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Clinical and Experimental Hypertension Volume 20, 1998 - Issue 5-6
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Original Article

A Labile Sodium Pump Inhibitor From The Peritoneal Dialysate of Hypertensive Renal Failure Patients: Estimates of Potency

S. W. Graves Departments of Medicine (Endocrine-Hypertension Div.) and Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, 02115; Department of Analytical Chemistry, University of Uppsala, 75121, Uppsala, Sweden
,
Q.-F. Tao Departments of Medicine (Endocrine-Hypertension Div.) and Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, 02115; Department of Analytical Chemistry, University of Uppsala, 75121, Uppsala, Sweden
,
K. E. Markides Departments of Medicine (Endocrine-Hypertension Div.) and Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, 02115; Department of Analytical Chemistry, University of Uppsala, 75121, Uppsala, Sweden
,
G. H. Williams Departments of Medicine (Endocrine-Hypertension Div.) and Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, 02115; Department of Analytical Chemistry, University of Uppsala, 75121, Uppsala, Sweden
&
N. K. Hollenberg Departments of Medicine (Endocrine-Hypertension Div.) and Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, 02115; Department of Analytical Chemistry, University of Uppsala, 75121, Uppsala, Sweden
Pages 611-616 | Published online: 03 Jul 2009

References

  • Glatter K. A., Graves S. W., Hollenberg N. K., Soszynski P. A., Tao Q.-F., Frem G. J., Williams G. H., Lazarus J. M. Sustained volume expansion and [Na,K]ATPase inhibition in chronic renal failure. Am J Hypertens. 1994; 7: 1016–1025
  • Tao Q.-F., Soszynski P. A., Hollenberg N. K., Graves S. W. Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate in chronic renal failure. Kidney Intl. 1996; 49: 420–429
  • Tao Q.-F., Soszynski P. A., Hollenberg N. K., Graves S. W. A sensitive assay for sodium pump inhibition. Clin Chem. 1994; 40: 1977–1978
  • Tao Q.-F., Soszynski P. A., Hollenberg N. K., Graves S. W. A sensitive [Na,K]ATPase assay, specific for inhibitors acting via the digitalis-binding site. J Cardiovasc Pharmacol. 1995; 25: 859–863
  • Graves S. W., Glatter K., Lazarus J. M., Hollenberg N. K. Volume expansion in renal failure patients: a paradigm for a clinically relevant [Na,K]ATPase inhibitor. J Cardiovasc Pharmacol. 1993; 22(Suppl 2)S54–S57
  • Graves S. W., Soszynski P. A., Tao Q.-F., Williams G. H., Hollenberg N. K. A labile endogenous Na-pump inhibitor. The Sodium Pump: Structure, Mechanism, Hormonal Control and its Role in Disease, Steinkopff, Darmstadt, E. Bamberg, W. Schoner. Springer, New York 1994; 771–774
  • Hollenberg N. K., Graves S. W. Koch's postulates and the digitalis-like factor. Hypertens Research. 1995; 18: 1–6
  • Hollenberg N. K., Graves S. W. Endogenous sodium pump inhibition: current status and therapeutic opportunities. Prog Drug Res. 1996; 46: 9–42
  • Xie L. Q., Markides K. E., Lee M. L., Hollenberg N. K., Williams G. H., Graves S. W. Bioanalytical applications of multidimensional open tubular column supercritical fluid chromatography. Chromatographia. 1993; 35: 363–371
  • Valdes R., Graves S. W. Protein binding of endogenous digoxin-immunoreactive factor in human serum and its variation with clinical condition. J Clin Endocrinol Metab. 1985; 60: 1135–1143
  • Krep H. H., Graves S. W., Price D. A., Lazarus M., Ensign A., Soszynski P. A., Hollenberg N. K. Reversal of sodium pump inhibitor induced vascular smooth muscle contraction with Digibind: stoichiometry and its implications. Am J Hypertens. 1995; 9: 39–46
  • Tao Q.-F., Hollenberg N. K., Price D. A., Graves S. W. Sodium pump isoform specificity for the digitalis-like factor isolated from human peritoneal dialysate. Hypertens. 1997; 29: 815–821
  • Haddy F. J., Overbeck H. W. The role of humoral agents in volume expanded hypertension. Life Sci. 1976; 19: 935–948
  • Buckalew V. M., Jr., Gruber K. A. Natriuretic hormone. Annu Rev Physiol. 1984; 46: 343–358
  • Graves S. W. The sodium pump in hypertension. Curr Opinion Nephrol Hypertens. 1994; 3: 107–111

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