Interleukin-10 and Gp130 Cytokines in Human Multiple Myeloma

References

• Moore K. W., O'garra de Waal A., Malefyt R., Vieira P., Mosmann T. R. Interleukin-10. Annu. Rev. Immunol 1993; 11: 165–190
   PubMed Web of Science ®Google Scholar
• Vieira P., De Waal-Malefyt R., Dang M. N., Johnson K. E., Kastelein R., Fiorentino D. E., Vries J. E., Roncarolo M. G., Mosmann T. R., Moore K. W. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology with Epstein-Barr virus open reading frame BCRF1. Proc. Natl. Acad. Sci. USA 1991; 88: 1172–1176
   PubMed Web of Science ®Google Scholar
• De Waal Malefyt R., Abrams J., Benett B., Figdor C. G., De Vries J. E. Interleukin-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991; 174: 1209–1220
   PubMed Web of Science ®Google Scholar
• De Waal Malefyt R., Haanen J., Spits H., Roncarolo M. G., Te Velde A., Figdor C., Johnson K., Kastelein R., Yssel H., De Vries J. E. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigenpresenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp. Med. 1991; 174: 915–924
   PubMed Web of Science ®Google Scholar
• Van Vlasselaer P., Borremans B., Heuvel Van Den R., Van Gorp U., De Waal Malefyt R. Interleukin-10 inhibits the osteogenic activity of mouse bone marrow. Blood 1993; 82: 2361–2370
   PubMed Web of Science ®Google Scholar
• Chen W. F., Zlotnik A. IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 1991; 147: 528–534
   PubMed Web of Science ®Google Scholar
• Bazan J. F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl Acad. Sci. U. S. A. 1990; 87: 6934–6938
   PubMed Web of Science ®Google Scholar
• Ho A. S. Y., Liu Y., Khan T. A., Hsu D. H., Bazan J. F., Moore K. W. A Receptor for Interleukin-10 Is Related to Interferon Receptors. Proc. Natl. Acad. Sci. USA 1993; 90: 11267–11271
   PubMed Web of Science ®Google Scholar
• Gibbs V. C., Pennica D. CRF2–4: isolation of cDNA clones encoding the human and mouse proteins. Gene 1997; 186: 97–101
   PubMed Web of Science ®Google Scholar
• Kotenko S. V., Krause C. D., Izotova L. S., Pollack B. P., Wu W., Pestka S. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 1997; 16: 5894–5903
   PubMed Web of Science ®Google Scholar
• Spencer S. D., Di Marco F., Hooley J., Pitts-Meek S., Bauer M., Ryan A. M., Sordat B., Gibbs V. C., Aguet M. The orphan receptor CRF2–4 is an essential subunit of the interleukin 10 receptor. J Exp. Med 1998; 187: 571–578
   PubMed Web of Science ®Google Scholar
• Ho A. S., Wei S. H., Mui A. L., Miyajima A., Moore K. W. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol. Cell Biol 1995; 15: 5043–5053
   PubMed Web of Science ®Google Scholar
• Kotenko S. V., Izotova L. S., Pollack B. P., Muthukumaran G., Paukku K., Silvennoinen O., Ihle J. N., Pestka S. Other kinases can substitute for Jak2 in signal transduction by interferon-gamma. J Biol Chem 1996; 271: 17174–17182
   PubMed Web of Science ®Google Scholar
• Rodig S. J., Meraz M. A., White J. M., Lampe P. A., Riley J. K., Arthur C. D., King K. L., Sheehan K. C., Yin L., Pennica D., Johnson E. M., Jr., Schreiber R. D. Disruption of the Jakl gene demonstrates obligatory and non-redundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998; 93: 373–383
   PubMed Web of Science ®Google Scholar
• Wehinger J., Gouilleux F., Groner B., Finke J., Mertelsmann R., Weber-Nordt R. M. IL-10 induces DNA binding activity of three STAT proteins (Statl, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett 1996; 394: 365–370
   PubMed Web of Science ®Google Scholar
