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Original Article

Modulation of Interleukin-6/Interleukin-6 Receptor Cytokine Loop in the Treatment of Multiple Myeloma

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Pages 11-23 | Accepted 30 Nov 1996, Published online: 01 Jul 2009

References

  • Alexanian R., Dimipoulos M. The treatment of multiple myeloma. N. Engl. J. Med. 1994; 330: 484–489
  • Gregory W. M., Richard M. A., Malpas J. S. Combination chemotherapy versus melphalan and prednisone in the treatment of multiple myeloma: An overview of published trials. J. Clin. Oncol. 1992; 10: 334–342
  • Jagannath S., Vesole D. H., Glenn L., Crowely J., Barlogie B. Low risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. Blood 1992; 80: 1666–1672
  • Fermand J-P., Chevert S., Ravaud P., et al. High-dose chemoradiotherapy and autologous blood stem cell transplantation in multiple myeloma: Results of a phaae II trial involving 63 patients. Blood 1993; 82: 2005–2009
  • Anderson K. C., Barut B. A., Ritz J., et al. Monoclonal antibody-purged autologous bone marrow transplantation therapy for multiple myeloma. Blood 1991; 77: 712–720
  • Attal M., Harousseau J.-L., Stoppa A.-M., et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N. Engl. J. Med. 1996; 335: 91–97
  • Barlogie B., Epstein J., Selvanayagain P., Alexanian R. Plasma cell myeloma-New biological insights and advances in therapy. Blood 1989; 73: 865–879
  • Mandelli F., Avviaati G., Tribalto M. Biology and treatment of multiple myeloma. Curr. Opinion in Oncol. 1992; 4: 73–86
  • Klein B., Zhang X.-G., Lu Z.-Y., Bataille R. Interleukin-6 in human multiple myeloma. Blood 1995; 85: 863–872
  • Chen Y.-H., Desai P., Shiao R.-T., Lavelle D., Haleem A., Chen J. Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: Synergy through modulation of interleukin-6 autocrine loop at multiple sites. Blood 1996; 87: 314–323
  • Kawano M., Hirano T., Matsuda T., et al. Autocrine generation and requirement of BSF-2/IL-6 for human myelomas. Nature 1988; 332: 83–85
  • Anderson K. C., Jones R. M., Morimoto C., Leavitt P., Barut B. A. Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 1989; 73: 1915–1924
  • Freeman G. J., Freeman A. S., Rabinowe S. N., et al. Interleukin 6 gene expression in normal and neoplastic B-cells. J. Clin. Invest. 1989; 83: 1512–1518
  • Schwab G., Siegall C. B., Aarden L. A., Neckers L. M., Nordan R. P. Characterization of an interleukin-6-mediated autocrine growth loop in the human myeloma cell line, U266. Blood 1991; 77: 587–593
  • Levy Y., Tsapis A., Brouet J.-C. Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines. J. Clin. Invest. 1991; 88: 696–699
  • Portier M., Rajzbaum G., Zhang X.-G., et al. In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma. Eur. J. Immunol. 1991; 21: 1759–1762
  • Klein B., Zhang X.-G., Jourdan M., et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 1989; 73: 517–526
  • Akira S., Taga T., Kishimoto T. Interleukin-6 in biology and medicine. Adv. Immunol. 1993; 54: 1–78
  • Lokhorst H. M., Lamme T., de Smet M., et al. Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 1994; 84: 2269–2277
  • Bataille R., Jourdan M., Zhang X.-G., Klein B. Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias. J. Clin. Invest. 1989; 84: 2008–2011
  • Reibnegger G., Krainer M., Herold M., Ludwig H., Wachter H., Huber H. Predictive value of interleukin-6 and neopterin in patients with multiple myeloma. Cancer Res. 1991; 51: 6250–6253
  • Bergui L., Schena M., Gaidano G., Riva M., Caligaris-Cappio F. Interleukin 3 and interleukin 6 synergisti-cally promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma. J. Exp. Med. 1989; 170: 613–618
