Recent advances in ligand targeted therapy

References

• Anabousi S, Bakowsky U, Schneider M, Huwer H, Lehr CM, Ehrhardt C. (2006). In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci, 29, 367–374.
   PubMed Web of Science ®Google Scholar
• Anbharasi V, Cao N, Feng SS. (2010). Doxorubicin conjugated to D-alpha-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy. J Biomed Mater Res A, 94, 730–743.
   PubMed Web of Science ®Google Scholar
• Arote RB, Hwang SK, Lim HT, Kim TH, Jere D, Jiang HL, Kim YK, Cho MH, Cho CS. (2010). The therapeutic efficiency of FP-PEA/TAM67 gene complexes via folate receptor-mediated endocytosis in a xenograft mice model. Biomaterials, 31, 2435–2445.
   PubMed Web of Science ®Google Scholar
• Askoxylakis V, Zitzmann-Kolbe S, Zoller F, Altmann A, Markert A, Rana S, Marr A, Mier W, Debus J, Haberkorn U. (2011). Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology. Molecules, 16, 1559–1578.
   PubMed Web of Science ®Google Scholar
• Balestrieri ML, Napoli C. (2007). Novel challenges in exploring peptide ligands and corresponding tissue-specific endothelial receptors. Eur J Cancer, 43, 1242–1250.
   PubMed Web of Science ®Google Scholar
• Barbas AS, Mi J, Clary BM, White RR. (2010). Aptamer applications for targeted cancer therapy. Future Oncol, 6, 1117–1126.
   PubMed Web of Science ®Google Scholar
• Bies C, Lehr CM, Woodley JF. (2004). Lectin-mediated drug targeting: history and applications. Adv Drug Deliv Rev, 56, 425–435.
   PubMed Web of Science ®Google Scholar
• Birn H, Nielsen S, Christensen EI. (1997). Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule. Am J Physiol, 272, F70–F78.
   PubMed Web of Science ®Google Scholar
• Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB. (2001). In-vivo measurement of activated microglia in dementia. Lancet, 358, 461–467.
   PubMed Web of Science ®Google Scholar
• Chandna P, Khandare JJ, Ber E, Rodriguez-Rodriguez L, Minko T. (2010). Multifunctional tumor-targeted polymer-peptide-drug delivery system for treatment of primary and metastatic cancers. Pharm Res, 27, 2296–2306.
   PubMed Web of Science ®Google Scholar
• Chen X, Plasencia C, Hou Y, Neamati N. (2005). Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem, 48, 1098–1106.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. (2004). Structure of the human transferrin receptor-transferrin complex. Cell, 116, 565–576.
   PubMed Web of Science ®Google Scholar
• Chiu SJ, Liu S, Perrotti D, Marcucci G, Lee RJ. (2006). Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes. J Control Release, 112, 199–207.
   PubMed Web of Science ®Google Scholar
• Choi CH, Alabi CA, Webster P, Davis ME. (2010). Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci USA, 107, 1235–1240.
   PubMed Web of Science ®Google Scholar
• Das M, Mohanty C, Sahoo SK. (2009). Ligand-based targeted therapy for cancer tissue. Expert Opin Drug Deliv, 6, 285–304.
   PubMed Web of Science ®Google Scholar
• Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. (2010). Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature, 464, 1067–1070.
   PubMed Web of Science ®Google Scholar
• de Jong M, Breeman WA, Kwekkeboom DJ, Valkema R, Krenning EP. (2009). Tumor imaging and therapy using radiolabeled somatostatin analogues. Acc Chem Res, 42, 873–880.
   PubMed Web of Science ®Google Scholar
• Decaudin D. (2004). Peripheral benzodiazepine receptor and its clinical targeting. Anticancer Drugs, 15, 737–745.
   PubMed Web of Science ®Google Scholar
• Dominska M, Dykxhoorn DM. (2010). Breaking down the barriers: siRNA delivery and endosome escape. J Cell Sci, 123, 1183–1189.
   PubMed Web of Science ®Google Scholar
• Dosio F, Arpicco S, Stella B, Brusa P, Cattel L. (2009). Folate-mediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system. Int J Pharm, 382, 117–123.
   PubMed Web of Science ®Google Scholar
• Dowlati A, Loo M, Bury T, Fillet G, Beguin Y. (1997). Soluble and cell-associated transferrin receptor in lung cancer. Br J Cancer, 75, 1802–1806.
