoto A., Satow Y. Platelet derived growth factor expression, myelofibrosis and chronic myelogenous leukemia. Leukemia Lymphoma 1995; 18: 237–242
  • Hiti-Harper J., Wohl H., Harper E. Platelet factor 1978; 4, An inhibitor of collagenase. Science; 199:991–992
  • Chernoff A., Levine R. F., Goodman D. S. Origin of platelet-derived growth factor in megakaryocytes in guinea pigs. J. Clin. Invest. 1979; 65: 926–930
  • Scher C. D., Shepard R. C., Antoniades H. N., Stiles C. D. Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochim. Biophys. Acta 1979; 560: 217–241
  • Burstein S. A., Malpass T. W., Yee E., Kadin M., Bridgen M., Adamson J. W., Marker L. A. Platelet factor 4-excretion in myeloproliferative disease: Implications for the aetiology of myelofibrosis. Br. J. Haematol. 1984; 57: 383–392
  • Assoian R. K., Grotendorst G. R., Miller D. M., Sporn M. B. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 1984; 309: 804–806
  • Castro-Malaspina H., Rabellino E., Yen A., Nachman R. L., Moore M. A. S. Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood 1981; 57: 781–787
  • Bernabei P. A., Arcangeli A., Casini M., Grossi A., Padovani R., Rossi Ferrini P. Platelet-derived growth factor(s) mitogenic activity in patients with myeloproliferative disease. Br. J. Haematol. 1992; 63: 353–357
  • Kimura A., Katoh O., Kuramoto A. Effects of platelet-derived growth factor, epidermal growth factor and transforming growth factor-β on the growth of human marrow fibroblasts. Br. J. Haematol. 1988; 69: 9–12
  • Katoh O., Kimura A., Kuramoto A. Platelet-derived growth factor is decreased in patients with myeloproliferative disorders. Am. J. Hematol. 1988; 27: 276–280
  • Baglin T. P., Price S. M., Boughton B. J. A reversible defect of platelet PDGF content in myeloproliferative disorders. Br. J. Haematol. 1988; 69: 483–486
  • Kimura A., Katoh O., Hyodo H., Kuramoto A. Transforming growth factor-β regulates growth as well as collagen and fibronectin synthesis of human marrow fibroblasts. Br. J. Haematol. 1989; 72: 486–491
  • Katoh O., Kimura A., Itoh T., Kuramoto A. Platelet derived growth factor messenger RNA is increased in bone marrow megakaryocytes in patients with myeloproliferative disorders. Am. J. Hematol. 1990; 35: 145–150
  • Rueda F., Piñol G., Marti F., Pujol-Moix N. Abnormal levels of platelet-specific proteins and mitogenic activity in myeloproliferative disease. Acta Haematol. 1991; 85: 12–15
  • Martyré M. C. Platelet PDGF and TGF: Levels in myeloproliferative disorders. Leukemia Lymphoma 1991; 6: 1–6
  • Kimura A., Nakata Y., Hyodo H., Kuramoto A., Satow Y. Platelet-derived growth factor expression in accelerated and blastic phase of chronic myelogeneous leukaemia with myelofibrosis. Br. J. Haematol. 1994; 86: 303–307
  • Martyré M. C., Romquin N., Bousse-Kerdiles M. C., Chewillard S., Benyahia B., Dupriez B., Demory J. L., Bauters F. Transforming growth factor-β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis. Br. J. Haematol. 1994; 88: 9–16
  • Maryré M. C. TGF-β and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders. Leukemia Lymphoma 1995; 20: 39–44
  • Wickenhauser C., Hillienhof A., Jungheim K., Lorenzen J., Ruskowski H., Hansmann M.-L., Thiele J., Fischer R. Detection and quantification of transforming growth factor β (TGF-β) and platelet derived growth factor (PDGF) release by normal human megakaryocytes. Leukemia 1995; 9: 310–315
