Serum Aldosterone Is Associated with Inflammation and Aortic Stiffness in Normotensive Overweight and Obese Young Adults

REFERENCES

• Mattace-Raso FU, van der Cammen TJ, Hofman A, . Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006; 113:657–663.
   PubMed Web of Science ®Google Scholar
• Boutouyrie P, Tropeano AI, Asmar R, . Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients—a longitudinal study. Hypertension 2002; 39:10–15.
   PubMed Web of Science ®Google Scholar
• Sutton-Tyrrell K, Najjar SS, Boudreau RM, . Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005; 111:3384–3390.
   PubMed Web of Science ®Google Scholar
• Laurent S, Boutouyrie P, Asmar R, . Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37:1236–1241.
   PubMed Web of Science ®Google Scholar
• Mahmud A. Arterial stiffness and the renin-anglotensin-aldosterone system. J Renin Angiotensin Aldosterone Syst 2004; 5:102–108.
   PubMed Web of Science ®Google Scholar
• Cachofeiro V, Miana M, Heras NDL, . Aldosterone and the vascular system. J Steroid Biochem Mol Biol 2008; 109: 331–335.
   PubMed Web of Science ®Google Scholar
• Blacher J, Amah G, Girerd X, . Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension. Am J Hypertens 1997; 10:1326–1334.
   PubMed Web of Science ®Google Scholar
• Park S, Kim JB, Shim CY, . The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients. J Hypertens 2007; 25:1279–1283.
   PubMed Web of Science ®Google Scholar
• Bernini G, Galetta F, Franzoni F, . Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism. J Hypertens 2008; 26:2399–2405.
   PubMed Web of Science ®Google Scholar
• Goodfriend TL, Egan BM, Kelley DE. Aldosterone in obesity. Endocr Res 1998; 24:789–796.
   PubMed Web of Science ®Google Scholar
• Perkins JM, Davis SN. The renin-angiotensin-aldosterone system: a pivotal role in insulin sensitivity and glycemic control. Curr Opin Endocrinol Diabetes Obes 2008; 15:147–152.
   PubMed Web of Science ®Google Scholar
• Lastra-Lastra G, Sowers JR, Restrepo-Erazo K, Manrique-Acevedo C, Lastra-Gonzalez G. Role of aldosterone and angiotensin II in insulin resistance: an update. Clin Endocrinol (Oxf) 2009; 71:1–6.
   PubMed Web of Science ®Google Scholar
• Kraus D, Jager J, Meier B, Fasshauer M, Klein J. Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. Horm Metab Res 2005; 37:455–459.
   PubMed Web of Science ®Google Scholar
• Duprez DA. Role of the renin-angiotensin-aldosterone system in vascular remodeling and inflammation: a clinical review. J Hypertens 2006; 24:983–991.
   PubMed Web of Science ®Google Scholar
• Singhal A. Endothelial dysfunction: role in obesity-related disorders and the early origins of CVD. Proc Nutr Soc 2005; 64:15–22.
   PubMed Web of Science ®Google Scholar
• Kidambi S, Kotchen JM, Krishnaswami S, Grim CE, Kotchen TA. Aldosterone contributes to blood pressure variance and to likelihood of hypertension in normal-weight and overweight African Americans. Am J Hypertens 2009; 22:1303–1308.
   PubMed Web of Science ®Google Scholar
• Shapiro Y, Boaz M, Matas Z, Fux A, Shargorodsky M. The association between the renin-angiotensin-aldosterone system and arterial stiffness in young healthy subjects. Clin Endocrinol (Oxf) 2008; 68:510–512.
   PubMed Web of Science ®Google Scholar
• Kimoto E, Shoji T, Shinohara K, . Regional arterial stiffness in patients with type 2 diabetes and chronic kidney disease. J Am Soc Nephrol 2006; 17:2245–2252.
   PubMed Web of Science ®Google Scholar
• Ellis D, Lloyd C, Becker DJ, Forrest KYZ, Orchard TJ. The changing course of diabetic nephropathy: low-density lipoprotein cholesterol and blood pressure correlate with regression of proteinuria. Am J Kidney Dis 1996; 27:809–818.
   PubMed Web of Science ®Google Scholar
• Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20:470–475.
   PubMed Web of Science ®Google Scholar
• Warnick GR, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res 1978; 19:65–76.
