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Research Article

Ascorbic Acid Levels and Neutrophil Superoxide Production in Blood of Pre-, Early and Late Hypertensive Stroke-Prone Spontaneously Hypertensive Rats

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Pages 397-403 | Received 31 Aug 2010, Accepted 11 Nov 2010, Published online: 07 Jun 2011

REFERENCES

  • Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 2008;31 suppl 2:S181–184.
  • Grunfeld S, Hamilton CA, Mesaros S, McClain SW, Dominiczak AF, Bohr DF, Malinski T. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension 1995;26:854–857.
  • Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 1999;33:1353–1358.
  • Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 2004;44:248–252.
  • Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989;86:6377–6381.
  • Fukuzawa K. Dynamics of lipid peroxidation and antioxidion of alpha-tocopherol in membranes. J Nutr Sci Vitaminol (Tokyo) 2008;54:273–285.
  • Heller R, Munscher-Paulig F, Grabner R, Till U. L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem 1999;274:8254–8260.
  • Ness AR, Chee D, Elliott P. Vitamin C and blood pressure–an overview. J Hum Hypertens 1997;11:343–50.
  • Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke 2000; 31:2287–2294.
  • May JM. How does ascorbic acid prevent endothelial dysfunction? Free Radic Biol Med 2000;28:1421–1429.
  • Okamoto K, Hazama F, Yamori Y, Haebara H, Nagaoka A. Pathogenesis and prevention of stroke in spontaneously hypertensive rats. Clin Sci Mol Med Suppl 1975;2:161s–163s.
  • Hamilton CA, Brosnan MJ, McIntyre M, Graham D, Dominiczak AF. Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 2001;37:529–534.
  • Sekiguchi F, Yanamoto A, Sunano S. Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J Smooth Muscle Res 2004;40:65–74.
  • Chen X, Touyz RM, Park JB, Schiffrin EL. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 2001;38:606–11.
  • Park JB, Touyz RM, Chen X, Schiffrin EL. Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. Am J Hypertens 2002;15:78–84.
  • Ulker S, McKeown PP, Bayraktutan U. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 2003;41:534–539.
  • Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke 2003;34:2518–2532.
  • Umegaki K, Hashimoto M, Yamasaki H, Fujii Y, Yoshimura M, Sugisawa A, Shinozuka K. Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. Free Radic Res 2001;34:427–435.
  • Umegaki K, Daohua P, Sugisawa A, Kimura M, Higuchi M. Influence of one bout of vigorous exercise on ascorbic acid in plasma and oxidative damage to DNA in blood cells and muscle in untrained rats. J Nutr Biochem 2000;11:401–407.
  • Yamada H, Yamada K, Waki M, Umegaki K. Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with and without diabetes complications. Diabetes Care 2004;27:2491–2492.
  • Tomita T, Umegaki K, Hayashi E. The appearance of exhausted platelets due to a duration of hypertension in stroke-prone spontaneously hypertensive rats. Thromb Res 1985;37:195–200.
  • Szucs S, Varga C, Ember I, Kertai P. The separation of the granulocytes from different rat strains. A comparative study. J Immunol Methods 1994;167:245–251.
  • Tabuchi M, Umegaki K, Ito T, Suzuki M, Tomita I, Ikeda M, Tomita T. Fluctuation of serum NO(x) concentration at stroke onset in a rat spontaneous stroke model (M-SHRSP). Peroxynitrite formation in brain lesions. Brain Res 2002;949: 147–156.
  • Umegaki K, Nakamura K, Ikeda M, Inoue Y, Tomita T. Changes in platelet function due to hypertension: comparison of experimental hypertension with spontaneous hypertension in rats. J Hypertens 1989;7:13–9.
  • Ikeda M, Umegaki K, Takeshita N, Mitsubori M, Tomita T, Tomita I. Congenital changes of platelet functions in stroke-prone SHR: aggregability of gel-filtered platelets, PRP and whole blood, and effects of hypotensive treatment. Thromb Res 1989;56:441–452.
  • Linster CL, Van Schaftingen E. Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J 2007;274:1–22.
  • Mendiratta S, Qu ZC, May JM. Erythrocyte ascorbate recycling: antioxidant effects in blood. Free Radic Biol Med 1998;24:789–797.
  • Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F. Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid. Life Sci 2003;72:1717–1732.
  • Umegaki K, Inoue Y, Tomita T, The appearance of “exhausted” platelets at the time of stroke in stroke-prone spontaneously hypertensive rats. Thromb Haemost 1985;54:764–767.
  • Umemoto S, Tanaka M, Kawahara S, Kubo M, Umeji K, Hashimoto R, Matsuzaki M. Calcium antagonist reduces oxidative stress by upregulating Cu/Zn superoxide dismutase in stroke-prone spontaneously hypertensive rats. Hypertens Res 2004;27:877–885.
  • Ohmori M, Kitoh Y, Kawaguchi A, Harada K, Sugimoto K, Fujimura A. Enhanced neutrophil superoxide anion production and its modification by beraprost sodium in spontaneously hypertensive rats. Am J Hypertens 2001;14:722–728.
  • Mehta JL, Lopez LM, Chen L, Cox OE. Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol. Am J Cardiol 1994;74:901–905.
  • Morawietz H, Weber M, Rueckschloss U, Lauer N, Hacker A, Kojda G. Upregulation of vascular NAD(P)H oxidase subunit gp91phox and impairment of the nitric oxide signal transduction pathway in hypertension. Biochem Biophys Res Commun 2001;285:1130–1135.

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