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Original Article

The Growth Inhibitory Role and Potential Clinical Value of Macrophage Inflammatory Protein 1 alpha in Myeloid Leukaemias

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Pages 41-53 | Received 01 Jul 1997, Published online: 01 Jul 2009

References

  • Wolpe S. D., Cerami A. Marcophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. Faseb J 1989; 3: 2565–73
  • Oppenheim J. J., Zachariae C. O., Mukaida N., Matsushima K. Properties of the novel proinflammatory supergene “intercrine” cytokine family. Annu Rev Immunol. 1991
  • Yamamura Y., Hattori T., Obaru K., Sakai K., Asou N., Takatsuki K., Ohmoto Y., Nomiyama H., Shimada K. Synthesis of a novel cytokine and its gene (LD78) expressions in hematopoietic fresh tumor cells and cell lines. J Clin Invest 1989; 84: 1707–12
  • Obaru K., Fukuda M., Maeda S., Shimada K. A cDNA clone used to study mRNA inducible in human tonsillar lymphocytes by a tumor promoter. J Biochem 1986; 99: 885–94
  • Nakao M., Nomiyama H., Shimada K. Structures of human genes coding for cytokine LD78 and their expression. Mol Cell Biol 1990; 10: 3646–58
  • Wolpe S. D., Davatelis G., Sherry B., Beutler B., Hesse D. G., Nguyen H. T., Moldawer L. L., Nathan C. F., Lowry S. F., Cerami A. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med 1988; 167: 570–81
  • Patel S. R., Evans S., Dunne K., Knight G. C., Morgan P. J., Varley P. G., Craig S. Characterization of the quaternary structure and conformational properties of the human stem cell inhibitor protein LD78 in solution. Biochemistry 1993; 32: 5466–71
  • Graham G. J., Freshney M. G., Donaldson D., Pragnell I. B. Purification and biochemical characterisation of human and murine stem cell inhibitors (SCI). Growth Factors 1992; 7: 151–60
  • Lord B. I., Heyworth C. M., Woolford L. B. Macrophage inflammatory protein: its characteristics, biological properties and role in the regulation of haemopoiesis. Int J Hematol 1993; 57: 197–206
  • Schall T. J. Biology of the RANTES/SIS cytokine family. Cytokine 1991; 3: 165–83
  • Miller M. D., Krangel M. S. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 1992; 12: 17–46
  • Khan S., Wigley C. Different effects of a macrophage cytokine on proliferation in astrocytes and Schwann cells. Neuroreport 1994; 5: 1381–5
  • Cook D. N., Beck M. A., Coffman T. M., Kirby S. L., Sheridan J. F., Pragnell I. B., Smithies O. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science 1995; 269: 1583–5
  • Cocchi F., Devico A. L., Oarzino Demo A., Arya S. K., Gallo R. C., Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T-cells. Science 1995; 270: 1811–5
  • Smith R. E., Strieter R. M., Phan S. H., Lukacs N. W., Huffnagle G. B., Wilke C. A., Burdick M. D., Lincoln P., Evanoff H., Kunkel S. L. Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced long injury. J Immunol 1994; 153: 4704–12
  • Karpus W. J., Lukacs N. W., McRae B. L., Strieter R. M., Kunkel S. L., Miller S. D. An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T-cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 1995; 155: 5003–10
  • Kasama T., Strieter R. M., Lukacs N. W., Lincoln P. M., Burdick M. D., Kunkel S. L. Interferon gamma modulates the expression of neutrophil-derived chemokines. J Investig Med 1995; 43: 58–67
  • Hirose K., Hakozaki M., Nyunoya Y., Kobayashi Y., Matsushita K., Takenouchi T., Mikata A., Mukaida N., Matsushima K. Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration. Br J Cancer 1995; 72: 708–14
