655
Views
35
CrossRef citations to date
0
Altmetric
Research Article

PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor

, , , , , , , & show all
Pages 33-42 | Received 09 Jul 2011, Accepted 18 Sep 2011, Published online: 08 Nov 2011

References

  • Aagaard L, Rossi JJ. (2007). RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev, 59, 75–86.
  • Dykxhoorn DM. (2009). RNA interference as an anticancer therapy: a patent perspective. Expert Opin Ther Pat, 19, 475–491.
  • He S, Zhang D, Cheng F, Gong F, Guo Y. (2009). Applications of RNA interference in cancer therapeutics as a powerful tool for suppressing gene expression. Mol Biol Rep, 36, 2153–2163.
  • Christie RJ, Nishiyama N, Kataoka K. (2010). Delivering the code: polyplex carriers for deoxyribonucleic acid and ribonucleic acid interference therapies. Endocrinology, 151, 466–473.
  • Fang J, Nakamura H, Maeda H. (2011). The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev, 63, 136–151.
  • Whitehead KA, Langer R, Anderson DG. (2009). Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov, 8, 129–138.
  • HJ, Ishii A, Miyata K, Lee Y, Wu S, Oba M, Nishiyama N, Kataoka K. (2010). Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J Control Release, 145, 141–148.
  • Miyata K, Oba M, Nakanishi M, Fukushima S, Yamasaki Y, Koyama H, Nishiyama N, Kataoka K. (2008). Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J Am Chem Soc, 130, 16287–16294.
  • Owens DE 3rd, Peppas NA. (2006). Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm, 307, 93–102.
  • Nomoto T, Matsumoto Y, Miyata K, Oba M, Fukushima S, Nishiyama N, Yamasoba T, Kataoka K. (2011). In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J Control Release, 151, 104–109.
  • Itaka K, Kataoka K. (2009). Recent development of nonviral gene delivery systems with virus-like structures and mechanisms. Eur J Pharm Biopharm, 71, 475–483.
  • Lee Y, Kataoka K. (2009). Biosignal-sensitive polyion complex micelles for the delivery of biopharmaceuticals. Soft Matter, 5, 3810–3817.
  • Soundara Manickam D, Oupický D. (2006). Polyplex gene delivery modulated by redox potential gradients. J Drug Target, 14, 519–526.
  • Park K, Lee MY, Kim KS, Hahn SK. (2010). Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate. Biomaterials, 31, 5258–5265.
  • Matsumoto S, Christie RJ, Nishiyama N, Miyata K, Ishii A, Oba M, Koyama H, Yamasaki Y, Kataoka K. (2009). Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules, 10, 119–127.
  • Takae S, Miyata K, Oba M, Ishii T, Nishiyama N, Itaka K, Yamasaki Y, Koyama H, Kataoka K. (2008). PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J Am Chem Soc, 130, 6001–6009.
  • Jones DP, Carlson JL, Mody VC, Cai J, Lynn MJ, Sternberg P. (2000). Redox state of glutathione in human plasma. Free Radic Biol Med, 28, 625–635.
  • Morré DJ, Morré DM. (2003). Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases. Free Radic Res, 37, 795–808.
  • Balendiran GK, Dabur R, Fraser D. (2004). The role of glutathione in cancer. Cell Biochem Funct, 22, 343–352.
  • Holmes K, Roberts OL, Thomas AM, Cross MJ. (2007). Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal, 19, 2003–2012.
  • Li SD, Chono S, Huang L. (2008). Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol Ther, 16, 942–946.
  • Akagi D, Oba M, Koyama H, Nishiyama N, Fukushima S, Miyata T, Nagawa H, Kataoka K. (2007). Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther, 14, 1029–1038.
  • AL-Badri ZM, Som A, Lyon S, Nelson CF, Nüsslein K, Tew GN. (2008). Investigating the effect of increasing charge density on the hemolytic activity of synthetic antimicrobial polymers. Biomacromolecules, 9, 2805–2810.
  • Matsumoto Y, Nomoto T, Cabral H, Matsumoto Y, Watanabe S, Christie RJ, Miyata K, Oba M, Ogura T, Yamasaki Y, Nishiyama N, Yamasoba T, Kataoka K. (2010). Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed Opt Express, 1, 1209–1216.
  • Navarro J, Obrador E, Carretero J, Petschen I, Aviñó J, Perez P, Estrela JM. (1999). Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo. Free Radic Biol Med, 26, 410–418.
  • Sun W, Davis PB. (2010). Reducible DNA nanoparticles enhance in vitro gene transfer via an extracellular mechanism. J Control Release, 146, 118–127.
  • Meng F, Hennink WE, Zhong Z. (2009). Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials, 30, 2180–2198.
  • Kim SH, Jeong JH, Lee SH, Kim SW, Park TG. (2008). Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J Control Release, 129, 107–116.
  • Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC. (2004). Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res, 32, e149.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.