  • Wickenhauser C., Lorenzen J., Thiele J., Hillienhof A., Jungheim K., Schmitz B., Hansmann M.-L., Fischer R. Secretion of cytokines (interleukins-1α, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood 1995; 85: 685–691
  • Schmitz B., Thiele J., Kaufmann R., Witte O., Wickenhauser C., Kuhn-Regnier F., Fischer R. Megakaryocytes and fibroblasts-interactions as determined in normal human bone marrow specimens. Leukemia Res. 1995; 19: 629–637
  • Schmitz B., Thiele J., Witte O., Kaufmann R., Wickenhauser C., Fischer R. Influence of cytokines (IL-1α, IL-3, IL-11, GM-CSF) on megakaryocyte-fibroblast interactions in normal human bone marrow. Eur. J. Haematol. 1995; 55: 24–32
  • Kimura A., Katoh O., Hyodo H., Kusumi S., Kuramoto A. Autocrinie and/or paracrine meachnism operate during the growth of human bone marrow fibroblasts. Br. J. Haematol. 1991; 78: 469–473
  • Singal R., Belliveau R. R. Quantification of megakaryocytes in normal bone marrow. Analyt. Quant. Cytol. Histol. 1988; 10: 33–36
  • Lazzarino M., Morra E., Castello A., Inverardi D., Coci A., Pagnuco G., Magrini U., Zei G., Bernasconi C. Myelofibrosis in chronic granulocytic leukemia. Br. J. Haematol. 1986; 64: 227–240
  • Burkhardt R. Bone marrow in megakaryocytic disorders. Hematol. Oncol. Clin. N. Am. 1988; 2: 695–733
  • Kaloutsi V., Fritsch R. S., Buhr T., Restrepo-Specht I., Widjaja W., Georgii A. Megakaryocytes in chronic myeloproliferative disorders: Numerical density correlated between different entities. Virchows Archiv A Pathol. Anat. 1991; 418: 493–497
  • Thiele J., Hoeppner B., Zankovich R., Fischer R. Histomorphometry of bone marrow biopsies in primary osteomyelofibrosis/-sclerosis (agnogenic myeloid metaplasia)—correlations between clinical and morphological features. Virchows Archiv A Pathol. Anat. 1989; 415: 191–202
  • Thiele J., Wienhold S., Zankovich R., Fischer R. A histomorphometric analysis of trephine biopsies of bone marrow from 65 patients with chronic myeloid leukemia. Classification of patients into subgroups with different survival patterns. Analyt. Quant. Cytol. Histol. 1990; 12: 103–116
  • Gatter K. C., Cordell J. L., Turley H., Heryet A., Kiefer N., Anstee D. J., Mason D. J. The immunohistological detection of platelet, megakaryocytes and thrombi in routinely processed specimens. Histopathology 1988; 13: 257–267
  • Thiele J., Fischer R. Megakaryocytopoiesis in haematological disorders: Diagnostic features of bone marrow biopsies. Virchows Archiv A Pathol. Anat. 1991; 418: 87–97
  • Thiele J., Kvasnicka H. M., Titius B. R., Parpert U., Nebel R., Zankovich R., Dienemann D., Stein H., Diehl V., Fischer R. Histological features of prognostic significance in CML-an immunohistochemical and morphometric study (multivariate regression analysis) on trephine biopsies of the bone marrow. Ann. Hematol. 1993; 66: 291–302
  • Thiele J., Kvasnicka H. M., Niederle N., Zirbes T. K., Schmidt M., Dammasch J., Meuter B. R., Leder L.-D., Kloke O., Diehl V., Fischer R. The impact of interferon versus busulfan therapy on the reticulin stain-measured fibrosis in CML-a comparative morphometric study on sequential trephine biopsies. Ann. Hematol. 1995; 70: 121–128
  • Kvasnicka H. M., Thiele J., Amend T., Fischer R. Three-dimensional (3D) reconstruction of histological structures in human bone marrow from serial sections of trephine biopsies: The stereological appearance of sinusoidal vessels in primary (idiopathic) osteomyelofibrosis. Analyt. Quant. Cytol. Histol. 1994; 16: 159–166