   PubMed Web of Science ®Google Scholar
• Dube D, Khatri K, Goyal AK, Mishra N, Vyas SP. (2010). Preparation and evaluation of galactosylated vesicular carrier for hepatic targeting of silibinin. Drug Dev Ind Pharm, 36, 547–555.
   PubMed Web of Science ®Google Scholar
• Elnakat H, Ratnam M. (2004). Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev, 56, 1067–1084.
   PubMed Web of Science ®Google Scholar
• Fischgräbe J, Wülfing P. (2008). Targeted therapies in breast cancer: established drugs and recent developments. Curr Clin Pharmacol, 3, 85–98.
   PubMedGoogle Scholar
• Gabizon A, Tzemach D, Gorin J, Mak L, Amitay Y, Shmeeda H, Zalipsky S. (2010). Improved therapeutic activity of folate-targeted liposomal doxorubicin in folate receptor-expressing tumor models. Cancer Chemother Pharmacol, 66, 43–52.
   PubMed Web of Science ®Google Scholar
• Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, Hammers A, Eggert K, Oertel W, Banati RB, Brooks DJ. (2006). In vivo imaging of microglial activation with [11C] (R)-PK11195 PET in idiopathic Parkinson’s disease. Neurobiol Dis, 21, 404–412.
   PubMed Web of Science ®Google Scholar
• Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer R S, Farokhzad OC. 2007. Targeted nanoparticles for cancer therapy. Nano Today, 2, 14–21.
   Web of Science ®Google Scholar
• Gullotti E, Yeo Y. (2009). Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Mol Pharm, 6, 1041–1051.
   PubMed Web of Science ®Google Scholar
• Gunawan RC, Auguste DT. (2010). The role of antibody synergy and membrane fluidity in the vascular targeting of immunoliposomes. Biomaterials, 31, 900–907.
   PubMed Web of Science ®Google Scholar
• Guo KT, Ziemer G, Paul A, Wendel HP. (2008). CELL-SELEX: Novel perspectives of aptamer-based therapeutics. Int J Mol Sci, 9, 668–678.
   PubMed Web of Science ®Google Scholar
• Guo P, Ma J, Li S, Guo Z, Adams AL, Gallo JM. (2001). Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. Cancer Chemother Pharmacol, 48, 169–176.
   PubMed Web of Science ®Google Scholar
• Heath VL, Bicknell R. (2009). Anticancer strategies involving the vasculature. Nat Rev Clin Oncol, 6, 395–404.
   PubMed Web of Science ®Google Scholar
• Herbst SM, Klegerman ME, Kim H, Qi J, Shelat H, Wassler M, Moody MR, Yang CM, Ge X, Zou Y, Kopechek JA, Clubb FJ, Kraemer DC, Huang S, Holland CK, McPherson DD, Geng YJ. (2010). Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1. Mol Pharm, 7, 3–11.
   PubMed Web of Science ®Google Scholar
• Hicke BJ, Stephens AW. (2000). Escort aptamers: a delivery service for diagnosis and therapy. J Clin Invest, 106, 923–928.
   PubMed Web of Science ®Google Scholar
• Huang RQ, Qu YH, Ke WL, Zhu JH, Pei YY, Jiang C. (2007). Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. FASEB J, 21, 1117–1125.
   PubMed Web of Science ®Google Scholar
• Jiang YY, Liu C, Hong MH, Zhu SJ, Pei YY. (2007). Tumor cell targeting of transferrin-PEG-TNF-alpha conjugate via a receptor-mediated delivery system: design, synthesis, and biological evaluation. Bioconjug Chem, 18, 41–49.
   PubMed Web of Science ®Google Scholar
• Jin Y, Liu S, Yu B, Golan S, Koh CG, Yang J, Huynh L, Yang X, Pang J, Muthusamy N, Chan KK, Byrd JC, Talmon Y, Lee LJ, Lee RJ, Marcucci G. (2010). Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia. Mol Pharm, 7, 196–206.
   PubMed Web of Science ®Google Scholar
• Kakimoto S, Moriyama T, Tanabe T, Shinkai S, Nagasaki T. (2007). Dual-ligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery. J Control Release, 120, 242–249.