  • Caligaris-Cappio F., Bergui L., Gregoretti M. G., et al. Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 1991; 77: 2688–2693
  • Zhang X.-G., Bataille R., Jourdan M., Saeland S., Banchereau J., Mannoni P. Granulocyte-macrophage colony-stimulating factor synergies with interleukin-6 in supporting the proliferation of human myeloma cells. Blood 1990; 76: 2599–2605
  • Lu Z. Y., Zhang X. G., Rodriguez C., et al. Interleukin-10 is a proliferation factor but not a differentiation factor but not a differentiation factor for human myeloma cells. Blood 1995; 85: 2521–2527
  • Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995; 86: 1243–1254
  • Pelliniemi T.-T., Irjala K., Mattila K., et al. lmmunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Blood 1995; 85: 765–771
  • Chen Y.-H., Magalhaes M. C. Hypoalbuminemia in patients with multiple myeloma. Arch. Intern. Med. 1990; 150: 605–610
  • Ohtani K., Ninomiya H., Hasegawa Y., et al. Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Brit. J. Haematol. 1995; 91: 116–120
  • Klein B., Wijdenes J., Zhang X.-G., et al. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 1991; 78: 1198–1204
  • Manolagas S. C., Jilka R. L. Bone marrow, cytokines, and bone remodeling. N. Engl. J. Med. 1995; 332: 305–311
  • Bataille R., Chappard D., Marcelli C., et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J. Clin. Invest. 1991; 88: 62–66
  • Bataille R., Chappard D., Klein B. Mechanisms of bone lesions in multiple myeloma. Hematol. Oncol. Clin. North. Amer. 1992; 6: 285–295
  • Mundy G., Raisz L. G., Cooper R. A., Schechter G. P., Salmon S. E. Evidence for the secretion of an osteo-clast stimulating factor in myeloma. N. Engl. J. Med. 1974; 291: 1041–1046
  • Pulkki K., Pelliniemi T.-T., Rajamaki A., Tienhaara A., Laakso M., Lahtinen R. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Brit. J. Haematol. 1996; 92: 370–374
  • Gaillard J.-P., Bataille R., Brailly H., et al. Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy. Eur. J. Immunol. 1993; 23: 820–824
  • Tamura T., Udagawa N., Takahashi N., et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc. Natl. Acad. Sci. USA 1993; 90: 11924–11928
  • Schwabe M., Brini A. T., Bosco M. C., et al. Disruption by interferon-α of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor α- and β-chains. J. Clin. Invest. 1994; 94: 2317–2325
  • Anthes J. C., Zhan A., Gilchrist H., Egan R. W., Siegel M. I., Billah M. M. Interferon-α down-regulates the interleukin-6 receptor in a human myeloma cell line. U266. Biochem. J. 1995; 309: 175–180
  • Lasfar A., Wietzerbin J., Billard C. Differential regulation of interleukin-6 receptors by interleukin-6 and interferons in multiple myeloma cell lines. Eur. J. Immunol. 1994; 24: 124–130
  • Tanaka H., Tanabe O., Iwato K., et al. Sensitive inhibitory effect of interferon-alpha on M-protein secretion on human myeloma cells. Blood 1989; 74: 1718–1722
  • Jernberg-Wiklund H., Pettersson M., Nilsson K. Recombinant interferon-γ inhibits the growth of IL-6-dependent human multiple myeloma cell lines in vitro. Eur. J. Haematol. 1991; 46: 231–239
  • Portier M., Zhang X.-G., Caron E., Lu Z.-Y., Bataille R., Klein B. γ-interferon in multiple myeloma: Inhibition of interleukin-6 (IL-6)-dependent myeloma cell growth and downregulation of IL-6-receptor expression in vitro. Blood 1993; 81: 3076–3082
  • Palumbo A., Battaglio S., Napoli P., et al. Recombinant interferon-γ inhibits the in vitro proliferation of human myeloma cells. Brit. J. Haematol. 1994; 86: 726–732
  • Palumbo A., Bruno B., Boccadoro M., Pileri A. Interferon-γ in multiple myeloma. Leukemia and Lymphoma 1995; 18: 215–219
