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Original Article

The Role of Interleukin-7 in Early T-Cell Development

&
Pages 87-99 | Received 27 Jul 1997, Published online: 01 Jul 2009

References

  • Zuniga Pflucker J. C., Lenardo M. J. Regulation of thymocyte development from immature progenitors. Curr Opin Immunol 1996; 8: 215
  • Lewis S. M., Wu G. E. The origins of V(D)J recombination. Cell 1997; 88: 159
  • Wilson R. K., Lai E., Concannon P., Barth R. K., Hood L. E. Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families. Immunol Rev 1988; 101: 149
  • Godfrey D. I., Zlotnik A. Control points in early T-cell development. Immunol Today 1993; 14: 547
  • Rodewald H. R. Pathways from hematopoietic stem cells to thymocytes. Curr Opin Immunol 1995; 7: 176
  • Spits H. L. L., Phillips J. Development of human T and natural killer cells. Blood 1995; 85: 2654
  • Zlotnik A. M. T. Cytokine production and requirements during T-cell development. Curr. Opin. Immunol. 1995; 7: 206
  • Donskoy E., Goldschneider I. Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice. J Immunol 1992; 148: 1604
  • Scollay R., Smith J., Stauffer V. Dynamics of early T-cells: prothymocyte migration and proliferation in the adult mouse thymus. Immunol Rev 1986; 91: 129
  • Zon L. I. Developmental biology of hematopoiesis. Blood 1995; 86: 2876
  • Levelt C. N., Eichmann K. Receptors and signals in early thymic selection. Immunity 1995; 3: 667
  • Wilson A. H. W., McDonald. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 1994; 179: 1355
  • Lin W. C., Desiderio S. V(D)J recombination and the cell cycle. Immunol Today 1995; 16: 279
  • Fehling H. J., Von Boehmer H. Early alpha-beta T-cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol 1997; 9: 263
  • Groettrup M. U. K., Azogui Palacios R., Owen M. J., Hayday A. C., Von Boehmer H. A novel disulfide-linked heterodimer on pre-T-cells consisits of the T-cell receptor beta chain and a novel 33 kD glycoprotein. Cell 1993; 75: 283
  • Saint-Ruf C. U. K., Groettrup M., Bruno L., Fehling H. J., Von Boehmer H. Analysis and expression of a cloned pre-TCR gene. Science 1994; 266: 1208
  • Wilson A., Macdonald H. R., Wilson A., Held W., Macdonald H. R. Expression of genes encoding the pre-TCR and CD3 complex during thymus development. Int Immunol 1995; 7: 1659
  • Malissen B., Malissen M. Functions of TCR and pre-TCR subunits: lessons from gene ablation. Curr Opin Immunol 1996; 8: 383
  • Guidos C. J. Positive selection of CD4+ and CD8+ T-cells. Curr Opin Immunol 1996; 8: 225
  • Von Boehmer H. Positive selection of lymphocytes. Cell 1994; 76: 219
  • Nossal G. J. Negative selection of lymphocytes. Cell 1994; 76: 229
  • Vanhecke D. L. G., Plum J., Vandekerchove B. Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants. J. Immunol. 1995; 155: 1862
  • Vanhecke D., Verhasselt B., Debacker V., Leclercq G., Plum J., Vanderkerchove B. Differentiation of T helper cell function in the thymus: gradual acquisition of T helper cell function by CD3+CD4+ cells. J. Immunol. 1995; 155: 4711
  • Ikuta K., Uchida N., Friedman J., Weissman I. L. Lymphocyte development from stem cells. Annu Rev Immunol 1992; 10: 759
  • Spangrude G. J., Heimfeld S., Weissman I. L. Purification and characterization of mouse hematopoietic stem cells [published erratum appears in Science 1989 Jun 2;244(4908):1030]. Science 1988; 241: 58
  • Peault B., Weissman I. L., Baum C., McCune J. M., Tsukamoto A. Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells. J Exp Med 1991; 174: 1283
  • Galy A., Cen D., Travis M., Chen S., Chen B. Delineation of progenitor cell activity within the CD34+ compartment of adult bone marrow. Blood 1995; 85: 2770
  • Plum J., De Smedt M., Defresne M., Leclercq G. B. V. Human CD34+ fetal liver stem cells differentiate to T-cells in a mouse thymic microenvironment. Blood 1994; 84: 1587
  • Galy A., Travis M., Cen D., Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 1995; 3: 459
  • Wu L., Scollay R., Egerton M., Pearse M., Spangrude G. J., Shortman K., Sotzik F., Rosenberg Y., Boyd A. W., Honeyman M., Metcalf D. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 1991; 349: 71
