31
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Influence of Low Dose rIL-2 Treatment on Endogenous Cytokine Production, Expression of Surface IL-2R and The Level of Soluble IL-2R in Patients With Minimal Residual Disease

, , , &
Pages 355-366 | Received 23 Jan 1999, Published online: 01 Jul 2009

References

  • Smith K. A. Interleukin-2: inception, impact and implications. Science 1988; 240: 1169–1176
  • Farace F., Angevin E., Dietrich P. Y., Leboullaire C., Vander-Plancke J., Escudier B., Triebel F. Low - dose IL-2 treatment: activation of discrete T and NK-cell subpopulations in vivo. Int. J. Cancer 1995; 62: 523–528
  • Economon J. S., Hoban M., Lee J. D., Essner R., Swisher S., McBride W., Hoon D. B., Morton D. L. Production of tumor necrosis factor and interferon-y in interleukin-2 treated patients: correlation with clinical toxicity. Cancer Immunol. Immunother. 1991; 34: 49–53
  • Gusella G. L., Musso T., Bosco M. C., Espinoza-Delgado J., Matsushima K., Varesio L. IL-2-up-regulates but IFN γ supressess IL-8 expression in human monocytes. J. Immunol. 1993; 151: 2725–2732
  • Larsson L. G., Carlson M., Schena M., Lantz M., Cali-garis-Cappio F., Nilson K. IL-2 enhances the production of TNF-α in activated B-cells. Leukemia 1993; 7: 226–234
  • Nedwin G. E., Svedersky I. P., Bringman T. S., Paladino M. A., Goeddel D. V. Effect of interleukin 2, interferon γ and mitogens on the production of tumor necrosis factors α and b˜. J. Immunol. 1985; 135: 2492–2495
  • Numerof R. P., Aronson F. R., Mier J. W. IL-2 stimulates the production of IL- lα and IL-1b˜ by human perpheral blood mononuclear cells. J. Immunol. 1988; 141: 4250–4257
  • Dmoszynska A, Rolinski J. Interleukin 2 receptor (IL-2R): Stiucture and function. Acta Haemat. Pol. 1995; 26: 257–261
  • Rubin LA, Nelson D. L. The soluble interleukin-2 receptors: biology. function and clinical application. Ann. Inter. Med. 1990; 113: 619–627
  • Voss S. D., Sondel P. M., Robb R. J. Characterization of interleukin 2 receptors (L2R) expressed on human natural killer cells activated in vitro by IL-2. Exp. Med. 1992; 176: 531–541
  • Rubin L. A., Kurman M., Fritz E., Biddison W. E., Boutin B., Yarchoan R., Nelson D. L. Soluble interleukin 2 receptors are released from activated lymphoid cells in vitro. J. Immunol. 1985; 135: 3172–3177
  • Aulitzky W. E., Schuler M., Peschel C., Huber C. Interleukins. Clinical pharmacology and therapeutic use. Drugs 1994; 48: 667–677
  • Robak T. Cytokines in the treatment of hematological disorders: recent progress and perspectives. Arch. Immunol. Ther. Exp. 1996; 44: 5–9
  • Lindenmann A., Brossart P., Höffken K., Flasshove M., Voli-Otis D., Diehl V., Hecker G., Wagner H., Mertelsmann R. Immunomodulatory effects of ultra-low-dose interleukin 2 in cancer patients: a phase IB study. Cancer Immunol. Immunother. 1993; 37: 307–315
  • Lindenmann A., Brossart P., Hoffken K., Flasshove M., Voli-Otis D., Diehl V., Kulmburg P., Wagner H., Mertelsmann R. Serum cytokine levels in cancer patients treated with different schedules of ultra-low-dose interleukin 2. J. Immunother. 1994; 15: 225–230
  • Meropol N. J., Porter M., Perez R. P., Vaickus L., Loewen G. M., Craven P. J., Wilkes K. A., Caliguri M. A. Low doses of interleukin 2: Daily subcutaneous injection results in selective in vivo expansion of natural killer (NK) cells with minimal toxicity. Proc ASCO 1994; 13: 965–967