  • Thiele J., Titius B. R., Kopsidis C., Fischer R. Atypical micromegakaryocytes, promegakaryoblasts and megakaryoblasts: A critical evaluation by immunohisto-chemistry and morphometry of bone marrow trephines in chronic myeloid leukemia and myelodysplastic syndromes. Virchows Archiv B Cell Pathol. 1992; 62: 275–282
  • Dekmezian R., Kantarjian H. M., Keating M., Talpaz M., McCredie K. B., Freireich E. J. The relevance of reticulin stain-measured fibrosis at diagnosis in chronic myelogenous leukemia. Cancer 1987; 57: 1739–1743
  • Lohmann T. B., Beckman E. N. Progressive myelofibrosis in agnogenic myeloid metaplasia. Arch. Pathol. Lab. Med. 1983; 107: 593–594
  • Manoharan A., Pitney W. R. Chemotherapy resolves symptoms and reverses fibrosis in myelofibrosis. Scand. J. Haematol. 1984; 33: 453–459
  • Charbord P., Neel H., Caillou B., Kahn E., Parmentier C. Effect of alkylating agents on hematopoiesis in myelofibrosis. Nouv. Rev. Fr. d'Hématol. 1984; 26: 361–369
  • Wolf B. C., Neiman R. S. Myelofibrosis with myeloid metaplasia: Pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly. Blood 1985; 65: 803–809
  • Ellis J. T., Peterson P., Geller S. A., Rappaport H. Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies. Semin. Hematol. 1989; 23: 144–155
  • Thiele J., Simon K. G., Fischer R., Zankovich R. Follow-up studies with sequential bone marrow biopsies in chronic myeloid leukemia and so-called primary (idiopathic) osteo-myelofibrosis. Evolution of histopathological lesions and clinical courses in 40 patients. Pathol. Res. Pract. 1988; 183: 434–445
  • Löfvenberg E., Wahlin A., Roos G., Öst Å. Reversal of myelofibrosis by hydroxyurea. Eur. J. Haematol. 1990; 44: 33–38
  • Hasselbach H., Lisse I. A sequential histological study of bone marrow fibrosis in idiopathic myelofibrosis. Eur. J. Haematol. 1991; 46: 285–289
  • Buhr T., Choritz H., Georgii A. The impact of megakaryocyte proliferation for the evolution of myelofibrosis. Histological follow-up study in 186 patients with chronic myeloid leukemia. Virchows Archiv A Pathol. Anal. 1992; 420: 473–478
  • Thiele J., Chen Y. S., Kvasnicka H. M., Diehl V., Fischer R. Evolution of fibro-osteosclerotic bone marrow lesions in primary (idiopathic) osteomyelofibrosis—a histomorphometric study on sequential trephine biopsies. Leukemia Lymphoma 1994; 14: 163–169
  • Mc Glave P. B., Brunning R. D., Hurd D. D., Kim T. H. Reversal of severe bone marrow fibrosis and osteosclerosis following allogeneic bone marrow transplantation for chronic granulocyte leukaemia. Br. J. Haematol. 1982; 52: 189–194
  • Oblon D. J., Elvenbein G. J., Braylam R. C., Jones J., Weiner R. S. The reversal of myelofibrosis associated with chronic myelogenous leukemia after allogeneic bone marrow transplantation. Exp. Hematol. 1983; 11: 681–685
  • Dokal I., Jones L., Deenmamode M., Lewis S. M., Goldman J. M. Allogeneic bone marrow transplantation for primary myelofibrosis. Br. J. Haematol. 1989; 71: 158–159
  • Ifrah N., Gardembas-Pain M., Hunault M., Saint-Andre J. P., Foussard C., Boasson M. Allogeneic bone marrow transplantation for primary myelofibrosis. Br. J. Haematol. 1989; 73: 575–576
  • Granstein R. D., Murphy G. F., Margolis R. J., Byrne M. H., Amento E. P. Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J. Clin. Invest. 1987; 79: 1254–1258
