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Clinical and Experimental Hypertension. Part A: Theory and Practice Volume 6, 1984 - Issue 9
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Original Article

The Blood Pressure and Metabolic Effects of 19-Nor-Deoxycorticosterone and 19-Nor-Progesterone in Sheep

Campbell D. Spence Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
,
John P. Coghlan Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
,
Derek A. Denton Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
,
Celso E. Gomez-sanchez Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, 33620, USA
,
Eric H. Mills Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
,
Mark A. Nelson Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
,
Judith A. Whitworth Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052; Department of Nephrology, Royal Melbourne Hospital, 3050, Australia
&
Bruce A. Scoggins Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052
 show all
Pages 1591-1600 | Published online: 03 Jul 2009

References

  • Whitworth J. A., Coghlan J. P., Denton D. A., Graham W. F., Humphery T. J., Scoggins B. A. Comparison of the effects of glucocorticoids and mineralocorticoid infusions on blood pressure in sheep. Clin. Exp. Hypertension. 1979; 1: 649–663
  • Mills E. H., Coghlan J. P., Denton D. A., Scoggins B. A., Spence C. D., Whitworth J. A. The effect of potassium loading and sodium depletion on DOC induced hypertension in sheep. Acta Endocrinologica. 1984, (in press)
  • Hall C. E., Gomez-Sanchez C. E., Holland O. B., Nasseth D. Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption and serum electrolytes, corticosterone and renin activity. Endocrinology 1979; 105: 600–604
  • Komanicky P., Melby J. C. Experimental hypertension induced by 19-nor-progesterone treatment in the rat. Endocrinology 1981; 109: 1164–1167
  • Hall C. E., Gomez-Sanchez C. E., Hungerford S., Gomez-Sanchez E. P. Mineralocorticoid and hypertensive effects of 19-nor-progesterone. Endocrinology 1981; 109: 1168–1175
  • Gomez-Sanchez C. E., Holland O. B., Murray B. A., Lloyd H. A., Milewich L. 19-Nor-deoxycorticosterone: a potent mineralocorticoid isolated from the urine of rats with regenerating adrenals. Endocrinology 1979; 105: 708–711
  • Dale S. L., Holbrook M. M., Melby J. C. 19-Nor-deoxycorticosterone in the neutral fraction of human urine. Steroids 1981; 37: 103–109
  • Axelrod D. J., Cates J. E., Johnson B. B., Luetscher J. A. Bioassay of mineralocorticoids: relationship of structure to physiological activity. Endocrinology 1954; 55: 568–574
  • Kagawa C. M., Van Arman C. G. Sodium retaining activity of 19-nor-steroids in adrenalectomized rats. Proc. Soc. Exp. Biol. Med. 1957; 94: 444–447
  • Funder J. W., Mercer J., Ingram B., Feldman D., Wynne K., Adam W. R. 19-Nor-deoxycorticosterone (19-nor-DOC): Mineralocorticoid receptor affinity higher than aldosterone, electrolyte activity lower. Endocrinology 1978; 103: 1514–1517
  • Perrone R. D., Bengele H. H., Dale S. L., Melby J. C., Alexander E. A. Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in adrenalectomized rats. Am. J. Physiol. 1982; 242: E305–E308
  • Funder J. W., Adam W. R. 19-Nor-progesterone is a mineralocorticoid agonist. Endocrinology 1981; 109: 313–315
  • Sandoval A., Thomas G. H., Djerassi C., Rosenkranz G., Sondheimer F., Steroids LXI. Synthesis of 19-nor-desoxycorticosterone, a potent mineralocorticoid hormone. J. Am. Chem. Soc 1955; 77: 148
  • Bowers A., Villoti R., Edwards J. A., Denat E., Halpern O. Steroids: CCII, A new route to 19-nor steroids. J. Am. Chem. Soc. 1962; 84: 3204
  • Scoggins B. A., Butkus A., Coghlan J. P., Denton D. A., Mason R. T., Meehan P. J., Mills E. H., Nelson M. A., Spence C. D., Whitworth J. A. The role of ‘mineralocorticoids’, ‘glucocorticoids’ and ‘hypertensinogenic’ steroids in ACTH-induced hypertension. ‘Mineralocorticoids and Hypertension’, W. Kaufmann, G. Wambach, A. Helber, KA. Meurer. Springer-Verlag. 1983; 113–128

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