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Research Article

Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell

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Pages 23-32 | Received 13 Jun 2011, Accepted 07 Sep 2011, Published online: 02 Nov 2011

References

  • Bai L, Lennon DP, Eaton V, Maier K, Caplan AI, Miller SD, Miller RH. (2009). Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, 57, 1192–1203.
  • Bonfield TL, Koloze M, Lennon DP, Zuchowski B, Yang SE, Caplan AI. (2010). Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 299, 760–770.
  • Brown DM, Ruoslahti E. (2004). Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell, 5, 365–374.
  • Bushman FD. (2007). Retroviral integration and human gene therapy. J Clin Invest, 117, 2083–2086.
  • Caplan AI, Dennis JE. (2006). Mesenchymal stem cells as trophic mediators. J Cell Biochem, 98, 1076–1084.
  • Chiu RC. (2008). MSC immune tolerance in cellular cardiomyoplasty. Semin Thorac Cardiovasc Surg, 20, 115–118.
  • Dennis JE, Cohen N, Goldberg VM, Caplan AI. (2004). Targeted delivery of progenitor cells for cartilage repair. J Orthop Res, 22, 735–741.
  • Dixon JA, Gorman RC, Stroud RE, Bouges S, Hirotsugu H, Gorman JH3rd, Martens TP, Itescu S, Schuster MD, Plappert T, St John-Sutton MG, Spinale FG. (2009). Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction. Circulation, 120, S220–S229.
  • Essler M, Ruoslahti E. (2002). Molecular specialization of breast vasculature: A breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature. Proc Natl Acad Sci USA, 99, 2252–2257.
  • Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ. (2006). Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J, 20, 661–669.
  • Hoffman JA, Giraudo E, Singh M, Zhang L, Inoue M, Porkka K, Hanahan D, Ruoslahti E. (2003). Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell, 4, 383–391.
  • Ishikane S, Ohnishi S, Yamahara K, Sada M, Harada K, Mishima K, Iwasaki K, Fujiwara M, Kitamura S, Nagaya N, Ikeda T. (2008). Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia. Stem Cells, 26, 2625–2633.
  • Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine P, Prockop DJ. (2007). Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun, 354, 700–706.
  • Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, Kalantzi M, Herbots L, Sinnaeve P, Dens J, Maertens J, Rademakers F, Dymarkowski S, Gheysens O, Van Cleemput J, Bormans G, Nuyts J, Belmans A, Mortelmans L, Boogaerts M, Van de Werf F. (2006). Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: Double-blind, randomised controlled trial. Lancet, 367, 113–121.
  • Järvinen TA, Ruoslahti E. (2007). Molecular changes in the vasculature of injured tissues. Am J Pathol, 171, 702–711.
  • Kang D, Hamasaki N. (2003). Mitochondrial oxidative stress and mitochondrial DNA. Clin Chem Lab Med, 41, 1281–1288.
  • Karp JM, Leng Teo GS. (2009). Mesenchymal stem cell homing: The devil is in the details. Cell Stem Cell, 4, 206–216.
  • Kean T, Roth S, Thanou M. (2005). Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency. J Control Release, 103, 643–653.
  • Ko IK, Kean TJ, Dennis JE. (2009). Targeting mesenchymal stem cells to activated endothelial cells. Biomaterials, 30, 3702–3710.
  • Koivunen E, Wang B, Ruoslahti E. (1994). Isolation of a highly specific ligand for the α 5 β 1 integrin from a phage display library. J Cell Biol, 124, 373–380.
  • Korf-Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer GP, Ganser A, Drexler H, Wollert KC. (2008). Bone marrow cells are a rich source of growth factors and cytokines: Implications for cell therapy trials after myocardial infarction. Eur Heart J, 29, 2851–2858.
  • Kuethe F, Richartz BM, Sayer HG, Kasper C, Werner GS, Höffken K, Figulla HR. (2004). Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int J Cardiol, 97, 123–127.
  • Kumar S, Ponnazhagan S. (2007). Bone homing of mesenchymal stem cells by ectopic α 4 integrin expression. FASEB J, 21, 3917–3927.
  • Le Blanc K, Ringdén O. (2006). Mesenchymal stem cells: Properties and role in clinical bone marrow transplantation. Curr Opin Immunol, 18, 586–591.
  • Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringdén O. (2003). HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol, 31, 890–896.
  • Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC, Gall JM, Tsang E, Yee MS, Fok H, Huang NF, Padbury JF, Larrick JW, Lum LG. (2007). Antibody targeting of stem cells to infarcted myocardium. Stem Cells, 25, 712–717.
  • Lennon, D., Haynesworth, S., Bruder, S., Jaiswal, N. & Caplan, A. 1996. Human and animal mesenchymal progenitor cells from bone marrow: Identification of serum for optimal selection and proliferation. Vitro Anim Cell Dev Biol, 32, 602–611.
  • Lien CY, Chih-Yuan Ho K, Lee OK, Blunn GW, Su Y. (2009). Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res, 24, 837–848.
