The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides

References

• Barnes MP, Shen WC. (2009). Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells. Int J Pharm, 369, 79–84.
   PubMed Web of Science ®Google Scholar
• Cahill K. (2010). Molecular electroporation and the transduction of oligoarginines. Phys Biol, 7, article number 016001.
   Web of Science ®Google Scholar
• El-Andaloussi S, Järver P, Johansson HJ, Langel U. (2007). Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study. Biochem J, 407, 285–292.
   PubMed Web of Science ®Google Scholar
• Fischer PM. (2007). Cellular uptake mechanisms and potential therapeutic utility of peptidic cell delivery vectors: progress 2001–2006. Med Res Rev, 27, 755–795.
   PubMed Web of Science ®Google Scholar
• Fischer R, Waizenegger T, Köhler K, Brock R. (2002). A quantitative validation of fluorophore-labelled cell-permeable peptide conjugates: fluorophore and cargo dependence of import. Biochim Biophys Acta, 1564, 365–374.
   PubMed Web of Science ®Google Scholar
• Gelman RA, Blackwell J. (1973). Heparin-polypeptide interactions in aqueous solution. Arch Biochem Biophys, 159, 427–433.
   PubMed Web of Science ®Google Scholar
• Lee HL, Dubikovskaya EA, Hwang H, Semyonov AN, Wang H, Jones LR, Twieg RJ, Moerner WE, Wender PA. (2008). Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells. J Am Chem Soc, 130, 9364–9370.
   PubMed Web of Science ®Google Scholar
• Lundberg M, Johansson M. (2001). Is VP22 nuclear homing an artifact? Nat Biotechnol, 19, 713–714.
   PubMed Web of Science ®Google Scholar
• Melikov K, Chernomordik LV. (2005). Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery. Cell Mol Life Sci, 62, 2739–2749.
   PubMed Web of Science ®Google Scholar
• Mueller J, Kretzschmar I, Volkmer R, Boisguerin P. (2008). Comparison of cellular uptake using 22 CPPs in 4 different cell lines. Bioconjug Chem, 19, 2363–2374.
   PubMed Web of Science ®Google Scholar
• Nakase I, Niwa M, Takeuchi T, Sonomura K, Kawabata N, Koike Y, Takehashi M, Tanaka S, Ueda K, Simpson JC, Jones AT, Sugiura Y, Futaki S. (2004). Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Mol Ther, 10, 1011–1022.
   PubMed Web of Science ®Google Scholar
• Patel LN, Wang J, Kim KJ, Borok Z, Crandall ED, Shen WC. (2009). Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm, 6, 492–503.
   PubMed Web of Science ®Google Scholar
• Patel LN, Zaro JL, Shen WC. (2007). Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Pharm Res, 24, 1977–1992.
   PubMed Web of Science ®Google Scholar
• Richard JP, Melikov K, Brooks H, Prevot P, Lebleu B, Chernomordik LV. (2005). Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors. J Biol Chem, 280, 15300–15306.
   PubMed Web of Science ®Google Scholar
• Rothbard JB, Kreider E, VanDeusen CL, Wright L, Wylie BL, Wender PA. (2002). Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake. J Med Chem, 45, 3612–3618.
   PubMed Web of Science ®Google Scholar
• Rothbard JB, Jessop TC, Lewis RS, Murray BA, Wender PA. (2004). Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells. J Am Chem Soc, 126, 9506–9507.
   PubMed Web of Science ®Google Scholar
• Sawant R, Torchilin V. (2010). Intracellular transduction using cell-penetrating peptides. Mol Biosyst, 6, 628–640.
   PubMed Web of Science ®Google Scholar
• Schmidt N, Mishra A, Lai GH, Wong GC. (2010). Arginine-rich cell-penetrating peptides. FEBS Lett, 584, 1806–1813.
   PubMed Web of Science ®Google Scholar
• Shen WC, Wan J, Ekrami H. (1992). Enhancement of polypeptide and protein absorption by macromolecular carriers via endocytosis and transcytosis. Adv Drug Deliv Rev, 8, 93–113.
   Web of Science ®Google Scholar
• Sonoda S, Schlamowitz M. (1970). Studies of 125I trace labeling of immunoglobulin G by chloramine-T. Immunochemistry, 7, 885–898.
   PubMedGoogle Scholar
• Ter-Avetisyan G, Tünnemann G, Nowak D, Nitschke M, Herrmann A, Drab M, Cardoso MC. (2009). Cell entry of arginine-rich peptides is independent of endocytosis. J Biol Chem, 284, 3370–3378.
   PubMed Web of Science ®Google Scholar
• Thorén PE, Persson D, Isakson P, Goksör M, Onfelt A, Nordén B. (2003). Uptake of analogs of penetratin, Tat(48–60) and oligoarginine in live cells. Biochem Biophys Res Commun, 307, 100–107.
   PubMed Web of Science ®Google Scholar
• Tung CH, Weissleder R. (2003). Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev, 55, 281–294.
   PubMed Web of Science ®Google Scholar
• Tünnemann G, Martin RM, Haupt S, Patsch C, Edenhofer F, Cardoso MC. (2006). Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells. FASEB J, 20, 1775–1784.
   PubMed Web of Science ®Google Scholar
• Vivès E, Schmidt J, Pèlegrin A. (2008). Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta, 1786, 126–138.
   Google Scholar
• Wender PA, Galliher WC, Goun EA, Jones LR, Pillow TH. (2008). The design of guanidinium-rich transporters and their internalization mechanisms. Adv Drug Deliv Rev, 60, 452–472.
   PubMed Web of Science ®Google Scholar
• Widera A, Norouziyan F, Shen WC. (2003). Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery. Adv Drug Deliv Rev, 55, 1439–1466.
   PubMed Web of Science ®Google Scholar
• Zaro JL, Shen WC. (2003). Quantitative comparison of membrane transduction and endocytosis of oligopeptides. Biochem Biophys Res Commun, 307, 241–247.
   PubMed Web of Science ®Google Scholar
• Zaro JL, Shen WC. (2005a). Evidence that membrane transduction of oligoarginine does not require vesicle formation. Exp Cell Res, 307, 164–173.
   PubMed Web of Science ®Google Scholar
• Zaro JL, Shen WC. (2005b). Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells. J Control Release, 108, 409–417.
   PubMed Web of Science ®Google Scholar
• Zaro JL, Rajapaksa TE, Okamoto CT, Shen WC. (2006). Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis. Mol Pharm, 3, 181–186.
   PubMed Web of Science ®Google Scholar
• Zhang X, Jin Y, Plummer MR, Pooyan S, Gunaseelan S, Sinko PJ. (2009). Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retro-inverso Tat cell penetrating peptide. Mol Pharm, 6, 836–848.
   PubMed Web of Science ®Google Scholar