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Original Article

Angiotensin I Converting Enzyme Gene Cosegregates with Blood Pressure and Heart Weight in F2 Progeny Derived from Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats

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Pages 753-771 | Published online: 03 Jul 2009

References

  • Yamori Y, Mori C, Nishio T, Ooshima A, Horie R, Ohtaka M, Soeda T, Saito M, Abe K, Nara Y, Nakao Y, Kihara M. Cardiac hypertrophy in early hypertension. Am J Cardiology 1979; 44: 964–969
  • Gray S D. Spontaneous hypertension in the neonatal rat. Clin Exper Hypertension-Theory and Practice 1984; A6: 755–781
  • Tanase H, Yamori Y, Hansen C T, Lovenberg W. Heart size in inbred strains of rat Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 1982; 4: 864–872
  • Grassi de Gende A O. Evaluation of right and left ventricular size in SHR-Wistar hybrids. Am J Physiol 1988; 255: H587–H591
  • Kunes J, Kren V, Klir P, Zicha J, Pravenec M. Genetic determination of heart and kidney weights studied using a set of recombinant inbred strains: the relationship to blood pressure. J Hypertension 1990; 8: 1091–1095
  • Harrap S B, Jones E F, Crapper E K, Datodi S R, Norman T L, Mitchell G A. Dissociation of cardiovascular hypertrophy and high blood pressure in the spontaneously hypertensive rat. Proceedings of High Blood Pressure Research Council of Australia. 1993, 47, (Abstract)
  • Lucarini A R, Spessot M, Picano E, Marini C, Lattanzi F, Pedrinelli R, Salvetti A. Lack of correlation between cardiac mass and arteriolar structural changes in mild-to-moderate hypertension. J Hypertension 1991; 9: 1187–1191
  • Hilbert P, Lindpaintner K, Beckmann J S, Serikawa T, Soubrier F, Dubay C, Cartwright P, de Gouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, Lathrop G M. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991; 353: 521–529
  • Jacob H J, Lindpaintner K, Lincoln S E, Kusumi K, Bunker R K, Mao Y P, Ganten D, Dzau V J, Lander E S. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991; 67: 213–224
  • Krege J H, John S WM, Langenbach L L, Hodgin J B, Hagaman J R, Bachman E S, Jennette J C, O'Brien D A, Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995; 375: 146–148
  • Schunkert H, Dzau V J, Tang S S, Hirsch A T, Apstein C S, Lorell B H. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy Effects in coronary resistance, contractility, and relaxation. J Clin Invest 1990; 86: 913–920
  • Okamoto H, Sano H, Kudo T, Yoneya K, Kawaguchi H. Increased gene expression for angiotensinogen, renin and angiotensin-converting enzyme in left ventricles of spontaneously hypertensive rats. (Abstract) Circulation 1994; 90: 1–130
  • Schunkert H, Hense H W, Holmer S R, Stender M, Perz S, Keil U, Lorell B H, Riegger G AJ. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Eng J Med 1994; 330: 1634–1638
  • Wong K K, Summers K M, Burstow D J, West M J. Angiotensin-converting enzyme and angiotensinogen genes in patterns of left ventricular hypertrophy and in diastolic dysfunction. Clin Exp Pharmacol Physiol 1995; 22: 438–440
  • Kreutz R, Hübner N, Jacob H, Ganten D, Lindpaintner K. Evidence that the hypertension-associated locus on rat chromosome 10, BP-SP1, is not identical with the angiotensin-converting enzyme (ACE) gene locus. Hypertension 1994; 24: 373, (Abstract)
  • Okamoto K, Yamori Y, Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 1974, Suppl. I: 34–35; I143–I143
  • Grunebaum L, Cazenave J P, Camerino G, Kloepfer C, Mandel J L, Tolstoshev P, Jaye M, De la Alle S, Lecocq J P. Carrier detection of hemophilia B by using a restriction site polymorphism associated with the coagulation factor IX gene. J Clin Invest 1984; 73: 1491–1495
  • Fisher L, van Belle G. Biostatistics: a methodology for the health sciences. J Wiley, New York 1993; 606–607
