Enhanced Antitumour Effects using a Combination of Two Antibodies Conjugated to Different Drugs

References

• S. Andrew, J. Teh, R. Johnstone, (1990a). Tumour localisation by combinations of monoclonal antibodies in a new human colon carcinoma cell line LIM 1899 Cancer Res. 50:5225–5230.
   PubMed Web of Science ®Google Scholar
• S. Andrew, R. Johnstone, S. Russell, (1990b). Comparison of in vitro binding characteristics of four monoclonal antibodies and their individual tumour localization properties in mice Cancer Res. 50:4423–4428.
   PubMed Web of Science ®Google Scholar
• M. Berenbaum. (1977). Synergy, additivism and antagonism in immunosuppression Clin. Exp. Immunol. 28:1–18.
   PubMed Web of Science ®Google Scholar
• M. Bradford. (1976). A rapid and sensitive method of quantitation of microgram quantities of protein utilising the principle of protein dye binding Anal. Biochem. 72:248–253.
   PubMed Web of Science ®Google Scholar
• V. Byers, I. Pawlucyzk, N. Berry, (1988). Potentiation of anticarcinoembryonic antigen immunotoxin cytotoxicity by monocolonal antibodies reacting with coexpressed carcinoembryonic antigen epitopes J. Immunol. 140:4055
   Google Scholar
• R. Ceriani, E. Blank. (1988). Experimental therapy of human breast tumors with 131Ilabeled monoclonal antibodies prepared against human milk fat globule Cancer Res. 48:4664–4672.
   PubMed Web of Science ®Google Scholar
• R. Ceriani, E. Blank, J. Peterson. (1987). Experimental immunotherapy of human breast carcinomas implanted in nude mice with a mixture of monoclonal antibodies against human milk fat globule components Cancer Res. 47:532–540.
   PubMed Web of Science ®Google Scholar
• P. Ey, S. Prowse, C. Jenkin. (1978). Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A sepharose Immunochemistry 15:429–434.
   PubMedGoogle Scholar
• P. Giacomini, O. Segatto, P. Natali. (1987). Multiple epitope recognition: an approach to improved radioimmunodetection of tumourassociated antigens Int. J. Cancer 39:729–736.
   PubMed Web of Science ®Google Scholar
• A. Goldin, N. Mantel. (1957). The employment of combinations of drugs in the chemotherapy of neoplasia: A review Cancer Res. 17:635–638.
   PubMed Web of Science ®Google Scholar
• P. Hand, M. Noti, D. Colcher, J. Scholm. (1983). Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumourassociated antigens Cancer Res. 43:728–735.
   PubMed Web of Science ®Google Scholar
• P. Hogarth, J. Edwards, I. McKenzie, (1982). Monoclonal antibodies to murine Ly2.1 cellsurface antigen Immunol. 46:135–144.
   PubMed Web of Science ®Google Scholar
• P. Hogarth, M. Henning, I. McKenzie. (1982). Alloantigenic phenotype of radiation induced thymomas in the mouse J. Natl. Cancer Inst. 69:619–625.
   PubMed Web of Science ®Google Scholar
• J. Horton, P. Gehrt, T. Cunningham, J. Sullivan. (1967). Comparison of combination and single drug chemotherapy in cancer of the colon, breast and other organs Proc. Am. Assoc. Cancer Res. 8:31
   Google Scholar
• A. Jarlonzinska, R. Richter, Z. Albert, H. Zawadzka. (1983). Antigenic heterogeneity of human lung cancer J. N. C. I. 70:427–133.
   PubMed Web of Science ®Google Scholar
• Z. Krizan, J. Murray, E. Hersh, (1985). Increased labelling of human melanoma cells in vitro using combinations of monoclonal antibodies recognising separate cell surface antigenic determinants Cancer Res. 45:4904–4910.
   PubMed Web of Science ®Google Scholar
• K. Mujoo, M. Rosenblum, J. Murray. (1991). Augmented binding of radiolabeled monoclonal antibodies to melanoma cells using specific antibody combinations Cancer Res. 51:2768–2772.
   PubMed Web of Science ®Google Scholar
• D. Munz, A. Alavi, K. Koprowski, D. Herlyn. (1986). Improved radioimaging of human tumour xenografts by mixtures of monoclonal antibody Fab'2 fragments J. Nucl. Med. 27:1739–1745.
