Thalidomide attenuates learning and memory deficits induced by intracerebroventricular administration of streptozotocin in rats

References

• Ahmad M, Saleem S, Ahmad AS, Yousuf S, Ansari MA, Khan MB, Ishrat T, Chaturvedi RK, Agrawal AK, Islam F (2005) Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J. Neurochem. 93: 94–104.
   PubMed Web of Science ®Google Scholar
• Akama KT, Van Eldik LJ (2000) Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. J. Biol. Chem. 275: 7918–7924.
   PubMed Web of Science ®Google Scholar
• Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K, Nabeshima T (2008) Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta induced impairment of recognition memory in mice. Behav. Brain Res. 189: 100–106.
   PubMed Web of Science ®Google Scholar
• Baratz R, Tweedie D, Rubovitch V, Luo W, Yoon JS, Hoffer BJ, Greig NH, Pick CG (2011) Tumor necrosis factor-α synthesis inhibitor, 3,6’-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J. Neurochem. 118: 1032–1042.
   PubMed Web of Science ®Google Scholar
• Beckman JS, Crow JP (1993) Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem. Soc. Trans. 21: 330–334.
   PubMed Web of Science ®Google Scholar
• Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S (2012) TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J. Neuroinflam. 9: 1–13.
   PubMed Web of Science ®Google Scholar
• Blokland A, Jolles J (1993) Spatial learning deficit and reduced hippocampal ChAT activity in rats after an i.c.v. injection of streptozotocin. Pharmacol. Biochem. Behav. 44: 491–494.
   PubMed Web of Science ®Google Scholar
• Chan ED, Riches DW (1998) Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNF-alpha. Biochem. Biophys. Res. Commun. 253: 790–796.
   PubMed Web of Science ®Google Scholar
• Clodfelder-Miller BJ, Zmijewska AA, Johnson GV, Jope RS (2006) Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin induced insulin deficiency. Diabetes 55: 3320–3325.
   PubMed Web of Science ®Google Scholar
• Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: implication for Alzheimer’s disease. Am. J. Pathol. 175: 2089–2098.
   PubMed Web of Science ®Google Scholar
• Grunblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system in STZ ICV treated rats generates hyperphosphorylated tau protein. J. Neurochem. 101: 757–770.
   PubMed Web of Science ®Google Scholar
• Heneka MT, O’Banion MK, Terwel D, Kummer MP (2010) Neuroinflammatory processes in Alzheimer’s disease. J. Neural. Transm. 117: 919–947.
   PubMed Web of Science ®Google Scholar
• Huang YJ, Liao JF, Tsai TH (2005) Concurrent determination of thalidomide in rat blood, brain and bile using multiple microdialysis coupled to liquid chromatography. Biomed. Chromatogr. 19: 488–493.
   PubMed Web of Science ®Google Scholar
• Jicha GA, Carr SA (2010) Conceptual evolution in Alzheimer’s disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease. J. Alzheimers Dis. 19: 253–272.
   PubMed Web of Science ®Google Scholar
• Koppal T, Drake J, Yatin S, Jordan B, Varadarajan S, Bettenhausen L, Butterfield DA (1999) Peroxynitrite induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer’s disease. J. Neurochem. 72: 310–317.
   PubMed Web of Science ®Google Scholar
• Li Y, Powers C, Jiang N, Chopp M (1998) Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat. J. Neurol. Sci. 156: 119–132.
   PubMed Web of Science ®Google Scholar
• Massoud F, Gauthier S (2010) Update on the pharmacological treatment of Alzheimer’s disease. Curr. Neuropharmacol. 8: 69–80.
   PubMed Web of Science ®Google Scholar
• Mayer G, Nitsch R, Hoyer S (1990) Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats. Brain Res. 532: 91–100.
   Web of Science ®Google Scholar
• Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11: 47–60.
   PubMed Web of Science ®Google Scholar
• Nakahara N, Iga Y, Mizobe F, Kawanishi G (1998) Effects of intracerebroventricular injection of AF64A on learning behaviors in rats. Jpn. J. Pharmacol. 48: 121–130.
