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Articles

Cilnidipine but not amlodipine suppresses sympathetic activation elicited by isometric exercise in hypertensive patients

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Pages 531-535 | Received 16 Oct 2014, Accepted 06 Dec 2014, Published online: 15 May 2015

References

  • Victor RG, Leimbach WN Jr, Seals DR, et al. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 1987;9:429–36
  • Leuenberger U, Sinoway L, Gubin S, et al. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol (1985) 1993;75:668–74
  • Matsukawa T, Gotoh E, Uneda S, et al. Augmented sympathetic nerve activity in response to stressors in youngt borderline hypertensive men. Acta Physiol Scand 1991;141:157–165
  • Esler M, Jennings G, Lambert G. Noradrenaline release and the pathophysiology of primary human hypertension. Am J Hypertens 1989;2:140–6
  • Matsukawa T, Mano T, Gotoh E, Ishii M. Elevated sympathetic nerve activity in patients with accelerated essential hypertension. J Clin Invest 1993;92:25–8
  • Saruta T. Current status of calcium antagonists in Japan. Am J Cardiol 1998;82:32R–4R
  • Eguchi K, Kario K, Shimada K. Differential effects of a long-acting angiotensin converting enzyme inhibitor (temocapril) and a long-acting calcium antagonist (amlodipine) on ventricular ectopic beats in older hypertensive patients. Hypertens Res 2002;25:329–33
  • Hamada T, Watanabe M, Kaneda T, et al. Evaluation of changes in sympathetic nerve activity and heart rate in essential hypertensive patients induced by amlodipine and nifedipine. J Hypertens 1998;16:111–18
  • Luscher TF, Cosentino F. The classification of calcium antagonists and their selection in the treatment of hypertension: a reappraisal. Drugs 1998;55:509–17
  • Minami J, Ishimitsu T, Kawano Y, et al. Comparison of 24-hour blood pressure, heart rate, and autonomic nerve activity in hypertensive patients treated with cilnidipine or nifedipine retard. J Cardiovasc Pharmacol 1998;32:331–6
  • Ishimitsu T, Minami J, Kawano Y, et al. Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients. Clin Exp Pharmacol Physiol 1999;26:500–4
  • Binggeli C, Corti R, Sudano I, et al. Effects of chronic calcium channel blockade on sympathetic nerve activity in hypertension. Hypertension 2002;39:892–6
  • Minami J, Ishimitsu T, Kawano Y, Matsuoka H. Effects of amlodipine and nifedipine retard on autonomic nerve activity in hypertensive patients. Clin Exp Pharmacol Physiol 1998;25:572–6
  • Kuramoto K, Ichikawa S, Hirai A, et al. Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure. Hypertens Res 2003;26:201–8
  • Lindqvist M, Kahan T, Melcher A, et al. Long-term calcium antagonist treatment of human hypertension with mibefradil or amlodipine increases sympathetic nerve activity. J Hypertens 2007;25:169–75
  • Furukawa T, Nukada T, Suzuki K, et al. Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol 1997;121:1136–40
  • Uneyama H, Takahara A, Dohmoto H, et al. Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones. Br J Pharmacol 1997;122:37–42
  • Sakata K, Shirotani M, Yoshida H, et al. Effects of amlodipine and cilnidipine on cardiac sympathetic nervous system and neurohormonal status in essential hypertension. Hypertension 1999;33:1447–52
  • Konda T, Takahara A, Maeda K, et al. Effects of a dual L/N-type Ca2+ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs. Eur J Pharmacol 2001;413:117–20
  • Takahara A, Fujita S, Moki K, et al. Neuronal Ca2+ channel blocking action of an antihypertensive drug, cilnidipine, in IMR-32 human neuroblastoma cells. Hypertens Res 2003;26:743–7
  • Yoshimoto R, Hashiguchi Y, Dohmoto H, et al. Effects of new dihydropyridine derivative, FRC-8653, on blood pressure in conscious spontaneously hypertensive rats. J Pharmacobiodyn 1992;15:25–32
