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Original Article

Cross-talk Between Retinoic Acid and Interferons: Molecular Mechanisms of Interaction in Acute Promyelocytic Leukemia Cells

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Pages 467-476 | Received 20 Nov 1997, Published online: 01 Jul 2009

References

  • Hong W.K., Itri L.M. Retinoids and human cancer. The retinoids: Biology, Chemistry and Medicine, 2nd edition, M.B. Sporn, A.B. Roberts, D.S. Goodman. Raven Press, New York, NY 1994; 597–630
  • Warrell R.P., Jr., Maslak P., Eardley A., Heller G., Miller W.H., Jr., Frankel S.R. Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience. Leukemia 1994; 8(Suppl 2)S33–S37
  • Chomienne C, Fenaux P., Degos L. Retinoid differentiation therapy in promyelocytic leukemia. FASEB, J 1996; 10: 1025–1030
  • Dombret H., Sutton L., Duarte M., Daniel M.T., Leblond V., Castaigne S., Degos L. Combined therapy with all-trans retinoic acid and high-dose chemotherapy in patients with hyperleukocytic acute promyelocytic leukemia and severe visceral hemorrage. Leukemia 1992; 6: 1237–1242
  • Kantarjian H.M., Keating M.J., Walters R.S., Estey E.H., McCredie K.B., Smith T.L., Dalton W.T., Jr., Cork A., Trujillo J.M., Freireich E.J. Acute promyelocytic leukemia. M.D. Anderson hospital experience. Am. J. Med. 1997; 80: 789–797
  • Grignani F., Fagioli M., Ferrucci P.F., Alcalay M., Pelicci P.G. The molecular genetics of acute promyelocytic leukemia. Blood Rev. 1993; 7: 87–93
  • Giannî M., Li Calzi M., Terao M., Guiso G., Caccia S., Barbui T., Rambaldi A., Garattini E. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood 1996; 87: 1520–1531
  • Giannî M., Terao M., Zanotta S., Barbui T., Rambaldi A., Garattini E. Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. Blood 1994; 83: 1909–1921
  • Giannî M., Terao M., Norio P., Barbui T., Rambaldi A., Garattini E. All-trans retinoic acid and cyclic adenosine monophosphate cooperate in the expression of leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. Blood 1995; 85: 3619–3635
  • Giannî M., Li Calzi M., Terao M., Rambaldi A., Garattini E. Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells. Biochem. Biophys. Res Commun. 1995; 208: 846–854
  • Lippman S., Parkinson D., Itri L., et al. 13-cis-retinoic acid and interferon-alfa 2a: effective combination therapy for advanced squamous cell carcinoma of the skin. J. Natl. Cancer Inst. 1992; 84: 235–241
  • Lippman S., Kavanagh J., Paredes-Espinoza M., et al. 13-cis retinoic acid plus interferon-alfa-2a: highly active systemic therapy for squamous cell carcinoma of the cervix. J. Natl. Cancer Inst. 1992; 84: 241–245
  • Marth C., Daxenbichler G., Dapunt O. Synergistic antiproliferative effect of human recombinant interferons and retinoic acid in cultured breast carcinoma cells. J. Natl. Cancer Inst. 1986; 77: 1197–1202
  • Giguere V., Ong E.S., Sequi P., Evans R.M. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330: 624–629
  • Brand N.J., Petkovich M., Krust A., Chambon P., de The H., Marchio A., Tiollais P., Dejean A. Identification of a second human retinoic acid receptor. Nature 1988; 330: 850–853
  • Krust A., Kastner P., Petkovich M., Zelent A., Chambon P. A third human retinoic acid receptor, hRAR-γ. Proc. Natl. Acad. Sci. USA 1989; 86: 5310–5314
  • Zelent A., Krust A., Petkovich M., Kastner P., Chambon P. Cloning of murine a and b retinoic acid receptors and a novel receptor g predominantly expressed in skin. Nature 1989; 339: 714–717
  • Zhang X-K., Hoffmann B., Tran PB-V., Graupner G., Pfahl M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 1992; 355: 441–446
  • Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992; 6: 329–344
  • Levin A.A., Sturzenbecker L.J., Kazmer S., Bosakowski T., Huselton C., Allenby G., Speck J., Kratzeisen C., Rosenberg M., Lovey A., Grippo J.F. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa. Nature 1992; 355: 359–361
  • Heyman R.A., Mangelsdorf D.J., Dyck J.A., Stein R.B., Eichele G., Evans R.M., Thaller C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992; 68: 397–406
  • Lanotte M., Martin Thouvenin V., Najman S., Balerini P., Valensi F., Berger R. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 1991; 77: 1080–1086
  • Agadir A., Cornic M., Jerome M., Menot M.L., Cambier N., Gaub M.P., Gourmel B., Lefebvre P., Degos L., Chomienne C. Characterization of nuclear retinoic acid binding activity in sensitive leukemic cell lines: cell specific uptake of ATRA and RARa protein modulation. Biochem. Biophys. Res. Commun. 1995; 213: 112–122
  • Chomienne C., Balitrand N., Ballerini P., Castaigne S., de The H., Degos L. All-trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells. J Clin. Invest. 1991; 88: 2150–2154
  • Giannî M., Terao M., Gambacorti Passerini C., Rambaldi A., Garattini E. Effects of 1,25-dihydroxy vitamin D3 on all-trans retinoic acid sensitive and resistant acute promyelocytic leukemia cells. Biochem. Biophys. Res Commun. 1996; 224: 50–56
  • Duprez E., Lillehaug J.R., Gaub M.P., Lanotte M. Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells. Oncogene 1996; 12: 2443–2450
  • Borrow J., Goddard A.D., Sheer D., Solomon E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990; 249: 1577–1580
  • Ruthardt M., Testa U., Nervi C., Ferrucci P.F., Grignani F., Puccetti E., Grignani F., Peschle C., Pelicci P.G. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor a (RARa) and PLZF-RARa fusion proteins on retinoic acid signalling. Mol. Cell. Biol. 1997; 17: 4859–4869
  • Nason Burchenal K., Gandini D., Botto M., Allopenna J., Seale J.R., Cross N.C., Goldman J.M., Dmitrovsky E., Pandolfi P.P. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood 1996; 88: 3926–3936
  • Chelbi-Alix M.K., Pelicano L., Quignon F., Koken M.H.M., Venturini L., Stadler M., Pavlovic J., Degos L., de The H. Induction of the PML protein by interferons in normal and APL cells. Leukemia 1995; 9: 2027
  • Giannî M., Zanotta S., Terao M., Rambaldi A., Garattini E. Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells: potentiation of the induction of retinoid-dependent differentiation markers. Int. J. Cancer 1996; 68: 75–83
  • Yoshida H., Kitamura K., Tanaka K., Omura S., Miyazaki T., Hachiya T., Ohno R., Naoe T. Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res. 1996; 56: 2945–2948
  • Raelson J.V., Nervi C., Rosenauer A., Benedetti L., Monczak Y., Pearson M., Pelicci P.G., Miller W.H.J. The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood 1996; 88: 2826–2832
  • Dermime S., Grignani F., Clerici M., Nervi C., Sozzi G., Talamo G.P., Marchesi E., Formelli F., Parmiani G., Pelicci P.G., Passerini-Gambacorti C. Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/rar alpha protein. Blood 1993; 82: 1573–1577
  • Garattini E., Gianni' M. Leukocyte alkaline phosphatase a specific marker for the post-mitotic neutrophilic granulocyte: regulation in acute promyelocytic leukemia. Leak. Lymphoma 1996; 23: 493–503
  • Tkatch L.S., Rubin K.A., Ziegler S.F., Tweardy D.J. Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. Leukocyte Biol. 1995; 57: 964–971
