Comorbid Pain, Depression, and Anxiety: Multifaceted Pathology Allows for Multifaceted Treatment

REFERENCES

• IASP Subcommittee on Taxonomy. Pain terms: a list with definitions and notes on usage. Pain 1979;6:249–52.
   PubMedGoogle Scholar
• Meyr AJ, Steinberg JS. The physiology of the acute pain pathway. Clin Podiatr Med Surg 2008;25:305–26.
   PubMedGoogle Scholar
• Bair MJ, Robinson RL, Katon W, Kroenke K. Depression and pain comorbidity: a literature review. Arch Intern Med 2003;163:2433–45.
   PubMed Web of Science ®Google Scholar
• Fishbain DA, Cole B, Cutler RB, Lewis J, Rosomoff HL, Rosomoff RS. Chronic pain and the measurement of personality: do states influence traits? Pain Med 2006;7:509–29.
   PubMed Web of Science ®Google Scholar
• Sharp TJ, Harvey AG. Chronic pain and post-traumatic stress disorder: mutual maintenance? Clin Psychol Rev 2001;21:857–77.
   PubMed Web of Science ®Google Scholar
• McLean SA, Clauw DJ, Abelson JL, Liberzon I. The development of persistent pain and psychological morbidity after motor vehicle collision: integrating the potential role of stress response systems into a biopsychosocial model. Psychosom Med 2005;67:783–90.
   PubMed Web of Science ®Google Scholar
• Fishbain D, Cutler R, Rosomoff H. Comorbid psychiatric disorders in chronic pain patients with psychoactive substance use disorders. Pain Clin 1998;11:79–87.
   Web of Science ®Google Scholar
• Roy-Bryne PP, Davidson KW, Kessler RC, et al. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry 2008;30:208–25.
   PubMedGoogle Scholar
• Mallen CD, Peat G, Thomas E, Dunn KM, Croft PR. Prognostic factors for musculoskeletal pain in primary care: a systematic review. Br J Gen Pract 2007;57:655–61.
   PubMed Web of Science ®Google Scholar
• Buffington AL, Hanlon CA, McKeown. Acute and persistent pain modulation of attention-related anterior cingulated fMRI activations. Pain 2005;113:172–84.
   PubMed Web of Science ®Google Scholar
• Giesecke T, Gracely RH, Williams DA, Geisser ME, Petzke FW, Clauw DJ. The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum 2005;52:1577–84.
   PubMed Web of Science ®Google Scholar
• Damsa C, Kosel M, Moussally J. Current status of brain imaging in anxiety disorders. Curr Opin Psychiatry 2009;22:96–110.
   PubMedGoogle Scholar
• Lautenbacher S, Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. Clin J Pain 1997;13:189–96.
   PubMed Web of Science ®Google Scholar
• Wilder-Smith CH, Schindler D, Loveblad K, Redmon SM, Nirkko A. Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut 2004;53:1595–601.
   PubMed Web of Science ®Google Scholar
• Stahl S, Briley M. Understanding pain in depression. Hum Psychopharmacol 2004;19 suppl 1: S9–13.
   PubMedGoogle Scholar
• Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP. Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry 2008;65:1275–84.
   PubMed Web of Science ®Google Scholar
• Delgado PL. Common pathways of depression and pain. J Clin Psychiatry 2004;65 suppl 12:16–9.
   PubMed Web of Science ®Google Scholar
• Stewart DE. Physical symptoms of depression: unmet needs in special populations. J Clin Psychiatry 2003;64 suppl 7:12–6.
   PubMedGoogle Scholar
• Austin DW, Richards JC. The catastrophic misinterpretation model of panic disorder. Behav Res Ther 2001;39:1277–91.
   PubMed Web of Science ®Google Scholar
• Baskin SM, Lipchik GL, Smitherman TA. Mood and anxiety disorders in chronic headache. Headache 2006;46 suppl 3:S76–87.
