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Original Article

Clinical Trials with an Anti-CD25 Ricin A-Chain Experimental and Immunotoxin (RFT5-SMPT-dgA) in Hodgkin's Lymphoma

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Pages 525-538 | Received 20 Sep 1997, Published online: 01 Jul 2009

References

  • De Vita V.T., Molloy Hubbard S. Hodgkin's lymphoma. New Engl. J. Med. 1983; 328: 560–565
  • Longo I.L., Young R.C., Wesley M. Twenty years of MOPP therapy for Hodgkin's lymphoma. J. Clin. Oncol 1986; 4: 1295–1306
  • Riethmüller G., Schneider-Gädicke E., Schlimok G., Schmiegel W., Raab R., Höffken K., Gruber R., Pichlmaier H., Hirche H., Pichlmayr R., Buggisch P., Witte R., and the German Cancer Aid 17-1A Study Group. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes'C colorectal carcinoma. Lancet 1994; 343: 1177–1183
  • J Ro D.C., Griffin J.D., Belvin M., Blättler W.A., Lambert J.M., Ritz J. Anti-My9-blocked ricin: An immunotoxin for selective targeting of acute myeloid leukemia cells. Blood 1991; 77: 2404–2412
  • Gribben J.G., Freedman A.S., Neuberg D., Roy D.C., Blake K.W., Woo S.D., Grossbard M.L., Rabinowe S.N., Coral F., Freeman G.L, Ritz J., Nadler L.M. Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N. Engl. J. Med. 1991; 325: 1525–1533
  • Simonsson B. Treatment of minimal residual disease in acute myelogenous leukemia (AML): focus on immunotherapeutic options. Leukemia 1996; 10 Suppl 2: 44–45
  • Mitchell M.S. Active specific immunotherapy of melanoma. Br. Med. Bull 1995; 51(3)631–645
  • Grossbard M.L., Gribben J.G., Freedman A.S., Lambert J., Kinsella J., Rabinowe S., Eliseo L., Taylor J., Blatter W., Epstein C., Nadler L. Adjuvant immunotoxin therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with B-cell non-Hodgkin's lymphoma. Blood 1993; 81: 2263–2271
  • J Schnell R., Barth S., Diehl V., Engert A. Hodgkin's disease. Future treatment strategies: fact or fiction. Baillieres Clinical Haematology, V. Diehl, 1996; 573–593
  • Hsu S.M., Jaffe E.S. Leu M1 and peanut agglutinin stain the neoplastic cells of Hodgkin's lymphoma. Am. J. Clin. Pathol 1984; 82: 29–32
  • Hsu S.M., Ho Y.S., Hsu P.L. Effect of monoclonal antibodies anti-2H9, anti-IRac, and anti-HeFi-1 on the surface antigens of Reed-Sternberg cells. J. Nat. Cancer Inst. 1987; 79: 1091–1097
  • Stein H., Mason D.Y., Gerdes J., O'Conner N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H., Schwarting R., Lennert K. The expression of the Hodgkin's-disease-associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Sternberg-Reed cells and histocytic malignancies are derived from activated lymphoid cells. Blood 1985; 66: 848–858
  • Agnarsson B.A., Kadin M.E. The immunophenotype of Reed-Sternberg cells. A study of 50 cases of Hodgkin's lymphoma using fixed frozen tissue. Cancer 1989; 63: 2083–2087
  • Casey T.T., Olson S.J., Cousar J.B., Collins R.D. Immunophenotypes of Reed-Sternberg cells: a study of 19 cases of Hodgkin's lymphoma in plastic-embedded sections. Blood 1989; 74: 5042–5046
  • Kennedy I.C., Hart D.N., Colls B.M. Nodular sclerosing, mixed cellularity and lymphocyte-depleted variants of Hodgkin's lymphoma are probable dendritic cell malignancies. Clin. Exp. Immunol. 1989; 76: 324–331
  • Delabie J., Ceuppens J.L., Vandenberghe P., de Boer M., Coorevits L., de Wolf-Peeters C. The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's lymphoma and contributes to the stimulating capacity of Hodgkin's lymphoma-derived cell lines. Blood 1993; 82: 2845–2852
  • Taniguchi T., Minami Y. The IL-2/IL-2 receptor system: a current overview. Cell 1993; 73: 5–8
  • Kreitman R.J., Pastan I. Recombinant single-chain immunotoxins against T- and B-cell leukemias. Leuk. Lymph. 1994; 13: 1–10
  • Strauchen J.A., Breakstone B.A. IL-2 receptor expression in human lymphoid lesions. Immunohistochemical study of 166cases.Am. J. Pathol. 1987; 126: 506–512
  • Till M., May R.D., Uhr J.W., Thorpe P.E., Vitetta E.S. An assay that predicts the ability of monoclonal antibodies to form potent ricin A chain-containing immunotoxins. Cancer Res. 1988; 48: 1119–1123
