The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Posttraumatic Stress Disorder

REFERENCES

• Germain A, Buysse DJ, Nofzinger E. Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses. Sleep Med Rev 2008;12:185–95.
   PubMed Web of Science ®Google Scholar
• Rasmusson AM, Vythilingam M, Morgan CA 3rd. The neuroendocrinology of posttraumatic stress disorder: new directions. CNS Spectr 2003;8:651–6, 665–7.
   PubMed Web of Science ®Google Scholar
• Wang Z, Neylan TC, Mueller SG, Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Arch Gen Psychiatry 2010;67:296–303.
   PubMed Web of Science ®Google Scholar
• Osser DN, Renner JA, Bayog R. Algorithms for the pharmacotherapy of anxiety disorders in patients with chemical abuse and dependence. Psychiatr Ann 1999;29:285–301.
   Google Scholar
• Davidson J, Bernik M, Connor KM, Friedman MJ, Jobson KO, Yoshiharo K. A new treatment algorithm for posttraumatic stress disorder. Psychiatr Ann 2005;35:887–98.
   Google Scholar
• Foa EB, Keane TM, Friedman MJ, Cohen JA. Effective treatments for PTSD: practice guidelines from the International Society for Traumatic Stress Studies. 2nd ed. New York: Guilford, 2008.
   Google Scholar
• National Collaborating Centre for Mental Health. Post-traumatic stress disorder: the management of PTSD in adults and children in primary and secondary care. London; Leicester, UK: Gaskell and the British Psychological Society, 2005.
   Google Scholar
• Bisson JI. Post-traumatic stress disorder. Clin Evid (Online). 2007 Aug 1; 2007. pii:1005.
   Google Scholar
• Bisson J, Andrew M. Psychological treatment of post-traumatic stress disorder (PTSD). Cochrane Database Syst Rev 2005;(2):CD003388.
   Google Scholar
• Benedek DM, Friedman MJ, Zatzick D, Ursano RJ. Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder. Arlington, VA: American Psychiatric Publishing, 2009.
   Google Scholar
• Committee on Treatment of Posttraumatic Stress Disorder, Institute of Medicine. Treatment of posttraumatic stress disorder: an assessment of the evidence. Washington, DC: National Academies, 2008.
   Google Scholar
• Hamoda HM, Osser DN. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on psychotic depression. Harv Rev Psychiatry 2008;16: 235–47.
   PubMed Web of Science ®Google Scholar
• Ansari A, Osser DN. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on bipolar depression. Harv Rev Psychiatry 2010;18:36–55.
   PubMed Web of Science ®Google Scholar
• Osser DN, Dunlop LR. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on generalized social anxiety disorder. Psychopharm Rev 2010;45:91–8.
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed., text rev. Washington, DC: American Psychiatric Press, 2000.
   Google Scholar
• van der Kolk BA, Dreyfuss D, Michaels M, Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry 1994;55:517–22.
   PubMed Web of Science ®Google Scholar
• Friedman MJ, Marmar CR, Baker DG, Sikes CR, Farfel GM. Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. J Clin Psychiatry 2007;68:711–20.
   PubMed Web of Science ®Google Scholar
• Strawn JR, Geracioti TD Jr. Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety 2008;25:260–71.
   PubMed Web of Science ®Google Scholar
• Chilcoat HD, Breslau N. Posttraumatic stress disorder and drug disorders: testing causal pathways. Arch Gen Psychiatry 1998;55:913–7.
   PubMed Web of Science ®Google Scholar
• Mason BJ, Kocsis JH, Ritvo EC, Cutler RB. A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression. JAMA 1996;275:761–7.
   PubMed Web of Science ®Google Scholar
• Otto MW, Perlman CA, Wernicke R, Reese HE, Bauer MS, Pollack MH. Posttraumatic stress disorder in patients with bipolar disorder: a review of prevalence, correlates, and treatment strategies. Bipolar Disord 2004;6:470–9.
   PubMed Web of Science ®Google Scholar
• Kozaric-Kovacic D, Pivac N. Quetiapine treatment in an open trial in combat-related post-traumatic stress disorder with psychotic features. Int J Neuropsychopharmacol 2007;10:253–61.
