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Original Article

The Effects of Peg-Interleukin-2 and Interleukin-2 on Essential Hypertension and Cellular Immune Function in the Spontaneously Hypertensive Rat

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Pages 435-457 | Received 18 Jun 1992, Accepted 16 Oct 1992, Published online: 03 Jul 2009

References

  • Norman R.A., Dzielak D.J., Bost K.L., Khraibi A.A., Galloway P.G. Immune system dysfunction contributes to the etiology of spontaneous hypertension. J Hypertens. 1985; 3: 261–268
  • Takeichi N., Suzuki K., Kobayashi H. Characterization of immunological depression in spontaneosly hypertensive rats. Eur J Immunol. 1981; 11: 483–487
  • Strausser H.R. Immune response modulation in the spontaneously hypertensive rat. Thymus 1983; 5: 19–33
  • Ba D., Takeichi N., Kodama T., Kobayashi H. Restoration of T cell depression and suppression of blood pressure in spontaneously hypertensive rats (SHR) by thymus grafts or thymus extracts. J Immunol. 1982; 128: 1211–1216
  • Gillis S., Smith K.A. Long-term culture of tumor-specific cytotoxic T cells. Nature 1977; 268: 154–156
  • Farrar J.J., Simon P.L., Koopman W.J., Fuller-Bonar J. Biochemical relationship of thymocyte mitogenic factor and factors enchancing humoral and cell-mediated immune responses. J Immunol. 1978; 121: 1353–1360
  • Shaw J., Monticone V., Mills G., Paetkau V. Effects of co-stimulator on immune responses in vitro. J Immunol. 1978; 120: 1974–1780
  • Gillis S., Union N.A., Baker P.E., Smith K.A. The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes. J Exp Med. 1979; 149: 1460–1476
  • Gillis S., Watson J. Interleukin-2 induction of hapten-specific cytolytic T cells in nude mice. J Immunol. 1981; 126: 1245–1248
  • Henney C.S., Kuribayashi S.K., Kern D.E., Gillis S. Interleukin-2 augments natural killer cell activity. Nature 1981; 291: 335–338
  • Ting C.C., Yang S.S., Hargrove M.E. Induction of suppressor T cells by interleukin-2. J Immunol. 1984; 133: 261–266
  • Tuttle R.S., Boppana D.P. Antihypertensive effect of interleukin-2. Hypertension 1990; 15: 89–94
  • Pascual D.W., Jin H., Bost K.L., Oparil S. Interleukin-2 does not attenuate hypertension in spontaneously hypertensive rats. Hypertension 1990; 16: 468–471
  • Dzielak D.J. Interleukin-2 and spontaneous hypertension. Hypertension 1991; 18: 171–175
  • Matory Y.L., Chang A.E., Lipford E.H., 3d, Braziel R., Hyatt C.L., McDonald H.D., Rosenberg S.A. Toxicity of recombinant IL-2 in rats following intravenous infusion. J Biol Resp Mod., 4: 377–390
  • Katre N.V. Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol. J Immunol. 1990; 144: 209–213
  • Glimcher L.H., Longo D.L., Green I., Schwartz R.H. Murine syngeneic mixed lymphocyte response. I. Target antigens are self la molecules. J Exp Med. 1981; 154: 1652–1670
  • Yamashita U., Ono S., Nakamura H. The syngeneic mixed leucocyte reaction in mice II. The I region control of suppressor T cell activity induced in the syngeneic mixed leucocyte reaction. J Immunol. 1982; 128: 1010–1017
  • James S.P., Yenokida G.G., Graeff S.S., Elson C.O., Strober W. Immunoregulatory function of T cells activated in the autologous mixed lymphocyte reaction. J Immunol. 1981; 127: 2605–2609
  • Smith J.B., Knowlton R.P. Activation of suppressor T cells in the human autologous mixed lymphocyte culture. J Immunol. 1979; 123: 419–422
  • Smith J.B., Pasternak R.D. Syngeneic mixed leucocyte reaction in mice: strain distribution, kinetics, participating cells and absence in NZB mice. J Immunol. 1978; 121: 1889–1892
  • Glimcher L.H., Steinberg A.D., House S.B., Green I. The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease. J Immunol. 1980; 125: 1832–1838
  • Horn J.T., Talal N. Decreased syngeneic mixed lymphocte response (SMLR) in genetically susceptible autoimmune mice. Scand J Immunol. 1982; 159: 195–203