• Finbloom D. S., Winestock K. D. IL-10 induces the tyrosine phosphorylation of tyk2 and Jakl and the differential assembly of STAT alpha and STAT3 complexes in human T cells and monocytes. J Immunol. 1995; 155: 1079–1090
   PubMed Web of Science ®Google Scholar
• Weber-Nordt R. M., Riley J. K., Greenlund A. C., Moore K. W., Darnell J. E., Schreiber R. D. Stat3 recruitment by two distinct ligand-induced, tyrosinephosphorylated docking sites in the interleukin-10 receptor intracellular domain. J Biol Chem 1996; 271: 27954–27961
   PubMed Web of Science ®Google Scholar
• Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enter-colitis. Cell 1993; 75: 263–274
   PubMed Web of Science ®Google Scholar
• MacMillan R., Longmire R. L., Yelenosky R., Lang J. E., Heath V., Craddock C. G. Immunoglobulin synthesis by human lymphoid tissues: normal bone marrow as a major site of IgG production. J. Immunol 1972; 109: 1386
   PubMed Web of Science ®Google Scholar
• Hibi T., Dosh H. M. Limiting dilution analysis of the B cell compartment in human bone marrow. Eur. J. Immunol 1986; 16: 139–145
   PubMed Web of Science ®Google Scholar
• MacLennan I. C. Germinal centers. Annu. Rev. Immunol. 1994; 12: 117–139
   PubMed Web of Science ®Google Scholar
• Banchereau J., Rousset F. Growth of human B lymphocytes in the CD40 system. Nature 1991; 353: 678–681
   PubMed Web of Science ®Google Scholar
• Choe J., Kim H. S., Armitage R. J., Choi Y. S. The functional role of B cell antigen receptor stimulation and IL-4 in the generation of human memory B cells from germinal center B cells. J. Immunol. 1997; 159: 3757–3766
   PubMed Web of Science ®Google Scholar
• Dubois B., Vanbervliet B., Fayette J., Massacrier C., Van Kooten C., Briere F., Banchereau J., Caux C. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes [see comments]. J. Exp. Med. 1997; 185: 941–951
   PubMed Web of Science ®Google Scholar
• Arpin C., Dechanet J., Van Kooten C., Merville P., Grouard G., Briere F., Banchereau J., Liu Y. J. Generation of memory B cells and plasma cells in vitro. Science 1995; 268: 720–722
   PubMed Web of Science ®Google Scholar
• Choe J., Choi Y. S. IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells. Eur. J. Immunol 1998; 28: 508–515
   PubMed Web of Science ®Google Scholar
• Slifka M. K., Antia R., Whitmire J. K., Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity 1998; 8: 363–372
   PubMed Web of Science ®Google Scholar
• Levy Y., Brouet J. C. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J. Clin. Invest. 1994; 93: 424–428
   PubMed Web of Science ®Google Scholar
• Rousset F., Garcia E., Defrance T., Péronne C., Vezzio N., Hsu D. H., Kastelein R., Moore K. W., Banchereau J. Interleukin-10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl Acad. Sci. USA 1992; 89: 1890–1893
   PubMed Web of Science ®Google Scholar
• Burdin N., Péronne C., Banchereau J., Rousset R. Epstein-Bar virus transformation induces B lymphocytes to produce human interleukin-10. J. Exp. Med. 1993; 177: 295–304
   PubMed Web of Science ®Google Scholar
• Beatty P. R., Krams S. M., Martinez O. M. Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines. J Immunol. 1997; 158: 4045–4051
   PubMed Web of Science ®Google Scholar
• Tanner J. E., Tosato G. Regulation of B-cell growth and immunoglobulin gene transcription by interleu-kin-6. Blood 1992; 79: 452–459
   PubMed Web of Science ®Google Scholar
• Masood R., Zhang Y., Bond M. W., Scadden D. T., Moudgil T., Law R. E., Kaplan M. H., Jung B., Espina B. M., Lunardi-Iskandar Y. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood 1995; 85: 3423–3430