  • Lord B. I., Mori K. J., Wright E. G., Lajtha L. G. Inhibitor of stem cell proliferation in normal bone marrow. Br J Haematol 1976; 34: 441–5
  • Graham G. J., Wright E. G., Hewick R., Wolpe S. D., Wilkie N. M., Donaldson D., Lorimore S., Pragnell I. B. Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature 1990; 344: 442–4
  • Parkinson E. K., Graham G. J., Daubersies P., Burns J. E., Heufler C., Plumb M., Schuler G., Pragnell I. B. Hemopoietic stem cell inhibitor (SCI/MIP-1 alpha) also inhibits clonogenic epidermal keratinocyte proliferation. J Invest Dermatol 1993; 101: 113–7
  • Hakovirta H., Vierula M., Wolpe S. D., Parvinen M. MIP-1 alpha is a regulator of mitotic and meiotic DNA synthesis during spermatogenesis. Mol Cell Endocrinol 1994; 99: 119–24
  • Simmons P. J., Lord B. I. Enrichment of CFU-S proliferation inhibitor-producing cells based on their identification by the monoclonal antibody F4/80. J Cell Sci 1985
  • Wright E. G., Garland J. M., Lord B. I. Specific inhibition of haemopoietic stem cell proliferation: characteristics of the inhibitor producing cells. Leuk Res 1980; 4: 537–45
  • Pojda Z., Dexter T. M., Lord B. I. Production of a multipotential cell (CFU-S) proliferation inhibitor by various populations of mouse and human macrophages. Br J Haematol 1988; 68: 153–7
  • Davatelis G., Tekamp-Olson P., Wolpe S. D., Hermsen K., Luedke C., Gallegos C., Coit D., Merryweather J., Cerami A. Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties [published erratum appears in J Exp Med 1989 Dec 1;170(6):2189]. J Exp Med 1988; 167: 1939–44
  • Clements J. M., Craig S., Gearing A. J., Hunter M. G., Heyworth C. M., Dexter T. M., Lord B. I. Biological and structural properties of MIP-1 alpha expressed in yeast. Cytokine 1992; 4: 76–82
  • Lord B. I., Dexter T. M., Clements J. M., Hunter M. A., Gearing A. J. Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo. Blood 1992; 79: 2605–9
  • Verfaillie C. M., Miller J. S. CD34+/CD33-cells reselected from macrophage inflammatory protein 1 alpha+interleukin-3-supplemented “stroma-noncontact” cultures are highly enriched for long-term bone marrow culture initiating cells. Blood 1994; 84: 1442–9
  • Verfaillie C. M., Catanzarro P. M., Li W. N. Macrophage inflammatory protein 1 alpha, interleukin 3 and diffusible marrow stromal factors maintain human hematopoietic stem cells for at least eight weeks in vitro. J Exp Med 1994; 179: 643–9
  • Keller J. R., Bartelmez S. H., Sitnicka E., Ruscetti F. W., Ortiz M., Gooya J. M., Jacobsen S. E. Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth. Blood 1994; 84: 2175–81
  • Jacobsen S. E., Ruscetti F. W., Ortiz M., Gooya J. M., Keller J. R. The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation of multiple inhibitors. Exp Hematol 1994; 22: 985–9
  • Broxmeyer H. E., Sherry B., Lu L., Cooper S., Oh K. O., Tekamp-Olson P., Kwon B. S., Cerami A. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood 1990; 76: 1110–6
  • Mayani H., Little M. T., Dragowska W., Thombury G., Lansdorp P. M. Differential effects of the hematopoietic inhibitors MIP-1 alpha, TGF-beta, and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver. Exp Hematol 1995; 23: 422–7
  • Broxmeyer H. E., Sherry B., Lu L., Cooper S., Carow C., Wolpe S. D., Cerami A. Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. J Exp Med 1989; 170: 1583–94