  • McIntyre O. S., Pajak T. F., Kyle R. A., Cornwell G. G., III, Leone L. Response rate and survival in myeloma patients receiving prednisone alone. Med. Pediatr. Oncol. 1985; 13: 239–243
  • Ishikawa H., Tanaka H., Iwato K., et al. Effect of glucocorticoids on the biologic activities of myeloma cells: Inhibition of interleukin-Iβ osteoclast activating factor-induced bone resorption. Blood 1991; 75: 715–720
  • Gomi M., Moriwaki K., Katagiri S., Kurata Y., Thompson E. B. Glucocorticoid effects on myeloma cells in culture: Correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA. Cancer Res. 1990; 50: 1873–1878
  • Shiao R.-T., Miglietta L., Khera S. Y., Wolfson A., Freter C. E. Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Leukemia and Lymphoma 1995; 17: 484–494
  • Shiao R.-T., McLeskey S. B., Khera S. Y., Wolfson A., Freter C. E. Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell lines. Leukemia and Lymphoma 1996; 21: 293–303
  • Hardin J., MacLeod S., Girgorieva I., et al. Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood 1994; 84: 3063–3070
  • Moali P. A., Pillay S., Weiner D., Leikin R., Rosen S. T. A mechanism of resistance to glucocorticoids in multiple myeloma: Transient expression of a truncated glucocorticoid receptor mRNA. Blood 1992; 79: 213–222
  • Ray A., Zhang D.-H., Siegel M. D., Ray P. Regulation of interleukin-6 gene expression by steroids. Interleukin-6 Type Cytokines, A. Mackiewicz, A. Koj, P. B. Sehgal. Acad. Sci., Ann., NY 1995; vol. 762: 79–88
  • Sidell N., Taga T., Hirano T., Kishimoto T., Saxon A. Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors. J. Immunol. 1991; 146: 3809–3814
  • Levy Y., Labaume S., Colombel M., Brouet J. C. Retinoic acid modulates the in vivo and in vitro growth of IL-6 autocrine human myeloma cell lines via induction of apoptosis. Clin. Exp. Immunol. 1996; 104: 167–172
  • Ogata A., Nishimoto N., Shima Y., Yoshizaki K., Kishimoto T. Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction. Blood 1994; 84: 3040–3046
  • Pulkki K., Neva M., Koskela K., Ollikainen H., Remes K., Pelliniemi T.-T. IL-6 receptor-mediated growth inhibition by all-trans retinoic acid but not by interferon-α in human myeloma cells. Interleukin-6 Type Cytokines, A. Mackiewicz, A. Koj, P. B. Sehgal. Acad. Sci., Ann., N. Y. 1995; vol. 762: 457–458
  • Strassmann G., Fong M., Freter C. E., Windsor D., D'Alessandro F., Nordan R. P. Suramin interferes with interleukin-6 receptor binding in vitro and inhibit colon-26 mediated experimental cancer cachexia in vivo. J. Clin. Invest. 1993; 92: 2152–2159
  • Taylor C. W., Lui R., Salmon S. E. Effects of suramin on in vitro growth of fresh human tumors. J. Natl. Cancer Inst. 1992; 84: 489–494
  • Stein C. A. Suramin: a novel antineoplastic agent with multiple potential mechanisms of action. Cancer Res 1993; 53: 2239–2248
  • Suzuki H., Yasukawa K., Saito T., et al. Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo. Eur. J. Immimol. 1992; 22: 1989–1993
  • Sporeno E., Savino R., Ciapponi L., et al. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells. Blood 1996; 87: 4510–4519
  • Demartis A., Bernassola F., Savino R., Melino G., Ciliberto G. Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death. Cancer Res. 1996; 56: 4213–4218
  • Morphological, biochemical, and flow cytometric assays of apoptosis. Curr. Protocols in Immunol, J. E. Coligan, A. M. Kruisbeek, D. M. Margulies, E. M. Shevach, W. Strober. John Wiley and Sons, Inc. 1991; 3.17.1–3.17.14
  • Kumar R., Pelletier D. Augmentation of interferon-mediated growth inhibitory and gene inducing responses of human hematopoietic tumor cell lines. Proc. Am. Asso. Cancer Res 1992; 33: 74, (abstr.)
