169
Views
41
CrossRef citations to date
0
Altmetric
Original Article

Stem Cell Factor, the JAK-STAT Pathway and Signal Transduction

, , , , , & show all
Pages 439-444 | Published online: 01 Jul 2009

References

  • McCormack F. Activators and effectors of ras p21 proteins. Current Opinion in Genetics and Development 1994; 4: 71–76
  • Barone M. V., Courtneidge S. A. Myc but not Fos rescue of PDGF signalling block caused by kinase‐inactive. Src. Nature 1995; 378: 509–512
  • Eisenman R. N., Cooper J. A. Beating a path to Myc. Nature 1995; 378: 438–439
  • Darnell J. E., Kerr I. M., Stark G. R. Jak‐STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins. Nature 1994; 264: 1415–1425
  • Ihle J. N. Cytokine receptor signalling. Nature 1995; 377: 591–594
  • Ihle J. N. STATs: signal transducers and activators of transcription. Cell 1996; 84: 331–334
  • Shuai K., Ziemiecki A., Wilks A. F., Harpur A. G., Sadowski H. B., Gilman M. Z., Darnell J. E. Polypeptide signalling to the nucleus through tyrosine phosphorylation of lak and Stat proteins. Nature 1993; 366: 580–585
  • Novak U., Harpur A. G., Paradise L., Kanagasundaram V., Jowarowski A., Wilks A. F., Hamilton J. A. CSF‐1‐induced STAT1 and STAT3 activation is accompanied by phosphorylation of tyk2 in macrophages and tyk2 and JAK1 in fibroblasts. Blood 1995; 86: 2948–2956
  • Vignais M‐L., Sadowski H. B., Watling D., Rogers N. C., Gilman M. Platelet‐derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol 1996; 16: 1759–1769
  • Leaman D. W., Pisharody S., Flickinger T. W., Commane M. A., Schlessinger J., Kerr I. M., Levy D. E., Stark G. R. Roles of JAKs in activation of STATs and stimulation of c‐fos gene expression by epidermal growth factor. Mol. Cell Biol. 1996; 16: 369–375
  • Silvennoinen O., Schnindler C., Schlessinger J., Levy D. E. Ras‐independent growth factor signaling by transcription factor tyrosine phosphorylation. Science 1993; 261: 1736–1739
  • Zhong Z., Wen Z., Darnell J. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin‐6. Science 1994; 264: 95–99
  • Sadowski H. B., Shuai K., Darnell J. E., Gilman M. Z. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 1993; 261: 1739–1741
  • Ruff‐Jamison S., Chen K., Cohen S. EGF induces the tyrosine phosphorylation and nuclear translocation of Stats in mouse liver. Proc. Natl. Acad. Sci. USA 1995; 92: 4215–4218
  • Novak U., Mui A., Miyajima A., Paradiso L. Formation of STAT5‐containing DNA binding complexes in response to colony‐stimulating factor‐1 and platelet‐derived growth factor. J. Biol. Chem. 1996; 271: 18350–18354
  • David M., Wong L., Glavell R., Thompson S. A., Wells A., Larner A. C., Johnson G. STAT activation by EGF and Amphiregulin. J. Biol. Chem. 1996; 271: 9185–9188
  • Fu X‐Y., Zhang J‐J. Transcription factorp91 interacts with the epidermal growth factor receptor and mediates activation of the c‐fos gene promoter. Cell 1993; 74: 1135–1145
  • Galli S. J., Zsebo K. M., Geissler E. N. The c‐Kit ligand, stem cell factor. Advances in Immunology 1994; 55: 1–96
  • Witte O. N. Steel locus defines a new multipotent growth factor. Cell 1990; 63: 5–6
  • Anderson D. M., Lyman S. D., Baird A., Wignall J. M., Eisenman J., Rauch C., March C. J., Boswell H. S., Gimpel S. D., Cosman D., Williams D. E. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 1990; 63: 235–245
  • Martin F. H., Suggs S. V., Langley K. E., Lu H. S., Ting J., Okino K. H., Morris C. F., McNiece I. K., Jacobsen F. W., Mendiaz E. A., Birkett N. C., Smith K. A., Johnson M. J., Parker V. P., Flores J. C., Patel A. C., Fisher E. F., Erjavec H. O., Herrera C. J., Wypych J., Sachdev R. K., Pope J. A., Leslie I., Wen D., Lin C‐H., Cupples R. L., Zsebo K. M. Primary structure and functional expression of rat and human stem cell factor DNAs. Cell 1990; 63: 203–213
  • Zsebo K. M., Wypych J., McNiece I. K., Lu H. S., Smith K. A., Karkare S. B., Sachdev R. K., Yuschenkoff V. N., Birkett N. C., Williams L. R., Satyagal V. N., Tung W., Bosselman R. A., Mendiaz E. A., Langley K. E. Identification, purification and biological characterization of hematopoietic stem cell factor from buffalo rat liver‐conditioned medium. Cell 1990; 63: 195–202
