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Original Article

Expression of CA IX in dysplasia adjacent to surgical resection margins of oral squamous cell carcinoma

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Pages 91-97 | Accepted 19 Feb 2013, Published online: 19 Aug 2013

References

  • Brewer CA, Liao, SY, Wilczynski SP, Pastorekova S, Pastorek J, Zavada J, Kurosaki T, Manetta A, Berman ML, DiSaia PG, Stanbridge EJ (1996). A study of biomarkers in cervical carcinoma and clinical correlation of the novel biomarker MN. Gyn. Oncol. 63: 337–344.
  • Brockton NT, Klimowicz AC, Bose P, Petrillo SK, Konno M, Rudmik L, Dean M, Nakoneshny SC, Matthews TW, Chandarana S, Lau HY, Magliocco AM, Dort JC (2012). High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma. Oral Oncol. 48: 615–622.
  • Chen CL, Chu JS, Su WC, Huang SC, Lee WY (2010). Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. Virchows Arch. 457: 53–61.
  • Chia, SK, Wykoff CC, Watson PH, Han C, Leek RD, Pastorek J, Gatter KC, Ratcliffe P, Harris AL (2001). Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J. Clin. Oncol. 19: 3660–3668.
  • Chien MH, Ying TH, Hsieh YH, Lin CH, Shih CH, Wei LH, Yang SF (2012). Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis. Oral Oncol. 48: 417–423.
  • Choi SW, Kim JY, Park JY, Cha IH, Kim J, Lee S (2008). Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma. Human Pathol. 39: 1317–1322.
  • Dewhirst MW, Ong ET, Braun RD, Smith B, Klitzman B, Evans SM, Wilson D (1999). Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br. J. Cancer79: 1717–1722.
  • Eckert AW, Lautner MH, Schutze A, Bolte K, Bache M, Kappler M, Schubert J, Taubert H, Bilkenroth U (2010). Co-expression of Hif1alpha and CAIX is associated with poor prognosis in oral squamous cell carcinoma patients. J. Oral Pathol. Med. 39: 313–317.
  • Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL (2001). Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 61: 7992–7998.
  • Harris AL (2002). Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer. 2: 38–47.
  • Hockel M, Vaupel P (2001). Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93: 266–276.
  • Kim SJ, Shin HJ, Jung KY, Baek SK, Shin BK, Choi J, Kim BS, Shin SW, Kim YH, Kim JS, Oosterwijk E (2007). Prognostic value of carbonic anhydrase IX and Ki-67 expression in squamous cell carcinoma of the tongue. Jpn. J. Clin. Oncol. 37: 812–819.
  • Kivela AJ, Parkkila S, Saarnio J, Karttunen TJ, Kivela J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Rajaniemi H (2000). Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. Histochem. Cell Biol. 114: 197–204.
  • Klatte T, Belldegrun AS, Pantuck AJ (2008). The role of carbonic anhydrase IX as a molecular marker for transitional cell carcinoma of the bladder. BJU Int. 101: 45–48.
  • Kondo Y, Yoshikawa K, Omura Y, Shinohara A, Kazaoka Y, Sano J, Mizuno Y, Yokoi T, Yamada S (2011). Clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, Ki-67 and p53 expression in oral squamous cell carcinoma. Oncol. Rep. 25: 1227–1233.
  • Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP (1998). Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 4: 844–847.
  • Le, QT (2007). Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches. Int. J. Rad. Oncol. 69: S56–8.
  • Le QT, Denko NC, Giaccia AJ (2004). Hypoxic gene expression and metastasis. Cancer Met. Rev. 23: 293–310.
  • Liu CM, Lin YM, Yeh KT, Chen MK, Chang JH, Chen CJ, Chou MY, Yang SF, Chien MH (2012). Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray. J. Oral Pathol. Med. 41: 533–539.
  • Osinsky S, Zavelevich M, Vaupel P (2009). Tumor hypoxia and malignant progression. Exp. Oncol. 31: 80–86.
  • Pastorekova S, Zavadova Z, Kostal M, Babusikova O, Zavada J (1992). A novel quasi-viral agent, MaTu, is a two-component system. Virology187: 620–626.