  • Dunlop D. J., Wright E. G., Lorimore S., Graham G. J., Holyoake T., Kerr D. J., Wolpe S. D., Pragnell I. B. Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo. Blood 1992; 79: 2221–5
  • Pragnell I. B., Wright E. G., Lorimore S. A., Adam J., Rosendaal M., Delamarter J. F., Freshney M., Eckmann L., Sproul A., Wilkie N. The effect of stem cell proliferation regulators demonstrated with an in vitro assay. Blood 1988; 72: 196–201
  • Lord B. L., Woolford L. B., Wood L. M., Czaplewski L. G., McCourt M., Hunter M. G., Edwards R. M. Mobilization of early hematopoietic progenitor cells with BB-10010: a genetically engineered variant of human macrophage inflammatory protein-1 alpha. Blood 1995; 85: 3412–5
  • McCourt M., Brotherton D., Comer M., Cribbes S., Czaplewski L., Hemmingway I., Heyworth C. M., Lord B., Wood L. M., Hunter M. G. BB-10010, a variant of the human stem cell inhibitor LD78, produces a rapid increase in both mature white blood cells and circulating haemopoietic progenitors. Bone Marrow Transplantation 1994; 14(Suppl. 2): S34
  • Graham G. J., Zhou L., Weatherbee J. A., Tsang M. L., Napolitano M., Leonard W. J., Pragnell I. B. Characterization of a receptor for macrophage inflammatory protein 1 alpha and related proteins on human and murine cells. Cell Growth Differ 1993; 4: 137–46
  • Oh K. O., Zhou Z., Kim K. K., Samanta H., Fraser M., Kim Y. J., Broxmeyer H. E., Kwon B. S. Identification of cell surface receptors for murine macrophage inflammatory protein-1 alpha. J Immunol 1991; 147: 2978–83
  • Avalos B. R., Bartynski K. J., Elder P. J., Kotur M. S., Burton W. G., Wilkie N. M. The active monomeric form of macrophage inflammatory protein-1 alpha interacts with high-and low-affinity classes of receptors on human hematopoietic cells. Blood 1994; 84: 1790–801
  • Neote K., Digregorio D., Mak J. Y., Horuk R., Schall T. J. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 1993; 72: 415–25
  • Gao J. L., Kuhns D. B., Tiffany H. L., McDermott D., Li X., Francke U., Murphy P. M. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J Exp Med 1993; 177: 1421–7
  • Power C. A., Wells T. N. Cloning and characterization of human chemokine receptors. Trends Pharmacol Sci 1996; 17: 209–13
  • Dragic T., Litwin V., Allaway G. P., Martin S. R., Huang Y., Nagashima K. A., Cayanan C., Maddon P. J., Koup R. A., Moore J. P., Paxton W. A. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 [see comments]. Nature 1996; 381: 667–73
  • Holyoake T. L., Freshney M. G., Sproul A. M., Richmond L. J., Alcorn M. J., Steward W. P., Fitzsimons E., Dunlop D. J., Franklin I. M., Pragnell I. B. Contrasting effects of rh-MIP-1 alpha and TGF-beta 1 on chronic myeloid leukemia progenitors in vitro. Stems Cells Dayt 1993; 11 Supply 3: 122–8
  • Eaves C. J., Cashman J. D., Wolpe S. D., Eaves A. C. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells. Proc Natl Acad Sci USA 1993; 90: 12015–9
  • Chasty R. C., Lucas G. S., Owen Lynch P. J., Pierce A., Whetton A. D. Macrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia. Blood 1995; 86: 4270–7
  • Cashman J. D., Eaves A. C., Eaves C. J. The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism. Blood 1994; 84: 1534–42
  • De Jong M. O., Wagemaker G., Wognum A. W. Separation of myeloid and erythroid progenitors based on expression of CD34 and c-kit. Blood 1995; 86: 4076–85
  • De Jong M. O., Rozemuller H., Bauman J. G., Visser J. W. Biotinylation of interleukin-2 (IL-2) for flow cytometric analysis of IL-2 receptor expression. Comparison of different methods. J Immunol Methods 1995; 184: 101–12