  • Rambaldi A., Terao M., Bettoni S., Tini M.L., Bassan R., Barbui T., Garattini E. Expression of leukocyte alkaline phosphatase gene in normal and leukemic cells: regulation of the transcript by granulocyte colony-stimulating factor. Blood 1990; 76: 2565–2571
  • Rambaldi A., Terao M., Bettoni S., Bassan R., Battista R., Barbui T., Garattini E. Differences in the expression of alkaline phosphatase mRNA in chronic myelogenous leukemia and paroxysmal nocturnal hemoglobinuria polymorphonuclear leukocytes. Blood 1989; 73: 1113–1115
  • Pedersen B. Functional and biochemical phenotype in relation to cellular age of differentiated neutrophils in chronic myeloid leukemia. Br. J. Haematol. 1982; 51: 339–344
  • Williams B.R.G., Haque S.J. Interacting pathways of interferon signaling. Sem. in Oncol 1997; 24(suppl. 9)S9.70–S9.77
  • Matikainen S., Ronni T., Hurme M., Pine R., Julkunen I. Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood 1996; 88: 114–123
  • Matikainen S., Ronni T., Lehtonen A., Sareneva T., Melen K., Nordling S., Levy D.E., Julkunen I. Retinoic acid induces signal transducer and activator of transcription (STAT)1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Cell Growth Diff. 1997; 8: 687–698
  • Gianni' M., Terao M., Fortino I., Li Calzi M., Viggiano V., Barbui T., Rambaldi A., Garattini E. Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Blood 1997; 89: 1001–1012
  • Kumar R., Korutla L. Growth inhibition of human acute promyelocytic leukemia NB-4 cells by inteferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways. Anticancer Res. 1995; 15: 353–360
  • Kolla V., Lindner D.J., Weihua X., Borden E.C., Kalvakolanu D.V. Modulation of interferon(IFN)-inducible gene expression by retinoic acid. J. Biol. Chem. 1996; 271: 10508–10514
  • Weihua X., Kolla V., Kalvakolanu D.V. Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. J. Biol. Chem. 1997; 272: 9742–9748
  • Nguyen H., Lin R., Hiscott J. Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/ReIA fusion proteins. Oncogene 1997; 15: 1425–1435
  • Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata T., Taniguchi T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 1989; 58: 729–739
  • Lamphier M., Taniguchi T. The transcription factors IRF-1 and IRF-2: linking the interferon response and cell growth control. The Immunologist 1994; 2: 167–171
  • Benech P., Mory Y., Revel M., Chebath J. Structure of two forms of interferon-induced (2′-5′) olygo A synthetase of human cells based on cDNAs and gene sequences. EMBO J. 1985; 4: 2249–2259
  • White J.A., Guo Y-D., Baetz K., Beckett-Jones B., Bonasoro J., Hsu K.E., Dilworth F.J., Jones G., Petkovich M. Identification of the retinoic acid-inducible all-trans retinoic acid 4-hydroxylase. J. Biol. Chem. 1996; 271: 29922–29927
  • Muindi J., Frankel S.R., Miller W.H., Jr, Jakubowski A., Scheinberg D.A., Young C.W., Dmitrovsky E., Warrell R.P.J. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid “resistance” in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]. Blood 1992; 79: 299–303
  • Kuwahara S.K., Mannering G.J. Effects of interferon, polyriboinosinic acid-polyribocytidilic acid and steroids on the cytochrome P450 system of cultured primary mouse hepatocytes. Pharmacol. Toxicol. 1993; 72: 199–204
  • Roller E., Krieger O., Kasparu H., Lutz D. Restoration of all-trans retinoic acid sensitivity by interferon in acute promyelocytic leukemia (letter). Lancet 1991; 338: 1154–1155
  • ITALIAN COOPERATIVE GROUP STUDY On CHRONIC MYELOID LEUKEMIA. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N. Engl. J Med. 1994; 330: 820–825

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