   PubMedGoogle Scholar
• Griffith JL, Razavi M. Pharmacological management of mood and anxiety disorders in headache patients. Headache 2006;46 suppl 3:S133–41.
   Google Scholar
• Lenze EJ, Karp JF, Muslant BH, et al. Somatic symptoms in late-life anxiety: treatment issues. J Geriatr Psychiatry Neurol 2005;18:89–96.
   PubMed Web of Science ®Google Scholar
• Ratcliffe GE, Enns MW, Belik S-L, Sareen J. Chronic pain conditions and suicidal ideation and suicide attempts: an epidemiologic perspective. Clin J Pain 2008;24:204–10.
   PubMed Web of Science ®Google Scholar
• Spiegel B, Schoenfeld P, Naliboff B. Systematic review: the prevalence of suicidal behavior in patients with chronic abdominal pain and irritable bowel syndrome. Aliment Pharmacol Ther 2007;26:183–93.
   PubMed Web of Science ®Google Scholar
• Smith MT, Edwards RR, Robinson RC, Dworkin RH. Suicidal ideation, plans, and attempts in chronic pain patients: factors associated with increased risk. Pain 2004;111:201–8.
   PubMed Web of Science ®Google Scholar
• Williams DA, Keefe FJ. Pain beliefs and the use of cognitive-behavioral coping strategies. Pain 1991;46:185–90.
   PubMed Web of Science ®Google Scholar
• Moulin DE, Clark AJ, Gilron I, et al. Pharmacological management of chronic neuropathic pain—consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag 2007;12:13–21.
   PubMed Web of Science ®Google Scholar
• Patrick DL, Feretich SL, Frame PS, et al. National Institutes of Health State-of-the-Science Conference Statement: symptom management in cancer: pain, depression, and fatigue, July 15–17, 2002. J Natl Cancer Inst Monogr 2004;32:9–16.
   Google Scholar
• Carville SF, Arendt-Nielsen S, Bliddal H, et al. EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 2008;67:536–41.
   PubMed Web of Science ®Google Scholar
• Chou R, Huffman LH. Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med 2007;147:505–14.
   PubMed Web of Science ®Google Scholar
• Faucher L, Furukawa K. Practice guidelines for the management of pain. J Burn Care Res 2006;27:659–68.
   PubMedGoogle Scholar
• Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch SL. Massachusetts General Hospital comprehensive clinical psychiatry. Philadelphia: Mosby, 2008.
   Google Scholar
• Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev 2007;(4):CDOO5454.
   Google Scholar
• Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326:1250–6.
   PubMed Web of Science ®Google Scholar
• Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo controlled studies. Pain 1992;49:205–9.
   PubMed Web of Science ®Google Scholar
• Bendtsen L, Jansen R, Olesen J. A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J Neurol Neurosurg Psychiatry 1996;61:285–90.
   PubMed Web of Science ®Google Scholar
• Uceyler N, Hauser W, Sommer C. A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. Arthritis Rheum 2008;59:1279–98.
   PubMed Web of Science ®Google Scholar
• Rockers DM, Fishman SM. Psychopharmacology for the pain specialist. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Bauer M, Moller HJ, Schneider E. Duloxetine: a new selective and dual acting antidepressant. Expert Opin Pharmacother 2006;7:421–7.
   PubMed Web of Science ®Google Scholar
• Grothe DR, Scheckner B, Albano D. Treatment of pain syndromes with venlafaxine. Pharmacotherapy 2004;24:621–9.
   PubMed Web of Science ®Google Scholar
• Kroenke K, Mesina N, Benattia I, Graepel J, Musgnung J. Venlafaxine extended release in the short-term treatment of depressed and anxious patients with multisomatoform disorder. J Clin Psychiatry 2006;67:72–80.
   PubMedGoogle Scholar
• Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326:1250–6.