  • Van Gils F. C., Van Teeffelen M. E., Neelis K. J., Hendrikx J., Burger H., Van Leen R. W., Knol E., Wagemaker G., Wognum A. W. Interleukin-3 treatment of rhesus monkeys leads to increased production of histamine-releasing cells that express interleukin-3 receptors at high levels. Blood 1995; 86: 592–7
  • Gao J. L., Murphy P. M. Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem 1995; 270: 17494–501
  • Post T. W., Bozic C. R., Rothenberg M. E., Luster A. D., Gerard N., Gerard C. Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol 1995; 155: 5299–305
  • Mantel C., Aronica S., Luo Z., Marshall M. S., Kim Y. J., Cooper S., Hague N., Broxmeyer H. E. Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line MO7e, events associated with growth suppression. J Immunol 1995; 154: 2342–50
  • Aronica S. M., Mantel C., Gonin R., Marshall M. S., Sams A., Cooper S., Hague N., Zhang X. F., Broxmeyer H. E. Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem 1995; 270: 21998–2007
  • McColl S. R., Hachicha M., Levasseur S., Neote K., Schall T. J. Uncoupling of early signal transduction events from effector function in human peripheral blood neutrophils in response to recombinant macrophage inflammatory proteins-1 alpha and-1 beta. J Immunol 1993; 150: 4550–60
  • Van Riper G., Nicholson D. W., Scheid M. P., Fischer P. A., Springer M. S., Rosen H. Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line. J Immunol 1994; 152: 4055–61
  • Uguccioni M. M. D. A., Loetscher M., Dewald B., Baggiolini M. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. Eur J Immunol 1995; 25: 64–8
  • Vaddi K., Newton R. C. Comparison of biological responses of human monocytes and THP-1 cells to chemokines of the intercrine-beta family. J Leukoc Biol 1994; 55: 756–62
  • Hunter M. G., Bawden L., Brotherton D., Craig S., Cribbes S., Czaplewski L. G., Dexter T. M., Drummond A. H., Gearing A. H., Heyworth C. M., et al. BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties. Blood 1995; 86: 4400–8
  • Mantel C., Kim Y. J., Cooper S., Kwon B., Broxmeyer H. E. Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer. Proc Natl Acad Sci USA 1993; 90: 2232–6
  • Graham G. J., Mackenzie J., Lowe S., Tsang M. L., Weatherbee J. A., Issacson A., Medicherla J., Fang F., Wilkinson P. C., Pragnell I. B. Aggregation of the chemokine MIP-1 alpha is a dynamic and reversible phenomenon. Biochemical and biological analyses. J Biol Chem 1994; 269: 4974–8
  • Hunter M. G., Wood L. M., Galloway W. A., Lewis P. J., Czaplewski L. G., Millar A., Powles R., Lord B. L., Marshall E., Dexter T. M., Edwards R. M. BB-10010, A variant of human MIP-1 alpha engineered for clinical evaluation. British J. Haematology 1996; 93 (Suppl. 2): 270
  • Broxmeyer H. E., Hague N. L., Sledge G. W., Rasmussen H., Gordon M. S. Suppression of marrow and mobilisation of blood myeloid progenitors in vivo by BB10010, a genetically engineered variant of human macrophage inflammatory protein (MIP)-1 alpha, in a phase I clinical trial in patients with relapsed refractory breast cancer. Blood 1995; 85 (Suppl. 1): 12a
  • Owen-Lynch P. J., Adams J. A., Brereton M. L., Gaplewski L. G., Whetton A. D., Yin J. A. L. The effect of the chemokine rhMiP-1α, and a non-aggregating variant BB-10010, on blast cells from patients with acute myeloid leukaemia. Brt. J. Haem. 1996; 95: 77–84

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