Dysregulation of the Protein Tyrosine Kinase LCK in Lymphoproliferative Disorders and in Other Neoplasias

References

• Brown M. T., Cooper J. A. Regulation, substrates and functions of src. Biochim. Biophys. Acta 1996; 1287: 121–149
   PubMed Web of Science ®Google Scholar
• Anderson S. J., Perlmutter R. M. A signaling pathway governing early thymocyte maturation. Immunol. Today. 1995; 16: 99–105
   PubMedGoogle Scholar
• Weil R., Veillette A. Signal transduction by the lymphocyte-specific tyrosine protein kinase p561ck. Curr. Top. Microbiol. Immunol. 1996; 205: 63–87
   PubMed Web of Science ®Google Scholar
• Xavier R., Brennan T., Qingqin L., McCormack C., Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity 1998; 8: 723–732
   PubMed Web of Science ®Google Scholar
• Montixi C., Langlef C., Bernard A. -M., Thimonier J., Dubois C., Wurbel M. -A., Chauvin J. -P., Pierres M., He H. -T. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 1998; 17: 5334–5348
   PubMed Web of Science ®Google Scholar
• Chan A. C., Desai D. M., Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 1994; 12: 555–592
   PubMed Web of Science ®Google Scholar
• D'Oro U., Vacchio M. S., Weissman A. M., Ashwell J. D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 1997; 7: 619–628
   PubMed Web of Science ®Google Scholar
• Brenner B., Gulbins E., Schlottmann K., Koppenhoefer U., Bush G. L., Walzog B., Steinhausen M., Coggeshall K. M., Linderkamp O., Lang F. L-selectin activates the Ras pathway via the tyrosine kinase p561ck. Proc. Natl. Acad. Sci. 1996; 93: 15376–15381
   PubMed Web of Science ®Google Scholar
• Uhlemann A. C., Brenner B., Gulbins E., Linderkamp O., Lang F. Stimulation of TKl lymphoma cells via alpha 4 beta 7 integrin results in activation of src-tyrosine and MAP-kinases. Biochem. Biophys. Res. Commun. 1997; 239: 68–73
   PubMed Web of Science ®Google Scholar
• Taher T. E., Smit L., Griftioen A. W., Schillder-Tol E. J., Borst J., Pals S. T. Signaling through CD44 is mediated by tyrosine kinases. Association with p561ck in T lymphocytes. J. Biol. Chem. 1996; 271: 2863–2867
   PubMed Web of Science ®Google Scholar
• Molina T. J., Kishihara K., Siderovski D. P., van Ewijk W., Narendran A., Timms E., Wakeham A., Paige C. J., Hart-Mann K. U., Veillette A., Davidson D., Mak T. W. Profound block in thymocyte development in mice lacking p561ck. Nature 1992; 357: 161–164
   PubMed Web of Science ®Google Scholar
• Levin S. D., Anderson S. J., Forbush K. A., Perlmutter R. M. A dominant-negative transgene defines a role for p561ck in thymopoiesis. EMBO J. 1993; 12: 1671–1680
   PubMed Web of Science ®Google Scholar
• Baldari C. T., Pelicci G., Di Somma M. M., Milia E., Giuli S., Pelicci P. G., Telford J. L. Inhibition of CD4/p561ck signaling by a dominant negative mutant of Shc. Oncogene 1995; 10: 1141–1147
   PubMed Web of Science ®Google Scholar
• McCormick F. How receptors turn Ras on. Nature 1993; 363: 15–16
   PubMed Web of Science ®Google Scholar
• Lin K., Abraham K. M. Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway. Int. Immunol. 1997; 9: 291–306
   PubMed Web of Science ®Google Scholar
• Thome M., Duplay P., Guttinger M., Acuto O. Syk and ZAP-70 mediate recruitment of p56lck/D4 to the activated T cell receptor/CD3/ complex. J. Exp. Med 1995; 181: 1997–2006
   PubMed Web of Science ®Google Scholar
• Straus D. B., Chan A. C., Patai B., Weiss A. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 1996; 271: 9976–9981
   PubMed Web of Science ®Google Scholar
• Fusaki N., Iwamatsu A., Iwashima M., Fujisawa Ji. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck. in T cell receptor signaling. J. Biol. Chem. 1997; 272: 6214–6229
   PubMed Web of Science ®Google Scholar
