53
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Functional Roles of Thrombopoietin-c-mpl System in Essential Thrombocythemia

, &
Pages 351-358 | Received 28 Apr 1998, Published online: 05 Aug 2009

References

  • Wehmeier A., Scharf R.E., Fricke S., Schneider W. Bleeding and thrombosis in chronic myeloproliferative didorders: Relations of platelet disorders to clinical aspects of the disease. Haemostasis 1989; 19: 251–259
  • Schafer AL. Bleeding and thrombosis in the myelo-proliferative disorders. Blood 1984; 64: 1–12
  • Fenaux P., Simon M., Caulier M.T., Lai J.L., Goudemand J., Bauters F. Clinical course of essential thrombocythemia in 147 cases. Cancer 1990; 66: 549–556
  • Chistolini A., Mazzucconi M.G., Ferrari A., La Verde G., Ferrzza G., Gragoni F., Vitale F., Arcieri R., Mandelli F. Essential thrombocythemia: A retrospective study on the clinical course of 100 patients. Haematologica 1990; 75: 537–540
  • Fialkow P.J., Faguet G.B., Jacobson R.J., Vaidya K., Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 1981; 58: 916–919
  • El-Kasser N., Hetet G., Briere J., Grandchamp B. Clonality analysis of hematopoiesis in essential thrombocythemia: Advantages of studying T lymphocytes and platelets. Blood 1997; 89: 123–134
  • Mazur E.M., Cohen J.L., Bogart L. Growth characteristics of circulating hematopoietic progenitor cells from patients with essential thrombocythemia. Blood 1988; 71: 1544–1550
  • Zauli G., Catani L., Gugliotta L., Gaggioli L., Vitale L., Mattioli M., Aglietta M., Bagnara G.P. Essential thrombocythemia: impaired regulation of megakaryocyte progenitors. Int J Cell Cloning 1991; 9: 43–56
  • Battegay E.J., Thomssen C., Nissen C., Gudat F., Speck B. Endogenous megakaryocyte colonies from peripheral blood in precursor cell cultures of patients with myeloproliferative disorders. Eur J Haematol 1989; 42: 321–326
  • Grossi A., Vannucchi A.M., Rafanelli D., Vannucchi L., Ferrini P.R. Megakaryocyte progenitors in the bone marrow and peripheral blood of patients with myeloproliferative diseases. Am J Hematol 1987; 25: 371–376
  • Komatsu N., Suda T., Sakata Y., Eguchi M., Kaji K., Saito M., Miura Y. Megakaryocytopoiesis in vitro of patients with thrombocythemia: effect of plasma and serum on megakaryocytic colony formation. Br J Hamatol 1986; 64: 241–252
  • Han Z.C., Briere J., Abgrall J.F., Sensebe L., Parent D., Guern G. Characteristics of megakaryocyte colony formation in normal individuals and in primary thrombocythemia: studies using an optimal cloning system. Exp Hamatol 1987; 17: 46–52
  • Hehlmann R., John M., Baumann B., Kopcke W. Essential thrombocythemia. Cancer 1988; 61: 2487–2496
  • Bellucci S., Janvier M., Tobelem G., Flandrin G., Charpak Y., Berger R., Boiron M. Essential thrombocythemias. Cancer 1986; 58: 2440–2447
  • Cortellazzo S., Barbui T., Bassan R., Dini E. Abnormal aggregation and increased size of platelets in myeloproliferative disorders. Thromb Haemost 1980; 43: 127–130
  • Preston F.E., Mwth J.F., Stewart R.W., Davies-Jones G.A.B. Thrombocytosis, circulating platelets aggregates and neurological dysfunction. Br Med J 1979; 2: 1561–1563
  • Bazzan M., Tamponi G., Schinco P., Marranca D., Pileri A., Bertello F., Pennone M., Bassignana A., Casaccia M. Platelet behavior in essential thrombocythemia: A study of 31 cases. Eur J Haematol 1989; 43: 350–351
  • Wehmeier A., Fricke S., Scharf R.E., Schneider W. A prospective study of haemostatic parameters in relation to the clinical course of myeloproliferative disorders. Eur J Haematol 1990; 45: 191–197
  • Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995; 86: 419–431
  • Kaushansky K., Lok S., Holly R.D., Broudy V.C., Lin N., Bailey M.C., Forstrom J.W., Buddle M.M., Oort P.J., Hagen F.S., Roth G.J., Papayannopoulou T., Foster D.C. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 1994; 369: 568–571
  • Farese A.M., Hunt P., Boone T., MacVittie T.J. Recombinant human megakaryocyte growth and development factor stimulates thrombopoiesis in normal nonhuman primates. Blood 1995; 85: 54–59
  • Zeigler F.C., Sauvage F., Widmer H.R., Keller G.A., Donahue C., Schreiber R.D., Malloy B., Hass P., Eaton D., Matthws W. In vitro megakaryopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84: 4045–4052
  • Gurney A.L., Carver-Moore K., Sauvage F.J., Moore M.W. Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445–1447
  • Alexander W.S., Robert A.W., Nicola N.A., Li R., Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages abd defective megakaryocyto-poiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 1996; 87: 2162–2170
  • de Sauvage F.J., Carver-Moor K., Luoh S.M., Ryan A., Dowd M., Eaton D.L., Moore M.W. Physiological regulation of early and late stages of megakaryopoiesis by thrombopoietin. J Exp Med 1996; 183: 651–656
  • Miyakawa Y., Oda A., Drucker B.J., Kato T., Miyazaki H., Handa M., Ikeda Y. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and She in human blood platelets. Blood 1995; 86: 23–27
  • Miyakawa Y., Oda A., Druker B.J., Miyazaki H., Handa M., Ohashi H., Ikeda Y. Thrombopoietin induces tyrosine phosphorylation of STAT3 and STAT5 in human blood platelets. Blood 1996; 87: 439–446
  • Ezumi Y., Takayama H., Okuma M. Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, Jak2, and STAT3, and enhances agonist-induced aggregation in platelets in vitro. FEBS Letters 1995; 374: 48–52
  • Kojima H., Hamazaki Y., Nagata Y., Todokoro K., Nagasawa T. Modulation of platelet activation in vitro by thrombopoietin. Thromb Haemost 1995; 74: 1541–1545
  • Chen J., Herceg-Harjacek, Groopman J.E., Grabarek J. Regulation of platelet activation in vitro by the c-Mpl ligand thrombopoietin. Blood 1995; 86: 4054–4062
  • Kuter D.J., Rosenverg R.D. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994; 84: 1464–1472
  • Stoffel R., Wiestner A., Skoda R.C. Thrombopoietin in the thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87: 567–573
  • Fielder P.J., Gurney A.L., Stefanich E., Marian M., Moore M.W., Carver-Moore K., de Sauvage F.J. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87: 2154–2161
  • Fielder P.J., Hass P., Nagel M., Stefanich E., Widmer R., Bennett G.L., Keller G.-A., de Sauvage F.J., Eaton D. Human platelets as a model for the binding and degradation of thrombopoietin. Blood 1997; 89: 2782–2788
  • Stefanich E., Senn T., Widmer R., Frantino C., Keller G.-A., Fielder P. J. Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice. Blood 1997; 89: 4063–4070
  • Horikawa Y., Matsumura I., Hashimoto K., Shiraga M., Kosugi S., Tadokoro S., Kato T., Miyazaki H., Tomiyama Y., Kurata Y., Matsuzawa Y., Kanakura Y. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood 1997; 90: 4031–4038
  • Kosugi S., Kurata Y., Tomiyama Y., Tahara T., Kato T., Tadokoro S., Shiraga M., Honda S., Kanakura Y., Matsuzawa Y. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Brit J Haematol 1996; 93: 704–706