   Google Scholar
• Neugroschl J, Sano M (2010) Current treatment and recent clinical research in Alzheimer’s disease. Mt. Sinai J. Med. 77: 3–16.
   PubMedGoogle Scholar
• Ren WJ, Liu Y, Zhou LJ, Li W, Zhong Y, Pang RP, Xin WJ, Wei XH, Wang J, Zhu HQ, Wu CY, Qin ZH, Liu G, Liu XG (2011) Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-α in rodents. Neuropsychopharmacology 36: 979–992.
   PubMed Web of Science ®Google Scholar
• Rodrigues L, Dutra MF, Ilha J, Biasibetti R, Quincozes-Santos A, Leite MC, Marcuzzo S, Achaval M, Goncalves CA (2010) Treadmill training restores spatial cognitive deficits and neurochemical alterations in the hippocampus of rats submitted to an intracerebroventricular administration of streptozotocin. J. Neural Transm. 117: 1295–1305.
   PubMed Web of Science ®Google Scholar
• Rodriguez GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman Jr A, Medeiros R, Calixto JB (2007) Preventive and therapeutic anti-inflammatory effects of systemic and topical thalidomide on endotoxin induced uveitis in rats. Exp. Eye Res. 84: 553–560.
   PubMed Web of Science ®Google Scholar
• Ryu JK, McLarnon JG (2008) Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-alpha in an animal model of inflamed Alzheimer's disease brain. Neurobiol. Dis. 29: 254–266.
   PubMed Web of Science ®Google Scholar
• Saxena G, Bharti S, Kamat PK, Sharma S, Nath C (2010) Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol. Biochem. Behav. 94: 397–403.
   PubMed Web of Science ®Google Scholar
• Shalit F, Sredni B, Rosenblatt-Bin H, Kazimirsky G, Brodie C, Huberman M (1997) Beta-amyloid peptide induces tumor necrosis factor-alpha and nitric oxide production in murine macrophage cultures. Neuroreport 8: 3577–3580.
   PubMed Web of Science ®Google Scholar
• Sharma M, Gupta YK (2001) Effect of chronic treatment of melatonin on learning, memory and oxidative deficiencies induced by intracerebroventricular streptozotocin in rats. Pharmacol. Biochem. Behav. 70: 325–331.
   PubMed Web of Science ®Google Scholar
• Sharma M, Gupta YK (2002) Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 71: 2489–2498.
   PubMed Web of Science ®Google Scholar
• Shi JQ, Shen W, Chen J, Wang BR, Zhong LL, Zhu YW, Zhu HQ, Zhang QQ, Zhang YD, Xu J (2011) Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res. 1368: 239–247.
   PubMed Web of Science ®Google Scholar
• Tobinick E (2010) Perispinal etanercept: a new therapeutic paradigm in neurology. Exp. Rev. Neurother. 10: 985–1002.
   PubMed Web of Science ®Google Scholar
• Tobinick EL, Gross, H (2008) Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration. J. Neuroinflam. 5: 1–10.
   PubMed Web of Science ®Google Scholar
• Tweedie D, Sambamurti K, Greig NH (2007) TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr. Alzheimer Res. 4: 378–385.
   PubMed Web of Science ®Google Scholar
• Weiss EM, Kohler CG, Vonbank J, Stadelmann E, Kemmler G, Hinterhuber H, Marksteiner J (2008) Impairment in emotion recognition abilities in patients with mild cognitive impairment, early and moderate Alzheimer disease compared with healthy comparison subjects. Am. J. Geriat. Psych. 16: 974–980.
   PubMed Web of Science ®Google Scholar
• Yang CH, Otsuka M, Ohama E (2003) An Immunohistochemical study of perivascular plaque in Alzheimer's disease and cerebral amyloid angiopathy. Yonago Acta Med. 46: 9–16.
   Google Scholar