  • Huang E., Nocka K., Beier D. R., Chu T‐Y., Buck J., Lahm H‐W., Wellner D., Leder P., Besmer P. The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c‐Kit receptor, the gene product of the IV locus. Cell 1990; 63: 225–236
  • Zsebo K. M., Williams D. A., Geissler E. N., Broudy V. C., Martin F. H., Atkins H. L., Hsu R‐Y., Birkett N. C., Okino K. H., Murdock D. C., Jacobsen F. W., Langley K. E., Smith K. A., Takeishi T., Cattanach B. M., Galli S. J., Suggs S. V. Stem cell factor is encoded at the 5/ locus of the mouse and is the ligand for the c‐Kit tyrosine kinase receptor. Cell 1990; 63: 213–220
  • Miyazawa K., Hendrie P. C., Mantel C., Wood L. D., Broxmeyer H. E. Comparative analysis of signaling pathways between mast cell growth factor and granulocyte‐macrophage colony‐stimulating factor in a human factor‐dependent myeloid cell line involves phosphorylation of raf‐1, GTPase activating protein and MAP kinase. Exp. Hemat. 1991; 19: 1110–1123
  • Okuda K., Sanghera J. S., Pelech S. L., Kanakura Y., Hallek M., Griffin J. D., Druker B. J. Granulocyte‐macrophage colony stimulating factor, interleukin‐3 and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 1992; 79: 2880–2887
  • Tauchi T., Boswell H. S., Leibowitz D., Broxmeyer H. E. Coupling between p210bcr‐abl and She and Grb2 adaptor proteins in hematopoietic cells permit growth factor receptor‐independent link to Ras activation pathway. J. Exp. Med. 1994; 179: 167–175
  • Matsuguchi T., Salgia R., Hallek M., Eder M., Druker B., Ernst T. J., Griffin J. D. She phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin 3 and steel factor and is constitu‐tively increased by p210bcr/abl. J. Biol. Chem. 1994; 269: 5016–5021
  • Weiler S., Mou S., DeBerry C., Ferris D. K., Ruscetti F., Keller J. R., Longo D., Linnekin D. JAK2 is associated with the c‐Kit proto‐oncogene product and is phosphory‐lated in response to stem cell factor. Blood 1996; 87: 3688–3693
  • Linnekin D., Mou S., DeBerry C., Weiler S., Ferris D. K., Ruscetti F., Keller J. R., Longo D. JAK2 is con‐stitutively associated with c‐Kit and is phosphorylated in response to stem cell factor. Acta Hematologica 1996; 95: 224–228
  • Brizzi M. F., Zini M. G., Aronica M. G., Blechman J. M., Yarden Y., Pegoraro L. Convergence of signaling by interleukin‐3, granulocyte‐macrophage colony‐stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J. Biol. Chem. 1994; 269: 31680–31687
  • Tang T., Mano H., Yi T., Ihle J. N. Tec kinase associates with c‐Kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol. Cell. Biol. 1994; 14: 8432–8440
  • O'Farrell A. M., Ichihara M., Mui A., Miyajima A. Signaling pathways activated in a unique mast cell line where interleukin 3 supports survival and stem cell factor is required for a proliferative response. Blood 1996; 87: 3655–3668
  • Klingmuller U., Lorenz U., Cantley L. C., Neel B. G., Lodish H. F. Specific recruitment of SH‐PTP1 to the Epo receptor causes inactivation of JAK2 and termination of proliferation signals. Cell 1995; 80: 729–738
  • Yi T., Ihle J. N. Association of HCP with c‐Kit after stimulation with c‐Kit ligand. Mol. Cell. Biol 1993; 13: 3350–3358
  • Linnekin D., DeBerry C. STAT1 associates with c‐Kit and is activated in response to stem cell factor. Exp. Hemat. 1996; 24, Abstract 471
  • Gotoh A., Takahira H., Mantel C., Litz‐Jackson S., Boswell S., Broxmeyer H. Steel factor induces serine phosphorylation of Stat3 in human growth factor‐dependent cell lines. Blood 1996; 88: 138–145
  • Pallard C., Gouilleux F., Benit L., Cocault L., Souyri M., Levy D., Groner B., Gisselbrecht S., Dusanter‐Fourt I. Thrombopoietin activates a STAT 5‐like factor in hematopoietic cells. EMBO J. 1995; 14: 2847–2856
  • Ohashi T., Masuda M., Ruscetti S. Induction of sequence‐specific DNA binding factors by erythropoietin and the spleen focus‐forming virus. Blood 1995; 85: 1454–1462

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.