  • Tominaga M, Ohya Y, Tsukashima A, et al. Ambulatory blood pressure monitoring in patients with essential hypertension treated with a new calcium antagonist, cilnidipine. Cardiovasc Drugs Ther 1997;11:43–8
  • Takeda S, Ueshiba H, Hattori Y, Irie M. Cilnidipine, the N- and L-type calcium channel antagonist, reduced on 24-h urinary catechol amines and C-peptide in hypertensive non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1999;44:197–205
  • Morimoto S, Takeda K, Oguni A, et al. Reduction of white coat effect by cilnidipine in essential hypertension. Am J Hypertens 2001;14:1053–7
  • Kishi T, Hirooka Y, Konno S, Sunagawa K. Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension. Clin Exp Hypertens 2009;31:241–9
  • Tanaka M, Sekioka R, Nishimura T, et al. Effects of cilnidipine on sympathetic nerve activity and cardiorenal function in hypertensive patients with type 2 diabetes mellitus: association with BNP and aldosterone levels. Diabetes Res Clin Pract 2014;106:504–10
  • Fotiou F, Fountoulakins KN, Goulas A, et al. Automated standardized pupillometry with optical method for purposes of clinical practice and research. Clin Physiol 2000;20:336–47
  • Fotiou F, Fountoulakins KN, Tsolaki M, et al. Changes in pupil reaction to light in Alzheimer’s disease patients: a preliminary report. Int J Psychophysiol 2000;37:111–20
  • Granholm E, Steinhauer SR. Pupillometric measures of cognitive and emotional processes. Int J Psychophysiol 2004;52:1–6
  • Yamaji K, Hirata Y, Usui S. A method for monitoring autonomous nervous activity by pupillary flash response. Syst Comput Jpn 2000;31:2447–56
  • Barbur JL. Learning from the pupil: studies of basic mechanisms and clinical applications. In: Chalupa LM, Werner JS, eds. The visual neurosciences. Cambridge: MIT Press; 2004:641–56
  • Fotiou DF, Brozou CG, Tsiptsios DJ, et al. Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research. Electromyogr Clin Neurophysiol 2007;47:11–22
  • Keivanidou A, Fotiou D, Arnaoutoglou C, et al. Evaluation of autonomic imbalance in patients with heart failure: a preliminary study of pupillomotor function. Cardiol J 2010;17:65–72
  • Pina SJ, Halonen JP. Infrared pupillometry in the assessment of autonomic function. Diabetes Res Clin Pract 1994;26:61–6
  • Stergou V, Fotiou D, Tsiptsios D, et al. Pupillometric findings in patients with Parkinson’s disease and cognitive disorder. Int J Psychophysiol 2009;72:97–101
  • Tsiptsios D, Fotiou DF, Haidich AB, et al. Evaluation of pupil mobility in patients with myasthenia gravis. Electromyogr Clin Neurophysiol 2008;48:209–18
  • Delaney EP, Greaney JL, Edwards DG, et al. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 2010;299:H1318–27
  • DiBona GF. The sympathetic nervous system and hypertension: recent developments. Hypertension 2004;43:147–50
  • Hayashi N, Someya N. Muscle metaboreflex activation by static exercise dilates pupil in human. Eur J Appl Physiol 2011;111:1217–21
  • Matsukawa K, Mitchell JH, Wall PT, Wilson LB. The effect of static exercise on renal sympathetic nerve activity in conscious cats. J Physiol 1991;434:453–67
  • Hirning LD, Fox AP, McCleskey EW, et al. Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 1988;239:57–61
  • Oike M, Inoue Y, Kitamura K, Kuriyama H. Dual action of FRC8653, a novel dihydropyridine derivate, on the Ba2+ current recorded from the rabbit artery. Circ Res 1990;57:993–1006
  • Fujii S, Kameyama K, Hosono M, et al. Effects of cilnidipine, a new dihydropyridine Ca++ channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1997;280:1184–91
  • Sakaki T, Naruse H, Masai M, et al. Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts. Ann Nucl Med 2003;17:321–6
  • Huang BS, Leenen FH. Sympathoinhibitory and depressor effects of amlodipine in spontaneously hypertensive rats. J Cardiovasc Pharmacol 2003;42:153–60

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