   PubMed Web of Science ®Google Scholar
• Kang H, O’Donoghue MB, Liu H, Tan W. (2010). A liposome-based nanostructure for aptamer directed delivery. Chem Commun (Camb), 46, 249–251.
   PubMed Web of Science ®Google Scholar
• Kim D, Jeong YY, Jon S. (2010). A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano, 4, 3689–3696.
   PubMed Web of Science ®Google Scholar
• Kim YK, Choi JY, Jiang HL, Arote R, Jere D, Cho MH, Je YH, Cho CS. (2009). Hybrid of baculovirus and galactosylated PEI for efficient gene carrier. Virology, 387, 89–97.
   PubMed Web of Science ®Google Scholar
• Krishna AD, Mandraju RK, Kishore G, Kondapi AK. (2009). An efficient targeted drug delivery through apotransferrin loaded nanoparticles. PLoS ONE, 4, e7240.
   PubMed Web of Science ®Google Scholar
• Kularatne SA, Low PS. (2010). Targeting of nanoparticles: folate receptor. Methods Mol Biol, 624, 249–265.
   PubMedGoogle Scholar
• Lam JK, Armes SP, Lewis AL, Stolnik S. (2009). Folate conjugated phosphorylcholine-based polycations for specific targeting in nucleic acids delivery. J Drug Target, 17, 512–523.
   PubMed Web of Science ®Google Scholar
• Laquintana V, Denora N, Musacchio T, Lasorsa M, Latrofa A, Trapani G. (2009). Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful as delivery systems of apoptotic agents. J Control Release, 137, 185–195.
   PubMed Web of Science ®Google Scholar
• Lee CC, Grandinetti G, McLendon PM, Reineke TM. (2010). A polycation scaffold presenting tunable “click” sites: conjugation to carbohydrate ligands and examination of hepatocyte-targeted pDNA delivery. Macromol Biosci, 10, 585–598.
   PubMed Web of Science ®Google Scholar
• Lee RJ, Low PS. (1994). Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J Biol Chem, 269, 3198–3204.
   PubMed Web of Science ®Google Scholar
• Lee RJ, Wang S, Low PS. (1996). Measurement of endosome pH following folate receptor-mediated endocytosis. Biochim Biophys Acta, 1312, 237–242.
   PubMed Web of Science ®Google Scholar
• Lehr CM. (2000). Lectin-mediated drug delivery: the second generation of bioadhesives. J Control Release, 65, 19–29.
   PubMed Web of Science ®Google Scholar
• Li X, Ding L, Xu Y, Wang Y, Ping Q. (2009). Targeted delivery of doxorubicin using stealth liposomes modified with transferrin. Int J Pharm, 373, 116–123.
   PubMed Web of Science ®Google Scholar
• Liu J, Liu J, Chu L, Wang Y, Duan Y, Feng L, Yang C, Wang L, Kong D. (2011). Novel peptide-dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer. Int J Nanomedicine, 6, 59–69.
   Web of Science ®Google Scholar
• Liu S. (2008). Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides. Adv Drug Deliv Rev, 60, 1347–1370.
   PubMed Web of Science ®Google Scholar
• Low PS, Kularatne SA. (2009). Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol, 13, 256–262.
   PubMed Web of Science ®Google Scholar
• Lu Y, Wu J, Wu J, Gonit M, Yang X, Lee A, Xiang G, Li H, Liu S, Marcucci G, Ratnam M, Lee RJ. (2007). Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Mol Pharm, 4, 707–712.
   PubMed Web of Science ®Google Scholar
• McIntyre GD, Scott CF Jr, Ritz J, Blättler WA, Lambert JM. (1994). Preparation and characterization of interleukin-2-gelonin conjugates made using different cross-linking reagents. Bioconjug Chem, 5, 88–97.
   PubMed Web of Science ®Google Scholar
• McPherson PS, Kay BK, Hussain NK. (2001). Signaling on the endocytic pathway. Traffic, 2, 375–384.
   PubMed Web of Science ®Google Scholar
• Mezo G, Manea M. (2010). Receptor-mediated tumor targeting based on peptide hormones. Expert Opin Drug Deliv, 7, 79–96.
   PubMed Web of Science ®Google Scholar
• Morille M, Passirani C, Letrou-Bonneval E, Benoit JP, Pitard B. (2009). Galactosylated DNA lipid nanocapsules for efficient hepatocyte targeting. Int J Pharm, 379, 293–300.