   PubMed Web of Science ®Google Scholar
• Breslau N, Davis GC, Peterson EL, Schultz LR. A second look at comorbidity in victims of trauma: the posttraumatic stress disorder-major depression connection. Biol Psychiatry 2000;48:902–9.
   PubMed Web of Science ®Google Scholar
• Gill J, Vythilingam M, Page GG. Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD. J Trauma Stress 2008;21:530–9.
   PubMed Web of Science ®Google Scholar
• Rasmusson AM, Wu R, Paliwal P, Anderson GM, Krishnan-Sarin S. A decrease in the plasma DHEA to cortisol ratio during smoking abstinence may predict relapse: a preliminary study. Psychopharmacology (Berl) 2006;186:473–80.
   PubMed Web of Science ®Google Scholar
• Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch Gen Psychiatry 2001;58:485–92.
   PubMed Web of Science ®Google Scholar
• Brady KT, Clary CM. Affective and anxiety comorbidity in post-traumatic stress disorder treatment trials of sertraline. Compr Psychiatry 2003;44:360–9.
   PubMed Web of Science ®Google Scholar
• Marshall RD, Beebe KL, Oldham M, Zaninelli R. Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. Am J Psychiatry 2001;158:1982–8.
   PubMed Web of Science ®Google Scholar
• Lewis CC, Simons AD, Nguyen LJ. Impact of childhood trauma on treatment outcome in the treatment for adolescents with depression study (TADS). J Am Acad Child Adolesc Psychiatry 2010;49:132–40.
   PubMed Web of Science ®Google Scholar
• Brand BL, Classen CC, McNary SW, Zaveri P. A review of dissociative disorders treatment studies. J Nerv Ment Dis 2009;197:646–54.
   PubMed Web of Science ®Google Scholar
• Marshall RD, Lewis-Fernandez R, Blanco C, A controlled trial of paroxetine for chronic PTSD, dissociation, and interpersonal problems in mostly minority adults. Depress Anxiety 2007;24:77–84.
   PubMed Web of Science ®Google Scholar
• Steiner H, Carrion V, Plattner B, Koopman C. Dissociative symptoms in posttraumatic stress disorder: diagnosis and treatment. Child Adolesc Psychiatr Clin N Am 2003;12:231–49, viii.
   PubMed Web of Science ®Google Scholar
• Menon SJ. Psychotropic medication during pregnancy and lactation. Arch Gynecol Obstet 2008;277:1–13.
   PubMed Web of Science ®Google Scholar
• Kirby AC, Hertzberg BP, Collie CF, Smoking in help-seeking veterans with PTSD returning from Afghanistan and Iraq. Addict Behav 2008;33:1448–53.
   PubMed Web of Science ®Google Scholar
• Cook J, Jakupcak M, Rosenheck R, Fontana A, McFall M. Influence of PTSD symptom clusters on smoking status among help-seeking Iraq and Afghanistan veterans. Nicotine Tob Res 2009;11:1189–95.
   PubMed Web of Science ®Google Scholar
• Hertzberg MA, Moore SD, Feldman ME, Beckham JC. A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic posttraumatic stress disorder. J Clin Psychopharmacol 2001;21:94–8.
   PubMed Web of Science ®Google Scholar
• Spoormaker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature? Sleep Med Rev 2008;12:169–84.
   PubMed Web of Science ®Google Scholar
• Belleville G, Guay S, Marchand A. Impact of sleep disturbances on PTSD symptoms and perceived health. J Nerv Ment Dis 2009;197:126–32.
   PubMed Web of Science ®Google Scholar
• Thompson CE, Taylor FB, McFall ME, Barnes RF, Raskind MA. Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin. J Trauma Stress 2008;21:417–20.
   Google Scholar
• Neylan TC, Marmar CR, Metzler TJ, Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Am J Psychiatry 1998;155:929–33.
   PubMed Web of Science ®Google Scholar
• Mellman TA, Knorr BR, Pigeon WR, Leiter JC, Akay M. Heart rate variability during sleep and the early development of posttraumatic stress disorder. Biol Psychiatry 2004;55: 953–6.
   PubMed Web of Science ®Google Scholar
• Raskind MA, Peskind ER, Kanter ED, Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry 2003;160:371–3.
   PubMed Web of Science ®Google Scholar
• Raskind MA, Peskind ER, Hoff DJ, A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry 2007;61:928–34.