   PubMed Web of Science ®Google Scholar
• Benjamin D., Knobloch T. J., Dayton M. A. Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992; 80: 1289–1298
   PubMed Web of Science ®Google Scholar
• Blay J. Y., Burdin N., Rousset F., Lenoir G., Biron P., Philip T., Banchereau J., Favrot M. Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor. Blood 1993; 82: 2169–2174
   PubMed Web of Science ®Google Scholar
• Voorzanger N., Touitou R., Garcia E., Delecluse H. J., Rousset F., Joab I., Favrot M. C., Blay J. Y. Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors. Cancer Res. 1996; 56: 5499–5505
   PubMed Web of Science ®Google Scholar
• Kato H., Kinoshita T., Suzuki S., Nagasaka T., Hatano S., Murate T., Saito H., Hotta T. Production and effects of interleukin-6 and other cytokines in patients with non-Hodgkin's lymphoma. Leuk. Lymphoma. 1998; 29: 71–79
   PubMed Web of Science ®Google Scholar
• Bakkus M., Heirman C., Van Riet I., Van Camp B., Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 1992; 80: 2326–2336
   PubMed Web of Science ®Google Scholar
• Klein B., Zhang X. G., Lu Z. Y., Bataille R. Interleukin-6 in human multiple myeloma. Blood 1995; 85: 863–872
   PubMed Web of Science ®Google Scholar
• Shimizu S., Yoshioka R., Hirose Y., Susumu S., Tachibana J., Konda S. Establishment of two interleukin-6 (B cell stimulatory factor 2/interferon β2) dependent human bone marrow-derived myeloma cell lines. J. Exp. Med. 1989; 169: 339–344
   PubMed Web of Science ®Google Scholar
• Zhang X. G., Gaillard J. P., Robillard N., Lu Z. Y., Gu Z. J., Jourdan M., Boiron J. M., Bataille R., Klein B. Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 1994; 83: 3654–3663
   PubMed Web of Science ®Google Scholar
• Westendorf J. J., Ahmann G. J., Greipp P. R., Witzig T. E., Lust J. A., Jelinek D. F. Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6. Leukemia 1996; 10: 866–876
   PubMed Web of Science ®Google Scholar
• Taga T., Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 1997; 15: 797–819
   PubMed Web of Science ®Google Scholar
• Klein B. Update of gp130 cytokines in multiple myeloma. Curr. Opin. Hematol 1998; 5: 186–191
   PubMedGoogle Scholar
• Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L. S., Cosman D. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 1996; 271: 32635–32643
   PubMed Web of Science ®Google Scholar
• Zhang X. G., Gu Z. J., Lu Z. Y., Yasukawa K., Yancopoulos G. D., Turner K., Shoyab M., Taga T., Kishimoto T., Bataille R., Klein B. Ciliary neurotropic factor, interleukin 11, leukemia inbitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130. J. Exp. Med. 1994; 179: 1337–1342
   PubMed Web of Science ®Google Scholar
• Nishimoto N., Ogata A., Shima Y., Tani Y., Ogawa H., Nakagawa M., Sugiyama H., Yoshizaki K., Kishimoto T. Oncostatin M, leukemia inhibitory factor, and interleukin-6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. J. Exp. Med. 1994; 179: 1343–1347
   PubMed Web of Science ®Google Scholar
• Westendorf J. J., Jelinek D. F. Growth regulatory pathways in myeloma. Evidence of autocrine oncostatin M expression. J. Immunol. 1996; 157: 3081–3088
   PubMed Web of Science ®Google Scholar
• Wijdenes J., Heinrich P. C., Muller Newen G., Roche C., Gu Z. J., Clement C., Klein B. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur. J. Immunol. 1995; 25: 3474–3481
   PubMed Web of Science ®Google Scholar
• Autissier P., Liautard J., Brochier J., Gaillard J. P. Activation of the gp130 signaling pathway by monoclonal antibodies directed against the gp130 molecule. Eur. J. Immunol. 1997; 27: 794–797