   PubMed Web of Science ®Google Scholar
• L. Nathanson, T. Hall, M. Dederick, (1966). Initial pharmacologic studies of three types of combination chemotherapy Cancer Chemotherapy Rept. 50:259–264.
   PubMedGoogle Scholar
• L. Nathanson, T. Hall, A. Schilling, S. Miller. (1969). Concurrent combination chemotherapy of human solid tumors: experience with a threedrug regimen and review of the literature Cancer Res. 29:419–425.
   PubMed Web of Science ®Google Scholar
• R. Oldham, M. Lewis, D. Orr, (1988). Adriamycin customtailored immunoconjugates in the treatment of human malignancies Mol. Biother. 1:103–113.
   PubMedGoogle Scholar
• G. Pietersz, I. McKenzie. (1992). Antibody conjugates for the treatment of cancer Immunological Rev. 129:57–80.
   PubMed Web of Science ®Google Scholar
• G. Pietersz, M. Smyth, I. McKenzie. (1988). Immunochemotherapy of a murine thymoma with the use of idarubicin monoclonal antibody conjugates Cancer Res. 48:926–931.
   PubMed Web of Science ®Google Scholar
• M. Pimm. (1988). Drugmonoclonal antibody conjugates for cancer therapy: potentials and limitations CRC Crit Rev. Therap. Drug Cancer System 5:189–227.
   PubMed Web of Science ®Google Scholar
• F. Primus, W. Kuhns, D. Goldenberg. (1983). Immunological heterogeneity of carcinembryonic antigen: immunohistochemical detection of carcinembryonic antigen determinants in colonic tumors with monoclonal antibodies Cancer Res. 43:693–701.
   PubMed Web of Science ®Google Scholar
• R. Reitemier, C. Moertel, R. Hahn. (1967). Comparative evaluation of palliation with fluorometholone and 5fluorouracil in advanced gastrointestinal cancer Cancer Chemotherapy Rept. 51:77–80.
   PubMedGoogle Scholar
• S. Salmon, A. Haut, J. Bonnet, M. Amare, (1983). Alternating combination chemotherapy and levamisole improves survival in multiple myeloma: a southwest oncology group study J. Clin. Oncol. 1:453–460.
   PubMed Web of Science ®Google Scholar
• M. Schneiderman, M. Myers, Y. Sathe, P. Koffsky. (1964). Toxicity, the therapeutic index and the ranking of drug Science 144:1212–1213.
   PubMed Web of Science ®Google Scholar
• M. Smyth, H. Foster, S. Andrew, (1993). Immunochemotherapy of human colon carcinoma xenografts in nude mice using combination of idarubicinmonoclonal antibody conjugates Immunol. Cell Biol. 71:167–179.
   PubMedGoogle Scholar
• M. Smyth, G. Pietersz, I. McKenzie. (1987). Selective enhancement of antitumour activity of Nacetyl melphalan upon conjugation to monoclonal antibodies Cancer Res. 47:62–69.
   PubMed Web of Science ®Google Scholar
• D. Stamignoni, R. Bowen, B. Atkinson, J. Schlom. (1983). Differential reactivity of monoclonal antibodies with human colon adenocarcinomas and adenomas Int. J. Cancer 31:543–552.
   PubMed Web of Science ®Google Scholar
• J. Tjandra, G. Pietersz, M. Smyth, (1989). Phase I clinical trial of drug monoclonal antibody conjugates in patients with advanced colorectal carcinoma a preliminary report Surgery 106:533–545.
   PubMed Web of Science ®Google Scholar
• D. Vallera, R. Ash, E. Zanjani, (1983). AntiTcell reagents for human bone marrow transplantation, ricin linked to three monoclonal antibodies Science 222:512–514.
   PubMed Web of Science ®Google Scholar
• Y. Yu, J. Crews, K. Cooper, (1990). Use of immunotoxins in combination to inhibit clongenic growth of human breast carcinoma cells Cancer Res. 50:3231–3238.
   PubMed Web of Science ®Google Scholar
• M. Smyth. G. Pietersz. I. McKenzie. (1988). Targeted Diagnosis and Therapy1:123–156.
   Google Scholar
• V. Sutton. (1984). Cell surface antigens
   Google Scholar