   PubMed Web of Science ®Google Scholar
• Lamarche LJ, De Koninck J. Sleep disturbance in adults with posttraumatic stress disorder: a review. J Clin Psychiatry 2007;68:1257–70.
   PubMed Web of Science ®Google Scholar
• Kobayashi I, Boarts JM, Delahanty DL. Polysomnographically measured sleep abnormalities in PTSD: a meta-analytic review. Psychophysiology 2007;44:660–9.
   PubMed Web of Science ®Google Scholar
• Taylor FB, Martin P, Thompson C, Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry 2008;63:629–32.
   PubMed Web of Science ®Google Scholar
• Byers MG, Allison KM, Wendel CS, Lee JK. Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety. J Clin Psychopharmacol 2010;30:225–9.
   PubMed Web of Science ®Google Scholar
• Nuzhat SS, Osser DN. Chest pain in a young patient treated with prazosin for PTSD. Am J Psychiatry 2009;166: 618–9.
   Google Scholar
• Contopoulos-Ioannidis DC, Gilbody SM, Trikalinos TA, Churchill R, Wahlbeck K, Ioannidis J. Comparison of large versus smaller trials for mental-health interventions. Am J Psychiatry 2005;162:578–84.
   Google Scholar
• Troxel WM, Buysse DJ, Matthews KA, Sleep symptoms predict the development of the metabolic syndrome. Sleep 2010;33:1633–40.
   PubMed Web of Science ®Google Scholar
• Chung. Effect of terazosin on posttraumatic nightmares. Poster (No. 356) presented at the annual meeting of the American Psychiatric Association, San Diego, CA, May 2007.
   Google Scholar
• De Jong J, Wauben P, Huijbrechts I, Oolders H, Haffmans J. Doxazosin treatment for posttraumatic stress disorder. J Clin Psychopharmacol 2010;30:84–5.
   Google Scholar
• Hertzberg MA, Feldman ME, Beckham JC, Davidson JR. Trial of trazodone for posttraumatic stress disorder using a multiple baseline group design. J Clin Psychopharmacol 1996;16:294–8.
   PubMed Web of Science ®Google Scholar
• Leshner HI, Bagdhoyan HA, Bennett SJ, Caples SM, DeRubeis RJ, Glynn RJ. NIH State-of-the-Science Conference Statement on manifestations and management of chronic insomnia in adults. NIH Consens State Sci Statements 2005;22(2):1–30.
   Google Scholar
• Warner MD, Dorn MR, Peabody CA. Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. Pharmacopsychiatry 2001;34:128–31.
   PubMed Web of Science ®Google Scholar
• Sadock BJ, Sadock VA. Trazodone. In: Kaplan and Sadock's pocket handbook of psychiatric drug treatment. New York: Lippincott Williams & Wilkins, 2001:237–40.
   Google Scholar
• Stahl SM. Mechanism of action of trazodone: a multifunctional drug. CNS Spectr 2009;14:536–46.
   PubMed Web of Science ®Google Scholar
• Walsh JK. Subjective hypnotic efficacy of trazodone and zolpidem in DSM III–R primary insomnia. Hum Psychopharmacol 1998;13:191–8.
   Web of Science ®Google Scholar
• Kaynak H, Kaynak D, Gozukirmizi E, Guilleminault C. The effects of trazodone on sleep in patients treated with stimulant antidepressants. Sleep Med 2004;5:15–20.
   PubMed Web of Science ®Google Scholar
• Nierenberg AA, Adler LA, Peselow E, Zornberg G, Rosenthal M. Trazodone for antidepressant-associated insomnia. Am J Psychiatry 1994;151:1069–72.
   PubMed Web of Science ®Google Scholar
• Davidson J, Kudler H, Smith R, Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry 1990;47:259–66.
   PubMed Web of Science ®Google Scholar
• Kosten TR, Frank JB, Dan E, McDougle CJ, Giller EL Jr. Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J Nerv Ment Dis 1991;179:366–70.
   PubMed Web of Science ®Google Scholar
• Scharf M, Rogowski R, Hull S, Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in elderly patients with primary insomnia: a randomized, double-blind, placebo-controlled crossover study. J Clin Psychiatry 2008;69:1557–64.