   PubMed Web of Science ®Google Scholar
• Portier M., Rajzbaum G., Zhang X. G., Attal M., Rusalen C., Wijdenes J., Mannoni P., Maraninchi D., Piechaczyk M., Bataille R., Klein B. In vivo interleukin-6 gene expression in the tumoral environment in multiple myeloma. Eur. J. Immunol 1991; 21: 1759–1762
   PubMed Web of Science ®Google Scholar
• Uchiyama H., Barut B. A., Mohrbacher A. F., Chauhan D., Anderson K. C. Adhesion of Human Myeloma-Derived Cell Lines to Bone Marrow Stromal Cells Stimulates Interleukin-6 Secretion. Blood 1993; 82: 3712–3720
   PubMed Web of Science ®Google Scholar
• Lokhorst H. M., Lamme T., De Smet M., Klein S., De Weger R. A., Van Oers R., Bloem A. C. Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 1994; 84: 2269–2277
   PubMed Web of Science ®Google Scholar
• Bataille R., Jourdan M., Zhang X. G., Klein B. Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyspasias. J. Clin. Invest 1989; 84: 2008–2011
   PubMed Web of Science ®Google Scholar
• Ludwig H., Nachbaur D. M., Fritz E., Krainer M., Huber H. Interleukin-6 is a prognostic factor in multiple myeloma [letter]. Blood 1991; 77: 2794–2795
   PubMed Web of Science ®Google Scholar
• Klein B., Wijdenes J., Zhang X. G., Jourdan M., Boiron J. M., Liautard J., Merlin M., Clement C., Morel-Fournier B., Lu Z. Y., Mannoni P., Sany J., Bataille R. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 1991; 78: 1198–1204
   PubMed Web of Science ®Google Scholar
• Bataille R., Barlogie B., Lu Z. Y., Rossi J. F., Lavabre-Bertrand T., Beck T., Wijdenes J., Brochier J., Klein B. Biologic effects of anti-interleukin-6 (IL-6) murine monoclonal antibody in advanced multiple myeloma. Blood 1995; 86: 685–691
   PubMed Web of Science ®Google Scholar
• Lu Z. Y., Zhang X. G., Wijdenes J., Morel-Fournier B., Harousseau J. L., Bataille R., Rossi J. F., Klein B. Interleukin-10 is a growth factor for human myeloma cells. Blood 1995; 85: 2521–2527
   PubMed Web of Science ®Google Scholar
• Gu Z. J., Costes V., Lu Z. Y., Zhang X. G., Pitard V., Moreau J. F., Bataille R., Wijdenes J., Rossi J. F., Klein B. Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop. Blood 1996; 88: 3972–3986
   PubMed Web of Science ®Google Scholar
• Merville P., Rousset F., Banchereau J., Klein B., Betaille R. Serum interleukin 10 in early stage multiple myeloma [letter]. Lancet 1992; 340: 1544–1545
   PubMed Web of Science ®Google Scholar
• Stasi R., Brunetti M., Bussa S., Pagano A. Serum interleukin-10 in plasma-cell dyscrasias. Am. J. Hematol 1997; 54: 335–337
   PubMed Web of Science ®Google Scholar
• Lu Z. Y., Gu Z. J., Zhang X. G., Wijdenes J., Neddermann P., Rossi J. F., Klein B. Interleukin-10 induces interleukin-11 responsiveness in human myeloma cell lines. FEBS Lett. 1995; 377: 515–518
   PubMed Web of Science ®Google Scholar
• Bartl R., Frisch B. Bone marrow biopsy and aspiration for diagnosis of multiple myeloma. Myeloma, Biology and Management, J. S. Malpas, D. E. Bergsagel, R. A. Kyle, K. C. Anderson. Oxford University Press, Oxford 1998; 89–121
   Google Scholar
• Manolagas S. C. The role of IL-6 type cytokines and their receptors in bone. Ann. N. Y. Acad. Sci. 1998; 840: 194–204
   PubMed Web of Science ®Google Scholar
• Lu Z. Y., Brailly H., Wijdenes J., Bataille R., Rossi J. F., Klein B. Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments. Blood 1995; 86: 3123–3131
   PubMed Web of Science ®Google Scholar
• Klein B., Brailly H. Cytokine-binding proteins: stimulating antagonists. Immunol. Today 1995; 16: 216–220
   PubMedGoogle Scholar