23
Views
9
CrossRef citations to date
0
Altmetric
Original Article

A Phase I Trial of Standard and Cyclophosphamide Dose-Escalated CHOP with Granulocyte Colony Stimulating Factor in Elderly Patients with Non-Hodgkin's Lymphoma

, , , &
Pages 591-600 | Received 22 Apr 1997, Published online: 01 Jul 2009

References

  • International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 1993; 329: 987–994
  • Hoskens P.J., Ng V., Spinelli J.J., Klimo P., Connors J.M. Prognostic variables in patients with diffuse large-cell lymphoma treated with MACOP-B. J Clin Oncol 1991; 9: 220–226
  • Coiffier B., Gisselbrecht C., Vose J.M., Tilly H., Herbrecht R., Bosly A., Armitage J.O. Prognostic factors in aggressive malignant lymphoma and validation of a prognostic index that could identify patients requiring a more intensive therapy. J Clin Oncol 1991; 9: 211–219
  • Vose J.M., Armitage J.O., Weisenburger D.D., Bierman P.J., Sorensen S., Hutchins M., Moravee D.F., Howe D., Dowling M.D., Maillard J., Johnson P.S., Pevnick W., Packard W.M., Okerbloom J., Thompson R.F., Langdon R.M., Soori G., Peterson C. The importance of age in survival of patients treated with chemotherapy for aggressive non-Hodgkin's lymphoma. J Clin Oncol 1988; 6: 1838–1844
  • Armitage J.O., Potter J.F. Aggressive chemotherapy for diffuse histiocytic lymphoma in the elderly. J Am Geriatr Soc 1984; 32: 269–273
  • Balducci L., Parker M., Sexton W., Tantranond P. Pharmacology of antineoplastic agents in the elderly patient. Semin Oncol 1989; 16: 76–84
  • McMaster M.L., Johnson D.H., Greer J.P., Wolff S.N., Hildreth C.R., Greco A., Hainsworth. A brief-duration combination chemotherapy for elderly patients with poor-prognosis non-Hodgkin's lymphoma. Cancer 1991; 67: 1487–1492
  • Tirelli U., Zagonel V., Serraino S.R., Talamini R., De Cicco M., Carbone A., Monfardini S. A prospective study of a new combination chemotherapy regimen in patients older than 70 years with unfavorable non-Hodgkin's lymphoma. J Clin Oncol 1992; 10: 228–236
  • O'Reilly S.E., Connors J.M., Howdle S., Hoskins P., Klasa R., Klimo P., Stuart DS. In search of an optimal regimen for elderly patients with advanced-stage diffuse large-cell lymphoma: Results of a phase II study of P/DOCE chemotherapy. J Clin Oncol 1993; 11: 2250–2257
  • Martelli M., Guglielmi C, Coluzzi S., Avvisati G., Amadori S., Giovannini M., Torromeo C., Mandelli F.P. VAPEC: A prospective study of a new weekly chemotherapy regimen for elderly aggressive non-Hodgkin's lymphoma. J Clin Oncol 1993; 11: 2362–2369
  • Meyer R.M., Browman G.P., Samosh M.L., Benger A.M., Bryant-Lukosius D., Wilsom W. E.C, Frank G.L., Laber B.F., Sternbach M.S., Foster G.A., Skingley P., Levine M.N. Randomized phase II comparison of standard CHOP with weekly CHOP in elderly patients with non-Hodgkin's lymphoma. J Clin Oncol 1995; 13: 2386–2393
  • Sonneveld P., de Ridder M., van der Lelie H., Nieuwenhuis K., Schouten H., Mulder A., van Reijswoud I., Hop W., Lowenberg B. Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP versus CNOP chemotherapy. J Clin Oncol 1995; 13: 2530–2539
  • Tirelli U., Van Glabbeke M., Teodorovic I., Thomas J., Bron D., Kluin-Nelemans J.C, Somers R., Rosti G., Roozendaal ZagonelV., Monfardini S., Noordijk E.M. A randomized comparison of CHOP vs. a new combination of VP-16, mitoxantrone and prednimustine (VMP) in patients >70 years of age with intermediate-high grade NHL. Proc Am Soc Clin Oncol 1995; 14: 398, abstr
  • McKelvey E.M., Gottlieb J.A., Wilson H.E., Haut A., Talley R.W., Stephens R., Lane M., Gamble J.F., Jones S.E., Grozea P.N., Gutterman J., Coltman C., Moon T.E. Hydroxyldaunorubicin (Adriamycin) combination chemotherapy in malignant lymphoma. Cancer 1976; 38: 1484–1493
  • Coiffier B., Biron P., Bastion Y., Haioun C, Bordessoulle D., Sebban C, Blanc M., Tilly H., Salles B., Bouabdallah R., Gisselbrecht C. Elderly lymphoma patients have a long survival if treated with a curative intent. A study from the G.E.L.A. on 453 patients older than 69 years. Proc ASCO 1996; 15: 417, abstr
  • Pettengell R., Gurney H., Radford J.A., Deakin D.A., James R., Wilkinson P.M., Kane K., Bentley J., Crowther D. Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: A randomized controlled trial. Blood 1992; 80: 1430–1436
  • Crawford J., Ozer H., Stoller R., Johnson D., LymanTabbara I., Kris M., Grous J., PicozziRausch G., Smith R., Gradishar W., Yahanda A., Vincent M., Stewart M., Glaspy J. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 1991; 325: 164–170
  • The Non-Hodgkin's Lymphoma Pathologic Classification Project. National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112–2135
  • Carbone P.P., Kaplan H.S., Musshoff K., Smithers D.W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 1971; 31: 1860–1861
  • Oken M.M., Creech R.H., Tormey D.C, Horton J., Davis T.E., McFadden E.T., Carbone P.P. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649–655
  • Miller A.B., Hogstraten B., Staquet M., Winkler A. Reporting results of cancer treatment. Cancer 1981; 47: 207–214
  • Hryniuk W.M. The importance of dose intensity in the outcome of chemotherapy. Advances in Oncology, S. Hellman, V. DeVita, S. Rosenberg. J.B. Lippincott Co., Philadelphia, Pa 1988; 121–141
  • Mood A., Graybill F., Boes D. Introduction to the Theory of Statistics, 3rd ed. McGraw-Hill Book Company. 1963
  • Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. Amer. Stat. Assoc. J. 1958; 53: 457–481
  • Meyer R.M., Quirt I.C, Skillings J.R., Cripps M.C, Bramwell V. H.C, Weinerman B.H., Gospodarowicz M.K., Burns B.F., Sargeant A.M., Shepherd L.E., Zee B., Hryniuk W.M. Escalated as compared with standard doses of doxorubicin in BACOP therapy for patients with non-Hodgkin's lymphoma. N Engl J Med 1993; 329: 1770–1776
  • Gaynor E.R., Dahlberg S., Fisher R.I. Factors affecting reduced survival of the elderly with intermediate and high grade lymphoma: an analysis of SWOG-8516 (INT 0067): The national high priority lymphoma study-A randomized comparison of CHOP vs m-BACOD vs ProMACE-CytaBOM vs MACOP-B. Proc ASCO 1994; 13: 370, abstr

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.