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Review Article

Detection of Minimal Residual Disease: Methods and Relationship to Outcome in T-Lineage Acute Lymphoblastic Leukemia

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Pages 65-75 | Received 01 Mar 1998, Published online: 01 Jul 2009

References

  • Wasserman R, Galili N, Ito Y, Silver J H, Reichard B A, Shane S, Womer R B, Lange B, Rovera G. Residual disease at the end of induction therapy as a predictor of relapse during therapy in childhood B-lineage acute lymphoblastic leukemia. Journal of Clinical Oncology 1992; 10: 1879–84
  • Brisco M J, Condon J, Hughes E, Neoh S H, Sykes P J, Seshadri R, Toogood I, Waters K, Tauro G, Ekert H. Outcome prediction in childhood acute lymphoblastic leukemia by molecular quantification of residual disease at the end of induction. Lancet 1994; 343: 196
  • Pullen D J, Crist W M, Falletta J M, . A Pediatric Oncology Group classification protocol for acute lymphoblastic leukemia (AlinC 13): immunologic phenotypes and correlation with treated results. Leukemia Research: Advances in Biology and Treatment, S Murphy, J Gilbert, et al. Elsevier in Hollan, Experta Medica, New York 1983; 22
  • Van Dongen J JM, Wolvers-Tettero I LM. Analysis of immunoglobulin and T-cell receptor genes. Part 1: Basic and technical aspects. Clinical Chimica Acta 1991; 198: 1
  • Davis M M, Bjorkmann P J. T-Cell antigen receptor genes and T-cell recognition. Nature 1988; 334: 395
  • La Faille J J, Decloux A, Bonneville M, Takagaki Y, Tonegawa S. Junctional sequences of T-cell receptor γδ genes: implications of γδ T-cell lineages and for a novel intermediate of V-(D)-J joining. Cell 1989; 59: 859–863
  • Breit T M, Wolvers- Tettero I LM, Hahlen K, Van Wering F R, Van Dongen J JM. Extensive junctional diversity of γδ T-cell receptors expressed by T-cell acute lymphoblastic leukemias: implications for the detection of minimal residual disease. Leukemia 1991; 5: 1076–1081
  • Carrol A J, Crist W M, Link M P, Amylon M D, Pullen D J, Ragab A H, Buchanan G R, Wimmer R S, Vietti T J. The t(1;14) (p3.4; q1.1) translocation is non-random and restricted to T-cell acute lymphoblastic leukemia. A Pediatric Oncology Group Study. Blood 1990; 76: 1220–24
  • Brown L, Cheng J-T, Chen Q, Siciliano M J, Crist W, Buchanan G R, Baer R. Site-specific recombination of the TAL 1 gene is a common occurrence in human T-cell leukemia. EMBO Journal 1990; 9: 3343–51
  • Bernard O, Lecointe N, Jonveaux P, Soury M, Mauchauffe M, Berger R, Larson C J, Mathie-Mahul D. Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5′ part of the TAL 1 gene. Oncogene 1991; 6: 1477–88
  • Apian P D, Lombardi P D, Reaman G H, Sather H R, Hammond G D, Krisch I R. Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. Blood 1992; 79: 1327–1333
  • Jonsson O G, Kitchens R L, Baer R J, Buchanan G R, Smith R G. Rearrangements of the TAL-1 locus as clonal markers for T-cell acute lymphoblastic leukemia. Journal of Clinical Investigation 1991; 87: 2029–34
  • Breit T M, Beishuizen A, Ludwig W D, Mol E J, Adriaasen H J, Van Wering E R, Van Dongen J JM. Tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease. Leukemia 1993; 7: 2004–11
  • Bash R O, Crist W, Shuster J J, Link M P, Amylon M, Pullen J, Carrol A, Buchanan G R, Smith G, Baer R. Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL 1 locus: a Pediatric Oncology Group Study. Blood 1993; 81: 2110–2117
  • Pui C H, Behm F G, Crist W M. Clinical and biological relevance of immunologic marker studies in childhood acute lymphoblastic leukemia. Blood 1993; 82: 343–9
  • Van Dongen J JM, Wolvers-Tettero I LM. Analysis of immunoglobulin and T-Cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders. Clinical Chimica Acta 1991; 198: 93–108
  • Breit T M, Wolvers-Tettero I LM, Beishuizen A, Verhoeven M AJ, Wering E R, Van Dongen J JM. Southern blot patterns, frequencies, and junctional diversity of T-cell receptor 5 gene rearrangements in acute lymphoblastic leukemia. Blood 1993; 82: 3063–70