  • Matsuzaki Y., Gyotoku J., Ogawa M., Nishikawa S., Katsura Y., Gachelin G., Nakauchi H. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. J Exp Med 1993; 178: 1283
  • Shortman K., Wu L. Early T-lymphocyte progenitors. Annu Rev Immunol 1996; 14: 29
  • Wu L., Antica M., Johnson G. R., Scollay R., Shortman K. Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med 1991; 174: 1617
  • Godfrey D. I., Kennedy J., Mombaerts P., Tonegawa S., Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. J Immunol 1994; 152: 4783
  • Penit C., Lucas B., Vasseur F. Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J Immunol 1995; 154: 5103
  • Dudley E. C., Petrie H. T., Shah L. M., Owen M. J., Hayday A. C. T-cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1994; 1: 83
  • Tourigny M., Mazel S., Burtrum D. B., Burtrum H. P. T-cell receptor beta gene recombination: dissociation from cellcycle regulation and developmental progression during T-cell ontogeny. J. Exp. Med. 1997; 185: 1549
  • Terstappen L. W., Huang S., Picker L. J. Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow. Blood 1992; 79: 666
  • Schmitt C., Ktorza S., Sarun S., Verpilleux M. P., Blanc C., Deugnier M. A., Dalloul A., Debre P. CD34-positive early stages of human T-cell differentiation. Leuk Lymphoma 1995; 17: 43
  • Barcena A., Muench M., Galy A. J. C., Roncarolo M., Phillips J., Spits H. Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus. Blood 1993; 82: 3401
  • Ramiro A. R., Trigueros C., Marquez C., San Millan J. L., Toribio M. L. Regulation of pre-T-cell receptor (pT alpha-TCR beta) gene expression during human thymic development. J Exp Med 1996; 184: 519
  • Hori T., Cupp J., Wrighton N., Lee F., Spits H. Identification of a novel human thymocyte subset with a phenotype of CD3-CD4+ CD8 alpha + beta-1. J Immunol 1991; 146: 4078
  • Georgopoulos K. Transcription factors required for lymphoid lineage commitment. Curr. Opin. Immunol. 1997; 9: 222
  • Molnar A., Wu P., Largespada D. A., Vortkamp A., Scherer S., Copeland N. G., Jenkins N. A., Bruns G., Georgopoulos K. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 1996; 156: 585
  • Georgopoulos K., Bigby M., Wong J., Molnar A., Wu P., Winandy S., Winandy A. S. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79: 143
  • Scott E. W., Simon M. C., Anastasi J., Singh H. Requirement of transcription factor PU. 1 in the development of multiple hematopoietic lineages. Science 1994; 265: 1573
  • Ting C. N., Olson M. C., Barton K. P., Leiden J. M. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 1996; 384: 474
  • Hromas R., Orazi A., Neiman R. S., Maki R., Van Beveran C., Moore J., Klemsz M. Hematopoietic lineage-and stage-restricted expression of the ETS oncogene family member PU. 1. Blood 1993; 82: 2998
  • Zhuang Y., Soriano P., Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994; 79: 875
  • Bain G., Maandag E. C., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub B. C., Krop I., Schlissel M. S., Feeney A. J., Van Roon M., et al. E2A proteins are required for proper B-cell development and initiation of immunoglobulin gene rearrangements. Cell 1994; 79: 885
  • Sun X. H. Constitutive expression of the Id1 gene impairs mouse B-cell development. Cell 1994; 79: 893
  • Spits H., Heemskerk M., Res P., Blom B., Nolan G., Bakker A. K. W. bHIH transcription factors play a critical role in T-cell development. Thymus Workshop. Rolduc. 1997
  • Hernandez Munain C., Lauzurica P., Krangel M. S. Regulation of T-cell receptor delta gene rearrangement by c-Myb. J Exp Med 1996; 183: 289
  • Hsiang Y. H., Goldman J. P., Raulet D. H. The role of c-Myb or a related factor in regulating the T-cell receptor gamma gene enhancer. J Immunol 1995; 154: 5195
  • Sleckman B. P., Gorman J. R., Alt F. W. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu Rev Immunol 1996; 14: 459
  • Bruno L., Fehling H. J., Von Boehmer H., Fehling H. J., Krotkova A., Saint Ruf C., Von Boehmer H. The alpha beta T-cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. Immunity 1996; 5: 343