   PubMed Web of Science ®Google Scholar
• Richardson GS, Roehrs TA, Rosenthal L, Koshorek G, Roth T. Tolerance to daytime sedative effects of H1 antihistamines. J Clin Psychopharmacol 2002;22:511–5.
   PubMed Web of Science ®Google Scholar
• Braun P, Greenberg D, Dasberg H, Lerer B. Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment. J Clin Psychiatry 1990;51:236–8.
   PubMed Web of Science ®Google Scholar
• Baker DG, Nievergelt CM, Risbrough VB. Post-traumatic stress disorder: emerging concepts of pharmacotherapy. Expert Opin Emerg Drugs 2009;14:251–72.
   PubMed Web of Science ®Google Scholar
• Pollack MH, Hoge EA, Worthington JJ. Eszopiclone for the treatment of posttraumatic stress disorder and associated insomnia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2011;72:892–7.
   PubMed Web of Science ®Google Scholar
• Wine JN, Sanda C, Caballero J. Effects of quetiapine on sleep in nonpsychiatric and psychiatric conditions. Ann Pharmacother 2009;43:707–13.
   PubMedGoogle Scholar
• Simon V, van Winkel R, De Hert M. Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review. J Clin Psychiatry 2009;70:1041–50.
   PubMed Web of Science ®Google Scholar
• Williams SG, Alinejad NA, Williams JA, Cruess DF. Statistically significant increase in weight caused by low-dose quetiapine. Pharmacotherapy 2010;30:1011–5.
   PubMed Web of Science ®Google Scholar
• Hamner MB, Canive J, Robert S, Calais LA, Villarreal G, Durkalski V. Quetiapine monotherapy in chronic posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. Paper presented at the annual meeting of the American Psychiatric Association, San Francisco, CA, May 2009.
   Google Scholar
• Hamner MB, Deitsch SE, Brodrick PS, Ulmer HG, Lorberbaum JP. Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy. J Clin Psychopharmacol 2003;23:15–20.
   PubMed Web of Science ®Google Scholar
• Cascade E, Kalali AH, Kennedy SH. Real-world data on SSRI antidepressant side effects. Psychiatry (Edgmont) 2009;6:16–8.
   PubMedGoogle Scholar
• Stein DJ, Ipser J, McAnda N. Pharmacotherapy of posttraumatic stress disorder: a review of meta-analyses and treatment guidelines. CNS Spectr 2009;14:25–31.
   PubMed Web of Science ®Google Scholar
• Brady K, Pearlstein T, Asnis GM, Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA 2000;283:1837–44.
   PubMed Web of Science ®Google Scholar
• Tucker P, Potter-Kimball R, Wyatt DB, Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo. Psychopharmacol Bull 2003;37:135–49.
   PubMedGoogle Scholar
• Martenyi F, Brown EB, Zhang H, Prakash A, Koke SC. Fluoxetine versus placebo in posttraumatic stress disorder. J Clin Psychiatry 2002;63:199–206.
   PubMed Web of Science ®Google Scholar
• Martenyi F, Soldatenkova V. Fluoxetine in the acute treatment and relapse prevention of combat-related post-traumatic stress disorder: analysis of the veteran group of a placebo-controlled, randomized clinical trial. Eur Neuropsychopharmacol 2006;16:340–9.
   Web of Science ®Google Scholar
• Martenyi F, Brown EB, Caldwell CD. Failed efficacy of fluoxetine in the treatment of posttraumatic stress disorder: results of a fixed-dose, placebo-controlled study. J Clin Psychopharmacol 2007;27:166–70.
   PubMed Web of Science ®Google Scholar
• Seedat S, Stein DJ, Emsley RA. Open trial of citalopram in adults with post-traumatic stress disorder. Int J Neuropsychopharmacol 2000;3:135–40.
   PubMedGoogle Scholar
• English BA, Jewell M, Jewell G, Ambrose S, Davis LL. Treatment of chronic posttraumatic stress disorder in combat veterans with citalopram: an open trial. J Clin Psychopharmacol 2006;26:84–8.
   Google Scholar
• Robert S, Hamner MB, Ulmer HG, Lorberbaum JP, Durkalski VL. Open-label trial of escitalopram in the treatment of posttraumatic stress disorder. J Clin Psychiatry 2006;67: 1522–6.