   PubMed Web of Science ®Google Scholar
• Müller C, Mindt TL, de Jong M, Schibli R. (2009). Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy. Eur J Nucl Med Mol Imaging, 36, 938–946.
   PubMed Web of Science ®Google Scholar
• Musacchio T, Laquintana V, Latrofa A, Trapani G, Torchilin VP. (2009). PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: synergistic anticancer effect. Mol Pharm, 6, 468–479.
   PubMed Web of Science ®Google Scholar
• Nakamura J, Nakajima N, Matsumura K, Hyon SH. (2010). Water-soluble taxol conjugates with dextran and targets tumor cells by folic acid immobilization. Anticancer Res, 30, 903–909.
   PubMed Web of Science ®Google Scholar
• Onyüksel H, Mohanty PS, Rubinstein I. (2009). VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: a novel targeted nanomedicine for breast cancer. Int J Pharm, 365, 157–161.
   PubMed Web of Science ®Google Scholar
• Ortner A, Wernig K, Kaisler R, Edetsberger M, Hajos F, Köhler G, Mosgoeller W, Zimmer A. (2010). VPAC receptor mediated tumor cell targeting by protamine based nanoparticles. J Drug Target, 18, 457–467.
   PubMed Web of Science ®Google Scholar
• Pan X, Guan J, Yoo JW, Epstein AJ, Lee LJ, Lee RJ. (2008). Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery. Int J Pharm, 358, 263–270.
   PubMed Web of Science ®Google Scholar
• Pan XQ, Wang H, Lee RJ. (2003). Antitumor activity of folate receptor-targeted liposomal doxorubicin in a KB oral carcinoma murine xenograft model. Pharm Res, 20, 417–422.
   PubMed Web of Science ®Google Scholar
• Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapère JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M. (2006). Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci, 27, 402–409.
   PubMed Web of Science ®Google Scholar
• Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, Leamon CP. (2005). Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem, 338, 284–293.
   PubMed Web of Science ®Google Scholar
• Pasqualini R, Koivunen E, Ruoslahti E. (1997). Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat Biotechnol, 15, 542–546.
   PubMed Web of Science ®Google Scholar
• Pastan I, Willingham MC. (1985). The Pathway of Endocytosis. New York: Plenum Press.
   Google Scholar
• Paulos CM, Turk MJ, Breur GJ, Low PS. (2004). Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev, 56, 1205–1217.
   PubMed Web of Science ®Google Scholar
• Pilkington GJ, Parker K, Murray SA. (2008). Approaches to mitochondrially mediated cancer therapy. Semin Cancer Biol, 18, 226–235.
   PubMed Web of Science ®Google Scholar
• Pinhassi RI, Assaraf YG, Farber S, Stark M, Ickowicz D, Drori S, Domb AJ, Livney YD. (2010). Arabinogalactan-folic acid-drug conjugate for targeted delivery and target-activated release of anticancer drugs to folate receptor-overexpressing cells. Biomacromolecules, 11, 294–303.
   PubMed Web of Science ®Google Scholar
• Prabaharan M, Grailer JJ, Steeber DA, Gong S. (2009). Thermosensitive micelles based on folate-conjugated poly(N-vinylcaprolactam)-block-poly(ethylene glycol) for tumor-targeted drug delivery. Macromol Biosci, 9, 744–753.
   PubMed Web of Science ®Google Scholar
• Pulkkinen M, Pikkarainen J, Wirth T, Tarvainen T, Haapa-aho V, Korhonen H, Seppälä J, Järvinen K. (2008). Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology: Formulation development and in vitro anticancer activity. Eur J Pharm Biopharm, 70, 66–74.
   PubMed Web of Science ®Google Scholar
• Ramteke S, Ganesh N, Bhattacharya S, Jain NK. (2009). Amoxicillin, clarithromycin, and omeprazole based targeted nanoparticles for the treatment of H. pylori. J Drug Target, 17, 225–234.
   PubMed Web of Science ®Google Scholar
• Reddy JA, Dorton R, Dawson A, Vetzel M, Parker N, Nicoson JS, Westrick E, Klein PJ, Wang Y, Vlahov IR, Leamon CP. (2009). In vivo structural activity and optimization studies of folate-tubulysin conjugates. Mol Pharm, 6, 1518–1525.