• Takemoto Y., Furuta M., Li X. K., Strong-Sparks W. J., Hashimoto Y. LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p561ck. EMBO J. 1995; 14: 3403–3414
   PubMed Web of Science ®Google Scholar
• Di Somma M. M., Majolini M. B., Burastero S. E., Telford J. L., Baldari C. T. Cyclosporin A sensitivity of the HIV-1 LTR identifies distinct p561ck dependent pathways activated by CD4 triggering. Eur. J. Immunol. 1996; 26: 2181–2188
   PubMed Web of Science ®Google Scholar
• Baldari C. T., Milia E., Di Somma M. M., Baldoni F., Telford J. L. Distinct signaling properties identify functionally different CD4 epitopes. Eur. J. Immunol. 1995; 25: 1843–1850
   PubMed Web of Science ®Google Scholar
• Adler H. T., Reynolds P. J., Kelley C. M., Sefton B. M. Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters. J. Virol. 1988; 62: 41134122
   Google Scholar
• Garvin A. M., Pawar S., Marth J. D., Perlmutter R. M. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol. Cell. Biol. 1988; 8: 3058–3064
   PubMed Web of Science ®Google Scholar
• Takadera T., Leung S., Gernone A., Koga Y., Takihara Y., Miyamoto N. G., Mak T. W. Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcript in T cells. Mol. Cell. Biol. 1989; 9: 2173–2180
   PubMed Web of Science ®Google Scholar
• Rouer E., Dreyfus F., Melle J., Benarous R. Pattern of expression of five alternative transcripts of the lck gene in different hematopoietic malignancies: correlation of the level of Ick messenger RNA I B with the immature phe-notype of the malignancy. Cell. Growth. Differ. 1994; 5: 659–666
   PubMedGoogle Scholar
• McCracken S., Leung S., Bosselut R., Ghysdael J., Miyamoto N. G. Myb and Ets related transcription factors are required for activity of the human lck type I promoter. Oncogene 1994; 9: 3609–3615, (3).
   PubMed Web of Science ®Google Scholar
• Muise-Helmericks R. C., Rosen N. Identification of a novel repressive element in the proximal Ick promoter. J. Biol. Chem. 1995; 270: 27538–27543
   PubMed Web of Science ®Google Scholar
• Garcia-Welsh A., Laskin D. L., Molloy C. J., Laskin J. D. Alterations in expression of p561ck during myeloid differentiation of LSTRA cells. Cell. Growth. Differ. 1994; 5: 1215–1223
   PubMedGoogle Scholar
• Yu C. L., ove R., Burakoff S. J. Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J. Immunol. 1997; 159: 5206–5210
   PubMed Web of Science ®Google Scholar
• Abraham K. M., Levin S. D., Marth J. D., Forbush K. A., Perlmutter R. M. Delayed thymocyte development induced by augmented expression of p561ck. J. Exp. Med. 1991; 173: 1421–1432
   PubMed Web of Science ®Google Scholar
• Tycko B., Smith S. D., Sklar J. Chromosomal translocation joining LCK and TCRB loci in human T cell leukemia. J. Exp. Med 1991; 174: 867–873
   PubMed Web of Science ®Google Scholar
• Wright D. D., Sefton B. M., Kamps M. P. Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol. Cell. Biol. 1994; 14: 2429–2437
   PubMed Web of Science ®Google Scholar
• Veillette A., Foss F. M., Sausville A., Bolen J. B., Rosen M. Expression of the lck tyrosine kinase gene in human tumor cell lines. Oncogene Res. 1987; 1: 357–374
   PubMedGoogle Scholar
• Nakamura K., Chijiiwa Y., Nawata H. Augmented expression of LCK message directed from the downstream promoter in human colorectal cancer specimens. Eur. J. Cancer 1996; 32A: 1401–1407
   PubMed Web of Science ®Google Scholar
• Mayer K., Ballhausen W. G. Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer cell lines. Anticancer Res. 1996; 16: 1733–1737
   PubMed Web of Science ®Google Scholar
• McCracken S., Kim C. S., Xu Y., Minden M., Miyamoto N. G. An alternative pathway for expression of p561ck from type I promoter transcripts in colon carcinoma. Oncogene 1997; 15: 2929–2937
   PubMed Web of Science ®Google Scholar