   PubMed Web of Science ®Google Scholar
• Canive JM, Clark RD, Calais LA, Qualls C, Tuason VB. Bupropion treatment in veterans with posttraumatic stress disorder: an open study. J Clin Psychopharmacol 1998;18:379–83.
   PubMedGoogle Scholar
• Becker ME, Hertzberg MA, Moore SD, Dennis MF, Bukenya DS, Beckham JC. A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. J Clin Psychopharmacol 2007;27:193–7.
   PubMed Web of Science ®Google Scholar
• Bahk WM, Pae CU, Tsoh J, Effects of mirtazapine in patients with post-traumatic stress disorder in Korea: a pilot study. Hum Psychopharmacol 2002;17:341–4.
   PubMed Web of Science ®Google Scholar
• Chung MY, Min KH, Jun YJ, Kim SS, Kim WC, Jun EM. Efficacy and tolerability of mirtazapine and sertraline in Korean veterans with posttraumatic stress disorder: a randomized open label trial. Hum Psychopharmacol 2004;19:489–94.
   PubMed Web of Science ®Google Scholar
• Davidson JR, Weisler RH, Butterfield MI, Mirtazapine vs. placebo in posttraumatic stress disorder: a pilot trial. Biol Psychiatry 2003;53:188–91.
   PubMed Web of Science ®Google Scholar
• Kim W, Pae CU, Chae JH, Jun TY, Bahk WM. The effectiveness of mirtazapine in the treatment of post-traumatic stress disorder: a 24-week continuation therapy. Psychiatry Clin Neurosci 2005;59:743–7.
   Google Scholar
• Preskorn SH. Outpatient management of depression: a guide for the practitioner. 3rd ed. West Islip, NY: Professional Communications, 2009.
   Google Scholar
• David D, Kutcher GS, Jackson EI, Mellman TA. Psychotic symptoms in combat-related posttraumatic stress disorder. J Clin Psychiatry 1999;60:29–32.
   PubMed Web of Science ®Google Scholar
• Moskowitz A, ed. Psychosis, trauma, and dissociation. Oxford: Wiley & Sons, 2009.
   Google Scholar
• Hamner MB, Faldowski RA, Ulmer HG, Frueh BC, Huber MG, Arana GW. Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms. Int Clin Psychopharmacol 2003;18:1–8.
   PubMed Web of Science ®Google Scholar
• Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH. Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry 2008;69:520–5.
   PubMed Web of Science ®Google Scholar
• Pivac N, Kozaric-Kovacic D, Muck-Seler D. Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related post-traumatic stress disorder. Psychopharmacology (Berl) 2004;175:451–6.
   PubMed Web of Science ®Google Scholar
• Robert S, Hamner MB, Durkalski VL, Brown MW, Ulmer HG. An open-label assessment of aripiprazole in the treatment of PTSD. Psychopharmacol Bull 2009;42:69–80.
   PubMed Web of Science ®Google Scholar
• Hamner MB, Canive J, Robert S, Calais LA, Villarreal G, Durkalski V. Quetiapine monotherapy in chronic posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. Paper presented at the annual meeting of the American Psychiatric Association, San Francisco, CA, May 2009.
   Google Scholar
• Southwick SM. Noradrenergic alterartions in posttraumatic stress disorder. Ann N Y Acad Sci 1997;821:125–41.
   PubMed Web of Science ®Google Scholar
• Murphy SE, Yiend J, Lester KJ, Cowen PJ, Harmer CJ. Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers. Int J Neuropsychopharmacol 2009;12:169–79.
   Google Scholar
• Reist C, Kauffmann CD, Haier RJ, A controlled trial of desipramine in 18 men with posttraumatic stress disorder. Am J Psychiatry 1989;146:513–6.
   PubMed Web of Science ®Google Scholar
• Davidson J, Baldwin D, Stein DJ, Treatment of posttraumatic stress disorder with venlafaxine extended release: a 6-month randomized controlled trial. Arch Gen Psychiatry 2006;63:1158–65.
   PubMed Web of Science ®Google Scholar
• Davidson J, Rothbaum BO, Tucker P, Asnis G, Benattia I, Musgnung JJ. Venlafaxine extended release in posttraumatic stress disorder: a sertraline- and placebo-controlled study. J Clin Psychopharmacol 2006;26:259–67.