   PubMed Web of Science ®Google Scholar
• Goldenberg D, Mayskiy M, Mossey C, Ruthazer R Schmid C. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. Arthritis Rheum 1996;39:1852–9.
   PubMed Web of Science ®Google Scholar
• Sapen, JR, Silberstein SD, Lake AE, Winters ME. Double-blind trial of fluoxetine: chronic daily headache and migraine. Headache 1994;34:497–502.
   PubMedGoogle Scholar
• Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. J Gen Intern Med 1997;12:384–9.
   PubMed Web of Science ®Google Scholar
• Krebs EE. Gaynes BN, Gartehner G, et al. Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and meta-analysis. Psychosomatics 2008;49:191–8.
   PubMedGoogle Scholar
• Semenchuk MR, Sherman S, Davis B. Double-blind, randomized trial of bupropion SR for the treatment of neuropathic pain. Neurology 2001;57:1583–8.
   PubMed Web of Science ®Google Scholar
• Katz J, Pennella-Vaughan J, Hetzel RD, Kanazi GE, Dworkin RH. A randomized, placebo-controlled trial of bupropion sustained release in chronic low back pain. J Pain 2005;6:656–61.
   PubMed Web of Science ®Google Scholar
• Bendtsen L, Jensen R. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 2004;62:1706–11.
   PubMed Web of Science ®Google Scholar
• Urquhart DM, Hoving JL, Assendelft WW, Roland M, van Tulder MW. Antidepressants for non-specific low back pain. Cochrane Database Syst Rev 2008;(1):CD001703.
   PubMed Web of Science ®Google Scholar
• Stillman MJ, Zajac D, Rybicki LA. Treatment of primary headache disorders with intravenous valproate: initial outpatient experience. Headache 2004;44:65–9.
   PubMed Web of Science ®Google Scholar
• Wiffen PJ, McQuay HJ, Moore RA. Carbamazepine for acute and chronic pain. Cochrane Database Syst Rev 2005;(3):CD005451.
   Google Scholar
• Kudoh A, Ishihara H, Matsuki A. Effect of carbamazepine on pain scores of unipolar depressed patients with chronic pain: a trial of off-on-off-on design. Clin J Pain 1998;14:61–5.
   PubMedGoogle Scholar
• Wiffen PJ, Rees J. Lamotrigine for acute and chronic pain. Cochrane Database Syst Rev 2007;2:CD006044.
   Google Scholar
• Lauria-Horner BA, Pohl RB. Pregabalin: a new anxiolytic. Expert Opin Investig Drugs 2003;12:663–72
   PubMed Web of Science ®Google Scholar
• Stein DJ, Baldwin DS, Baldinetti F, Mandel F. Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies. Eur Neuropsychopharmacol 2008;18:422–30.
   PubMed Web of Science ®Google Scholar
• Bennett MI, Simpson KH. Gabapentin in the treatment of neuropathic pain. Palliat Med 2004;18:5–11.
   PubMed Web of Science ®Google Scholar
• Nemeroff CB. The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacol Bull 2003;37:133–46.
   PubMedGoogle Scholar
• Ekbom K. Lithium for cluster headache: review of the literature and preliminary results of long-term treatment. Headache 1981;21:132–9.
   PubMed Web of Science ®Google Scholar
• Levin GM, Grum C, Eisele G. Effect of over-the-counter dosages of naproxen sodium and acetaminophen on plasma lithium concentrations in normal volunteers. J Clin Psychopharmacol 1998;18:237–40.
   PubMedGoogle Scholar
• Fishbain DA, Cutler RB, Lewis J, Cole B, Rosomoff RS, Rosomoff, HL. Do the second-generation “atypical neuroleptics” have analgesic properties? A structured evidence-based review. Pain Med 2004;5:359–65.
   PubMed Web of Science ®Google Scholar
• Glassman AH, Bigger JT Jr. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry 2001;158:1774–82.
   PubMed Web of Science ®Google Scholar
• Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS. Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 2003;23:802–5.
