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REVIEW

The Role of Oxytocin in Mother-Infant Relations: A Systematic Review of Human Studies

, MBBS, MPM, FRANZCP, , PhD, , PhD & , MBBS, MD, FRACOG
Pages 1-14 | Received 11 Nov 2009, Accepted 12 Apr 2010, Published online: 20 Jan 2011

REFERENCES

  • Insel T, Young AH. Neuropeptides and the evolution of social behaviour. Curr Opin Neurobiol 2000;10:784–9.
  • Carter CS, Altemus M. Integrative functions of lactational hormones in social behavior and stress management. Ann N Y Acad Sci 1997;807:164–74.
  • Numan M, Fleming AS, Levy F. Maternal Behaviour. In: Neill JD, ed. Knobil and Neill's physiology of reproduction. 3rd ed. Amsterdam, Boston: Elsevier, 2006.
  • Williams GL, Gazal OS, Leshin LS, Stanko RL, Anderson LL. Physiological regulation of maternal behavior in heifers: roles of genital stimulation, intracerebral oxytocin release, and ovarian steroids. Biol Reprod 2001;65:295–300.
  • Febo M, Numan M, Ferris CF. Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling. J Neurosci 2005;25:11637–44.
  • Pedersen CA, Vadlamudi SV, Boccia ML, Amico JA. Maternal behavior deficits in nulliparous oxytocin knockout mice. Genes Brain Behav 2006;5:274–81.
  • Algers B, Uvnas-Moberg K. Maternal behavior in pigs. Horm Behav 2007;52:78–85.
  • Dwyer CM. Individual variation in the expression of maternal behaviour: a review of the neuroendocrine mechanisms in the sheep. J Neuroendocrinol 2008;20:526–34.
  • Pedersen CA, Boccia ML. Oxytocin links mothering received, mothering bestowed and adult stress responses. Stress 2002;5:259–67.
  • Champagne F, Diorio J, Sharma S, Meaney MJ. Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proc Natl Acad Sci U S A 2001;98:12736–41.
  • Champagne F, Meaney MJ. Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity. Prog Brain Res 2001;133:287–302.
  • Francis DD, Champagne FC, Meaney MJ. Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. J Neuroendocrinol 2000;12: 1145–8.
  • Prior V, Glaser D. Understanding attachment and attachment disorders. Theory, evidence and practice. London: Jessica Kingsley, 2006.
  • Meins E, Fernyhough C, Fradley E, Tuckey M. Rethinking maternal sensitivity: mothers’ comments on infants’ mental processes predict security of attachment at 12 months. J Child Psychol Psychiatry 2001;42:637–48.
  • Meins E, Fernyhough C, Wainwright R, Das Gupta M, Fradley E, Tuckey M. Maternal mind-mindedness and attachment security as predictors of theory of mind understanding. Child Dev 2002;73:1715–26.
  • Arnott B, Meins E. Links among antenatal attachment representations, postnatal mind-mindedness, and infant attachment security: a preliminary study of mothers and fathers. Bull Menninger Clin 2007;71:132–49.
  • Klaus MH, Trause MA, Kennell JH. Does human maternal behaviour after delivery show a characteristic pattern? Ciba Found Symp 1975;(33):69–85.
  • Krpan KM, Coombs R, Zinga D, Steiner M, Fleming AS. Experiential and hormonal correlates of maternal behavior in teen and adult mothers. Horm Behav 2005;47:112–22.
  • Robson KM, Kumar R. Delayed onset of maternal affection after childbirth. Br J Psychiatry 1980;136:347–53.
  • Sosa R, Kennell J, Klaus M, Robertson S, Urrutia J. The effect of a supportive companion on perinatal problems, length of labour, and mother-infant interaction. N Engl J Med 1980;303:597–600.
  • Flinn M, Ward C, Noone R. Hormones and the human family. In: Buss DM, ed. The handbook of evolutionary psychology. Hoboken, NJ: John Wiley & Sons, 2005.
  • Schore AN. Affect regulation and the origin of the self. Hillsdale, NJ: Lawrence Erlbaum, 1994.
  • Greenbough W, Black J. Induction of brain structure by experience: substrates for cognitive development. In: Gunnar MR, Nelson CA, eds. Developmental behavioral neuroscience. Hillsdale, NJ: Lawrence Erlbaum, 1992:155–200.
  • Felitti VJ, Anda RF, Nordenberg D, Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med 1998;14:245–58.
  • Fonagy P, Target M, Gergely G. Attachment and borderline personality disorder. Psychiatr Clin North Am 2000;23: 103–22.
  • Zeanah CH Jr., ed. Handbook of infant mental health. 2nd ed. New York: Guilford, 2000.