   PubMed Web of Science ®Google Scholar
• Rothbaum BO, Davidson JR, Stein DJ, A pooled analysis of gender and trauma-type effects on responsiveness to treatment of PTSD with venlafaxine extended release or placebo. J Clin Psychiatry 2008;69:1529–39.
   Web of Science ®Google Scholar
• Stein DJ, Pedersen R. Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis. Int J Neuropsychopharmacol 2009;12:23–31.
   Google Scholar
• Gelenberg AJ. Nefazedone hepatotoxicity: black box warning. Biol Ther Psychiatry 2002;25:2.
   Google Scholar
• Davis LL, Nugent AL, Murray J, Kramer GL, Petty F. Nefazodone treatment for chronic posttraumatic stress disorder: an open trial. J Clin Psychopharmacol 2000;20:159–64.
   PubMedGoogle Scholar
• Garfield DA, Fichtner CG, Leveroni C, Mahableshwarkar A. Open trial of nefazodone for combat veterans with posttraumatic stress disorder. J Trauma Stress 2001;14:453–60.
   Google Scholar
• Davis LL, Jewell ME, Ambrose S, A placebo-controlled study of nefazodone for the treatment of chronic posttraumatic stress disorder: a preliminary study. J Clin Psychopharmacol 2004;24:291–7.
   PubMed Web of Science ®Google Scholar
• McRae AL, Brady KT, Mellman TA, Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder. Depress Anxiety 2004;19:190–6.
   PubMed Web of Science ®Google Scholar
• Hidalgo R, Hertzberg MA, Mellman T, Nefazodone in post-traumatic stress disorder: results from six open-label trials. Int Clin Psychopharmacol 1999;14:61–8.
   Web of Science ®Google Scholar
• Hertzberg MA, Feldman ME, Beckham JC, Moore SD, Davidson JR. Open trial of nefazodone for combat-related posttraumatic stress disorder. J Clin Psychiatry 1998;59:460–4.
   PubMedGoogle Scholar
• Hertzberg MA, Feldman ME, Beckham JC, Moore SD, Davidson JR. Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder. Ann Clin Psychiatry 2002;14:215–21.
   Google Scholar
• Zisook S, Chentsova-Dutton YE, Smith-Vaniz A, Nefazodone in patients with treatment-refractory posttraumatic stress disorder. J Clin Psychiatry 2000;61:203–8.
   PubMed Web of Science ®Google Scholar
• Fesler FA. Valproate in combat-related posttraumatic stress disorder. J Clin Psychiatry 1991;52:361–4.
   PubMed Web of Science ®Google Scholar
• Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F. Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol 2008;28:84–8.
   PubMed Web of Science ®Google Scholar
• Hertzberg MA, Butterfield MI, Feldman ME, A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry 1999;45:1226–9.
   PubMed Web of Science ®Google Scholar
• Tucker P, Trautman RP, Wyatt DB, Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2007;68:201–6.
   PubMed Web of Science ®Google Scholar
• Lindley SE, Carlson EB, Hill K. A randomized, double-blind, placebo-controlled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder. J Clin Psychopharmacol 2007;27:677–81.
   PubMed Web of Science ®Google Scholar
• Kinrys G, Wygant L, Pardo T, Melo M. Levetiracetam for treatment-refractory posttraumatic stress disorder. J Clin Psychiatry 2006;67:211–4.
   PubMed Web of Science ®Google Scholar
• Connor KM, Davidson JR, Weisler RH, Zhang W, Abraham K. Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl) 2006;184:21–5.
   PubMed Web of Science ®Google Scholar
• Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH. The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. J Clin Psychopharmacol 2007;27:85–8.
   PubMed Web of Science ®Google Scholar
• Pae CU, Lim HK, Peindl K, The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Int Clin Psychopharmacol 2008;23:1–8.
   PubMed Web of Science ®Google Scholar
• Monnelly EP, Ciraulo DA, Knapp C, Keane T. Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. J Clin Psychopharmacol 2003;23:193–6.
   PubMed Web of Science ®Google Scholar
• Krystal J, Rosenheck R, Cramer J. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD. JAMA 2011;306: 493–502.
   PubMed Web of Science ®Google Scholar
• Ahearn EP, Mussey M, Johnson C, Krohn A, Krahn D. Quetiapine as an adjunctive treatment for post-traumatic stress disorder: an 8-week open-label study. Int Clin Psychopharmacol 2006;21:29–33.