  • Perez-Sayans M, Garcia-Garcia A, Reboiras-Lopez MD, Gandara-Vila P (2009a). Role of V-ATPases in solid tumors: importance of the subunit C. Int. J. Oncol. 34: 1513–1520.
  • Perez-Sayans M, Somoza-Martin JM, Barros- Angueira F, Reboiras-Lopez MD, Gandara Rey JM, Garcia-Garcia A (2009b). Genetic and molecular alterations associated with oral squamous cell cancer. Oncol. Rep. 22: 1277–1282.
  • Perez-Sayans M, Suarez-Penaranda JM, Pilar GD, Barros-Angueira F, Gandara-Rey JM, Garcia-Garcia A (2011). Hypoxia-inducible factors in OSCC. Cancer Lett. 313: 1–8.
  • Perez-Sayans M, Garcia-Garcia A, Scozzafava A, Supuran CT (2012a). Inhibition of V-ATPase and carbonic anhydrases as interference strategy with tumor acidification processes. Curr. Pharm. Des. 18: 1407–1413.
  • Perez-Sayans M, Suarez-Penaranda JM, Pilar GD, Supuran CT, Pastorekova S, Barros-Angueira F, Gandara-Rey JM, Garcia-Garcia A (2012b). Expression of CA IX is associated with advanced stage tumors and poor survival in oral squamous cell carcinoma patients. J. Oral Pathol. Med. 41: 667–674.
  • Perez-Sayans M, Supuran CT, Pastorekova S, Suarez-Penaranda JM, Pilar GD, Barros-Angueira F, Gandara-Rey JM, Garcia-Garcia A (2012c). The role of carbonic anhydrase IX in hypoxia control in OSCC. J. Oral Pathol. Med. 42: 1–8.
  • Potter CP, Harris AL (2003). Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br. J. Cancer. 89: 2–7.
  • R Development Core Team (2011). R: a Language and Environment for Statistical Computing [article online], 2009. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available: http://www.R-project.org [2011, 10/21].
  • Roh JL, Cho KJ, Kwon GY, Ryu CH, Chang HW, Choi SH, Nam SY, Kim SY (2009). The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol. 45: 63–68.
  • Saarnio J, Parkkila S, Parkkila AK, Haukipuro K, Pastorekova S, Pastorek J, Kairaluoma MI, Karttunen TJ (1998). Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am. J. Pathol. 153: 279–285.
  • Sly WS, Hu PY (1995). Human carbonic anhydrases and carbonic anhydrase deficiencies. Ann. Rev. Biochem. 64: 375–401.
  • Turner JR, Odze RD, Crum CP, Resnick MB (1997). MN antigen expression in normal, preneoplastic, and neoplastic esophagus: a clinicopathological study of a new cancer-associated biomarker. Human Pathol. 28: 740–744.
  • Vaupel P (2010). Metabolic microenvironment of tumor cells: a key factor in malignant progression. Exp. Oncol. 32: 125–127.
  • Vaupel P, Thews O, Hoeckel M (2001). Treatment resistance of solid tumors: role of hypoxia and anemia. Med. Oncol. 18: 243–259.
  • Vaupel P, Mayer A, Hockel M (2004). Tumor hypoxia and malignant progression. Meth. Enzymol. 381: 335–354.
  • Vermylen P, Roufosse C, Burny A, Verhest A, Bosschaerts T, Pastorekova S, Ninane V, Sculier JP (1999). Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lung carcinoma. Eur. Resp. J. 14: 806–811.
  • Vigneswaran N, Wu J, Song A, Annapragada A, Zacharias W (2011). Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC). Exp. Mol. Pathol. 90: 215–225.
  • Vullo D, Franchi M, Gallori E, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT (2003). Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulphonamides. Bioorg. Med. Chem. Lett. 13: 1005–1009.
  • Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT (2005). Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorg. Med. Chem. Lett. 15: 963–969.
  • WHO (World Health Organization Classification of Tumours) (2005). Head and neck tumors. In: Pathology and Genetics, 9th ed., Barnes L, Eveson JW, Reichart P, Sidransky D, Eds., IARC Press, Lyon. pp. 177–180.
  • Zat’ovicova M, Tarabkova K, Svastova E, Gibadulinova A, Mucha V, Jakubickova L, Biesova Z, Rafajova M, Ortova Gut M, Parkkila S, Parkkila AK, Waheed A, Sly WS, Horak I, Pastorek J, Pastorekova S (2003). Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX. J. Immunol. Methods282: 117–134.

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