  • Diehl V., Kirchner H.H., Schaadt M., Fonatsch C., Stein H., Gerdes J., Boie C. Hodgkin's disease: establishment and characterization of four in vitro cell lines. J. Cancer Res. Clin. Oncol. 1981; 101: 111–124
  • Casellas P., Brown J.P., Gros O., Gros P., Hellstrom I., Jansen F.K., Poncelet P., Roncucci R., Vidal H., Hellstrom K.E. Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97. Int. J. Cancer 1981; 30: 437–443
  • Engert A., Martin G., Amlot P., Wijdenes J., Diehl V., Thorpe P. Immunotoxins constructed with anti-CD25 monoclonal antibodies and deglycosylated ricin A-chain have potent anti-tumour effects against human Hodgkin cells in vitro and solid Hodgkin tumours in mice. Int. J. Cancer 1991; 49: 450–456
  • Winkler U., Gottstein C, Schön G., Kapp U., Wolf J., Hansmann M.L., Bohlen H., Thorpe P., Diehl V., Engert A. Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins. Blood 1994; 83: 466–475
  • Engert A., Diehl V., Schnell R., Radszuhn A., Hatwig M.T., Drillich S., Schön G., Bohlen H., Tesch H., Hansmann M.L., Barth S., Schindler J., Ghetie V., Uhr J., Vitetta E. A Phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma. Blood 1997; 89(2)403–410
  • Vitetta E.S., Stone M., Amlot P., Fay J., May R., Till M., Newman J., Clark P., Collins R., Cunningham D., Ghetie V., Uhr J., Thorpe P. Phase-I immunotoxin trial in patients with B-cell lymphoma. Cancer Res. 1991; 51: 4052–4058
  • Amlot P., Stone M.J., Cunningham D., Fay J., Newman J., Collins R., May R., McCarthy M., Richardson J., Ghetie V., Ramillo O., Thorpe P., Uhr J., Vitetta E.S. A Phase-I study of an anti-CD22-deglycosylated ricin A-chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy. Blood 1993; 82: 2624–2633
  • Sausville E.A., Headlee D., Stetler-Stevenson M., Jaffe E.S., Solomon D., Figg W.D., Herdt J., Kopp W.C, Rager H., Steinberg S.M., Ghetie V., Schindler J., Uhr J.W., Wittes R.E., Vitetta E.S. Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: A Phase-1 study. Blood 1995; 85: 3457–3465
  • Stone M.J., Sausville E.A., Fay J.W., Headlee D., Collins R.H., Figg W.D., Stetler-Stevenson JainM.V., Jaffe E.S., Solomon D., Lush R.M., Senderowilz A., Ghetie V., Schindler J., Uhr J.W., Vitetta E.S. A Phase-1 study of bolus vs. continuous infusion of the anti-CD19 immunotoxin, IgG-HL37-dgA in patients with B cell lymphoma. Blood 1996; 88(4)1188–1197
  • Vitetta E.S., Thorpe P.E., Uhr J.W. Immunotoxins: magic bullets or misguided missiles?. Immunol. Today 1993; 14: 252–259
  • Byers V.S., Baldwin R.W. Rationale for clinical use of immunotoxins in cancer and autoimmune diseases. Sent. Cell Biol. 1991; 2: 59–70
  • Durrant L.G., Byers V.S., Scannon P.J., Rodvien R., Grant K., Robins R.A., Marksman R.A., Baldwin R.W. Humoral immune resonses to XMMCO-791-RTA immunotoxins in colorectal cancer patients. Clin. Exp. Immunol. 1989; 75: 258–264
  • Junghans R.P., Waldmann T.A. Metabolism of TAC (IL2Rα): Physiology of cell surface shedding and renal catabolism, and suppression of catabolism by antibody binding. J. Exp. Med. 1996; 185: 1587–1602
  • Kreitman R.J., Chaudhary V.K., Kozak R.W., FitzGerald D.J.P., Waldmann T.A., Pastan I. Recombinant toxins containing the variable domains of the anti-TAC monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia. Blood 1992; 80: 2344–2352
  • Kreitman R.J., Chaudhary V.K., Waldmann T.A., Hanchard B., Cranston B., FitzGerald D.J.P., Pastan I. Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or Diphteria toxin toward lymphocytes from patients with adult T-cell leukemia. Leukemia 1993; 7: 553–562
  • Foss F.M., Borkowski T.A., Gilliom M., Stetler-Stevenson M.A., Jaffe E.S., Figg W.D., Tompkins A., Bastian A., Nylen P., Woodworth T., Udey M.C., Sausville E.A. Chimeric fusion protein toxin DAB486IL-2 in advanced mycosis fungoides and the Sezary syndrome: Correlation of activity and interleukin-2 receptor expression in a Phase-II study. Blood 1994; 84: 1765–1774
  • Foss F.M., Nichols J., Parker K. Seragen Lymphoma Study Group. Phase-I/II trial of DAB389IL-2 in patients with NHL, HL and CTCL. Fourth International Symposium on Immunotoxins. 1995; 159A