  • Benveniste P., Cohen A. p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency. Proc Natl Acad Sci USA 1995; 92: 8373
  • Mombaerts P., Clarke A. R., Rudnicki M. A., Iacomini J., Itohara S., Lafaille J. J., Wang L., Ichikawa Y., Jaenisch R., Hooper M. L., et al. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491]. Nature 1992; 360: 225
  • Van Oers N. S., Von Boehmer H., Weiss A. The pre-T-cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. J Exp Med 1995; 182: 1585
  • Levelt C., Ehrfeld A., Eichman K. Regulation of thymocyte development through CD 3. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program. J. Exp. Med. 1993; 177: 707
  • Mombaerts P., Anderson S. J., Perlmutter R. M., Mak T. W., Tonegawa S. An activated lck transgene promotes thymocyte development in RAG1 mutant mice. Immunity 1994; 1: 261
  • Gravestein L. A., Van Ewijk W., Ossendorp F., Borst J. CD27 cooperates with the pre-T-cell receptor in the regulation of murine T-cell development. J Exp Med 1996; 184: 675
  • Hoffman E. S., Passoni L., Crompton T., Leu T. M., Schatz D. G., Koff A., Owen M. J., Hayday A. C. Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev 1996; 10: 948
  • Namen A. E., Lupton S., Hjerrild K., Wignall J., Mochizuki D. Y., Schmierer A., Mosley B., March C. J., Urdal D., Gillis S. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 1988; 333: 571
  • Sudo T., Ito M., Ogawa Y., Iizuka M., Kodama H., Kunisada T., Hayashi S., Ogawa M., Sakai K., Nishikawa S. Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 1989; 170: 333
  • Goodwin R. G., Lupton S., Schmierer A., Hjerrild K. J., Jerzy R., Clevenger W., Gillis S., Cosman D., Namen A. E. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci U S A 1989; 86: 302
  • Goodwin R. G., Friend D., Ziegler S. F., Jerzy R., Falk B. A., Gimpel S., Cosman D., Dower S. K., March C. J., Namen A. E., et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990; 60: 941
  • Kondo M., Takeshita T., Higuchi M., Nakamura M., Sudo T., Nishikawa S., Sugamura K. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science 1994; 263: 1453
  • Wells J. A., De Vos A. M. Hematopoietic receptor complexes. Annu Rev Biochem 1996; 65: 609
  • Schindler C., Darnell J. E., Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995; 64: 621
  • Foxwell B. M., Beadling C., Guschin D., Kerr I., Cantrell D. Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T-cells. Eur J Immunol 1995; 25: 3041
  • Nosaka T., Van Deursen J. M., Tripp R. A., Thierfelder W. E., Witthuhn B. A., McMickle A. P., Doherty P. C., Grosveld G. C., Ihle J. N. Defective lymphoid development in mice lacking Jak3. Science 1995; 270: 800
  • Van Der Plas D. C., Smiers F., Pouwels K., Hoefsloot L. H., Lowenberg B., Touw I. P. Interleukin-7 signaling in human B-cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. Leukemia 1996; 10: 1317
  • Ihle J. N. STATs: signal transducers and activators of transcription. Cell 1996; 84: 331
  • Yoshimura A., Ichihara M., Kinjyo I., Moriyama M., Copeland N. G., Gilbert D. J., Jenkins N. A., Hara T., Miyajima A. Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. Embo J 1996; 15: 1055
  • Clegg C. H., Rulffes J. T., Wallance P. M., Haugen H. S. Regulation of an extrathymic T-cell development pathway by oncostatin M. Nature 1996; 384: 261
  • Alderson M. R., Tough T. W., Ziegler S. F., Grabstein K. H. Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med 1991; 173: 923
  • Ktorza S., Sarun S., Rieux Laucat F., De Villartay J. P., Debre P., Schmitt C., Schmitt C. CD34-positive early human thymocytes: T-cell receptor and cytokine receptor gene expression. Eur J Immunol 1995; 25: 2471
  • Peschon J. J., Morrissey P. J., Grabstein K. H., Ramsdell F. J., Maraskovsky E., Gliniak B. C., Park L. S., Ziegler S. F., Williams D. E., Ware C. B., et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180: 1955
  • He Y. W., Malek T. R. Interleukin-7 receptor alpha is essential for the development of gamma delta + T-cells, but not natural killer cells. J Exp Med 1996; 184: 289
