22
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Actions of DES-ASP-Angiotensin I on the Aortic Rings of the Normo- and Hypertensive Rats

&
Pages 105-117 | Received 01 Oct 1996, Accepted 19 May 1997, Published online: 03 Jul 2009

References

  • Sim M K, Radhakrishnan R. Novel central action of des-Asp-angiotensin I. Eur J Pharamcol. 1994; 257: R1–R3
  • Radhakrishnan R, Sim M K. Actions of D-amino acid-substituted analogues of des-Asp-angiotensin I on the central pressor action of angiotensin III. Eur J Pharmacol 1995; 294: 337–339
  • Sim M K. Degradation of angiotensin I in the endothelium and smooth muscle of the rat aorta. Biochem Pharmacol 1993; 47: 1524–1527
  • Sim M K, Yuan H T. Effects of des-Asp-angiotensin I on the contractile action of angiotensin II and angiotensin III. Eur J Pharmacol 1995; 278: 175–178
  • Campbell W B, Schmitz J M, Itskovitz H D. (Des-asp1) Angiotensin I: A study of its pressor and steroidogenic activities in conscious rats. Endocrinology 1977; 100: 46–51
  • Ackerly J A, Tsai B S, Peach M J. Role of converting enzyme in the responses of rabbit atria, aortas, and adrenal zona glomerulosa to [des-Asp1] angiotensin I. Circ Res 1977; 41: 231–238
  • Sexton J M, Britton S L, Beierwaltes W H, Fiksen-Olsen M J, Romero J C. Formation of angiotensin III from [des-Asp1] angiotensin I in the mesenteric vasculature. Am J Physiol 1979; 237: H218–H223
  • Sim M K, Manjeet S. Decrease responsiveness of the aorta of hypertensive rats to acetylcholine, histamine and noradrenaline. Br J Pharmacol 1987; 90: 147–150
  • Tsai B S, Peach M J, Khosla M C, Bumpus F M. Synthesis and evaluation of des-aspartate-angiotensin I as a precursor for des-aspartate-angiotensin II (angiotensin III). J Med Chem 1975; 18: 1180–1183
  • Wright J W, Roberts K A, Cook I V, Murray C E, Sardina M F, Harding J W. Intracerebroventricularly infused [d-Arg1] angiotensin III is superior to [d-Asp1]angiotensin II as a pressor agent in rats. Brain Res 1990; 514: 5–10
  • Radhakrishnan R, Sim M K. Enhanced pressor response to angiotensin III in spontaneously hypertensive rats: effects of losartan. Eur J Pharmacol 1994; 259: 87–90
  • Sim M K, Kuttan S C. Effects of noradrenaline and prostaglandin F2αon angiotensin-induced contraction and tachyphylaxis in rat aortic rings. Pharmacol Toxicol 1992; 70: 60–64
  • Sim M K, Radhakrishnan R. In vivo study of angiotensin II tachyphylaxis in freely moving normo- and hypertensive rats. Pharmacol Toxicol 1994; 74: 223–227
  • Timmermans P BMWM, Wong P C, Chiu A T, Herblin W F, Benfield P, Carini D J, Lee R J, Wexler R R, Saye J AM, Smith R D. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993; 45: 205–251
  • Garcia Del Rio C W, Smellie W A, Morton J J. des-Asp-angiotensin I: Its identification in rat blood and confirmation as a substrate for converting enzyme. Endocrinology 1981; 108: 406
  • Rubanyi G M, Kauser K, Graser T. Effect of cilazapril and indomethacin on endothelial dysfunction in the aortas of spontaneously hypertensive rats. J Cardiovasc Pharmacol 1993; 22(S5)S23–30

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.