  • Kessler RC, Magee WJ. Childhood adversities and adult depression: basic patterns of association in a US national survey. Psychol Med 1993;23:679–90.
  • Wakschlag LS, Hans SL. Early parenthood in context: implications for development and intervention. In: Zeanah CH, ed. Handbook of infant mental health. 2nd ed. New York: Guilford, 2000:129–44.
  • Main M, Goldwyn R. Predicting rejection of her infant from mother's representations of her own experience: implications for the abused-abusing intergenerational cycle. Child Abuse Negl 1984;8:203–17.
  • Insel TR. A neurobiological basis of social attachment. Am J Psychiatry 1997;154:726–35.
  • Burbach JPH, Young LJ, Russell JA. Oxytocin: synthesis, secretion and reproductive functions. In: Neill JD, ed. Knobil and Neill's physiology of reproduction. Elsevier, 2006.
  • Frasch A, Zetzsche T, Steiger A, Jirikowski GF. Reduction of plasma oxytocin levels in patients suffering from major depression. Adv Exp Med Biol 1995;395:257–8.
  • Carter CS. Oxytocin and sexual behavior. Neurosci Biobehav Rev 1992;16:131–44.
  • Uvnas-Moberg K, Widstrom A-M, Nissen E, Bjorvell H. Personality traits in women 4 days postpartum and their correlation with plasma levels of oxytocin and prolactin. J Psychosom Obstet Gynaecol 1990;11:261–73.
  • Chiodera P, Salvarani C, Bacchi-Modena A, Relationship between plasma profiles of oxytocin and adrenocorticotropic hormone during suckling or breast stimulation in women. Horm Res 1991;35:119–23.
  • Light KC, Smith TE, Johns JM, Brownley KA, Hofheimer JA, Amico JA. Oxytocin responsivity in mothers of infants: a preliminary study of relationships with blood pressure during laboratory stress and normal ambulatory activity. Health Psychol 2000;19:560–7.
  • Uvnas-Moberg K, Bjokstrand E, Hillegaart V, Ahlenius S. Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology (Berl) 1999;142:95–101.
  • Mezzacappa ES, Katlin ES. Breast-feeding is associated with reduced perceived stress and negative mood in mothers. Health Psychol 2002;21:187–93.
  • Domes G, Heinrichs M, Michel A, Berger C, Herpertz SC. Oxytocin improves “mind-reading” in humans. Biol Psychiatry 2007;61:731–3.
  • Wismer Fries AB, Ziegler TE, Kurian JR, Jacoris S, Pollack SD. Early experience in humans is associated with changes in neuropeptides critical for regulating social behaviour. Proc Natl Acad Sci U S A 2005;102:17237–40.
  • Meinlschmidt G, Heim C. Sensitivity to intranasal oxytocin in adult men with early parental separation. Biol Psychiatry 2007;61:1109–11.
  • Pennebaker JW, Susman JR. Disclosure of traumas and psychosomatic processes. Soc Sci Med 1988;26:327–32.
  • Levine A, Zagoory-Sharon O, Feldman R, Weller A. Oxytocin during pregnancy and early postpartum: individual patterns and maternal-fetal attachment. Peptides 2007;28: 1162–9.
  • Cranley MS. Development of a tool for the measurement of maternal attachment during pregnancy. Nurs Res 1981;30: 281–4.
  • Feldman R, Weller A, Zagoory-Sharon O, Levine A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci 2007;18: 965–70.
  • Feldman R, Weller A, Leckman JF, Kvint J, Eidelman AI. The nature of the mother's tie to her infant: maternal bonding under conditions of proximity, separation and potential loss. J Child Psychol Psychiatry 1999;40:929–40.
  • Tops M, van Peer JM, Korf J, Wijers AA, Tucker DM. Anxiety, cortisol, and attachment predict plasma oxytocin. Psychophysiology 2007;44:444–9.
  • Cloninger C, Przybeck T, Svrakic D, Wetzel R. The temperament and character inventory (TCI): a guide to its development and use. St. Louis, MO: Center for Psychobiology of Personality, Washington University, 1994.
  • Gordon I, Zagoory-Sharon O, Schneiderman I, Leckman JF, Weller A, Feldman R. Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress. Psychophysiology 2008;45: 349–52.
  • Brennan KA, Clark CL, Shaver PR. Self-report measurement of adult attachment: an integrative overview. In: Simpson JA, Rholes WS, eds. Attachment theory and close relationships. New York: Guilford, 1998.
  • Strathearn L, Fonagy P, Amico J, Montague PR. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 2009;34:2655–66.
  • Bick J, Dozier M. Mothers’ concentrations of oxytocin following close, physical interactions with biological and nonbiological children. Dev Psychobiol 2009;52:100–7.