  • Parmeggiani L., Ferrant A., Rodhain J., Michaux J. L., Sokal G. Alpha interferon in the treatment of symptomatic myelofibrosis with myeloid metaplasia. Eur. J. Haematol. 1987; 39: 228–232
  • Hasselbalch H. Interferon in myelofibrosis. Lancet 1988; I: 355
  • Barosi G., Liberato L. N., Costa A., Ascari E. Cytoreductive effect of recombinant alpha interferon in patients with myelofibrosis with myeloid metaplasia. Blut 1989; 58: 271–274
  • Barosi G., Liberato L. N., Costa A., Buratti A., Di Dio F., Salvatore S., Ascari E. Induction and maintenance alpha-interferon therapy in myelofibrosis with myeloid metaplasia. Eur. J. Haematol. 1990; 45: 12–14
  • McCarthy D., Clark J., Giles F. The treatment of myelofibrosis with α-interferon. Br. J. Haematol. 1991; 78: 590–591
  • Sacchi S. The role of a α-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM) A concise update. Leukemia Lymphoma 1995; 19: 13–20
  • Bauermeister D. E. Quantification of bone marrow reticulin: A normal range. Am. J. Clin. Pathol. 1971; 56: 24–31
  • Beelen D. W., Graeven U., Elmaagacli A. H., Niederle N., Kloke O., Opalka B., Schaefer W. Prolonged administration of interferon-α in patients with chronic-phase Philadelphia chromosome-positive chronic myelogenous leukemia before allogeneic bone marrow transplantation may adversely affect transplant outcome. Blood 1995; 6: 2981–2990
  • Branehög I., Ridell B., Swolin B., Weinfeld A. Megakaryocyte quantifications in relation to thrombokinetics in primary thrombocythemia and allied diseases. Scand. J. Haematol. 1975; 15: 321–332
  • Thiele J., Zankovich R., Schneider G., Kremer B., Fischer R., Diehl V. Primary (essential) thrombocythemia versus polycythemia vera rubra. A histomorphometric analysis of bone marrow features in trephine biopsies. Analyt. Quant. Cytol. Histol. 1988; 10: 375–382
  • Nafe R., Kaloutsi V., Fritsch R. S., Georgii A. Quantitative cytomorphology of megakaryocytes in chronic myeloproliferative disorders-Analysis of planimetric and numeric characteristics by means of a knowledge based system. Exp. Pathol. 1990; 40: 213–219
  • Nafe R., Georgii A., Kaloutsi V., Fritsch R. S., Choritz H. Planimetric analysis of megakaryocytes in the four main groups of chronic myeloproliferative disorders. Virchows Archiv B Cell Pathol. 1991; 61: 111–116
  • Thiele J., Wagner S., Bertsch H. P., Wienhold S., Fischer R. Pro-megakaryoblasts in bone marrow tissue from patients with primary (idiopathic) osteo-myelofibrosis (agnogenic myeloid metaplasia). Path. Res. Pract. 1990; 186: 586–596
  • Thiele J., Wagner S., Degel C., Dienemann D., Wienhold S., Zankovich R., Fischer R., Stein H. Megakaryocyte precursors (pro- and megakaryoblasts) in bone marrow tissue from patients with reactive thrombocytosis, polycythemia vera and primary (essential) thrombocythemia. An immunomorphometric study. Virchows Archiv B Cell Pathol. 1990; 58: 295–302
  • Thiele J., Wagner S., Weuste R., Dienemann D., Wienhold S., Zankovich R., Fischer R., Stein H. An immunomorphometric study on megakaryocyte precursor cells in bone marrow tissue from patients with chronic myeloid leukemia (CML). Eur. J. Haematol. 1990; 44: 63–70
  • Thiele J., Hoefer M., Kvasnicka H. M., Bertsch H. P., Zankovich R., Fischer R. Erythropoiesis in CML-immunomorphometric quantification, PCNA-reactivity, and influence on survival. Hematol. Pathol. 1993; 7: 239–249
  • Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British cooperative group. Ann. Intern. Med. 1985; 103: 460–462
  • Den Ottolander G. J., Velde J., Brederoo P., Geraedts J. P. M., Slee P. H. T., Willemze R., Zwaan F. E., Haak H. L., Muller H. P., Bieger R. Megakaryoblastic leukaemia (acute myelofibrosis) A report of three cases. Br. J. Haematol. 1979; 42: 9–20
  • Bain B. J., Catovsky D., O'Brien M., Prentice H. G., Lawlor E., Kumaran T. O., McCann S. R., Matutes E., Galton D. A. G. Megakaryoblastic leukemia presenting as acute myelofibrosis—a study of four cases with the platelet-peroxidase reaction. Blood 1981; 58: 206–213
  • Huang M. J., Li C. Y., Nichols W. L., Young J. H., Katzmann J. A. Acute leukemia with megakaryocyte differentiation: A study of 12 cases identified immunocytochemically. Blood 1984; 64: 427–439
  • Hruban R. H., Kuhajda F. P., Mann R. B. Acute myelofibrosis. Am. J. Clin. Pathol. 1987; 88: 578–588
  • Ribeiro R. C., Oliveira M. S. P., Fairclough D., Hurwitz C., Mirro J., Behm F. G., Head D., Silva M. L. M., Raimondi S. C., Crist W. M., Krance R. Acute megakaryoblastic leukemia in children and adolescents: A retrospective analysis of 24 cases. Leukemia Lymphoma 1993; 10: 299–306
  • Terui T., Niitsu Y., Mahara K., Fujisaki Y., Urushizaki Y., Kohgo Y., Watanabe N., Ogura M., Saito H. The production of transforming growth factor-β in acute megakaryoblastic leukemia and its possible implication in myelofibrosis. Blood 1990; 75: 1540–1548
  • Reilly J. T., Barnett D., Dolan G., Forrest P., Eastham J., Smith A. Characterization of an acute micromegakaryocytic leukaemia: Evidence for the pathogenesis of myelofibrosis. Br. J. Haematol. 1993; 83: 58–62
  • Cervantes F., Rozman C. A multivariate analysis of prognostic factors in chronic myeloid leukemia. Blood 1982; 60: 1298–1304
  • Sokal J. E., Cox E. B., Baccarani M., Tura S., Gomez G. A., Robertson J. D., Tso C. Y., Braun T. J., Clarkson B. D., Cervantes F., Rozman C. The Italian Cooperative CML Study Group. Prognostic discrimination in “good-risk” chronic granulocytic leukemia. Blood 1984; 63: 789–799
  • Kantarjian H. M., Smith T. L., McCredie K. B., Keating M. J., Walters R. S., Talpaz M., Hester J. P., Bligham G., Gehan E., Freireich E. J. Chronic myelogenous leukemia: A multivariate analysis of the associations of patient characteristics and therapy with survival. Blood 1985; 66: 1326–1335
  • Sokal J. E., Baccarani M., Russo D., Tura S. Staging and prognosis in chronic myelogenous leukemia. Semin. Hematol. 1988; 25: 49–61
  • Kantarjian H., Keating M. J., Smith T. L., Talpaz M., McCredie K. B. Proposal for a simple synthesis prognostic staging system in chronic myelogenous leukemia. Am. J. Med. 1990; 88: 1–8
  • The Italian Cooperative Study Group On Chronic Myeloid Leukemia. Confirmation and improvement of Sokal's prognostic classification of Ph+ chronic myeloid leukemia—the value of early evaluation of the course of the disease. Ann. Hematol. 1991; 63: 307–314
  • Kantarjian H. M., Deisseroth A. S., Kurzrock R., Estrov Z., Talpaz M. Chronic myelogenous leukemia: a concise update. Blood, 82: 691–703
  • Hehlmann R., Heimpel H., Hasford J., Kolb H. J., Pralle H., Hossfeld D. K. Randomized comparison of interferon-α with busulfan and hydroxyurea in chronic myelogenous leukemia. Blood 1994; 84: 4064–4077, the German CML Study Group.