   PubMed Web of Science ®Google Scholar
• Calandre EP, Hidalgo J, Rico-Villademoros F. Use of ziprasidone in patients with fibromyalgia: a case series. Rheumatol Int 2007;27:473–6.
   PubMed Web of Science ®Google Scholar
• Bruera E, Chadwick S, Brenneis C, Hanson J, MacDonald RN. Methylphenidate associated with narcotics for the treatment of cancer pain. Cancer Treat Rep 1987;71:67–70.
   PubMedGoogle Scholar
• Huffman JC, Stern TA. Using psychostimulants to treat depression in the medically ill. Prim Care Companion J Clin Psychiatry 2004;6:44–6.
   PubMedGoogle Scholar
• Prommer E. Modafinil: is it ready for prime time? J Opioid Manag 2006;2:130–6.
   PubMedGoogle Scholar
• Rogers WO, Hall MA, Brissie RM, Robinson CA. Detection of alprazolam in three cases of methadone/benzodiazepine overdose. J Forensic Sci 1997;42:155–6.
   PubMedGoogle Scholar
• Maurer PM, Bartkowski RR. Drug interactions of clinical significance with opioid analgesics. Drug Saf 1993;8:30–48.
   PubMedGoogle Scholar
• Ballantyne J. Nonsteroidal anti-inflammatory drugs. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Steiner TJ. Evaluation and management of headache in primary care. Expert Rev Neurother 2004;4:425–37.
   PubMedGoogle Scholar
• Loke YK, Trivedi AN, Singh S. Meta-Analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40.
   PubMed Web of Science ®Google Scholar
• Argoff CE. New analgesics for neuropathic pain: the lidocaine patch. Clin J Pain 2000;16:S62–6.
   PubMedGoogle Scholar
• Ballantyne JC, Shin NS. Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain 2008;24:469–78.
   PubMed Web of Science ®Google Scholar
• Shochet RB, Murray GB. Neuropsychiatric toxicity of meperidine. J Intensive Care Med 1988;3:246–52.
   Google Scholar
• Linderbeck LR. Update of the clinical issues regarding methadone (dolophine) therapy in pain management. AACN Adv Crit Care 2008;19:253–7.
   PubMedGoogle Scholar
• Emrich HM, Vogt P, Herz A. Possible antidepressive effects of opioids: action of buprenorphine. Ann N Y Acad Sci 1982;398:108–12.
   PubMed Web of Science ®Google Scholar
• Bodkin JL, Zornberg GL, Lukas SE, Cole JO. Buprenorphine treatment of refractory depression. J Clin Psychopharmacol 1995;16:49–57.
   Web of Science ®Google Scholar
• Ripple MG, Pestaner JP, Levine BS, Smialek JE. Lethal combination of tramadol and multiple drugs affecting serotonin. Am J Forensic Med Pathol 2000;21:370–4.
   PubMed Web of Science ®Google Scholar
• Stahl SM, Felker A. Monoamine oxidase inhibitors: a modern guide to an unrequited class of antidepressants. CNS Spectr 2008;12:855–70.
   Google Scholar
• Ballantyne JC, Shin NS. Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain 2008;24:469–78.
   PubMed Web of Science ®Google Scholar
• Katz NP, Adams EH, Chilcoat H, et al. Challenges in the development of prescription opioid abuse-deterrent formulations. Clin J Pain 2007;31:648–60.
   Google Scholar
• Ives TJ, Chelminski PR, Hammett-Stabler CA, et al. Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res 2006;6:46.
   PubMed Web of Science ®Google Scholar
• Gourlay D, Heit H, Almahrezi A. Universal precautions in pain medicine: a rational approach to the treatment of chronic pain. Pain Med 2005;6:107–12.
   PubMed Web of Science ®Google Scholar
• Saper JR, Lake AE, Hamel RL, et al. Daily scheduled opioids for intractable head pain. Neurology 2004;62:1687–94.