   PubMed Web of Science ®Google Scholar
• Villarreal G, Calais LA, Canive JM, Lundy SL, Pickard J, Toney G. Prospective study to evaluate the efficacy of aripiprazole as a monotherapy in patients with severe chronic posttraumatic stress disorder: an open trial. Psychopharmacol Bull 2007;40:6–18.
   PubMed Web of Science ®Google Scholar
• Mello MF, Costa MC, Schoedl AF, Fiks JP. Aripiprazole in the treatment of posttraumatic stress disorder: an open-label trial. Rev Bras Psiquiatr 2008;30:358–61.
   PubMed Web of Science ®Google Scholar
• Butterfield MI, Becker ME, Connor KM, Sutherland S, Churchill LE, Davidson JR. Olanzapine in the treatment of post-traumatic stress disorder: a pilot study. Int Clin Psychopharmacol 2001;16:197–203.
   PubMed Web of Science ®Google Scholar
• Stein MB, Kline NA, Matloff JL. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. Am J Psychiatry 2002;159:1777–9.
   PubMed Web of Science ®Google Scholar
• Siddiqui Z, Marcil WA, Bhatia SC, Ramaswamy S, Petty F. Ziprasidone therapy for post-traumatic stress disorder. J Psychiatry Neurosci 2005;30:430–1.
   PubMed Web of Science ®Google Scholar
• Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009;360:225–35.
   PubMed Web of Science ®Google Scholar
• Pies R. Should psychiatrists use atypical antipsychotics to treat nonpsychotic anxiety? Psychiatry (Edgmont) 2009;6:29–37.
   Google Scholar
• Kinzie JD, Leung P. Clonidine in Cambodian patients with posttraumatic stress disorder. J Nerv Ment Dis 1989;177:546–50.
   PubMed Web of Science ®Google Scholar
• Ziegenhorn AA, Roepke S, Schommer NC, Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol 2009;29:170–3.
   PubMed Web of Science ®Google Scholar
• Neylan TC, Lenoci M, Samuelson KW, No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. Am J Psychiatry 2006;163:2186–8.
   PubMed Web of Science ®Google Scholar
• Davis LL, Ward C, Rasmusson A, Newell JM, Frazier E, Southwick SM. A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans. Psychopharmacol Bull 2008;41:8–18.
   PubMed Web of Science ®Google Scholar
• Pitman RK, Sanders KM, Zusman RM, Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry 2002;51:189–92.
   PubMed Web of Science ®Google Scholar
• Vaiva G, Ducrocq F, Jezequel K, Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiatry 2003;54:947–9.
   PubMed Web of Science ®Google Scholar
• Stein MB, Kerridge C, Dimsdale JE, Hoyt DB. Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress 2007;20:923–32.
   PubMed Web of Science ®Google Scholar
• Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK. Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res 2008;42:503–6.
   PubMed Web of Science ®Google Scholar
• Shestatzky M, Greenberg D, Lerer B. A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatry Res 1988;24:149–55.
   PubMed Web of Science ®Google Scholar
• Baker DG, Diamond BI, Gillette G, et al. A double-blind, randomized, placebo-controlled, multi-center study of brofaromine in the treatment of post-traumatic stress disorder. Psychopharmacology (Berl) 1995;122:386–9.
   PubMed Web of Science ®Google Scholar
• Katz RJ, Lott MH, Arbus P, et al. Pharmacotherapy of post-traumatic stress disorder with a novel psychotropic. Anxiety 1994;1:169–74.
   PubMedGoogle Scholar
• American Psychiatric Association. Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder. Arlington, VA: APA, 2004.
   Google Scholar
• Foa EB, Davidson JR, Frances A. The expert consensus guidelines: treatment of posttraumatic stress disorder. J Clin Psychiatry 1999;60 (suppl 16).
   Google Scholar
• Canadian Psychiatric Association. Clinical practice guidelines. Management of anxiety disorders. Can J Psychiatry 2006; 51(8 suppl 2):9S–91S.
   Google Scholar
• United States Department of Veterans Affairs; United States Department of Defense. Clinical practice guideline for management of post-traumatic stress. Washington, DC: Veterans Health Administration, DoD, 2010.
   Google Scholar