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Research Article

Selective Targeting of Malignant Cells with Cytotoxin-Folate Conjugates

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Pages 101-112 | Received 25 Aug 1993, Accepted 18 Nov 1993, Published online: 20 Oct 2008

References

  • A. Antony. (1992). The biological chemistry of folate receptors Blood 79:2807–2820.
  • A. Antony, M. Kane, R. Portillo, P. Elwood, J. Kolhouse. (1985). Studies of the role of a particulate folatebinding protein in the uptake of 5methyltetrahydrofolate by cultured human KB cells J. Biol. Chem. 260:14911–14917.
  • P. Bacha, D. Williams, C. Waters, J. Williams, J. Murphy, T. Strom. (1988). Interleukin 2 receptormediated cytoxicity: Interleukin 2 receptormediated action of a diphtheria toxinrelated interleukin 2 fusion protein J. Exp. Med. 167:612–622.
  • S. Basu. (1990). Receptormediated endocytosis of macromolecular conjugates in selective drug delivery Biochemical Pharmacology 40:1941–1946.
  • I. Campbell, T. Jones, W. Foulkes, Trowsdale. (1991). Folatebinding protein is a marker for ovarian cancer Cancer Research 51:5329–5338.
  • L. Coney, A. Tomassetti, L. Carayannopoulos, V. Frasca, B. Kamen, M. Colnaghi, V. Zurawski. (1991). Cloning of a tumorassociated antigen: Movl8 and Movl9 antibodies recognize a folatebinding protein Cancer Research 51:6125–6132.
  • P. Elwood, J. Deutsch, J. Kolhouse. (1991). The conversion of the human membraneassociated folate binding protein folate receptor to the soluble folate binding protein by a membraneassociated metalloprotease J. Biol. Chem. 266:2346–2353.
  • G. Henderson. (1990). Folatebinding proteins Annu. Rev. Nutr. 10:319–335.
  • G. Henderson, J. Tsuji, H. Kumar. (1988). Mediated uptake of folate by a highaffinity binding protein in sublines of L1210 cells adapted to a nanomolar concentrations of folate J. Membrane Biol. 101:247–258.
  • G. Jansen, I. Kathmann, B. Rademaker, B. Braakhuis, G. Westerhof, G. Rijksen, J. Schornagel. (1989). Identification of a membraneassociated folatebinding protein in human leukemia CCRFCEM cells with transportrelated methotrexate resistance Cancer Research 49:2455–2459.
  • B. Kamen, A. Capdevilla. (1986). Receptormediated folate accumulation is regulated by the cellular folate content Proc. Natl. Acad. Sci., U. S. A. 83:5983–5987.
  • M. Kane, S. Waxman. (1989). Biology of disease: Role of folate binding proteins in folate metabolism Lab. Invest. 60:737–746.
  • M. Kane, P. Elwood, R. Portillo, A. Antony, V. Najfeld, A. Finley, S. Waxman, J. Kolhouse. (1988). Influence of immunorreactive folatebinding proteins of extracellular folate concentration in cultured human cells J. Clin. Invest. 81:1398–1406.
  • S. Lacey, J. Sanders, K. Rothberg, R. Anderson, B. Kamen. (1989). Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosylphosphatidylinositol J. Clin. Invest. 84:715–720.
  • C. Leamon, P. Low. (1993). Membrane folate binding proteins are responsible for folateprotein conjugate endocytosis into cultured cells Biochemical J. 291:885–860.
  • C. Leamon, P. Low. (1992). Cytotoxicity of momordinfolate conjugates in cultured human cells J. Biol. Chem. 267:24966–24971.
  • C. Leamon, P. Low. (1991). Delivery of macromolecules into living cells: A method that exploits folate receptor endocytosis Proc. Natl. Acad. Sci., U. S. A. 88:3572–5576.
  • C. Luhrs, B. Slomiany. (1989). A human membraneassociated folate binding protein is anchored by a glycosylphosphatidylinositol tail J. Biol. Chem. 264:21446–21449.
  • L. Pai, K. Batra, D. FitzGerald, M. Willingham, I. Pastan. (1991). Antitumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin Proc. Natl. Acad. Sci., USA 88:3358–3362.
  • K. Rothberg, Y. Ying, J. Kolhouse, B. Kamen, R. Anderson. (1990). The glycophospholipidlinked folate receptor internalizes folate without entering the clathrincoated pit endocytic pathway J. Cell Biol. 110:637–649.
  • F. Stirpe, L. Barbieri. (1986). Ribosomeinactivating proteins up to date FEBS Letters 195:1–8.
  • C. Theuer, D. FitzGerald, I. Pastan. (1992). A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing J. Biol. Chem. 267:16872–16877.
  • R. Verma, S. Gullapalli, A. Antony. (1992). Evidence that the hydrophobicity of isolated, in situ, and de novosyntnesized native human placental folate receptors is a function of glycosylphosphatidylinositol anchoring to membranes J. Biol. Chem. 267:4119–4127.
  • S. Weitman, R. Lark, L. Coney, D. Fort, V. Frasca, V. Zurawski, B. Kamen. (1992). Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues Cancer Research 52:3396–3401.
  • S. Weitman, A. Weinberg, L. Coney, V. Zurawski, D. Jennings, B. Kamen. (1992). Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis Cancer Research 52:6708–6711.
  • G. Westerhof, G. Jansen, N. van Emmerik, I. Kathmann, G. Rijksen, A. Jackman, J. Schornagel. (1991). Membrane transport of natural folates and antifolate compounds in murine leukemia cells: Role of carrier and receptormediated transport systems Cancer Research 51:5507–5513.
  • M. Magerstadt. (1991). Antibody Conjugates and Malignant Disease
  • V. Raso. M. Basala. (1984). ReceptorMediated Targeting of Drugs

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