  • Morra E., Lazzarino M., Alimena G., Liberati A. M., Grignani F., Mandelli F., Bernasconi C. The role of interferon in the treatment of chronic myelogenous leukemia: Results and prospects. Leukemia Lymphoma 1992; 6: 305–315
  • Ozer H., George S. L., Schiffer C. A., Rao K., Rao P. N., Wurster-Hill D. H., Arthur D. D., Powell B., Gottlieb A., Peterson B. A., Rai K., Testa J. R., LeBeau M., Tantravahi R., Bloomfield C. D. Prolonged subcutaneous administration of recombinant α2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: Effect on remission duration and survival: Cancer and Leukemia Group B Study 8583. Blood 1993; 82: 2975–2984
  • Niederle N., Kloke O., Wandl U. B., Becher R., Moritz T., Opalka B. Long-term treatment of chronic myelogenous leukemia with different interferons: Results from three studies. Leukemia Lymphoma 1993; 9: 111–119
  • The Italian Cooperative Study Group On Chronic Myeloid Leukimia. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N. Engl. J. Med. 1994; 330: 820–825
  • Kantarjian H. M., Smith T. L., O'Brien S., Beran M., Pierce S., Talpaz M. Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-α therapy. Ann. Intern. Med. 1995; 122: 254–261, The Leukemia Service.
  • Allan N. C., Richards S. M., Shepherd P. C. A. on behalf of the UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia. UK Medical Researche Council randomised, multicentre trial of interferon-αnl for chronic myeloid leukaemia: improved survival irrespective of cytogenic response. Lancet 1995; 345: 1392–1397
  • Gralnick H. R., Harbor J., Vogel C. Myelofibrosis in chronic granulocytic leukemia. Blood 1971; 37: 152–162
  • Byssens N., Bourgeois N. H. Chronic myelocytic leukemia versus idiopathic myelofibrosis. A diagnostic problem in bone marrow biopsies. Cancer 1977; 40: 1548–1561
  • Clough V., Geary C. G., Hashimi K., Davson G., Knowlson T. Myelofibrosis in chronic granulocytic leukaemia. Br. J. Haematol. 1979; 42: 515–526
  • Thiele J., Kvasnicka H. M., Zankovich R., Fischer R., Diehl V. Parameters of predictive value in CML-the prognostic impact of histopathological variables in a multivariate regression analysis. Leukemia Lymphoma 1991; 4: 63–74
  • Thiele J., Kvasnicka H. M., Niederle N., Koke O., Schmidt M., Lienhard H., Zirbes T., Meuter R. B., Leder L. D., Fischer R. Clinical and histological features retain their prognostic impact under interferon therapy of CML: A pilot study. Am. J. Hematol. 1995; 50: 30–39
  • Lorand-Metze I., Vasallo J., Souza C. A. Histological and cytological heterogeneity of bone marrow in Philadelphia-positive chronic myelogenous leukaemia at diagnosis. Br. J. Haematol. 1987; 67: 45–49
  • Lorand-Metze I. Bone marrow morphology at diagnosis as a prognostic parameter in Philadelphia-positive chronic myelogenous leukaemia (CML). Br. J. Haematol. 1989; 71: 163
  • Charbord P. Increased vascularity of bone marrow in myelofibrosis. Br. J. Haematol. 1989; 62: 595–596
  • Van Dyke D., Anger H. O., Parker H., McRae J., Dobson E. L., Yano Y., Naets J. P., Linfoot J. Markedly increased bone blood flow in myelofibrosis. J. Nucl. Med. 1971; 72: 506–512
  • Miyazono K., Okabe T., Urabe A., Takaku F., Heldin C. H. Purification and properties of an endothelial cell growth factor from human platelets. J. Biol. Chem. 1987; 262: 4098–4103