  • Williams D.P., Parker K., Bacha P., Bishai W., Borowksi M., Genbauffe F., Strom T.B., Murphy J.R. Diphtheria toxin receptor binding domain substitution with interleukin-2: Genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. Prot Eng 1987; 1: 493–498
  • LeMaistre C.F., Craig F.E., Meneghetti C.M., McMullin B., Parker K., Reuben J., Boldt D.H., Rosenblum M., Woodworth T. Phase-I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. Cancer Res 1993; 53: 3930–3934
  • LeMaistre C.F., Meneghetti C, Rosenblum M., Reuben J., Parker K., Shaw J., Deisseroth A., Woodworth T., Parkinson D.R. Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB48JL-2) in hematologic malignancies expressing the IL-2 receptor. Blood 1992; 79: 2547–2554
  • Tepler I., Schwartz G., Parker K., Charette J., Kadin M.E., Woodworth T.G., Schnipper L.E. Phase-I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: Complete response in a patient with Hodgkin's disease refractory to chemotherapy. Cancer 1994; 73: 1276–1285
  • Schwab U., Stein H., Gerdes J., Kirchner H., Schaadt M., Diehl V. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's lymphoma and a subset of normal lymphoid cells. Nature 1982; 299: 65–67
  • Tazzari P.L., Bolognesi A., de Totero D., Falini B., Lemoli R.M., Soria M.R., Pileri S., Gobbi M., Stein H., Flenghi L., Martelli M.F., Stirpe F. Ber-H2 (anti-CD30)-saporin immunotoxin: a new tool for the treatment of Hodgkin's lymphoma and CD30+ lymphoma: in vitro evaluation. Br. J. Haematol. 1992; 81: 203–211
  • Pasqualucci L., Wasik M., Teicher B.A., Flenghi L., Bolognesi A., Stirpe F., Polito L., Falini B., Kadin ME. Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood 1995; 85: 2139–2146
  • Falini B., Bolognesi A., Flenghi L., Tazzari P.L., Broe M.K., Stein H., Durkop H. Response of refractory Hodgkin's lymphoma to monoclonal anti-CD30 immunotoxin. Lancet 1992; 339: 1195–1196
  • Falini B., Pasqualucci L., Flenghi L., Bolognesi A., Kadin M., Stein H., Martinelli M.F., Stirpe F. Anti-CD30 immunotoxins: experimental and clinical studies. Abstracts of the Fourth International Symposium on Immunotoxins. 1995; 160
  • Engert A., Burrows F., Jung W., Tazzari P.L., Stein H., Pfreundschuh M., Diehl V., Thorpe P. Evaluation of ricin A-chain-containing immunotoxins directed against the CD30 antigen as potential reagents for the treatment of Hodgkin's lymphoma. Cancer Res. 1990; 50: 84–88
  • Engert A., Martin G., Pfreundschuh M., Amlot P., Hsu S.M, Diehl V., Thorpe P.E. Antitumor effects of ricin A-chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's lymphoma tumors in mice. Cancer Res. 1990; 50: 2929–2935
  • Horn-Lohrens O., Tiemann M., Lange H., Kobarg J., Hafner M., Hansen H., Sterry W., Parwaresch R.M., Lemke H. Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4). In. J. Cancer 1995; 60: 539–544
  • Schnell R., Linnartz C., Schön G., Katouzi A., Bohlen H., Horn-Lohrens O., Parwaresch R., Diehl V., Lemke H., Engert A. Development of new ricin A-chain immunotoxins with potent anti-tumor effects against human Hodgkin cells in vitro and disseminated Hodgkin tumors in SCID mice using high-affinity monoclonal antibodies directed against the CD30 antigen. Int. J. Cancer 1995; 63: 238–244
  • Engert A., Gottstein C, Bohlen H., Winkler U., Schön G., Manske O., Schnell R., Diehl V., Thorpe P. Cocktails of ricin A-chain immunotoxins against different antigens of Hodgkin and Sternberg-Reed cells have superior anti-tumor effects against H-RS cells in vitro and solid Hodgkin tumors in mice. Int. J. Cancer 1995; 63: 304–309
  • Katz F.E., Janossy G., Cumber A., Ross W., Blacklock H.A., Tax W., Thorpe P.E. Elimination of T cells from human peripheral blood and bone marrow using a cocktail of three anti-T cell immunotoxins. Brit. J. Haematol. 1987; 67: 407–411
  • Ghetie M.A., Tucker K., Richardson L, Uhr J.W., Vitetta E.S. The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD 19 antibody or an anti-CD19 immunotoxin. Blood 1992; 80: 2315–2320

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