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Clinical and Experimental Hypertension. Part A: Theory and Practice Volume 13, 1991 - Issue 5
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Original Article

The Anti-Tachycardic Mechanism of a Direct-Acting Vasodilator, Budralazine, in Rats

Mitsuhiro Yoshioka First Department of Pharmacology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060, Japan
,
Masaru Minami Department of Pharmacology, Higashi-Nippon Gakuen University Faculty of Pharmaceutical Sciences, Ishikari-Tobetsu, Hokkaido, 061-02, Japan
&
Hideya Saito First Department of Pharmacology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060, Japan
Pages 1107-1114 | Published online: 03 Jul 2009

References

  • Akashi A., Chiba T., Suzuki I., Hashimoto H. Pharmacology of budralazine, a new antihypertensive drug. Arch. int. Pharmacodyn. 1978; 135: 134–146
  • Chiba T., Hirohashi M., Suzuki I., Tanaka S., Watanabe K., Akashi A. Characterization of the Vasodilator Action of Antihypertensive Drug Budralazine. Arzneim.-Forsch. 1983; 33: 112–116
  • Stein D. H., Hecht H. H. Cardiovascular and renal responses to the combination of hexamethonium and 1-hydrazinophthalazine (Apresoline) in hypertensive subjects. J. Clin. Invest. 1955; 34: 867–874
  • Åblad B. A study of the mechanism of hemodynamic effects of hydralazine in man. Acta Pharmacol. Toxicol. 1963; 20(suppl.1)1–15
  • Yoshioka M., Togashi H., Minami M., Saito H. Effects of hydralazine on adrenal and cardiac sympathetic nerve activity in anesthetized rats. Res. Commun. Chem. Pathol. Pharmacol. 1986; 54: 313–320
  • Akashi A., Chiba T., Kasahara A. Antihypertensive activity of 1-[2- (1,3)-dimethyl-2-butenylidene]-phthalazine (DJ-1461), a new phthalazine derivatives. European J. Pharmacol. 1974; 29: 161–164
  • Konno K., Nonaka K., Ueno A. Hypotensive and cardiovascular action of budralazine in unanesthetized and unrestrained dogs. Arzneim.-Forsch. 1981; 31: 1072–1075
  • Takeuchi J., Taniguchi K., Iesaka Y. Long effects of budralazine (DJ-1461) on essential Hypertension. Shinryo to Shinyaku 1980; 17: 2381–2385, (in Japanese)
  • Yoshinaga K., Miura Y. Treatment of hypertension with budralazine. Progress in Medicine 1985; 5: 2223–2232, (in Japanese)
  • Sapru H. N., Krieger A. J. Carotid and aortic chemorceptor function in the rat. J. Appl. Physiol. 1977; 42: 344–348

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