  • Maraskovsky E., Teepe M., Morrissey P. J., Braddy S., Miller R. E., Lynch D. H., Peschon J. J. Impaired survival and proliferation in IL-7 receptor-deficient peripheral T-cells. J Immunol 1996; 157: 5315
  • Noguchi M., Yi H., Rosenblatt H. M., Filipovich A. H., Adelstein S., Modi W. S., McBride O. W., Leonard W. J. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993; 73: 147
  • Conley M. E. Molecular approaches to analysis of X-linked immunodeficiencies. Annu Rev Immunol 1992; 10: 215
  • Sleasman J. W., Harville T. O., White G. B., George J. F., Barrett D. J., Goodenow M. M. Arrested rearrangement of TCR V beta genes in thymocytes from children with X-linked severe combined immunodeficiency disease. J Immunol 1994; 153: 442
  • Cao X., Shores E. W., Hu Li J., Anver M. R., Kelsall B. L., Russell S. M., Drago J., Noguchi M., Grinberg A., Bloom E. T., et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2: 223
  • Von Freeden Jeffry U., Vieira P., Lucian L. A., McNeil T., Burdach S. E., Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonre-dundant cytokine. J Exp Med 1995; 181: 1519
  • Kenai H., Matsuzaki G., Nakamura T., Yoshikai Y., Nomoto K. Thymus-derived cytokine(s) including interleukin-7 induce increase of T-cell receptor alpha/beta+ CD4-CD8-T-cells which are extrathymically differentiated in athymic nude mice. Eur J Immunol 1993; 23: 1818
  • Moore T., Von Freeden-Jeffry U., Murray R., Zlotnik A. Inhibition of gamma-delta T-cell development and early thymocyte maturation in IL7-/-mice. (1996). J. Immunol. 1996; 157: 2366
  • Vicari A., Herbelin A., Docarmo Leite-De-Moraes M., Von Freeden-Jeffry U., Murray R., Zlotnik A. NK1.1+ T-cells from IL-7 deficient mice have a normal distribution and selection but exhibit impaired cytokine production. Int. Immunol. 1996; 8: 1759
  • Friend S. L., Hosier S., Nelson A., Foxworthe D., Williams D. E., Farr A. A thymic stromal cell line supports in vitro development of surface IgM+ B-cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol 1994; 22: 321
  • Giri J., Ahdieh M., Eisenman J., Shanebeck K., Grabstein K., Kumaki S., Namen A., Park L., Cosman D., Anderson D. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J., 13: 2822
  • Bhatia S. K., Tygrett L. T., Grabstein K. H., Waldschmidt T. J. The effect of in vivo IL-7 deprivation on T-cell maturation. J Exp Med 1995; 181: 1399
  • Grabstein K. H., Waldschmidt T. J., Finkelman F. D., Hess B. W., Alpert A. R., Boiani N. E., Namen A. E., Morrissey P. J. Inhibition of murine B-and T-lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med 1993; 178: 257
  • He Y. W., Levy R. B., Malek T. R. Blockade of T-and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7. Proc Natl Acad Sci U S A 1995; 92: 5689
  • Hozumi K., Kondo M., Nozaki H., Kobori A., Nishimura T., Nishikawa S., Sugamura K., Habu S. Implication of the common gamma chain of the IL-7 receptor in intrathymic development of pro-T-cells. Int Immunol 1994; 6: 1451
  • Plum J., De Smedt M., Leclercq G., Verhasselt B., Vandekerchkove B. Interleukin-7 is a critical growth factor in early human T-cell development. Blood 1996; 88: 4239
  • Rich B. E., Leder P. Transgenic expression of interleukin 7 restores T-cell populations in nude mice. J Exp Med 1995; 181: 1223
  • Mertsching E., Burdet C., Ceredig R. Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential. Int Immunol 1995; 7: 415
  • Morrissey P. J., Conlon P., Charrier K., Braddy S., Alpert A., Williams D., Namen. Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lym-phadenopathy Effect of IL-7 on the growth of fetal thymocytes in culture. J Immunol 1991; 147: 561
  • Faltynek C. R., Wang S., Miller D., Young E., Tiberio L., Kross K., Kelley M., Kloszewski E. Administration of human recombinant IL-7 to normal and irradiated mice increases the numbers of lymphocytes and some immature cells of the myeloid lineage. J Immunol 1992; 149: 1276
  • Levy R. B., Jones M., Hamilton B. L., Paupe J., Horowitz T., Riley R. IL-7 drives donor T-cell proliferation and can costimulate cytokine secretion after MHC-matched allogeneic bone marrow transplantation. J Immunol 1995; 154: 106
