The Involvement of Central Alpha Adrenoceptors in the Antihypertensive Actions of Methyldopa and Clonidine in the Rat

References

• Conway E L, Louis W J, Jarrott B. The effect of acute alpha-methyldopa administration on catecholamine levels in anterior hypothalamic and medullary nuclei in rat brain. Neuropharmacol. 1979; 18: 279–286
   PubMed Web of Science ®Google Scholar
• Jarrott B, Louis W J, Summers R J. Characterization of central alpha adrenoceptors using3H-clonidine and its derivatives. Chest 1983; 83: 339–340
   PubMed Web of Science ®Google Scholar
• Conway E L, Jarrott B. Clonidine distribution in the rat: Temporal relationship between tissue levels and blood pressure response. Brit J Pharmacol. 1980; 71: 473–478
   PubMed Web of Science ®Google Scholar
• Schmitt H. The pharmacology of clonidine and related products. Handbook of Experimental Pharmacology, Vol 39, F. Gross. Springer-Verlag, Berlin 1979; 299–396
   Google Scholar
• Conway E L, Jarrott B. Tissue pharmacokinetics of clonidine in rats. J Pharmacokin Biophamr. 1982; 10: 187–200
   PubMedGoogle Scholar
• U'Prichard D C, Bechtel W D, Rouot B M, Snyder S H. Multiple apparent alpha-noradrenergic receptor binding sites in rat brain. Effect of 6-hydroxydopamine. Mol Pharmacol. 1979; 16: 47–60
   PubMed Web of Science ®Google Scholar
• U'Prichard D C, Greenberg D A, Snyder S H. Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors. Mol Pharmacol. 1977; 13: 454–473
   PubMed Web of Science ®Google Scholar
• Jarrott B, Louis W J, Summers R J. The characteristics of3H-clonidine binding to an alpha adrenoceptor in membranes from guinea pig kidney. Brit J Pharm. 1979; 65: 663–670
   PubMed Web of Science ®Google Scholar
• McPherson G A, Summers R J. Localization of3H-clonidine binding to membranes from guinea pig renal tubules. Biochem Pharmacol. 1982; 31: 583–587
   PubMed Web of Science ®Google Scholar
• Summers R J, Jarrott B, Louis W J. Selectivity of a series of clonidine-like drugs for alpha1 and alpha2 adrenoceptors in rat brain. Neurosci Lett. 1980; 20: 347–350
   PubMed Web of Science ®Google Scholar
• Doxey J C, Frank L W, Hersocn A S. Studies of the pre-and postjunctional activities of alpha adrenoceptor agonists and their cardiovascular effects in the anaesthetized rat. J Auton Pharmacol. 1981; 1: 157–169
   PubMedGoogle Scholar
• Jarrott B, Louis W J, Summers R J. 3H-guanfacine: A radioligand that selectively labels high affinity alpha2-adrenoceptor sites in homogenates of rat brain. Brit J Pharmacol. 1982; 75: 401–408
   PubMed Web of Science ®Google Scholar
• Young W S, Kuhar M J. Noradrenergic alphai and alpha2-receptors. Light microscopic autoradiographic localization. Proc. Nat Acad Sci. 1980; 77: 1696–1700
   PubMed Web of Science ®Google Scholar
• Weber M A. Discontinuation syndrome following cessation of treatment with clonidine and other antihypertensive agents. J Cardiovas Pharmacol. 2; Suppl. 1980; 1: 573–589
   Google Scholar
• Dix R K, Johnson E M. Withdrawal syndrome upon cessation of chronic clonidine treatment in rats. Eur J Pharmacol. 1977; 44: 153–159
   PubMed Web of Science ®Google Scholar
• Atkinson J, Boillat N, Para-Bally R, Peters-Haefeli L, Kirchertz E J. Effects of chronic treatment and its abrupt cessation on mean pressure of rats with a normal or an elevated blood pressure. Clin Sci Mol Med. 1979; 57: 195–201
   Google Scholar
• Oates H F, Stoker L M, MacCarthy E P, Monoghan J C, Stokes G S. Comparative haemodynamic effects of clonidine and guanfacine. Arch Int Pharmacodyn Ther. 1978; 231: 148–156
   PubMedGoogle Scholar
• Salzmann R. The effects of treatment and of withdrawal of treatment with guanfacine and clonidine on blood pressure and heart rate in normotensive and renal hypertensive rats. J Pharm Pharmacol. 1979; 31: 212–216
   PubMed Web of Science ®Google Scholar
• Distephano P, Fox G, Johnson E M. Characterization of the clonidine withdrawal syndrome in the normotensive rat. J Pharmacol exp Ther. 1980; 214: 263–268
   PubMed Web of Science ®Google Scholar
• Koike Y, Togashi H, Shimamura K, Yomaida I, Saito H. Effects of abrupt cessation of treatment with clonidine and guanfacine on blood pressure and heart rate in spontaneously hypertensive rats. Clin Exp Hypertension 1981; 3: 103–120
   PubMed Web of Science ®Google Scholar
• Paalzow L K, Edlund P O. Pharmacokinetics of clonidine in the rat and cat. J Pharmacokin Biopharm. 1979; 7: 481–494
   PubMedGoogle Scholar
• Anavekar S N, Jarrott B, Toscano M, Louis W J. Pharmacokinetic and pharmacodynamic studies of oral clonidine in normotensive subjects. Eur J Clin Pharmacol 1981; 23: 1–5
   Web of Science ®Google Scholar
• Davies D S, Wing L M. H, Reid J L, Neill E, Tippett P, Dollery C T. Pharmacokinetics and concentration-effect relationships of intravenous and oral clonidine. Clin Pharmacol Ther. 1977; 21: 593–601
   PubMed Web of Science ®Google Scholar
• Thoolen M J, Timmermans van P BMWM, Zwieten P A. Withdrawal syndrome after continuous infusion of clonidine in the normotensive rat. J Pharm Pharmacol. 1981; 33: 232–235
   PubMed Web of Science ®Google Scholar
• Thoolen M J, Timmermans Van P BMWM, Zwieten P A. Morphine suppresses the blood pressure responses to clonidine withdrawal in the spontaneously hypertensive rat. Eur J Pharmacol. 1981; 71: 351–353
   PubMed Web of Science ®Google Scholar
• Conway E L, Jarrott B. Effects of clonidine infusion and withdrawal on blood pressure and behaviour in the rat. A preliminary study. Clin Exp Hyper. 1981; 4: 1323–1334
   Web of Science ®Google Scholar
• Kleinlogel H, Scholtysik G, Sayers A C. Effects of clonidine and BS 100–141 on the sleep pattern of rats. Eur J Pharmacol. 1975; 33: 159–163
   PubMed Web of Science ®Google Scholar
• Autret A, Minz M, Beillevaire T, Cathala H P, Schmitt H. Effect of clonidine on sleep patterns in man. Eur J Clin Pharmacol. 1977; 12: 319–322
   PubMed Web of Science ®Google Scholar
• Maling T J. B, Dollery C T, Hamilton C A. Clonidine and sympathetic activity during sleep. Clin Sci. 1979; 57: 509–514
   PubMed Web of Science ®Google Scholar
• Hossmann V, Maling T J. B, Hamilton C A, Reid J L, Dollery C T. Sedative and cardiovascular effects of clonidine and nitrazep. Am. Clin Pharmacol Ther. 1980; 28: 167–176
   PubMed Web of Science ®Google Scholar