References
- Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP, Weinberg RA. requent inactivation of the retinoblasoma anti-oncogene is restricted to a subset of human tumor cells. Roc. Natl. Acad. Sci. USA 1990; 87: 2775–9
- Cordon-Cardo C, Wartinger D, Petrylak D, Dalbagni G, Fair WR, Fuks Z, Reuter VE. Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer. JNCI 1992; 84: 12516
- Harbour JW, Li S-L, Wang-Peng J, Gazdar AF, Minna JD, Kaye FJ. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 1988; 241: 353–358
- T'Ang A, Wu KJ, Hashimoto T, Liu WY, Takahashi R, Shi XH, Mihara K, Zhang FH, Chen YY, Du C, Qian J, Lin Y, Fung YK. Genomic organization of the human retinoblastoma gene. Oncogene 1989; 4: 401–7
- Bookstein R, Shew JY, Chen P-L, Scully P, Lee WH. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 1990; 247: 712–5
- Komblau SM, Xu H-J, Zhang W, Hu S-X, Beran M, Smith TL, Hester J, Estey EH, Benedict W. Levels of retinoblastoma protein expression in newly diagnosed acute myel-ogenous leukemia. Blood 1994; 84: 256–61
- Kornblau SM, Xu H-J, del Giglio A, Zhang W, Calvert L, Beran M, Estey EH, Andreeff M, Trujillo J, Cork MA, Smith TL, Benedict WF, Deisseroth AB. Clinical implications of decreased retinoblastorna protein expression in acute myelogenous leukemia. Cancer Research 1992; 52: 4587–90
- Kornblau SM, Andreeff M, Hu S-X Xu H-J, Patel S, Theri-Ault A, Koller C, Kantarjian H, Estey EH, Deisseroth AB, Benedict WF. Low and maximally phosphorylated levels of the retinoblastoma protein confer poor prognosis in newly diagnosed acute myelogenous leukemia: A prospective study. Clin Can Res 1998; 4: 1955–63
- Counts JL, Goodman JI. Alterations in DNA methyla-tion may play a variety of roles in carcinogenesis. Cell 1995; 83: 13
- Herman JG, Jen J, Merlo A, Baylin SB. Hypermethy-lation associated inactivation indicates a tumor suppressor role for P15 INK4B. Cancer Research. 1996; 56: 722–727
- Drexler H. G. Review of alterations of the cyclindependent kinasae inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 1998; 12: 845–859
- Stirzaker C, Millar DS, Paul CL, Warnecke PM, Harrison J, Vincent PC, Frommer M, Clark SJ. Extensive DNA methylation spanning the Rb promotor in retinoblastoma tumors. Cancer Res 1997; 57: 2229–37
- Ohtani-Fujita N, Fujita T, Osifchin NE, Robbins PD, Sakai T. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 1993; 8: 1063–7
- Munier FL, Thonney F, Balmer A, Heon E, Pescia G, Schor-Deret DF. Sex mutation ratio in retinoblastoma and retinoma: relevance to genetic counseling. Klinische Monats-blatter fur Augenheilkunde. 1996; 208: 400–3
- Naumova A, Hansen M, Strong L, Jones PA, Hadjistilianou D, Mastrangelo D, Greigel S, Rajewsky MF, Shields J, Donoso L. Concordance between parental origen of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma. Am. J. Hum. Genet 1994; 54: 274–81
- Lohmann DR, Gerick M, Brandt B, Oelschalger U, Lorenz B, Passarge E, Horsthemke B. Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. Am. J. Hum. Genet 1997; 61: 282–94
- Ohtani-Fujita N, Dryja TP, Rapaport JM, Fujita T, Mat-Sumura S, Ozasa K, Watanabe Y, Hayashi K, Maeda K, Kinoshita S, Matsumura T, Ohnishi Y, Hotta Y, Takahaashi R, Kato MV, Ishizaki K, Sasaki MS, Horsthemke B, Minoda K, Sakai T. Hypermethylation in the retinoblastoma gene is associated with unilateral sporadic retinoblastoma. Can Gen Cyto 1997; 98: 43–9
- Mancini D, Singh S, Ainsworth P, Rodenhiser D. Constituitively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RBI). Am. J. Hum. Genet. 1997; 61: 80–7
- Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM. Allele-specific hypermethylation of the retinblastoma tumor-suppressor gene. Am. J. Hum. Genet. 1991; 48: 880–8
- Clark SJ, Harrison J, Paul CL, Frommer M. High sensitivity mapping of methylated cytosines. Nuc Acid Res. 1994; 22: 2990–2997