A Randomised, Double-Blinded, Placebo-Controlled Study of the Phosphodiesterase Type 5 Inhibitor Sildenafil for the Treatment of Preeclampsia

REFERENCES

• Villar J, Say L, Shennan A, Lindheimer M, Duley L, Conde-Agudelo A, Merialdi M. Methodological and technical issues related to the diagnosis, screening, prevention, and treatment of preeclampsia and eclampsia. Int J Gynaecol Obstet 2004; 85:S28–41.
   PubMed Web of Science ®Google Scholar
• Confidential Enquiry into Maternal and Child Health. Why Mothers Die 2000–2002. Sixth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom, London, RCOG Press; 2004.
   Google Scholar
• Draper ES, Manktelow B, Field DJ, James D. Prediction of survival for preterm births by weight and gestational age: retrospective population based study. BMJ 1999; 319:1093–1097.
   PubMed Web of Science ®Google Scholar
• Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972; 1:177–191.
   PubMedGoogle Scholar
• Matijevic R, Johnston T. In vivo assessment of failed trophoblastic invasion of the spiral arteries in preeclampsia. Br J Obstet Gynaecol 1999; 106:78–82.
   PubMedGoogle Scholar
• Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161:1200–1204.
   PubMed Web of Science ®Google Scholar
• Ashworth JR, Warren AY, Baker PN, Johnson IR. Loss of endothelium-dependent relaxation in myometrial resistance arteries in preeclampsia. Br J Obstet Gynaecol 1997; 104:1152–1158.
   PubMedGoogle Scholar
• Kenny LC, Baker PN, Kendall DA, Randall MD, Dunn WR. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and preeclampsia. Clin Sci (Lond) 2002; 103:67–73.
   PubMed Web of Science ®Google Scholar
• Lees C, Valensise H, Black R, Harrington K, Byiers S, Campbell S. The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of preeclampsia and its complications: a randomized double-blinded placebo-controlled trial. Ultrasound Obstet Gynecol 1998; 12:334–338.
   PubMed Web of Science ®Google Scholar
• Makino Y, Izumi H, Makino I, Shirakawa K. The effect of nitric oxide on uterine and umbilical artery flow velocity waveform in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 73:139–143.
   PubMed Web of Science ®Google Scholar
• Nakatsuka M, Takata M, Tada K, Asagiri K, Habara T, Noguchi S, Kudo T. A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia. J Ultrasound Med 2002; 21:831–836.
   PubMed Web of Science ®Google Scholar
• Thaler I, Amit A, Kamil D, Itskovitz-Eldor J. The effect of isosorbide dinitrate on placental blood flow and maternal blood pressure in women with pregnancy induced hypertension. Am J Hypertens 1999; 12:341–347.
   PubMed Web of Science ®Google Scholar
• Coppage K, Baker R, Clark K. Reversal of reduced uteroplacental blood flow by sildenafil (Viagra) in an ovine model. Am J Obstet Gynecol 2003; 189:S193.
   Web of Science ®Google Scholar
• Wareing M, Myers JE, O'Hara M, Kenny LC, Warren AY, Taggart MJ, Skillern L, Machin I, Baker PN. Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries. Am J Obstet Gynecol 2004; 190:1283–1290.
   PubMed Web of Science ®Google Scholar
• Lacassie HJ, Germain AM, Valdes G, Fernandez MS, Allamand F, Lopez H. Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine. Obstet Gynecol 2004; 103:1118–1120.
   PubMed Web of Science ®Google Scholar
• Molelekwa V, Akhter P, McKenna P, Bowen M, Walsh K. Eisenmenger's Syndrome in a 27 week pregnancy – management with bosentan and sildenafil. Ir Med J 2005; 98:87–88.
   PubMedGoogle Scholar
• Galie N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, Simonneau G. Sildenafil use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353:2148–2157.
   PubMed Web of Science ®Google Scholar
• . World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2000; 284:3043–3045.
   PubMed Web of Science ®Google Scholar
• Sibai BM, Mercer BM, Schiff E, Friedman SA. Aggressive versus expectant management of severe preeclampsia at 28 to 32 weeks gestation: A randomized controlled trial. Am J Obstet Gynecol 1994; 171:818–822.
   PubMed Web of Science ®Google Scholar
• Moher D, Schulz KF, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. CONSORT Group (Consolidated Standards of Reporting Trials). JAMA 2001, 285:1987–1991.
   Google Scholar
• Haddad B, Deis S, Goffinet F, Paniel BJ, Cabrol D, Sibai BM. Maternal and perinatal outcomes during expectant management of 239 severe preeclamptic women between 24 and 33 weeks gestation. Am J Obstet Gynecol 2004; 190:1590–1597.
   PubMed Web of Science ®Google Scholar
• Wareing M, Myers JE, O'Hara M, Kenny LC, Taggart MJ, Skillern L, Machin I, Baker PN. Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and preeclampsia. Eur J Obstet Gynecol Reprod Biol 2006; 127:41–49.
   PubMed Web of Science ®Google Scholar
• Boyce EG, Umland EM. Sildenafil Citrate: A Therapeutic Update. Clin Ther 2001; 23:2–23.
   PubMed Web of Science ®Google Scholar
• Wareing M, Myers JE, O'Hara M, Baker PN. Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction. J Clin Endo Metab 2005; 90:2550–2555.
   PubMed Web of Science ®Google Scholar