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Original Article

The Emerging Role of Thiazolidinediones in the Treatment of Diabetes-Mellitus and Related Disorders

Pages 121-136 | Published online: 03 Jul 2009

References

  • Kahn R. Consensus development conference on insulin resistance. Diabetes Care 1998; 21: 310–314
  • Sohda T., Mizuno K., Momose Y., Ikeda H., Fujita T., Meguro K. Studies on antidiabetic agents. II. Novel thiazolidinedione derivatives as potent hypoglycemic and hpolipidemic agents. J. Med. Chem. 1992; 35: 2617–2626
  • Horikoshi H., Yoshioka T. Troglitazone - a novel antidiabetic drug for treating insulin resistance. Drug Discovery Today 1998; 3: 79–88
  • Yoshioka T., Fujita T., Kanai T., Aizawa Y., Kurumada T., Hasegawa K., Horikoshi H. Studies on hindered phenols and analogous. 1. Hypolipidemic agents with ability to inhibit lipid peroxidation. J. Med. Chem. 1989; 32: 421–428
  • Horikoshi H., Yoshioka T., Kawasaki T., Nakamura K-I., Matsunuma N., Yamaguchi K., Sasahara K. Troglitazone (CA-045) a new antidiabetic drug. Annu Rep. Sankyo. Res. Lab. 1994; 46: 1–57
  • Bowen L., Stein P. P., Stevenson R., Shulman G. I. The effect of CP 68, 722, a thiazolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 1991; 40: 1025–1030
  • Oakes N. D., Kennedy C. J., Jenkins A. B., Laybulf D. R., Chisholm D. J., Kraegen E. W. A new anudiabetic agent, BRL-49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 1994; 43: 1203–1210
  • Berger J., Biswas C., Hayes N., Ventre J., Wu M., Doebber T. W. An anudiabetic thiazolidinedione potentiates insulin stimulation of glycogen synthase in rat adipose tissue. Endocrinology 1996; 137: 1984–1990
  • Fujiwara T., Wada M., Fukuda K., Fukami M., Yoshioka S., Yoshioka T., Horikoshi H. Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice. Metabolism. 1991; 40: 1213–1218
  • Fujiwara T., Yoshioka S., Yoshioka T., Ushiyama I., Horikoshi H. Characterization of a new antidiabetic agent CS-045: studies in KK and ob/ob mice and Zucker fatty rats. Diabetes 1988; 37: 1849–1888
  • Ikeda H., Taketomi S., Sugiyama Y., Shimura Y., Sohda T., Meguro K., Fujita T. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant rats. Drug Res. 1990; 40: 156–162
  • Stevenson R. W., McPherson R. K., Genereux P. E., Danbury B. H., Kreutter D. K. Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia. Metabolism 1991; 40: 1268–1274
  • Sohda T., Mizuno K., Momose Y., Ikeda H., Fujita T., Meguro K. Studies on antidiabetic agents II. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents. J. Med. Chem. 1992; 35: 2617–2626
  • Lefebvre A-M., Onsurbe J. P., Leitersdorf I., Briggs M. R., Paterniti J. R. Fruchart. Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates. Artertoscler Thromb Vasc Biol. 1997; 17: 1756–1764
  • Kletzien R. F., Clarke S. D., Ulrich R. G. Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Molecular Pharmacology 1991; 41: 393–398
  • Lehmann J. M., Moore L. B., Smith-Oliver T. A., Wilkinson W. O., Wilson T. M., Kliewer S. A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activitated receptor (PPAR). J Biol. Chem. 1995; 270: 12953–12956
  • Wilson T. M., Cobb J. E., Cowan D. J., Wiethe R. W., Correa I. D., Prakash S. R., Beck K. D., Moore L. B., Kliewer S. A., Lehmann J. M. The structure-activity relationship between peroxisome proliferator-activated receptory agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 1996; 39: 665–668
  • Hotamisligil G. S., Shargill N. S., Spiegelman B. M. Adipose Expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993; 259: 87–91
  • Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 1995; 95: 2409–2415
  • Hotamisligil G. S., Murray D. L., Choy L. N., Spiegelman B. M. Tumor necrosis factor α inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. 1994; 91: 4854–4858
  • Miles P. D.G., Romeo O. M., Higo K., Cohen A., Rafaat K., Olefsky J. M. TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 1997; 46: 1678–1683
  • Peraldi P., Xu M., Spiegelman B. M. Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling. J. Clin. Invest. 1997; 100: 1863–1869
  • Iwamoto Y., Kuzuya T., Matsuda A., Awata T., Kumakura S., Inooka G., Shiraishi I. Effect of new oral antidiabetic agent CS-045 on gluose tolerance and insulin secretion in patients with NIDDM. Diabetes Care 1991; 14: 1083–1086
  • Suter S. L., Nolan J. J., Wallace P., Gumbiner B., Olefsky J. M. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 1992; 15: 193–203
  • Mimura K., Umeda F., Hiramatsu S., Taniguchi S., Ono Y., Nakashima N., Kobayashi K., Masakado M., Sako Y., Nawata H. Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type II diabetes. Diabetic Medicine 1994; 11: 685–691
  • Iwamoto Y., Kosaka K., Kuzuya T., Akanuma Y., Shigeta Y., Kaneko T. Effects of troglitazone: a new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy. Diabetes Care 1996; 19: 151–156
  • Kumar S., Boulton A. J.M., Beck-Nielson H., Berthezene F., Muggeo M., Person B., Spinas G. A., Donoghue S., Lettis S., Stewart-Long P. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Diabetdogia 1996; 39: 701–709
  • Ghazzi M. N., Perez J. E., Antonucci T. K., Driscoll J. H., Huang S. M., Faja B. W. The Troglitazone Study Group, and Whitcomb, R. Cardiac and glycerruc benefits of troglitazone treatment in NIDDM. Diabetes 1997; 46: 433–439
  • Nolan J. J., Ludvik B., Beerdsen P., Joyce M., Olefsky J. M. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 1994; 331: 1188–1193
  • Depres J. P., Lamarche B., Mauriege P., Cantin B., Dagenais G. R., Moorjani S., Lupien P.-J. Hyperinsulinemia as an independent risk factor for ischemic heart disease. The New England Journal of Medicine 1996; 334: 952–957
  • O'Shaughnessy I. M., Kotchen T. A. Epidemiologic, Physiologic, and clinical implications of hypertension and insulin resistance. Curr. Opin. Cardiol. 1993; 8: 757–764
  • Lind L., Berne C., Lithell H. Prevalence of insulin resistance in essential hypertension. J. Hypertens. 1995; 13: 1457–1462
  • Dubey R. K., Zhang H. Y., Reddy S. R., Boegehold M. A., Kotchen T. A. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am. J. Physiol. 1993; 265: R726–R732
  • Yoshioka S., Nishino H., Shiraki T., Ikeda K., Koike H., Okuna A., Wada M., Fujiwara T., Hosikoshi H. Anuhypertensive effects of CS-045 treatment in obese Zucker rats. Metabolism 1993; 42: 75–80
  • Zhang H. Y., Reddy S. R., Kotchen T. A. Antihypertensive effect of pioglitazone is not invariably associated with increased insulin sensitivity. Hypertension 1994; 24: 106–110
  • Valiquett T., Balagtas C., Whitcomb R. Troglitazone dose-response study in patients with NIDDM (abstract). Diabetes 1996; 44(suppl. 1)109
  • Lohray B. B., Bhushan V., Bheema Rao P., Madhavan G. R., Murali N., Narasimha Roa K., Anantha Reddy K., Jajesh B. M., Ganapathi Reddy P., Chakraborti R., Vikramadithyan R. K., Rajagopalan R., Rao Mamidi N. V.s., Jajoo H. K., Subramaniam S. Novel thiazolidmedione-2–4-diones as potent euglycemic and hypolipidaemicagents. Journal of Medicinal Chemistry, in press

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