   PubMed Web of Science ®Google Scholar
• Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973; 19: 476–482.
   PubMed Web of Science ®Google Scholar
• Bondar RJL, Mead DC. Evaluation of glucose-6-phosphate dehydrogenase from leuconostoc mesenteroides in the hexokinase method for determining glucose in serum. Clin Chem 1974; 20:586–590.
   PubMed Web of Science ®Google Scholar
• Chen H, Sullivan G, Quon MJ. Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes 2005; 54:1914–1925.
   PubMed Web of Science ®Google Scholar
• Lieb W, Larson MG, Benjamin EJ, . Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation 2009; 119:37–43.
   PubMed Web of Science ®Google Scholar
• Pratt JH, Rebhun JF, Zhou L, . Levels of mineralocorticoids in whites and blacks. Hypertension 1999; 34:315–319.
   PubMed Web of Science ®Google Scholar
• Price DA, Fisher ND. The renin-angiotensin system in blacks: active, passive, or what? Curr Hypertens Rep 2003; 5:225–230.
   PubMed Web of Science ®Google Scholar
• Mahmud A, Feely J. Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension. Am J Hypertens 2005; 18:50–55.
   PubMed Web of Science ®Google Scholar
• Edwards NC, Steeds RP, Stewart PM, Ferro CJ, Townend JN. Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease a randomized controlled trial. J Am Coll Cardiol 2009; 54:505–512.
   PubMed Web of Science ®Google Scholar
• Joffe HV, Adler GK. Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation. Heart Fail Rev 2005; 10:31–37.
   PubMed Web of Science ®Google Scholar
• Yasmin McEniery CM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB. C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol 2004; 24:969–974.
   PubMed Web of Science ®Google Scholar
• Kullo IJ, Seward JB, Bailey KR, . C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community. Am J Hypertens 2005; 18:1123–1129.
   PubMed Web of Science ®Google Scholar
• Kusche-Vihrog K, Urbanova K, Blanque A, . C-reactive protein makes human endothelium stiff and tight. Hypertension 2011; 57:231–237.
   PubMed Web of Science ®Google Scholar
• Brown NJ. Aldosterone and vascular inflammation. Hypertension 2008; 51:161–167.
   PubMed Web of Science ®Google Scholar
• Nguyen XM, Lane J, Smith BR, Nguyen NT. Changes in inflammatory biomarkers across weight classes in a representative US population: a link between obesity and inflammation. J Gastrointest Surg 2009; 13:1205–1212.
   PubMed Web of Science ®Google Scholar
• Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ. Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 1999; 7:355–362.
   PubMedGoogle Scholar
• Garg UC, Arnett DK, Folsom AR, . Lack of association between platelet glycoprotein IIb/IIIa receptor PlA polymorphism and coronary artery disease or carotid intima-media thickness. Thromb Res 1998; 89:85–89.
   PubMed Web of Science ®Google Scholar
• Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev 2007; 28:463–491.
   PubMed Web of Science ®Google Scholar
• Hayden MR, Sowers JR. Pancreatic renin-angiotensin-aldosterone system in the cardiometabolic syndrome and type 2 diabetes mellitus. J Cardiometab Syndr 2008; 3:129–131.
   PubMedGoogle Scholar
• Mosso LM, Carvajal CA, Maiz A, . A possible association between primary aldosteronism and a lower beta-cell function. J Hypertens 2007; 25:2125–2130.
   PubMed Web of Science ®Google Scholar
• Cooper SA, Whaley-Connell A, Habibi J, . Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance. Am J Physiol Heart Circ Physiol 2007; 293:H2009–H2023.
   PubMed Web of Science ®Google Scholar
• Lombes M, Oblin ME, Gasc JM, . Immunohistochemical and biochemical-evidence for a cardiovascular mineralocorticoid receptor. Circ Res 1992; 71:503–510.
   PubMed Web of Science ®Google Scholar
• Stowasser M. New perspectives on the role of aldosterone excess in cardiovascular disease. Clin Exp Pharmacol Physiol 2001; 28:783–791.
   PubMed Web of Science ®Google Scholar
• Davies J, Gavin A, Band M, Morris A, Struthers A. Spironolactone reduces brachial pulse wave velocity and PIIINP levels in hypertensive diabetic patients. Br J Clin Pharmacol 2005; 59: 520–523.
   PubMed Web of Science ®Google Scholar