110
Views
8
CrossRef citations to date
0
Altmetric
Articles

Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men

, , &
Pages 580-586 | Received 03 Feb 2015, Accepted 18 Feb 2015, Published online: 20 May 2015

References

  • Söhl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res 2004;62:228–32
  • de Wit C. Connexins pave the way for vascular communication. News Physiol Sci 2004;19:148–53
  • Wagner C. Function of connexins in the renal circulation. Kidney Int 2008;73:547–55
  • Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 2008;80:9–19
  • Haefliger JA, Nicod P, Meda P. Contribution of connexins to the function of the vascular wall. Cardiovasc Res 2004;62:345–56
  • Kirchhoff S, Nelles E, Hagendorff A, et al. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 1998;8:299–302
  • Simon AM, Goodenough DA, Paul DL. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol 1998;8:295–8
  • Hagendorff A, Schumacher B, Kirchhoff S, et al. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation. Circulation 1999;99:1508–15
  • Tamaddon HS, Vaidya D, Simon AM, et al. High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res 2000;87:929–36
  • de Wit C, Roos F, Bolz SS, et al. Impaired conduction of vasodilation along arterioles in connexin40 deficient mice. Circ Res 2000;86:649–55
  • Jobs A, Schmidt K, Schmidt VJ, et al. Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension. Hypertension 2012;60:1422–9
  • de Wit C, Roos F, Bolz SS, Pohl U. Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol Genomics 2003;13:169–77
  • Wagner C, de Wit C, Kurtz L, et al. Connexin40 is essential for the pressure control of renin synthesis and secretion. Circ Res 2007;100:556–63
  • Wagner C, Jobs A, Schweda F, et al. Selective deletion of connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. Kidney Int 2010;78:762–8
  • Dupays L, Mazurais D, Rucker-Martin C, et al. Genomic organization and alternative transcripts of the human Connexin40 gene. Gene 2003;305:79–90
  • Gollob MH, Jones DL, Krahn AD, et al. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med 2006;354:2677–88
  • Groenewegen WA, Firouzi M, Bezzina CR, et al. A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ Res 2003;92:14–22
  • Firouzi M, Ramanna H, Kok B, et al. Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circ Res 2004;95:e29–33
  • Wirka RC, Gore S, Van Wagoner DR, et al. A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2011;4:87–93
  • Firouzi M, Kok B, Spiering W, et al. Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men. J Hypertens 2006;24:325–30
  • Pfenniger A, van der Laan SW, Foglia B, et al. Lack of association between connexin40 polymorphisms and coronary artery disease. Atherosclerosis 2012;222:148–53
  • Felix-Redondo FJ, Fernandez-Berges D, Calderon A, et al. Prevalence of left-ventricular hypertrophy by multiple electrocardiographic criteria in general population: Hermex study. J Hypertens 2012;30:1460–7
  • Muscholl MW, Hense HW, Brockel U, et al. Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey. BMJ 1998;317:565–70
  • Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics 1997;53:1253–61
  • Groenewegen WA, van Veen TA, van der Velden HM, Jongsma HJ. Genomic organization of the rat connexin40 gene: identical transcription start sites in heart and lung. Cardiovasc Res 1998;38:463–71
  • Seul KH, Tadros PN, Beyer EC. Mouse connexin40: gene structure and promoter analysis. Genomics 1997;46:120–6
  • Lübkemeier I, Machura K, Kurtz L, et al. The Connexin40 A96S mutation causes renin-dependent hypertension. J Am Soc Nephrol 2011;22:1031–40
  • Figueroa XF, Paul DL, Simon AM, et al. Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Circ Res 2003;92:793–800
  • Bierhuizen MF, van Amersfoorth SC, Groenewegen WA, et al. Characterization of the rat connexin40 promoter: two Sp1/Sp3 binding sites contribute to transcriptional activation. Cardiovasc Res 2000;46:511–22
  • Firouzi M, Bierhuizen MFA, Kok B, et al. The human Cx40 promoter polymorphism −44G-->A differentially affects transcriptional regulation by Sp1 and GATA4. Biochim Biophys Acta 2006;1759:491–6
  • Chaldoupi SM, Hubens LEG, Smit Duijzentkunst DA, et al. Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (−44 G - > A). Europace 2012;14:1199–205
  • Yamada Y, Izawa H, Ichihara S, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002;347:1916–23
  • O'Donnell CJ, Lindpaintner K, Larson MG, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998;97:1766–72
  • Higaki J, Baba S, Katsuya T, et al. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study. Circulation 2000;101:2060–5

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.