  • Tanase H, Suzuki Y, Ooshima A, Yamori Y, Okamoto K. Genetic analysis of blood pressure in spontaneously hypertensive rats. Japan Circ J 1970; 34: 1197–1212
  • Cutilletta A F, Benjamin M, Culpepper W S, Oparil S. Myocardial hypertrophy and ventricular performance in the absence of hypertension in spontaneously hypertensive rats. J Mol Cell Cardiol 1978; 10: 689–703
  • Dobesova Z, Zicha J, Heller J, Kunes J. The lack of cardiac hypertrophy in newborn Prague hypertensive rats. Physiol Res 1991; 40: 373–376
  • Allemann Y, Aeschbacher B, Zwyssig P, Ferrari P, Hopf M, Shaw S, Gurtner H P, Weidmann P. Left ventricular structure and determinants in normotensive offspring of essential hypertensive parents. J Hypertension 1992; 10: 1257–1264
  • Frohlich E D, Pfeffer M A, Pfeffer J M. Systemic haemodynamics and cardiac function in spontaneously hypertensive rats: Similarities with essential hypertension. “The Heart In Hypertension”, B E Strauer. Springer-Verlag, Berlin 1981; 425–535
  • Kuwajima I, Kardon M B, Pegram B L, Sesoko S, Frohlich E D. Regression of left ventricular hypertrophy in two-kidney, one clip Goldblatt hypertension. Hypertension 1982; 4(suppl II)II-113–II-118
  • Sen S, Tarazi R C, Bumpus F M. Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res 1974; 35: 775–781
  • Sun L, McArdle S, Chun M, Wolff D W, Pettinger W A. Cosegregation of the renin gene with an increase in mean arterial blood pressure in the F2 rats of SHR-WKY cross. Clin Exper Hypertens 1994; 16: 535–543
  • Nara Y, Nabika T, Ikeda K, Sawamura M, Endo J, Yamori Y. Blood pressure cosegregates with a microsatellite of angiotensin converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP). Biochem Biophys Res Commun 1991; 181: 941–946
  • Deng Y, Rapp J P. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nature Genetics 1992; 1: 267–272
  • Nabika T, Nara Y, Ikeda K, Endo J, Yamori Y. Genetic heterogeneity of the spontaneously hypertensive rat. Hypertension 1991; 18: 12–16
  • Samani N J, Swales J D, Jeffreys A J, Morton D B, Naftilan A J, Lindpaintner K, Ganten D, Brammar W J. DNA fingerprinting of spontaneously hypertensive and Wistar-Kyoto rats: implications for hypertension research. J Hypertension 1989; 7: 809–816
  • Gong G, Dobin A, McArdle S, Sun L, Johnson M L, Pettinger W A. Sex influence in renal α2-adrenergic receptor density in the spontaneously hypertensive rat. Hypertension 1994; 23: 607–612
  • Turner M E, Johnson M L, Ely D L. Separate sex-influenced and genetic components in spontaneously hypertensive rat hypertension. Hypertension 1991; 17: 1097–1103
  • Iwai N, Kurtz T W, Inagami T. Further evidence of the SA gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem Biophys Res Commun 1992; 188: 64–69
  • Wu J N, Berecek K H. Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with the angiotensin converting enzyme inhibitor captopril. Hypertension 1993; 22: 139–146
  • Black M J, Bertram J F, Campbell J H, Campbell G R. Angiotensin II induces cardiovascular hypertrophy in perindopril-treated rats. J Hypertension 1995; 13: 683–692
  • Luft F C, Steinberg H, Ganten U, Meyer D, Gless K H, Lang R E, Fineberg N S, Rascher W, Unger T, Ganten D. Effect of sodium chloride and sodium bicarbonate on blood pressure in stroke-prone spontaneously hypertensive rats. Clin Sci 1988; 74: 577–585
  • Harris E L, Phelan E L, Thompson C M, Millar J A, Grigor M R. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. J Hypertension 1995; 13: 397–404
  • Rapp J P, Wang S M, Dene H. Effect of genetic background on cosegregation of renin alleles and blood pressure in Dahl rats. Am J Hypertens 1990; 3: 391–396
  • Cicila G T, Rapp J P, Bloch K D, Kurtz T W, Pravenec M, Kren V, Hong C C, Quertermous T, Ng S C. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J Hypertension 1994; 12: 643–651

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