• Mayer K., Hieronymus T., Castrop J., Clevers H., Ballhausen W. G. Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overex-pression in colorectal cancer cells. Int. J. Cancer 1997; 72: 625–630
   PubMed Web of Science ®Google Scholar
• Krystal G. W., DeBeny C. S., Linnekin D., Litz J. Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PPI. Cuncer Res. 1998; 58: 4660–4666
   PubMed Web of Science ®Google Scholar
• Majolini M. B., D'Elios M. M., Galieni P., Boncristiano M., Lauria F., Del Prete G., Telford J. L., Baldari C. T. Expression of the T-cell-specific tyrosine kinase Lck in normal B-1 cells and in chronic lymphocytic leukemia B cells. Blood 1998; 91: 3390–3396
   PubMed Web of Science ®Google Scholar
• Von Knethen A., Abts H., Kube D., Diehl V., Tesch H. Expression of p561ck in B-cell neoplasias. Leuk. Lymphoma 1997; 26: 551–562
   PubMed Web of Science ®Google Scholar
• Kantor A. B. The development and repertoire of B-1 cells (CD5 B cells). Imunol. Today 1991; 12: 389–391
   PubMedGoogle Scholar
• Karras J. G., Wang Z., Huo L., Howard R. G., Frank D. A., Rothstein T. L. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes. J. Exp. Med. 1997; 185: 1035–1042
   PubMed Web of Science ®Google Scholar
• Cheung R. K., Dosch H. M. The tyrosine kinase Lck is critically involved in the growth transformation of human B lymphocytes. J. Biol. Chem. 1991; 266: 8667–8670
   PubMed Web of Science ®Google Scholar
• Koga Y., Oh-Hori N., Sato H., Yamamoto N., Kimura G., Nomoto K. Absence of transcription of Ick (lymphocyte specific protein tyrosine kinase) message in 1L-2 independent, HTLV-1 transformed T cell lines. J. Immunol. 1989; 142: 4493–4499
   PubMed Web of Science ®Google Scholar
• Lemasson I., Robert-Hebmann V., Hamaia S., Duc Dodon M., Gazzolo L., Devaux C. Transrepression of Ick gene expression by human T-cell leukemia virus type 1-encoded p40tax. J. Virol. 1997; 71: 1975–1983
   PubMed Web of Science ®Google Scholar
• Migone T. S., Lin J. X., Cereseto A., Mulloy J. C., O'Shea J. J., Franchini G., Leonard W. J. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 1995; 269: 79–81
   PubMed Web of Science ®Google Scholar
• Miyazaki T., Liu Z. J., Taniguchi T. Selective cooperation of HTLV-1-encoded p40tax-1 with cellular oncoproteins in the induction of hematopoietic cell proliferation. Oncogene 1996; 12: 2403–2408
   PubMed Web of Science ®Google Scholar
• Noraz N., Saha K., Ottones F., Smith S., Taylor N. Constitutive activation of TCR signaling molecules in IL-2-independent Herpesvirus Saimiri-transformed T cells. J. Immunol. 1998; 160: 2042–2045
   PubMed Web of Science ®Google Scholar
• Biesinger B., Tsygankov A. Y., Fickenscher H., Emmrich F., Fleckenstein B., Bolen J. B., Broker B. M. The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p561ck in transformed cells. J. Biol. Chem. 1995; 270: 4729–4734
   PubMed Web of Science ®Google Scholar
• Lund T., Medveczky M. M., Medveczky P. G. Herpesvirus saimiri Tip484 membrane protein markedly increases p561ck activity in T cells. J. virol. 1997; 71: 378–382
   PubMed Web of Science ®Google Scholar
• Lund T. C., Garcia R., Medveczky M. M., Jove R., Medveczky P. G. Activation of STAT transcription factors by herpesvirus Saimiri Tip484 requires p561ck. J. Virol 1997; 71: 6617–6682
   Google Scholar
• Duboise S. M., Lee H., Guo J., Choi J. K., Czajak S., Simon M., Desrosiers R. C., Jung J. U. Mutation of the Lck-binding motif of Tip enhances lymphoid cell activation by herpesvirus saimiri. J. Virol. 1998; 72: 2607–2614
   PubMed Web of Science ®Google Scholar
• Uckun F. M., Evans W. E., Forsyth C. J., Waddick K. G., Ahlgren L. T., Chelstrom L. M., Burkhardt A., Bolen J., Myers D. E. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases. Science 1995; 267: 886–891
   PubMed Web of Science ®Google Scholar