  • Bonati A, Zanelli P, Savi M, Neri T M. TcR P chain gene rearrangement and expression in human T-cell development and in leukemia. Leukemia 1994; 8: 918–922
  • Kneba M, Bolz I, Linke B, Hiddemann W. Analysis of rearranged T-cell receptor β-chain genes by polymerase chain reaction (PCR) DNA sequencing and automated high-resolution PCR fragment analysis. Blood 1995; 86: 3930–7
  • Lefranc M P, Forster A, Rabbitts T H. Rearrangement of two distinct T-cell gamma chain variable region genes in human DNA. Nature 1986; 319: 420–2
  • Lefranc M P, Forster A, Baer M, Stinson M, Rabbitts T H. Diversity and rearrangement of the human T-cell rearranging gamma genes: nine germline variable genes belonging of two subgroups. Cell 1986; 45: 237–24
  • Chen Z, Font M P, Loiseau P, Bories C, Duparc L, Degos L, Lefranc M P, Sigaux F. The Vy locus: cloning of new segments and the study of Vy rearrangements in neoplastic B and T cells. Blood 1988; 72: 776–783
  • Taylor J J, Rowe D, Williamson I K, Christmas S E, Proctor S J, Middleton P G. Detection of T-cell receptor y chain V gene rearrangements using the polymerase chain reaction: application of the study of clonal disease cells in acute lymphoblastic leukemia. Blood 1991; 77: 1989–1995
  • Steward G C, Goulden J N, Potter M N, Oakhill A. The use of polymerase chain reaction to detect minimal residual disease in childhood acute lymphoblastic leukemia. European Journal of Cancer 1993; 29: 1192–8
  • Macintyre E A, D'Auriol L, Duparc N, Leverger G, Galibert F, Sigaux F. Use of oligonucleotide probes directed against T-cell antigen receptor gamma delta Variable-(Diversity)-Joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias. Journal of Clinical Investigation 1990; 86: 2125–2135
  • Trainor K J, Brisco M J, Wan J H, Neoh S, Grist S, Morley A A. Gene rearrangement in B- and T-lymphoproliferative disease detected by polymerase chain reaction. Blood 1991; 78: 192–196
  • Tycko B, Palmer J D, Link M P, Smith S D, Sklar J. Polymerase chain reaction amplification of rearranged antigen receptor genes using junction-specific oligonucleotides: possible application for detection of minimal residual disease in acute lymphoblastic leukemia. Cancer Cell 1989; 7: 47–52
  • Veeklen H, Tycko B, Sklar J. Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasm by a polymerase chain reaction-mediated ribonuclease protection assay. Blood 1991; 78: 1318–1326
  • Norris M D, Kwan E, Haber M, Marshall C M. Detection of evolving immunoglobulin heavy-chain gene rearrangements in acute lymphoblastic leukemia: a PCR-based assay employing overlapping DJH primers. Leukemia 1995; 9: 1779–82
  • Haber M, Kwan E, Zhu L, Marshall G M, Norris M D. Sensitive non-radioactive PCR detection of clonal T-cell receptor-gamma gene rearrangements in childhood acute lymphoblastic leukaemia. British Journal of Haematology 1997; 98: 995–8
  • Biondi A, Champagne F, Rossi V, Giudici G, Cantu-Rajnoldi A, Masera G, Mantovani A, Mak T W, Minden M D. T-cell receptor delta gene rearrangement in T-cell acute lymphoblastic leukemia. Blood 1989; 73: 2133–2138
  • Hata S, Brenner M., Kragel M. Identification of putative human T cell receptor 8 complementary DNA clones. Science 1987; 238: 678–682
  • Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reiman J, Minden M, Mak T. Sequence and organization of the diversity, joining and constant region genes of the human T-cell δ chain gene. Proceeding National Academy of Science USA 1988; 85: 6097–6101
  • Satyanarayana K, Hata S, Devlin P, Roncarolo M G, De Vries E, Spits H, Strominger J L, Krangel M S. Genomic organization of the human T-cell receptor α/δ locus. Proceeding National Academy of Science USA 1988; 85: 8166–8170
  • Biondi A, Di Celle P F, Rossi V, Casorati G, Matullo G, Giudici G, Foa R, Migone N. High prevalence of Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood 1990; 75: 1834–40
  • Yokota S, Hansen-Hagge T, Bartram C R. T-cell receptor δ gene recombination in common acute lymphoblastic leukemia: preferential use of Vδ2 and frequent involvement of the Jα cluster. Blood 1991; 77: 141–8