  • Shand F.L., Orme I.M., Ivanyi J. The induction of suppressor T cells by concanavalin A is independent of cellular proliferation and protein synthesis. Scand J Immunol. 1980; 12: 223–231
  • Smith C.I, Svejgaard A. Concanavalin-A-induced suppressor lymphocytes in normal individuals. Scand J Immunol. 1981; 13: 483–492
  • Knauf M.J., Bell D.P., Hirtzer P., Luo Z.P., Young J.D., Katre N.V. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J Biol Chem. 1988; 263: 15064–15070
  • Gillis S., Ferm M.M., Ou W., Smith K.A. T-cell growth factor: parameters of production and a quantitative microaay for activity. J Immunol. 1978; 120: 2027–2032
  • Sette A., Adorini L, Marubini E., Doria G. A microcomputer program for probit analysis of interleukin-2 (IL-2) titration data. J Immunol Methods 1986; 86: 265–277
  • Julius M.H., Simpson E., Herzenberg LA. A rapid method for the isolation of functional thymus-derived lymphocytes. Eur J Immunol. 1973; 3: 645–649
  • Wysocki LJ., Sato V.L. “Panning” for lymphocytes. A method for cell separation. Proc Natl Acad sci. (USA) 1978; 75: 2844–2848
  • Allison A.C. Mechanisms by which activated macrophages inhibit lymphocyte responses. Immunol Rev. 1978; 40: 3–27
  • Chang A.E., Rosenberg S.A. Systemic administration of recombinant interleukin-2 in mice. Surg Forum 1984; 35: 137–141
  • Donohue J.H., Rosenberg SA. The fate of interleukin-2 after in vivo administration. J Immunol. 1983; 130: 2203–2208
  • Katre N.V., Knauf M.J., Laird WJ. Chemical modification of recombinant interleukin-2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model. Proc Natl Acad Sci. (USA) 1987; 84: 1487–1491
  • Lisi PJ., Van Es T., Abuchowski A., Palczuk N.C., Davis F.F. Polyethylene glycol: β-Glucuronidase conjugates as potential therapeutic agents in acid mucopolysaccaridosis. J Appl Biochem. 1982; 4: 19–33
  • Allegretta M., Atkins M.B., Dempsey R.A., Bradley E.C., Konrad M.W., Childs A., Wolfe S.N., Mier J.W. The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2. J Clin Immunol. 1986; 6: 481–490
  • Krigel R.L., Padavic-Shaller KA., Rudolph A.R., Litwin S., Konrad M., Bradley E.C., Comis R.L. A phase I study of recombinant interleukin-2 plus recombinant β-interferon. Cancer Res. 1988; 48: 3875–3881
  • Sehon A.H., Lee W.Y. Specific down-regulation of IgE antibodies by tolerogenic conjugates of haptens and allergens with synthetic polymers. Int Arch Allergy Appl Immunol. 1981; 66: 39–42
  • Cotran R.S., Pober J.S., Gimbrone MA., Springer T.A., Wiebke E.A., Gaspari A.A, Rosenberg S.A., Lotze M.T. Endothelial activation during interleukin-2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol. 1987; 139: 258–294
  • Bendich A., Belisle E.H., Strausser H.R. Immune system modulation and its effect on blood preure of spontaneously hypertensive male and female rat. Biochem Biophys Res Commun. 1981; 99: 600–607
  • Takeichi N., Suzuki K., Okayasu T., Kobayashi H. Immunological depreion in spontaneously hypertensive rats. Clin Exp Immunol. 1980; 40: 120–126
  • Khraibi AA., Norman RA, Dzielak D.J. Chronic immunosuppression attenuates hypertension in Okamoto spontaneously hypertensive rats. Am J Physiol. (Heart Circ. Physiol) 1984; 247: H722–H726
  • Wagner H.C., Hardt H., Heeg K., Rollinghoff M., Pfizenmaier K. T-cell derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice. Nature 1980; 284: 278–280
  • Lehmann K.R., Kotzin B.L., Portanova J.P., Santoro TJ. Interleukin-2 is a proliferative signal for B cells from autoimmune mice. Eur J Immunol. 1986; 16: 1105–1110
  • Gajewski T.F., Joyce J., Fitch F.W. Antiproliferative effect of IFN-γ in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ. J Immunol 1989; 143: 15–22
  • Smith K.A., Cantrell D.A. Interleukin-2 regulates its own receptors. Proc. Natl. Acad. Sci. (USA) 1985; 82: 864–868

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