  • Morrissey P. J., Goodwin R. G., Nordan R. P., Anderson D., Grabstein K. H., Cosman D., Sims J., Lupton S., Acres B., Reed S. G. Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T-cells. J Exp Med 1989; 169: 707
  • Hickman C. J., Crim J. A., Mostowski H. S., Siegel J. P. Regulation of human cytotoxic T-lymphocyte development by IL-7. J Immunol 1990; 145: 2415
  • Armitage R. J., Namen A. E., Sassenfeld H. M., Grabstein K. H. Regulation of human T-cell proliferation by IL-7. J Immunol 1990; 144: 938
  • Bertagnolli M., Herrmann S. IL-7 supports the generation of cytotoxic T-lymphocytes from thymocytes. Multiple lymphokines required for proliferation and cytotoxicity. J Immunol 1990; 145: 1706
  • Grabstein K. H., Namen A. E., Shanebeck K., Voice R. F., Reed S. G., Widmer M. B. Regulation of T-cell proliferation by IL-7. J Immunol 1990; 144: 3015
  • Suda T., Zlotnik A. IL-7 maintains the T-cell precursor potential of CD3-CD4-CD8-thymocytes. J Immunol 1991; 146: 3068
  • Plum J., De Smedt M., Leclercq G. Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+ CD25+/-precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture. J. Immunol. 1994
  • Borger P., Kauffman H. F., Postma D. S., Vellenga E. IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. J Immunol 1996; 156: 1333
  • Candeias S., Muegge K., Durum S. IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity 1997; 6: 501
  • Appasamy P. M. IL 7-induced T-cell receptorgamma gene expression by pre-T-cells in murine fetal liver cultures. J Immunol 1992; 149: 1649
  • Appasamy P. M., Kenniston T. W., Jr., Weng Y., Holt E. C., Kost J., Chambers W. H. Interleukin 7-induced expression of specific T-cell receptor gamma variable region genes in murine fetal liver cultures. J Exp Med 1993; 178: 2201
  • Candeias S., Peschon J., Muegge K., Durum S. Defective TCR gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunology Letters 1997; 57: 9
  • Tsuda S., Rieke S., Hashimoto Y., Nakauchi H., Takahama Y. II-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells. J Immunol 1996; 156: 3233
  • Muegge K., Vila M. P., Durum S. K. Interleukin-7: a cofactor for V(D)J rearrangement of the T-cell receptor beta gene. Science 1993; 261: 93
  • Oosterwegel M., Haks M., Jeffry U., Murray R., Kruisbeek A. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC Class n expressing thymic stromal cells. Immunity 1997; 6: 351
  • Crompton T., Outram S. V., Buckland J., Owen M. J. A transgenic T-cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice. Eur J Immunol 1997; 27: 100
  • Hernandez Caselles T., Martinez Esparza M., Sancho D., Rubio G., Aparicio P. Interleukin-7 rescues human activated T lymphocytes from apoptosis induced by glucocorticosteroids and regulates bcl-2 and CD25 expression. Hum Immunol 1995; 43: 181
  • Lee S. H., Fujita N., Mashima T., Tsuruo T. Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression. Oncogene 1996; 13: 2131
  • Maraskovsky E., O'Reilly L., Teepe M., Corcoran L., Peschon J., Strasser A. Bcl-2 can rescue T-lymphocyte development in interleukin-7 receptor deficient mice but not in mutant RAG1-/-mice. Cell 1997; 89: 1011
  • Akashi K., Kondo M., Von Freeden-Jeffry U., Murray R., Weissman I. Bcl-2 rescues T lymphopoiesis in IL-7 receptor deficient mice. Cell 1997; 89: 1033
  • Veis D. J., Sorenson C. M., Shutter J. R., Korsmeyer S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993; 75: 229
  • Depinho R. A., Schreiber Agus N., Alt F. W. myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res 1991; 57: 1
  • Packham G., Porter C. W., Cleveland J. L. c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene 1996; 13: 461
  • Seckinger P., Milili M., Schiff C., Fougereau M. Interleukin-7 regulates c-myc expression in murine T-cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization. Eur J Immunol 1994; 24: 716
  • Perumal N., Kenniston T. W., Tweardy D. J., Dyer K. F., Hoffman R., Peschon J., Appasamy P. TCR-γ genes are rearranged but not transcribed in IL-7Rα-deficient mice. J. Immunol. 1997; 158: 5744

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