  • Van Dongen J JM, Breit T M, Adriaansen H J, Beishuizen A, Hooijkaas H. Detection of minimal residual disease in acute leukemia by immunological marker analysis and polymerase chain reaction. Leukemia 1992; 6: 47–59
  • Neale G AM, Menarguez J, Kitchingman G R, Fitzgerald T J, Koehler M, Mirro J, Jr, Goorha R M. Detection of minimal residual disease in T-cell acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse. Blood 1991; 78: 739–45
  • Cave H, Guidal C, Rohrlich P, Defau M H, Broyart A, Lescoeur B, Rahimy C, Fenneteau O, Monplaisir N, D'Auriol L, Elion J, Vilmer E, Grandhamp B. Prospective monitoring and quantitation of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of Ig H and T-cell receptor genes. Blood 1994; 83: 1892–97
  • Seriu T, Hansen-Hagge T E, Erz D HR, Bartram C M. Improved detection of minimal residual leukemia through modifications of polymerase chain reaction analyses based on clone-specific T-cell receptor junctions. Leukemia 1995; 9: 316–320
  • Taube T, Seeger K, Beyermann B, Hanel C, Duda S, Linderkamp C, Henze G. Multiplex PCR for simultaneous detection of the most frequent T cell receptor-δ gene rearrangements in childhood ALL. Leukemia 1997; 11: 1978–1982
  • Dibenedetto S P, Lo Nigro L, Pine Mayer S, Rovera C, Schiliro G. Detectable molecular residual disease at the beginning of maintenance therapy indicates poor outcome in children with T-cell acute lymphoblastic leukemia. Blood 1997; 90: 1226–1232
  • Raimondi S C. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237–2251
  • Campana D, Pui C H. Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance. Blood 1995; 85: 1416–1434
  • Biondi A, Yokota S, Hansen-Hagge T E, Rossi V, Giudici G, Maglia O, Basso G, Tell C, Maserag, Bartram C R. Minimal residual disease in childhood acute lymphoblastic leukemia: analysis of patients in continuous complete remission or with consecutive relapse. Leukemia 1992; 6: 282–288
  • Kitchingman G R. Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia. Blood 1993; 81: 775–783
  • Steenbergen E J, Verhagen O JHM, Leeuwen E F, Berg H, Borne A EGKr, Schoot C E. Frequent ongoing T-cell receptor rearrangements in childhood B-precursor acute lymphoblastic leukemia: Implications for monitoring minimal residual disease. Blood 1995; 86: 692–706
  • Ghali D W, Panzer S, Fischer S, Tirita A A, Haas O A, Kovar H, Gadner H, Grumayer E RP. Heterogeneity of the T-cell receptor δ gene indicating subclone formation in acute precursor B-cell leukemias. Blood 1995; 85: 2795–2801
  • Beishuizen A, Verhoeven M J, Van Wering E R, Hahlen K, Hooijkaas And Van Dongen J JM. Analysis of Ig and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection of minimal residual disease by polymerase chain reaction. Blood 1994; 83: 2238–2247
  • Saiki R K, Gelfand D M, Stoffel S, Scharf S J, Miguchi R, Horn G T, Mullis K B, Erlich H A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988; 239: 487–492
  • Baruchel A, Cayuela J M, Macintyre E, Berger R, Sigaux F. Assessment of clonal evolution at Ig/TCR loci in acute lymphoblastic leukemia by single-strand conformation polymorphism studies and highly resolutive PCR-derived methods: implication for a general strategy of minimal residual disease detection. British Journal of Haematology 1995; 90: 85–93
  • Yamada M, Wasserman R, Lange B, Reichard B A, Womer R B, Rovera G. Minimal residual disease in childhood B-lineage lymphocytic leukemia: persistence of leukemic cells during the first 18 months of treatment. New England Journal of Medicine 1990; 323: 448–455
  • Yokota S, Hansen-Hagge T E, Ludwig W D, Reiter A, Raghavackar A, Kleihauer E, Bartram C R. Use of polymerase chain reaction to monitor minimal residual disease in acute lymphocytic leukemia patients. Blood 1991; 77: 331–337
  • Nizet Y, Van Daele S, Lewalle P, Vaerman J L, Philippe M, Vermylen C, Cornu G, Ferrant A, Michaux J L, Martial P. Long term follow up of residual disease in ALL patients in complete remission using clonogenic IgH probes and the polymerase chain reaction. Blood 1993; 82: 1618–1624
