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Leukemia & Lymphoma Volume 30, 1998 - Issue 5-6
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Original Article

Methylguazone, Vindesine and Cisplatin for the Treatment of Patients with Relapsed or Refractory Malignant Lymphoma: An Eastern Cooperative Oncology Group Study (PA482)

Peter H. Wiernik Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY
,
Vincent Phillip Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY
,
Fernando J. Camacho Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY
,
Martin M. Oken Virginia Piper Cancer Institute, Minneapolis, MN
&
Michael J. O'connell Mayo Clinic, Rochester, MN, USA
Pages 619-624 | Received 12 Dec 1997, Published online: 01 Jul 2009

References

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  • Warrell R.P., Jr., Lee B.J., Kempin S.T., Lacher M.J., Straus D.J., Young C.W. Effectiveness of methyl-GAG (methylglyoxal-bis guanylhydrazone) in patients with advanced malignant lymphoma. Blood 1981; 57: 1011–1014
  • Cavalli F., et al. Phase II trial of cis-dichlorodiammine-platinum (II) in advanced malignant lymphoma: A study of the Cancer and Acute Leukemia Group B. Cancer 1981; 48: 1927–1930
  • Pleshkewych A., Kramer D.L., Kelly E., et al. Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal bis (guanylhydrazone). Cancer Res 1980; 40: 4533–4540
  • Zwelling L.A., Kohn K.W. Mechanism of action of cis-dichlorodiammineplatinum (II). Cancer Treat Rep 1979; 63: 1439–1444
  • Dyke R.W., Nelson R.L. Phase I anti-cancer agents: Vindesine (desacetyl vinblastine amide sulfate). Cancer Treat Rev 1977; 4: 135–142
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  • Freelander B.L., French F.A. Carcinostatic action of polycarbonyl compounds and their derivatives. II Glyoxal bis (Guanylhydrazone) and derivatives. Cancer Res 1958; 18: 360–363
  • Levine A.M., Tulpule A., Tessman D., Kaplan L., Giles F., Luskey B.D., Scadden D.T., Northfelt D.W., Silverberg I., Wernz J., Espina B., Von Hoff D. Mitoguazone therapy in patients with refractory relapsed AIDS-related lymphoma: Results from a multicenter phase II trial. J Clin Oncol 1997; 15: 1094–1103
  • Wiernik P.H., Moore D.F., Bennett J.M., Vogl S.E., Harris J.E., Luger S., Oken M.M., Glick J.H. Phase II study of mitoguazone, cyclophosphamide, doxorubicin, vincristine and prednisone for patients with diffuse histologic subtypes of non-Hodgkin's lymphoma: An Eastern Cooperative Oncology Group study (PE481). Leukemia and Lymphoma 1997, in press

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