  • Ichikawa N., Ishida F., Shimodaira S., Tahara T., Kato T., Kitano K. Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anemia and idiopathic thrombocytopenic purpura. Thromb Haemost 1996; 76: 156–160
  • Tahara T., Usuki K., Sato H., Ohashi H., Morita H., Tsumura H., Matsumoto A., Miyazaki H., Urabe A., Kato T. A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haematopoietic disorders. Brit J Haematol 1996; 93: 783–788
  • Emmons R.V.B., Reid D.M., Cohen R.L., Meng G., Young G.M., Dunber C.E., Shulman N.R. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996; 87: 4068–4071
  • Cerutti A., Custodi P., Duranti M., Noris P., Balduini C. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Brit J Haematol 1997; 99: 281–284
  • Moliterno A.R., Hankins D., Spivak J.L. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. New Eng J Med 1998; 338: 572–580
  • Matsumura I., Kanakura Y., Kato T., Ikeda H., Ishikawa J., Horikawa Y., Hashimoto K., Moriyama Y., Tsujimura T., Nishiura T., Miyazaki H., Matsuzawa Y. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood 1995; 86: 703–708
  • Vigon I., Mornon J.P., Cocault L., Mitjavila M.T., Tambourin P., Gisselbrecht S., Souyri M. Molecular cloning and characterization of MPL, the human homolog of v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992; 89: 5640–5644
  • Deveaux S., Filipe A., Lemarchandel V., Ghysdael J., Romeo P.-H., Mignotte V. Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood 1996; 87: 4678–4685
  • Lemarchandel V., Ghysdael J., Mignotte V., Rahuel C., Romeo P.-H. GATA and Ets cis-acting sequences mediate megakaryocyte specific expression. Mol Cell Biol 1993; 13: 668–676
  • Kaywin P., McDonough M., Insel P., Shattil S.J. Platelet function in essential thrombocythemia: Decreased epinephrine responsiveness associated with a deficiency of platelet α-adrenergic receptors. New Eng J Med 1978; 299: 505–509
  • Schafer A.I. Defiencies of platelet lipoxygenase activity in myeloproliferative disorders. New Eng J Med 1982; 306: 381–386
  • Cooper B., Schafer A.I., Puchalsky D., Handin R.I. Platelet resistance to prostagrandin D2 in patients with myeloproliferative disorders. Blood 1978; 52: 618–626
  • Moore A., Nachman R.L. Platelet Fc receptor: Increased expression in myeloproliferative disease. J Clin Invest 1981; 67: 1064–1071
  • Lowenberg B., Touw P. Hematopoietic growth factors and their receptors in acute leukemia. Blood 1993; 81: 281–292
  • Furitsu T., Tsujimura T., Tono T., Ikeda H., Kitayama H., Koshimizu U., Sugahara H., Butterfield J.H., Ashman L.K., Kanayama Y., Matsuzawa Y., Kitamura Y., Kanakura Y. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993; 92: 1736–1744
  • Li Y, Hetet G., Kiladjian J.-J., Gardin C., Grandchamp B., Briere J. Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders. Brit J Haematol 1996; 92: 60–66
  • Kiladjian J.J., Elkasser N., Hetet G., Briere J., Grandchamp B., Gardin C. Study of the thrombopoietin receptor in essential thrombocythemia. Leukemia 1997; 11: 1821–1826
  • Williams E.C., Shahidi N.T. Benign familial thrombocytosis. Am J Hematol 1991; 37: 124–125
  • Schlemper R.J., van der Maas A.P.C., Eikenboom J.C.J. Familial essential thrombocythemia: clinical characteristics of 11 cases in one family. Ann Hematol 1994; 68: 153–158
  • Wiestner A., Schlemper R.J., van der Maas A.P.C., Skoda R.C. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nature Genetics 1998; 18: 49–52

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.