  • Ito Y, Wasserman R, Galili N, Reichard B, Shane S, Lange B, Rovera G. Molecular residual disease status at the end of chemotherapy fails to predict subsequent relapse in children with B-lineage acute lymphocytic leukemia. Journal of Clinical Oncology 1993; 11: 546–553
  • Privitera E, Rivolta A, Ronchetti D, Mosna G, Giudici G, Biondi A. Reverse transcriptase/polymerase chain reaction follow-up and minimal residual disease detection in t(1;19)-positive acute lymphoblastic leukaemia. British Journal of Haematology 1996; 92: 653–658
  • Cimino G, Elia L, Rivolta A, Rapanotti M C, Rossi V, Alimena G, Annino I., Canaani E, Lo Coco F, Biondi A. Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL-1/AF-4 positive-acute lymphoblastic leukaemia. British Journal of Haematology 1996; 92: 659–664
  • Goulden N, Langlands K, Steward C, Kats F, Potter M, Chessels J, Oakhill A. PCR assessment of bone marrow status in isolated extramedullary relapse of childhood B-precursor acute lymphoblastic leukaemia. British Journal of Haematology 1994; 87: 282–5
  • Kitchingman G. R. Residual disease detection in multiple follow-up samples in children with acute lymphoblastic leukaemia. Leukemia 1994; 8: 395–401
  • Ito Y, Miyamura K. Clinical significance of minimal residual disease in leukemia detected by polymerase chain reaction: is molecular remission a milestone for achieving a cure?. Leukemia and Lymphoma 1994; 16: 57–64
  • Seriu T., Yokota S., Nakao M, Misawa S., Takaue Y, Koizumi S., Kawai S, Fujimoto T. Prospecting monitoring of minimal residual disease during the course of chemotherapy in patients with lymphoblastic leukemia, and detection of contaminating tumor cells in peripheral blood stem cells for auto-transplantation. Leukemia 1995; 9: 615–623
  • Steenbergen E J, Verhagen O J, Van Leeuwen E F, Van Den Berg H, Behrendt H, Slater R M, Van Dem Borne A E, Van Der Schoot C E. Prolonged persistence of PCR-detect-able minimal residual disease after diagnosis of first relapse predicts poor outcome in childhood B-precursor acute lymphoblastic leukemia. leukemia 1995; 9: 1726–1734
  • Hansen-Hagge T E, Yokota S, Bartram C R. Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T cell receptor y sequences. Blood 1989; 74: 1762–8
  • Reiter A, Schrappe M, Ludwig W D. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Result and conclusions of the multicenter trial ALL-BFM 86. Blood 1994; 84: 3122–29
  • Schorin M, Blattner S, Gelber R. Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85–01. Journal of Clinical Oncology 1994; 12: 740–6
  • Smith M, Arthur D, Camitta B, Carrol A J, Crist W, Caynon P, Gelber R, Heerema N, Korn E L, Link M, Murphy S, Pui C H, Pullen J, Reaman G, Sallan S E, Sather H, Shuster J, Simon R, Trigg M, Tubergen D, Uckun F, Ungerleider R. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Journal of Clinical Oncology 1996; 14: 18–25
  • Uckun F M, Sensel M G, Sun L, Steinherz P G, Trigg M E, Heerema N A, Sather H N, Reaman G H, Gaynon P S. Biology and treatment of childhood T-lineage acute lymphoblastic leukemia. Blood 1998; 91: 735–746
  • Iolascon A, Faienza M F, Coppola B, Moretti A, Basso G, Amaru R, Vigano G, Biondi A. Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p3.2 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL-1 gene. Leukemia 1997; 11: 359–363
  • Van Den Berg, et al. Favorable outcome after 1-year treatment of childhood T-cell lymphoma/T-cell acute lymphoblastic leukemia. Medical Pediatric Oncology 1998; 30: 46–51
  • Moonka D, Loy E Y. A consensus primer to amplify a and P chains of the human T cell receptor. Journal of Immunological Methods 1994; 169: 41–46
  • Roberts M W, Estrov Z, Ouspenskaia M V, Johnston D A, McClain K L, Zipf T F. Measurement of residual leukemia during remission in childhood acute lymphoblastic leukemia. New England Journal of Medicine 1997; 336: 317–323
  • Dibenedetto S P, Schiliro G. Residual clones in childhood leukemia. New England Journal of Medicine 1997; 337: 50
  • Greaves M. Silence of leukemic clone. New England Journal of Medicine 1997; 336: 367–9

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