   PubMedGoogle Scholar
• Ballantyne JC. Chronic pain following treatment for cancer: the role of opioids. Oncologist 2003;8:567–75.
   PubMed Web of Science ®Google Scholar
• Brodner RA, Taub A. Chronic pain exacerbated by long-term narcotic use in patients with nonmalignant disease: clinical syndrome and treatment. Mt Sinai J Med 1978;45:233–7.
   PubMedGoogle Scholar
• Criostomo RA, Schmidt JE, Hooten WM, Kerkvliet JL, Townsend CO, Bruce BK. Withdrawal of analgesic medication for chronic low-back pain patients: improvement in outcomes of multidisciplinary rehabilitation regardless of surgical history. Am J Phys Med Rehabil 2008;87:527–36.
   PubMedGoogle Scholar
• Gruber SA, Silveri MM, Yurgelen-Todd DA. Neuropsychological consequences of opiate use. Neuropsychol Rev 2007;17:299–315.
   PubMed Web of Science ®Google Scholar
• Vadalouca A, Moka E, Argyra E, Sikioti P, Siafaka I. Opioid rotation in patients with cancer: a review of the current literature. J Opioid Manag 2008;4:213–50.
   PubMedGoogle Scholar
• Cluff RS. Adjuvant treatments. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Thieme K, Flor H, Turk DC. Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioral and cognitive behavioral treatments. Arthritis Res Ther 2006;8:R121.
   PubMed Web of Science ®Google Scholar
• Chen E, Cole SW, Kato PM. A review of empirically supported psychosocial interventions for pain and adherence outcomes in sickle cell disease. J Pediatr Psychol 2004;29:197–209.
   PubMed Web of Science ®Google Scholar
• Redd WH, Montgomery GH, DuHamel KN. Behavioral intervention for cancer treatment side effects. J Natl Cancer Inst 2001;93:810–23.
   PubMed Web of Science ®Google Scholar
• Cuijpers P, van Straten A, Andersson G. Internet-administered cognitive behavioral therapy for health problems: a systematic review. J Behav Med 2008;31:169–77.
   PubMed Web of Science ®Google Scholar
• Rogovik AL, Goldman RD. Hypnosis for treatment of pain in children. Can Fam Physician 2007;53:823–5.
   PubMedGoogle Scholar
• James H, Cooper P, Miller V, Brooks N, Whorwell PJ. Treatment of non-cardiac chest pain: a controlled trial of hypnotherapy. Gut 2006;55:1403–8.
   PubMedGoogle Scholar
• Gonsalkolare WM, Miller V, Afzal A, Whorwell PJ. Long term benefits of hypnotherapy for irritable bowel syndrome. Gut 2003;52:1623–9.
   PubMedGoogle Scholar
• Babu AS, Matthew E, Danda D, Prakash H. Management of patients with fibromyalgia using biofeedback: a randomized controlled trial. Indian J Med Sci 2007;61:455–61.
   PubMedGoogle Scholar
• Ye ZQ, Cai D, Lan RZ, et al. Biofeedback therapy for chronic pelvic pain syndrome. Asian J Androl 2003;5:155–8.
   PubMedGoogle Scholar
• de Charms RC, Maeda F, Glover DH, et al. Control over brain activation and pain learned by using real time functional MRI. Proc Natl Acad Sci U S A 2005;102:18626–31.
   PubMedGoogle Scholar
• Nicholas MK. Pain management in musculoskeletal conditions. Best Pract Res Clin Rheumatol 2008;22:451–70.
   PubMed Web of Science ®Google Scholar
• Valim V, Oliveria L, Suda A, et al. Aerobic fitness effects in fibromyalgia. J Rheumatol 2003;30:1060–9.
