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Research Article

Epithelial cell permeability of a series of peptidic HIV protease inhibitors: Aminoterminal substituent effects

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Pages 167-171 | Received 03 Nov 1993, Accepted 27 Dec 1993, Published online: 20 Oct 2008

References

  • P. BurtonR. ConradiA. HilgersN. HoL. Maggiora1992The relationship between peptide structure and transport across epithelial cell monolayersJ. Controlled Release19:8798
  • P. CarruptB. TestaA. BechalanyN. El TayarP. DescasPerissoud1991Morphine 6glucuronide and morphine 3glucuronide as molecular chameleons with unexpected lipophilicityJ. Med. Chem.34:12721275
  • R. ConradiA. HilgersN. HoP. Burton1991The influence of peptide structure on transport across Caco2 cellsPharm. Res.8:14531460
  • R. ConradiA. HilgersN. HoP. Burton1992The influence of peptide structure on transport across Caco2 cells II. Peptide bond modification which results in improved permeabilityPharm. Res.9:435439
  • D. EnglemanT. Steitz1981The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesisCell23:411422
  • A. HilgersR. ConradiP. Burton1990Caco2 cell monolayers as a model for drug transport across the intestinal mucosaPharm. Res.7:902910
  • R. Jones1964Steric inhibition of hydrogenbonding in a secondary amideSpectrochim. Acta20:18791882
  • D. PatersonR. ConradiT. VidmarA. HilgersP. Burton1994A nonaqueous partition coefficient for predicting oral bioavailability of peptidesQuant. StructAct. Relat.:
  • M. Roseman1988Hydrophilicity of the peptide CONH hydrogen bonded groupJ. Mol. Biol.201:621623
  • P. Seiler1974Interconversions of lipophilicities from the hydrocarbon/water system into the octanol/water systemEur. J. Med. Chem.9:473479
  • R. YoungR. MitchellT. BrownC. GanellinR. GriffithsM. JonesK. RanaD. SaundersI. SmithN. SoreT. Wilks1988Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonistsJ. Med. Chem.31:656671
  • W. Stein1967The Movement of Molecules Across Cell Membranes65125

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