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Clinical and Experimental Hypertension. Part A: Theory and Practice Volume 6, 1984 - Issue 5
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Original Article

Evidence Supporting the Renal Synthesis of 19-NOR-Deoxycorticosterone

C. H. L. Shackleton Departments of Laboratory Medicine and Pharmaceutical Chemistry, University of California, San Francisco, CA, 94143
,
J. Winter St. Luke's-Roosevelt Institute for Health Sciences, New York, NY, 10025
,
E. G. Biglieri Medical Service, San Francisco General Hospital, San Francisco, CA, 94110
&
C. Gomez-sanchez Department of Medicine, University of South Florida College of Medicine, Tampa, FL, 33612; James A. Haley Veterans Administration Hospital, Tampa, FL, 33612
Pages 939-949 | Published online: 03 Jul 2009

References

  • Axelson M., Sjövall J. “Separation and Computerized Gas Chromatography/Mass Spectrometry of Unconjugated Neutral Steroids in Plasma,”. J. Steroid Biochem 1971; 5: 733
  • Bokkenheuser V. D., Winter J., Dehazya O., DeLeon P., Kelly W. G. “Formation and Metabolism of Tetrahydrodeoxy-corticosterone by Human Fecal Flora,”. J. Steroid Biochem 1976; 7: 837
  • Dale S. L., Holbrook M. M., Melby J. C. “19-Nor-deoxy-corticosterone in the Neutral Fraction of Human Urine,”. Steroids 1981; 37: 103
  • Gomez-Sanchez CD, Gomez-Sanchez E. P., Shackleton CHL, Milewich L. “Identification of 19-Hydroxydeoxycorticos-terone, 19-Oxo-deoxycorticosterone, and 19-Oic-deoxycorticos-terone as Products of Deoxycorticosterone Metabolism by Rat Adrenals,”. Endocrinology 1982; 110: 384
  • Gomez-Sanchez C. D., Holland O. B., Murry HA, Lloyd B. A., Milewich L. “19-Nor-deoxycorticosterone: A Potent Mineralocorticoid Isolated from the Urine of Rats with Regenerating Adrenals,”. Endocrinology 1979; 105: 708
  • Hall C. E., Gomez-Sanchez CD, Holland O. B., Nasseth D. “Influence of 19-Nor-deoxycorticosterone on Blood Pressure, Saline Consumption, and Serum Electrolytes, Corticosterone, and Renin Activity,”. Endocrinology 1979; 105: 600
  • Jänne O., Vihko R., Sjövall J., Sjövall K. “Determination of Steroid Mono- and Disulphates in Human Plasma,”. Clin. Chim. Acta 1969; 23: 405
  • Setchell K. DR, Shackleton C. HL. “The Group Separation of Plasma and Urinary Steroids by Column Chromatography on Sephadex LH-20,”. Clin. Chim. Acta 1973; 47: 381
  • Shackleton C. H.L. “Evidence Against Significant 19-Nor-deoxycorticosterone Production in Patients with 17α-Hydroxy-lase Deficiency,”. Clin. Exper. Hyper. 1982; 4: 1529
  • Shackleton C. HL, Whitney J. O. “Use of Sep-pak Cartridges for Urinary Steroid Extraction: Evaluation of the Method for Use Prior to Gas Chromatographic Analysis,”. Clin. Chim. Acta 1980; 107: 231
  • Ward R. J., Lawson A. M., Shackleton C. H.L. “Screening by Gas Chromatography/Mass Spectrometry for Metabolites of Five Commonly Used Anabolic Steroid Drugs.”. In Mass Spectrometry in Drug Metabolism, A. Frigerio, E.L. Ghisalberti. Plenum Press, New York 1977; p. 465

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