   PubMed Web of Science ®Google Scholar
• Sabharanjak S, Mayor S. (2004). Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev, 56, 1099–1109.
   PubMed Web of Science ®Google Scholar
• Sahoo SK, Labhasetwar V. (2005). Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol Pharm, 2, 373–383.
   PubMed Web of Science ®Google Scholar
• Samuelson LE, Dukes MJ, Hunt CR, Casey JD, Bornhop DJ. (2009). TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization. Bioconjug Chem, 20, 2082–2089.
   PubMed Web of Science ®Google Scholar
• Sanz L, Qiao J, Vile RG, Alvarez-Vallina L. (2005). Antibody engineering, virus retargeting and cellular immunotherapy: one ring to rule them all? Curr Gene Ther, 5, 63–70.
   PubMed Web of Science ®Google Scholar
• Seymour LW, Ulbrich K, Wedge SR, Hume IC, Strohalm J, Duncan R. (1991). N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice. Br J Cancer, 63, 859–866.
   PubMed Web of Science ®Google Scholar
• Simard P, Leroux JC. (2009). pH-sensitive immunoliposomes specific to the CD33 cell surface antigen of leukemic cells. Int J Pharm, 381, 86–96.
   PubMed Web of Science ®Google Scholar
• Srinivasan R, Marchant RE, Gupta AS. (2010). In vitro and in vivo platelet targeting by cyclic RGD-modified liposomes. J Biomed Mater Res A, 93, 1004–1015.
   PubMedGoogle Scholar
• Stein BS, Bensch KG, Sussman HH. (1984). Complete inhibition of transferrin recycling by monensin in K562 cells. J Biol Chem, 259, 14762–14772.
   PubMedGoogle Scholar
• Stahl P, Schwartz AL. (1986). Receptor-mediated endocytosis. J Clin Invest, 77, 657–662.
   PubMed Web of Science ®Google Scholar
• Sudheesh MS, Jain V, Shilakari G, Kohli DV. (2009). Development and characterization of lectin-functionalized vesicular constructs bearing amphotericin B for bio-film targeting. J Drug Target, 17, 148–158.
   PubMed Web of Science ®Google Scholar
• Taratula O, Garbuzenko OB, Kirkpatrick P, Pandya I, Savla R, Pozharov VP, He H, Minko T. (2009). Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. J Control Release, 140, 284–293.
   PubMed Web of Science ®Google Scholar
• Terada K, Manchikalapudi P, Noiva R, Jauregui HO, Stockert RJ, Schilsky ML. (1995). Secretion, surface localization, turnover, and steady state expression of protein disulfide isomerase in rat hepatocytes. J Biol Chem, 270, 20410–20416.
   PubMed Web of Science ®Google Scholar
• Thomas M, Kularatne SA, Qi L, Kleindl P, Leamon CP, Hansen MJ, Low PS. (2009). Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Ann N Y Acad Sci, 1175, 32–39.
   PubMed Web of Science ®Google Scholar
• Trapani G, Laquintana V, Latrofa A, Ma J, Reed K, Serra M, Biggio G, Liso G, Gallo JM. (2003). Peripheral benzodiazepine receptor ligand-melphalan conjugates for potential selective drug delivery to brain tumors. Bioconjug Chem, 14, 830–839.
   PubMed Web of Science ®Google Scholar
• Tu X, Zang L, Lan D, Liang W. (2009). Screening and identification of a peptide specifically targeted to NCI-H1299 cells from a phage display peptide library. Mol Med Report, 2, 1005–1010.
   Web of Science ®Google Scholar
• van Rooy I, Mastrobattista E, Storm G, Hennink WE, Schiffelers RM. (2011). Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. J Control Release, 150, 30–36.
   PubMed Web of Science ®Google Scholar
• Vandewalle B, Granier AM, Peyrat JP, Bonneterre J, Lefebvre J. (1985). Transferrin receptors in cultured breast cancer cells. J Cancer Res Clin Oncol, 110, 71–76.
   PubMed Web of Science ®Google Scholar
• Venneti S, Lopresti BJ, Wiley CA. (2006). The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol, 80, 308–322.
   PubMed Web of Science ®Google Scholar
• Wang H, Ross JF, Ratnam M. (1998). Structure and regulation of a polymorphic gene encoding folate receptor type gamma/gamma’. Nucleic Acids Res, 26, 2132–2142.