  • Liu C, Bhattacharjee G, Boisvert W, Dilley R, Edgington T. (2003). In vivo interrogation of the molecular display of atherosclerotic lesion surfaces. Am J Pathol, 163, 1859–1871.
  • Liu Y, Mu R, Wang S, Long L, Liu X, Li R, Sun J, Guo J, Zhang X, Guo J, Yu P, Li C, Liu X, Huang Z, Wang D, Li H, Gu Z, Liu B, Li Z. (2010). Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther, 12, R210.
  • Lum LG, Sen M. (2001). Activated T-cell and bispecific antibody immunotherapy for high-risk breast cancer. Bench to bedside. Acta Haematol, 105, 130–136.
  • Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. (2000). Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res, 9, 841–848.
  • Malgieri A, Kantzari E, Patrizi MP, Gambardella S. (2010). Bone marrow and umbilical cord blood human mesenchymal stem cells: State of the art. Int J Clin Exp Med, 3, 248–269.
  • Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55–63.
  • Ojha N, Roy S, Radtke J, Simonetti O, Gnyawali S, Zweier JL, Kuppusamy P, Sen CK. (2008). Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol, 294, H2435–H2443.
  • Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. (2001). Bone marrow cells regenerate infarcted myocardium. Nature, 410, 701–705.
  • Penn MS, Mangi AA. (2008). Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res, 102, 1471–1482.
  • Pilch J, Brown DM, Komatsu M, Järvinen TA, Yang M, Peters D, Hoffman RM, Ruoslahti E. (2006). Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci USA, 103, 2800–2804.
  • Rao VS, La Bonte LR, Xu Y, Yang Z, French BA, Guilford WH. (2007). Alterations to myofibrillar protein function in nonischemic regions of the heart early after myocardial infarction. Am J Physiol Heart Circ Physiol, 293, 654–659.
  • Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R. (2008). Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med, 14, 181–187.
  • Sarkar D, Vemula PK, Teo GS, Spelke D, Karnik R, Wee le Y, Karp JM. (2008). Chemical engineering of mesenchymal stem cells to induce a cell rolling response. Bioconjug Chem, 19, 2105–2109.
  • Schinköthe T, Bloch W, Schmidt A. (2008). In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev, 17, 199–206.
  • Schuleri KH, Amado LC, Boyle AJ, Centola M, Saliaris AP, Gutman MR, Hatzistergos KE, Oskouei BN, Zimmet JM, Young RG, Heldman AW, Lardo AC, Hare JM. (2008). Early improvement in cardiac tissue perfusion due to mesenchymal stem cells. Am J Physiol Heart Circ Physiol, 294, 2002–2011.
  • Sen M, Wankowski DM, Garlie NK, Siebenlist RE, Van Epps D, LeFever AV, Lum LG. (2001). Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors. J Hematother Stem Cell Res, 10, 247–260.
  • Srinivasan M, Domanico SZ, Kaumaya PT, Pierce SK. (1993). Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response. Eur J Immunol, 23, 1011–1016.
  • Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Girard OM, Hanahan D, Mattrey RF, Ruoslahti E. (2009). Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell, 16, 510–520.
  • Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. (2007). Myocardial infarct size measurement in the mouse chronic infarction model: Comparison of area- and length-based approaches. J Appl Physiol, 102, 2104–2111.
  • Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, Ikeda Y, Matsuzaki M, Hamano K. (2006). Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol, 291, H886–H893.
  • Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E. (2009). C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci USA, 106, 16157–16162.
  • Terrovitis J, Charitos C, Dolou P, Papalois A, Eleftheriou A, Tsolakis E, Charitos E, Mponios M, Karanastasis G, Koudoumas D, Agapitos E, Nanas JN. (2004). No effect of stem cell mobilization with GM-CSF on infarct size and left ventricular function in experimental acute myocardial infarction. Basic Res Cardiol, 99, 241–246.
  • Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. (2002). Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation, 105, 93–98.
  • Uccelli A, Moretta L, Pistoia V. (2008). Mesenchymal stem cells in health and disease. Nat Rev Immunol, 8, 726–736.
  • VCCLAB. (2005). Virtual computational chemistry laboratory [Online]. Available at: http://www.vcclab.org. Accessed on 14 January 2008.
  • Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Zhang G, Suntharalingam P, Boozer S, Mhashilkar A, Panetta CJ, Swingen C, Deans R, From AH, Bache RJ, Verfaillie CM, Zhang J. (2007). Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation, 115, 1866–1875.
  • Zhang L, Hoffman JA, Ruoslahti E. (2005). Molecular profiling of heart endothelial cells. Circulation, 112, 1601–1611.
  • Zhao TC, Tseng A, Yano N, Tseng Y, Davol PA, Lee RJ, Lum LG, Padbury JF. (2008). Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction. J Appl Physiol, 104, 1793–1800.

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