   PubMed Web of Science ®Google Scholar
• Busch AJ, Barber KAR, Overend TJ, Peloso PMJ, Schachter CL. Exercise for treating fibromyalgia syndrome. Cochrane Database Syst Rev 2007;(4):CD003786.
   PubMed Web of Science ®Google Scholar
• Karapolat H, Akkoc S, Sari I, et al. Comparison of group-based exercise versus home-based exercise in patients with ankylosing spondylitis: effects on Bath Ankylosing Spondylitis Indices, quality of life and depression. Clin Rheumatol 2008;27:695–700.
   PubMed Web of Science ®Google Scholar
• Wang C. Tai Chi improves pain and functional status in adults with rheumatoid arthritis: results of a pilot single-blind randomized controlled trial. Med Sport Sci 2008;52:218–29.
   PubMedGoogle Scholar
• Cohen AJ, Menter A, Hale L. Acupuncture: role in comprehensive cancer center. Integr Cancer Ther 2005;4:131–43.
   PubMedGoogle Scholar
• Cassileth BR, Vickeers AJ. Massage therapy for symptom control: outcome study at a major cancer center. J Pain Symptom Manage 2004;28:244–9.
   PubMed Web of Science ®Google Scholar
• Nicholas MK. Pain management in musculoskeletal conditions. Best Pract Res Clin Rheumatol 2008;22:451–70.
   PubMed Web of Science ®Google Scholar
• Deng G, Cassileth BR. Integrative oncology: complementary therapies for pain, anxiety, and mood disturbance. CA Cancer J Clin 2005;55:109–16.
   PubMed Web of Science ®Google Scholar
• Fellowes D, Barnes K, Wilkinson S. Aromatherapy and massage for symptom relief in patients with cancer. Cochrane Database Syst Rev 2004;(2):CD002287.
   Google Scholar
• Siedliecki SL, Good M. Effect of music on power, pain depression and disability. J Adv Nurs 2006;54:553–62.
   PubMed Web of Science ®Google Scholar
• Ryder E, Ballantyne J. Postoperative pain in adults. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Kaplan B, Rabinerson D, Lurie S, Bar J, Krieser UR, Neri A. Transcutaneous electrical nerve stimulation (TENS) for adjuvant pain-relief during labor and delivery. Int J Gynaecol Obstet 1998;60:251–5.
   PubMed Web of Science ®Google Scholar
• Quessy SN, Rowbotham MC. Placebo response in neuropathic pain trials. Pain 2008;138:479–83.
   PubMed Web of Science ®Google Scholar
• Walsh BT, Seidman SN, Sysko R, Gould M. Placebo response in studies of major depression: variable, substantial, and growing. JAMA 2002;287:1840–7.
   PubMed Web of Science ®Google Scholar
• Khan A, Kolts RL, Rapaport MH, Krishnan KR, Brodhead AE, Browns WA. Magnitude of placebo response and drug-placebo differences across psychiatric disorders. Psychol Med 2005;35:743–9.
   PubMed Web of Science ®Google Scholar
• Lidstone SC, Stoessl AJ. Understanding the placebo effect: contributions from neuroimaging. Mol Imaging Biol 2007;9:176–85.
   PubMed Web of Science ®Google Scholar
• Vallance AK. A systematic review comparing the functional neuroanatomy of patients with depression who respond to placebo to those who recover spontaneously: is there a biological basis for the placebo effect in depression? J Affect Disord 2007;98:177–85.
   PubMedGoogle Scholar
• Abdi S, Zhou Y. Diagnostic and therapeutic procedures for pain management. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Stojanovic M. Interventional treatment for chronic pain. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Cosgrove GR, Eskandar E. Neurosurgical interventions for chronic pain. In: Ballantyne J, Fishman S, Abdi S, eds. The Massachusetts General Hospital handbook of pain management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
   Google Scholar
• Borckardt JJ, Anderson B, Kozel FA, et al. Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression. Neurocase 2006;12:216–20.
   PubMed Web of Science ®Google Scholar