Expression of the C-Kit Receptor (CD117) is a Feature of Almost All Subtypes of De Novo Acute Myeloblastic Leukemia (AML), Including Cytogenetically Good-Risk AML, and Lacks Prognostic Significance

References

• Rosnet O., Birnbaum D. Hematopoietic receptors of class III receptor-type tyrosine kinases. Critical Reviews in Oncogenesis 1993; 4: 595–613
   PubMed Web of Science ®Google Scholar
• Broudy V. C. Stem cell factor and hematopoiesis. Blood 1997; 90: 1345–1364
   PubMed Web of Science ®Google Scholar
• Strobl H., Takimoto M., Majdic O., Höcker P., Knapp W. Antigenic analysis of human haemopoietic progenitor cells expressing the growth factor receptor c-kit. British Journal of Haematology 1992; 82: 287–294
   PubMed Web of Science ®Google Scholar
• Muroi K., Amemiya Y., Miura Y. Specificity of CD117 expression in the diagnosis of acute myeloid leukemia. Leukemia 1996; 10: 1048
   PubMed Web of Science ®Google Scholar
• Kubota A., Okamura S., Shimoda K., Harada M., Niho Y. The c-kit molecule and the surface immunophenotype of human acute leukemia. Leukemia and Lymphoma 1994; 14: 421–428
   PubMed Web of Science ®Google Scholar
• Di Noto R., Lo Pardo C., Schiavone E. M., Manzo C., Vacca C., Ferrara F., Del Vecchio L. Stem cell factor receptor (c-kit, CD117) is expressed on blast cells from most immature types of acute myeloid malignancies but is also a characteristic of a subset of acute promyelocytic leukaemia. British Journal of Haematology 1996; 92: 562–564
   PubMed Web of Science ®Google Scholar
• Smith F. O., Broudy V. C., Zsebo K. M., Lampkin B. C., Buckley C. V., Buckley J. D., Opie T., Woods W. G., Hammond G. D., Bernstein I. D. Cell surface expression of c-kit receptors by childhood acute myeloid leukemia blasts is not of prognostic value: a report from the childrens cancer group. Blood 1994; 84: 847–852
   PubMed Web of Science ®Google Scholar
• Muroi K., Nakamura M., Amemiya Y., Suda T., Miura Y. Expression of c-kit receptor (CD117) and CD34 in leukemic cells. Leukemia and Lymphoma 1995; 16: 297–305
   PubMed Web of Science ®Google Scholar
• Béné M. C., Bernier M., Casasnovas R. O., Castoldi G., Knapp W., Lanza F., Ludwig W. D., Matutes E., Orfao A., Sperling C., Van't Veer M. B. The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias. Blood 1998; 92: 596–599
   PubMed Web of Science ®Google Scholar
• Reuss-Borst M. A., Bühring H. J., Schmidt H., Müller C. A. AML: Immunophenotypic heterogeneity and prognostic significance of c-kit expression. Leukemia 1994; 8: 258–263
   PubMed Web of Science ®Google Scholar
• Valverde L. R., Matutes E., Farahat N., Heffernan A., Owusu-Ankomah K., Morilla R., Catovsky D. C-kit receptor (CD117) expression in acute leukemia. Annals of Hematology 1996; 72: 11–15
   PubMed Web of Science ®Google Scholar
• Wells S. J., Bray R. A., Stempora L. L., Farhi D. C. CD117/CD34 expression in leukemic blasts. Hematopathology 1996; 106: 192–195
   Google Scholar
• Lauria F., Bagnara G. P., Rondelli D., Raspadori D., Strippoli P., Bonsi L., Ventura M. A., Montanaro L. L., Bubola G., Tura S., Broudy V. C. Cytofluorimetric and functional analysis of c-kit receptor in acute leukemia. Leukemia and Lymphoma 1995; 18: 451–455
   PubMed Web of Science ®Google Scholar
• Ashman L. K., Roberts M. M., Gadd S. J., Cooper S. J., Juttner C. A. Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5.B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia. Leukemia Research 1988; 12: 923–928
   PubMed Web of Science ®Google Scholar
• Broudy V. C., Smith F. O., Lin N., Zsebo K. M., Egrie J., Bernstein I. D. Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor. Blood 1992; 80: 60–67
   PubMed Web of Science ®Google Scholar
• Ikeda H., Kanakura Y., Tamaki T., Kurui A., Kitayama H., Ishikawa J., Kanayama Y., Yonezawa T., Tarui S., Griffin J. D. Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood 1991; 78: 2962–2968
   PubMed Web of Science ®Google Scholar
• Pietsch T., Kyas U., Steffens U., Yakisan E., Hadam M. R., Ludwig W. D., Zsebo K. M., Welte K. Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors. Blood 1992; 80: 1199–1206
   PubMed Web of Science ®Google Scholar
