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Original Article

Endothelial Dysfunction in Hypertension

Pages 635-646 | Published online: 03 Jul 2009

References

  • Furchtgott R. F., Zawadsky JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373–376
  • Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1989; 332: 411–15
  • Vane J. R., Anggard E. E., Hotting RM. Regulatory functions of the endothelium. N Engl J Med 1990; 323: 27–36
  • Linder L., Kiowski W., Buhler F. R., Luscher TF. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation 1990; 81: 1762–7
  • Panza J. A., Quyyumi A. A., Brush J. J., Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension [see comments]. N Engl J Med 1990; 323: 22–7
  • Gilligan D. M., Panza J. A., Kilcoyne C. M., Waclawiw M. A., Casino P. R., et al. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 1994; 90: 2853–8
  • Haynes W. G., Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 1994; 344: 852–4
  • Quyyumi A. A., Dakak N., Andrews N. P., Husain S., Arora S., et al. Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis. J Clin Invest 1995; 95: 1747–55
  • Hornig B., Maier V., Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 1996; 93: 210–4
  • Treasure C. B., Manoukian S. V., Klein J. L., Vita J. A., Nabel E. G., et al. Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients. Circ Res 1992; 71: 776–81
  • Ross R. The pathogenesis of atherosclerosis—an update. N Engl J Med 1986; 314: 488–500
  • Palmer RMJ, Ferrige A. G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–526
  • Taddei S., Virdis A., Mattei P., Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993; 21: 929–33
  • Rossi M., Taddei S., Fabbri A., Tintori G., Credidio L., et al. Cutaneous vasodilation to acetylcholine in patients with essential hypertension. J Cardiovasc Pharmacol 1997; 29: 406–11
  • Panza J. A., Casino P. R., Kilcoyne C. M., Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993; 87: 1468–74
  • Iiyama K., Nagano M., Yo Y., Nagano N., Kamide K., et al. Impaired endothelial function with essential hypertension assessed by ultrasonography. Am Heart J 1996; 132: 779–82
  • Cockcroft J. R., Chowienczyk P. J., Benjamin N., Ritter JM. Preserved endothelium-dependent vasodilatation in patients with essential hypertension. N Engl J Med 1994; 330: 1036–40
  • Pedrinelli R., Dell'Omo G., Prontera C., Corchia A., Gampietro O. Comparison of circulating von Willebrand factor levels and acetylcholine responsiveness as markers of endothelial dysfunction in hypertensive and atherosclerotic patients. J A Coll Cardiol 1997; 29, (supplA)
  • Panza J. A., Casino P. R., Kilcoyne C. M., Quyyumi AA. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. J Am Coll Cardiol 1994; 23: 1610–6
  • Taddei S., Virdis A., Ghiadoni L., Uleri S., Magagna A., et al. Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients. Hypertension 1997; 30: 1606–12
  • Panza J. A., Casino P. R., Badar D. M., Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475–81
  • Cardillo C., Kilcoyne C. M., Quyyumi A. A., Cannon RS, Panza JA. Decreased vasodilator response to isoproterenol during nitric oxide inhibition in humans. Hypertension 1997; 30: 918–21
  • Cardillo C., Kilcoyne C. M., Quyyumi A. A., Cannon R3, Panza JA. Selective defect in nitric oxide synthesis may explain ihe impaired endothelium-dependent vasodilation in patients with essential hypertension. Circulation 1998; 97: 851–6
  • Taddei S., Virdis A., Ghiadoni L., Magagna A., Salvetti A., Vitamin C. improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998; 97: 2222–9
  • Solzbach U., Hornig B., Jeserich M., Just H., Vitamin C. improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997; 96: 1513–9
  • Preik M., Kelm M., Feelisch M., Strauer BE. Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. J Hypertens 1996; 14: 903–8
  • Adams M. R., Robinson J., McCredie R., Scale J. P., Sorensen K. E., et al. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol 1998; 32: 123–7
  • Taddei S., Virdis A., Mattel P., Arzilli F., Salvetti A. Endothelium-dependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension. J Cardiovasc Pharmacol 1992; 20: S193–5, (suppl 2)
  • Rizzoni D., Ported E., Castellano M., Bettoni G., Muiesan M. L., et al. Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure. Hypertension 1998; 31: 335–41
  • Bracht C., Brunner H. P., Suetsch G., Kiowski W. Endothelial function in cyclosporine A treated patients early and late after cardiac transplantation. J Hypertension, (in press)
  • Chowienczyk P. J., Cockcroft J. R., Ritter JM. Blood flow responses to intra-arterial acetylcholine in man: effects of basal flow and conduit vessel length. Clin Sci Colch 1994; 87: 45–51
  • Quyyumi A. A., MuIcahy D., Andrews N. P., Husain S., Panza J. A., et al. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P. Circulation 1997; 95: 104–10
  • Egashira K., Suzuki S., Hirooka Y., Kai H., Sugimachi M., et al. Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P. Hypertension 1995; 25: 201–6
  • Kato M., Shiode N., Yamagata T., Matsuura H., Kajiyama G. Coronary segmental responses to acetylcholine and bradykimn in patients with atherosclerotic risk factors. Am J Cardiol 1997; 80: 751–5
  • Houghton J. L., Davison C. A., Kuhner P. A., Torossov M. T., Strogatz D. S., et al. Heterogeneous vasomotor responses of coronary conduit and resistance vessels in hypertension. J Am Coll Cardiol 1998; 31: 374–82
  • Anderson T. J., Uehata A., Gerhard M. D., Meredith I. T., Knab S., et al. Close relation of endothelial function in the human coronary and peripheral. Circulation s. J Am Coll Cardiol 1995; 26: 1235–41
  • Nishimura R. A., Lerman A., Chesebro J. H., Ilstrup D. M., Hodge D. O., et al. Epicardial vasomotor responses to acetylcholine are not predicted by coronary atherosclerosis as assessed by intracoronary ultrasound. J Am Coll Cardiol 1995; 26: 41–9, [published erratum appears in J Am Coll Cardiol 1995 Nov 15; 26(6): 1564].
  • Gerhard M., Roddy M. A., Creager S. J., Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996; 27: 849–53
  • Taddei S., Virdis A., Mattei P., Ghiadoni L., Gennari A., et al. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 1995; 91: 1981–7
  • Woo K. S., McCrohon J. A., Chook P., Adams M. R., Robinson J. T., et al. Chinese adults are less susceptible than whites to age-related endothelial dysfunction. J Am Coll Cardiol 1997; 30: 113–8
  • Panza J. A., Quyyumi A. A., Callahan T. S., Epstein SE. Effect of antihypertensive treatment on endotheliurri-dependent vascular relaxation in patients with essential hypertension. J Am Coll Cardiol 1993; 21: 1145–51
  • Kiowski W., Linder L., Nuesch R., Martina B. Effects of cilazapril on vascular structure and function in essential hypertension. Hypertension 1996; 27: 371–6
  • Creager M. A., Roddy MA. Effect of captopril and enalapril on endothelial function in hypertensive patients. Hypertension 1994; 24: 499–505
  • Lip G. Y., Blann A. D., Jones A. F., Lip P. L., Beevers DG. Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy. Am J Cardiol 1997; 80: 1566–71
  • Jern S., Wall U., Bergbrant A., Selin S. L., Jern C. Endothelium-dependent vasodilation and tissue-type plasminogen activator release in borderline hypertension. Arterioscler Thromb Vase Biol 1997; 17: 3376–83

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