  • Folkman J., Klagsbrun M. Angiogenic factors. Science 1987; 235: 442–447
  • Roberts A. B., Heine U. I., Flanders K. C., Spron M. B. Transforming growth factor-β: Major role in regulation of extracellular matrix. Ann. NY. Acad. Sci. 1990; 580: 225–232
  • Vaughan J. M., Harrison C. V. Leuco-erythroblastic anaemia and myelosclerosis. J. Pathol. Bacteriol 1939; 48: 339–352
  • Partanen S., Ruutu T., Vuopio P. Circulating haematopoietic progenitors in myelofibrosis. Scand. J. Haematol. 1982; 29: 325–330
  • Hibbin J. A., Njoku O. S., Matutes E., Lewis S. M., Goldman J. M. Myeloid progenitor cells in the circulation of patients with myelofibrosis and other myeloproliferative disorders. Br. J. Haematol. 1984; 57: 495–503
  • Grossi A., Vannuchi A. M., Rafanelli D., Vannucchi L., Ferrini P. R. Megakaryocyte progenitors in the bone marrow and peripheral blood of patients with myeloproliferative diseases. Am. J. Hematol. 1987; 25: 371–376
  • Han Z. C., Briere J., Nedellec G., Abgrall J. F., Sensebe L., Parent D., Guern G. Characteristics of circulating megakaryocyte progenitors (CFU-MK) in patients with primary myelofibrosis. Eur. J. Haemtol. 1988; 40: 130–135
  • Wolf B. C., Neiman R. S. Hypothesis: Splenic filtration and the pathogenesis of extramedullary hematopoiesis in agnogenic myeloid metaplasia. Hematol. Pathol. 1987; 1: 77–80
  • Falk S., Mix D., Stutte H. J. The spleen in osteomyelofibrosis. A morphological and immunohisto-chemical study of 30 cases. Virchows Archiv A Pathol Anat. 1990; 416: 437–442
  • O'Keane J. C., Wolf B. C., Neiman R. S. The pathogenesis of splenic extramedullary hematopoiesis in metastatic carcinoma. Cancer 1989; 63: 1539–1543
  • Thiele J., Klein H., Falk S., Bertsch H. P., Fischer R., Stutte H. J. Splenic megakaryocytopoiesis in primary (idiopathic) osteomyelofibrosis. Acta Haematol. 1992; 87: 176–180
  • Lichtman M. A., Chamberlain J. K., Simon W., Santillo P. A. Parasinuoidal location of megakaryocytes in marrow: A determinant of platelet release. Am. J. Hematol. 1978; 4: 303–312
  • Young K. M. Localization of megakaryocytes in bone marrow. Blood cells 1989; 15: 15–21
  • Thiele J., Kvasnicka H. M., Amend T., Fischer R. Megakaryocytes and sinus walls in primary osteomyelofibrosis: Transendothelial migration as revealed by three-dimensional reconstruction of serial sections following sequential double-immunostaining. Virchows Archiv 1994; 424: 383–387
  • Becker R. P., DeBruyn P. P. H. The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation. Am. J. Anat. 1976; 145: 183–206
  • Tavassoli M., Aoki M. Migration of entire megakaryocytes through the marrow blood barrier. Br. J. Haematol. 1981; 48: 25–29
  • Melamed M. R., Clifton E. E., Mercer C., Koss L. G. The megakaryocyte blood count. Am. J. Med. Sci. 1966; 252: 301–309
  • Maniatis A. K. Megakaryocytes and platelets in central venous and arterial blood. Am. J. Haemtol. 1969; 42: 330–335
  • Hansen M., Pedersen N. T. Circulating megakaryocytes in blood from the antecubital vein in healthy adult humans. Scand. J. Haematol. 1978; 20: 371–376
  • Pedersen N. T. Occurrence of megakaryocytes in various vessels and their retention in the pulmonary capillaries in man. Scand. J. Haematol. 1978; 221: 369–375

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