• Bradstock K., Matthews J., Benson E., Page F., Bishop J, The Australian Leukaemia Study Group. Prognostic value of immunophenotyping in acute myeloid leukemia. Blood 1994; 84: 1220–1225
   PubMed Web of Science ®Google Scholar
• Mrózek K., Heinonen K., De la Chapelle A., Bloomfield C. D. Clinical significance of cytogenetics in acute myeloid leukemia. Seminars in Oncology 1997; 24: 17–31
   PubMed Web of Science ®Google Scholar
• Sperling C., Schwartz S., Buchner T., Thiel E., Ludwig W. D. Expression of the stem cell factor receptor c-kit (CD117) in acute leukemias. Haematologica 1997; 82: 617–621
   PubMed Web of Science ®Google Scholar
• Creutzig U., Harbott J., Sperling C., Ritter J., Zimmermann M., Löffler H., Riehm H., Schellong G., Ludwig W. D. Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87. Blood 1995; 86: 3097–3108
   PubMed Web of Science ®Google Scholar
• Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A.G., Gralnick H. R., Sultan C. Proposed revised criteria for the classification of acute myeloid leukemia. Annals of Internal Medicine 1985; 103: 626–629
   PubMedGoogle Scholar
• Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A.G., Gralnick H. R., Sultan C. Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-M0). British Journal of Haematology 1991; 78: 325–329
   PubMed Web of Science ®Google Scholar
• Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A.G., Gralnick H. R., Sultan C. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). Annals of Internal Medicine 1985; 103: 460–462
   PubMed Web of Science ®Google Scholar
• Stollmann B., Fonatsch C., Havers W. Persistent Epstein-Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders. British Journal of Haematology 1985; 60: 183–196
   PubMed Web of Science ®Google Scholar
• ISCN. Guidelines for cancer cytogenetics. Supplement to an international system for human cytogenetic nomenclature, F Mitelman. S. Karger, Basel 1991, 1991
   Google Scholar
• ISCN. An International System for Human Cytogenetic Nomenclature, F Mitelman. S. Karger, Basel 1995, 1995
   Google Scholar
• Dastugue N., Payen C., Lafage-Pochitaloff M., Bernard P., Leroux D., Huguet-Riga) F., Stoppa A. M., Marit G., Molina L., Michallet M., Maraninchi D., Attal M., Reiffers J. Prognostic significance of karyotype in de novo adult acute myeloid leukemia. Leukemia 1995; 9: 1491–1498
   PubMed Web of Science ®Google Scholar
• Schoch C., Haase D., Fonatsch C., Haferlach T., Löffler H., Schlegelberger B., Hossfeld D. K., Becher R., Sauerland M. C., Heinecke A., Wörmann B., Büchner T., Hiddemann W. The significance of trisomy 8 in de novo acute myeloid leukaemia: the accompanying chromosome aberrations determine the prognosis. British Journal of Haematology 1997; 99: 605–611
   PubMed Web of Science ®Google Scholar
• Cox D. R., Oakes D. Analysis of survival data. Chapman and Hall, London 1984
   Google Scholar
• Venditti A., Del Poeta G., Buccisano F., Tamburini A., Cox M. C., Stasi R., Bruno A., Aronica G., Maffei L., Suppo G., Simone M. D., Forte L., Cordero V., Postorino M., Tuffili V., Isacchi G., Masi M., Papa G., Amadori S. Minimally differentiated acute myeloid leukemia (AML-M0): Comparison of 25 cases with other French-American-British subtypes. Blood 1997; 89: 621–629
   PubMed Web of Science ®Google Scholar
• Porwit-MacDonald A., Janossy G., Ivory K., Swirsky D., Peters R., Wheatley K., Walker H., Turker A., Goldstone A. H., Burnett A. Leukemia-associated changes identified by quantitative flow cytometry. IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21). Blood 1996; 87: 1162–1169
   PubMed Web of Science ®Google Scholar
• Pui C. H., Kane J. R., Crist W. M. Biology and treatment of infant leukemias. Leukemia 1995; 9: 762–769
   PubMed Web of Science ®Google Scholar
• Abrahamson J. L.A., Lee J. M., Bernstein A. Regulation of p53-mediated apoptosis and cell cycle arrest by steel factor. Molecular and Cellular Biology 1995; 15: 6953–6960
   PubMed Web of Science ®Google Scholar
• Löwenberg B., Van Putten W. L.J., Touw I. P., Delwel R., Santini V. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. The New England Journal of Medicine 1993; 328: 614–619
   PubMed Web of Science ®Google Scholar