  • Siegel D., Niesvizky R., Miller W. H., Jr., Busquets X., Kumar R., Michaeli J. All trans retinoic acid (ATRA) and interferonα (INFα) synergistically inhibit myeloma cell growth and induce retinoic acid receptor α (RARα) expression. Blood 1992; 80(suppl.)121a, (abstr.)
  • Alexanian R., Dimopoulos M. A., Delasalle K., Barlogie B. Primary dexamethasone treatment of multiple myeloma. Blood 1992; 80: 887–890
  • Salmon S. E., Croweley J. J., Grogan T. M., Finley P., Pugh R. P., Barlogie B. Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: A southwest oncology group study. J. Clin Oncol. 1994; 12: 2405–2414
  • Cooper M. R. A review of the clinical studies of alpha-interferon in the management of multiple myeloma. Sem. Oncol. 1991; 18(suppl 7)18–29
  • Cooper M. R., Dear K., McIntyre O. R., et al. A randomized clinical trial comparing melphalan/prednisone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: A cancer and leukemia group B study. J. Clin. Oncol. 1993; 11: 155–110
  • Oken M. M., Kyle R. A., Greipp P. R., et al. Possible survival with chemotherapy plus interferon (rhINF α 2) in the treatment of multiple myeloma. Proc. Am. Soc. Clin. Oncol. 1992; 11: 358, (abstr.)
  • Osterborg A., Bjokholm M., Bjoreman M., et al. Natural interferon-α in combination with melphalan/ prednisone versus melphalan/prednisone in the treatment of multiple myeloma stages II and III: A randomized study from the myeloma group of central Sweden. Blood 1993; 81: 1428–1434
  • Mandelli F., Avvisati G., Amadori S., et al. Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy. N. Engl. J. Med. 1990; 322: 1430–1434
  • Browman G. P., Bergsagel D., Sicheri D., et al. Randomized trial of interferon maintenance in multiple myeloma: A study of the national cancer institute of Canada clinical trails group. J. Clin. Oncol. 1995; 13: 2354–2360
  • Niesvizky R., Siegel D. S., Busquets X., et al. Hypercalcemia and increased serum interleukin-6 levels induced by all-trans retinoic acid in patients with multiple myeloma. Brit. J. Haematol. 1995; 89: 217–218
  • Vesole D., Kornbluth J., Jagannath S., et al. Biological response modifiers (BRM) in refractory multiple myeloma (MM): Lack of clinical efficacy of recombinant human interleukin-4 (rhIL-4) and all-trans retinoic acid (ATRA). Blood 1993; 82(suppl)263a, (abstr.)
  • Musto P., Falcone A., Sajeva M. S., D'Arena G., Bonini A., Carotenuto M. All-trans retinoic acid for advanced multiple myeloma. Blood 1994; 85: 3769–3770
  • Musto P., Sajeva M. R., Falcone A., et al. In vivo effects of all-trans retinoic acid (ATRA), as single agent or in association with alfa-interferon (INF) and high dose dexamethasone (HDDEX), in patients with advanced multiple myeloma (MM). Haematologica (Pavia). 4th Cong. Italian Soc. Exp. Hematol. 1996, (abstr.)
  • Bataille R., Barlogie B., Lu Z. Y., et al. Biologic effects on anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 1995; 86: 685–691
  • Chen Y., Feng X.-X., Hagen K. Usefulness of flow cytometric detection of cell surface interleukin-6 receptors in human myeloma cell lines. Clin. Lab. Haematol. 1996; 18: 161–169

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