   PubMed Web of Science ®Google Scholar
• Wang H, Zhao P, Liang X, Gong X, Song T, Niu R, Chang J. (2010). Folate-PEG coated cationic modified chitosan–cholesterol liposomes for tumor-targeted drug delivery. Biomaterials, 31, 4129–4138.
   PubMed Web of Science ®Google Scholar
• Willingham MC, Pastan I. (1980). The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts. Cell, 21, 67–77.
   PubMed Web of Science ®Google Scholar
• Wong HL, Bendayan R, Rauth AM, Xue HY, Babakhanian K, Wu XY. (2006). A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J Pharmacol Exp Ther, 317, 1372–1381.
   PubMed Web of Science ®Google Scholar
• Wu J, Liu Q, Lee RJ. 2006. A folate receptor-targeted liposomal formulation for paclitaxel. Int J Pharm; 316, 148–153.
   PubMed Web of Science ®Google Scholar
• Zhan C, Gu B, Xie C, Li J, Liu Y, Lu W. (2010). Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect. J Control Release, 143, 136–142.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun Y, Xu X, Zhang X, Zhu H, Huang L, Qi Y, Shen YM. (2010). Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates. J Med Chem, 53, 3262–3272.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun Y, Xu X, Zhu H, Huang L, Zhang X, Qi Y, Shen YM. (2010). Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate. Bioorg Med Chem Lett, 20, 927–931.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Thomas TP, Desai A, Zong H, Leroueil PR, Majoros IJ, Baker JR. (2010). Targeted dendrimeric anticancer prodrug: A methotrexate-folic acid-poly(amidoamine) conjugate and a novel, rapid, “one pot” synthetic approach. Bioconjugate Chem, 21, 489–95.
   PubMed Web of Science ®Google Scholar
• Zhang YF, Wang JC, Bian DY, Zhang X, Zhang Q. (2010). Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies. Eur J Pharm Biopharm, 74, 467–473.
   PubMed Web of Science ®Google Scholar
• Zhao X, Li H, Lee RJ. (2008). Targeted drug delivery via folate receptors. Expert Opin Drug Deliv, 5, 309–319.
   PubMed Web of Science ®Google Scholar
• Zhao R, Min SH, Wang Y, Campanella E, Low PS, Goldman ID. (2009). A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. J Biol Chem, 284, 4267–4274.
   PubMed Web of Science ®Google Scholar
• Zhao XB, Muthusamy N, Byrd JC, Lee RJ. (2007). Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes. J Pharm Sci, 96, 2424–2435.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Cai Z, Song X, Yu B, Bi Y, Chen Q, Zhao D, Xu J, Hou S. (2009). Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. Int J Pharm, 382, 262–269.
   PubMed Web of Science ®Google Scholar
• Xia W, Hilgenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. (2009). A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood, 113, 438–446.
   PubMed Web of Science ®Google Scholar
• Xiang G, Wu J, Lu Y, Liu Z, Lee RJ. (2008). Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int J Pharm, 356, 29–36.
   PubMed Web of Science ®Google Scholar
• Yamada A, Taniguchi Y, Kawano K, Honda T, Hattori Y, Maitani Y. (2008). Design of folate-linked liposomal doxorubicin to its antitumor effect in mice. Clin Cancer Res, 14, 8161–8168.
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, Sakaguchi S. (2007). Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity, 27, 145–159.
   PubMed Web of Science ®Google Scholar
• Yang J, Chen H, Vlahov IR, Cheng JX, Low PS. (2006). Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging. Proc Natl Acad Sci USA, 103, 13872–13877.
   PubMed Web of Science ®Google Scholar
• Yang J, Chen H, Vlahov IR, Cheng JX, Low PS. (2007). Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates. J Pharmacol Exp Ther, 321, 462–468.
   PubMed Web of Science ®Google Scholar
• Yang SJ, Lin FH, Tsai KC, Wei MF, Tsai HM, Wong JM, Shieh MJ. (2010). Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. Bioconjug Chem, 21, 679–689.
   PubMed Web of Science ®Google Scholar
• Yu W, Zhang N, Li C. (2009). Saccharide modified pharmaceutical nanocarriers for targeted drug and gene delivery. Curr Pharm Des, 15, 3826–3836.
   PubMed Web of Science ®Google Scholar