  • Pederson D, Moran G, Sitko C, Campbell K, Ghesquire K, Acton H. Maternal sensitivity and the security of infant-mother attachment: a Q-sort study. Child Dev 1990;61:1974–83.
  • Zak PJ, Kurzban R, Matzner WT. Oxytocin is associated with human trustworthiness. Horm Behav 2005;48:522–7.
  • Muller ME. A critical review of prenatal attachment research. Sch Inq Nurs Pract 1992;6:5–21.
  • Muller ME, Ferketich S. Factor analysis of the maternal fetal attachment scale. Nurs Res 1993;42:144–7.
  • Takagi T, Tanizawa O, Otsuki Y, Sugita N, Haruta M, Yamaji K. Oxytocin in the cerebrospinal fluid and plasma of pregnant and nonpregnant subjects. Horm Metab Res 1985;17:308–10.
  • Dawood MY, Ylikorkala O, Trivedi D, Fuchs F. Oxytocin in maternal circulation and amniotic fluid during pregnancy. J Clin Endocrinol Metab 1979;49:429–34.
  • Leake RD, Waters C, Rubin RT, Buster JE, Fisher D. Oxytocin and prolactin responses in long-term breast-feeding. Obstet Gynecol 1983;62:565–8.
  • Leake RD, Weitzman RE, Glatz TH, Fisher DA. Plasma oxytocin concentrations in men, nonpregnant women, and pregnant women before and during spontaneous labor. J Clin Endocrinol Metab 1981;53:730–3.
  • Turner RA, Altemus M, Enos T, Cooper B, McGuinness T. Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. Psychiatry 1999;62:97–113.
  • Yasuda T, Mohri Z, Murakami Y, Enzyme immunoassay for oxytocin. Endocrinol Jpn 1989;36:641–6.
  • Crittenden PM. Patterns of attachment in adulthood: a dynamic-maturational approach to analyzing the Adult Attachment Interview. 2004.
  • Hesse E. The adult attachment interview: protocol, method of analysis and empirical studies. In: Cassidy J, Shaver PR, eds. Handbook of attachment theory, research and clinical applications. 2nd ed. New York: Guilford, 2008.
  • Roisman GI, Holland A, Fortuna K, Fraley RC, Clausell E, Clarke A. The adult attachment interview and self-reports of attachment style: an empirical rapprochement. J Pers Soc Psychol 2007;92:678–97.
  • Chotai J, Jonasson M, Hagglof B, Adolfsson R. Adolescent attachment styles and their relation to temperament and character traits of personality in a general population. Eur Psychiatry 2005;20:251–9.
  • Aroskar JP, Chan WY, Stouffer JE, Schneider CH, Murti VV, Duvigneaud V. Renal excretion and tissue distribution of radioactivity after administration of tritium-labeled oxytocin to rats. Endocrinology 1964;74:226–32.
  • Boyd NR, Chard T. Human urine oxytocin levels during pregnancy and labor. Am J Obstet Gynecol 1973;115:827–9.
  • Amico JA, Ulbrecht JS, Robinson AG. Clearance studies of oxytocin in humans using radioimmunoassay measurements of the hormone in plasma and urine. J Clin Endocrinol Metab 1987;64:340–5.
  • Anderson GM. Report of altered urinary oxytocin and AVP excretion in neglected orphans should be reconsidered. J Autism Dev Disord 2006;36:829–30.
  • Meisenberg G, Simmons WH. Minireview. Peptides and the blood-brain barrier. Life Sci 1983;32:2611–23.
  • Shaver PR, Mikulincer M. What do self-report attachment measures assess? In: Rholes WS, Simpson JA, eds. Adult attachment theory, research and clinical implications. New York: Guilford, 2004.
  • Altemus M, Fong J, Yang R, Damast S, Luine V, Ferguson D. Changes in cerebrospinal fluid neurochemistry during pregnancy. Biol Psychiatry 2004;56:386–92.
  • Bakermans-Kranenburg MJ, van Ijzendoorn M. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cogn Affect Neurosci 2008;3:128–34.
  • Champagne FA. Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol 2008;29:386–97.
  • Uvnas-Moberg K. Oxytocin and behaviour. Ann Med 1994;26:315–7.
  • Uvnas-Moberg K, Eriksson M. Breastfeeding: physiological, endocrine and behavioural adaptations caused by oxytocin and local neurogenic activity in the nipple and mammary gland. Acta Paediatr 1996;85:525–30.
  • Naber F, van IJzendoorn M, Deschamps P, van Engeland H, Bakermans-Kranenburg M. Intranasal oxytocin increases fathers’ observed responsiveness during play with their children: a double-blind within-subject experiment. Psychoneuroendocrinology 2010;35:1583–6.

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