  • Peest D., Leo R., Bloche S., Hein B., Stannat-Kiessling S., Tschechne B., Fett W., Harms P., Hoffmann L., Bad R., Wacker H. H., Gorg S., Atzpodien J., Kirchner H., Deicher H. Low-dose recombinant interleukin-2 therapy in advanced multiple myeloma. Brit. J. Haematol. 1995; 89: 328–337
  • Chronic Leukemia-Myeloma Task Force, National Cancer Institute. Proposed guidelines for protocol studies. Cancer Chemother. Rep. 1973; 4: 145–152
  • Daniluk J., Kandefer-Szerszeh M. Interferon production by peripheral blood cells of patients with alcoholic liver disease (ALD). Arch. Immunol. Ther. Exp. 1994; 42: 231–238
  • Mossman T. Rapid colorimetric method for cellular growth and cytotoxicity assay. J. Immunol. Meth. 1983; 65: 55–63
  • Gisselbrecht C., Maraminchi D., Pico J. L., Milpied N., Coifier B., Divine M., Tiberghien P., Bosly A., Elly H., Boulat O., Brandely M. Interleukin-2 treatment in lymphoma: A phase II multicenter study. Blood 1994; 83: 2081–2085
  • Hussein M. A., Synder J., Rayman P., Lichtin A., McLain D. A., Finke J., Bukowski R. M. IL-2 maintenance therapy in multiple myeloma: a preliminary clinical report. Proc ASCO 1997; 13: 114
  • Nagler A., Ackerstein A., Or R., Naparstek E., Slawin S. Immunotherapy with recombinant human interleukin-2 and recombinant interferon α in lymphoma postautolo-gous marrow or stem cell transplantation. Blood 1997; 89: 3951–3959
  • Rolnski J., Legiec W., Dmoszynska A. Influence of low doses subcutaneous IL-2 therapy on NK cell population in' patients with haematological malignancies. Ann. M. Curie- Sktodowska Univ. 1996; 51: 143–148
  • Williams J. G., Jurkovich G. J., Maier R. V. Current research review. Interferon γ a key immunoregulatory lym-phokine. J. Surg. Res. 1993; 54: 79–93
  • Foa R., Massaia M., Cardona S., Tos A. G., Bianchi A., Atti-Sano C, Guarini A., di Celle P. E., Fierro M. T. Production of TNF-α by B-cell CLL a possible regulatory role of TNF in the progression of the disease. Blood 1990; 76: 393–400
  • Agganval B. B., Kohr W. J. Human tumor necrosis factor. Production, purification and characterization. J. Biol. Chem. 1985; 260: 2345–2354
  • Steinberger J., Beubassat H., Hochberg E., Lorberboumgal-Ski H. Interleukin-2 (IL-2) receptor alpha, beta and gamma subunit expression as a function of B-cell lineage ontogeny: the use of IL-2 PE66 (4 Glu) to characterize inter-nalization via IL-2 receptor subunits. Scand. J. Immunol. 1997; 46: 129–136
  • Semenzano G., Foa R., Agostini C., Zambello R., Trentin L., Vinante F., Benedetti M., Chilosi M., Pizzolo G. High serum levels of soluble interleukin 2 receptor in patients with chronic lymphocytic leukemia. Blood 1987; 70: 396–400
  • Zwierzina H., Herold M., Schollenberger S., Geisler D., Schmalzl. detection of soluble IL-2 receptor in serum of patients with myelodysplastic syndromes: induction under therapy with GM-CSF. Brit. 1. Haematol. 1991; 79: 438–443
  • Pui C. H., Ip S. H., Kung P., Dodge R. K., Berard C. W., Crist W. M., Murphy S. B. High serum interleukin 2 receptor levels are related to advanced disease and poor outcome in childhood non-Hodgkin's lymphoma. Blood. 1987; 70: 624–628
  • Pui C. H., Ip S. H., Iflash S., Behm F. G., Grose B. H., Dodge R. K., Crist W. M., Furman W. L., Murphy S. B., Riviera G. K. Serum interleukin 2 receptor levels in childhood acute lymphoblastic leukemia. Blood 1988; 71: 1135–1137

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.