Current Perspectives on the Pharmacotherapy of Depressive Disorders in Children and Adolescents

References

• Weller EB, Weller RA. Historical and theoretical perspectives on childhood depression. Current perspectives on major depressive disorders in children, EB Weller, RA Weller, MA Fristad. American Psychiatric Press, Washington, DC 1984; 2–18
   Google Scholar
• Kovacs M, Goldston D. Cognitive and social cognitive development of depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 1991; 30: 388–92
   PubMed Web of Science ®Google Scholar
• Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria. Arch Gen Psychiatry 1978; 35: 773–82
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders3rd ed. American Psychiatric Association, Washington, DC 1980
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders3rd ed, revised. American Psychiatric Association, Washington, DC 1987
   Google Scholar
• Fleming JE, Offord DR. Epidemiology of childhood depressive disorders: a critical review. J Am Acad Child Adolesc Psychiatry 1990; 29: 571–80
   PubMed Web of Science ®Google Scholar
• Fleming JE, Boyle MH, Offord DR. The outcome of adolescent depression in the Ontario Child Health Study follow-up. J Am Acad Child Adolesc Psychiatry 1993; 32: 28–33
   PubMed Web of Science ®Google Scholar
• Kovacs M, Goldston D, Gatsonis C. Suicidal behaviors and childhood-onset depressive disorders: a longitudinal investigation. J Am Acad Child Adolesc Psychiatry 1993; 32: 8–20
   PubMed Web of Science ®Google Scholar
• DeMaso D, Ross L, Beardslee W. Depressive disorders and suicidal intent in adolescent suicide attemptors. J Dev Behav Pediatr 1994; 15: 74–7
   Google Scholar
• Kashani JH, Sherman DD. Childhood depression: epidemiology, etiological models, and treatment implications. Integr Psychiatry 1988; 6: 1–8
   Google Scholar
• Petti TA. Depression in hospitalized child psychiatry patients: approaches to measuring depression. J Am Acad Child Adolesc Psychiatry 1978; 17: 49–59
   Google Scholar
• Ling W, Oftedal G, Weinberg W. Depressive illness in childhood presenting as severe headache. Am J Dis Child 1970; 120: 122–4
   PubMedGoogle Scholar
• Kashani JH, Barbero GJ, Bolander FD. Depression in hospitalized pediatric patients. J Am Acad Child Psychiatry 1981; 20: 123–34
   PubMedGoogle Scholar
• Carlson GA, Cantwell DP. A survey of depressive symptoms, syndrome and disorder in a child psychiatric population. J Child Psychol Psychiatry 1980; 21: 19–25
   PubMed Web of Science ®Google Scholar
• Weller EB, Weller RA. Depressive disorders in childhood and adolescents. Psychiatric disorders in children and adolescents, BD Garfinkel, GA Carlson, EB Weller. WB Saunders, Philadelphia 1990; 3–20
   Google Scholar
• Ryan N, Puig-Antich J, Ambrosini P, Rabinovich H, Robinson D, Nelson B, et al. The clinical picture of major depression in children and adolescents. Arch Gen Psychiatry 1987; 44: 854–61
   PubMed Web of Science ®Google Scholar
• Kovacs M, Feinberg T, Crouse-Novak M, Paulauskas S, Pollock M, Finkelstein R. Depressive disorders in childhood. II. A longitudinal study of the risk for a subsequent major depression. Arch Gen Psychiatry 1984; 41: 643–9
   PubMed Web of Science ®Google Scholar
• Kovacs M, Feinberg T, Crouse-Novak M, Paulauskas S, Finkelstein R. Depressive disorders in childhood. I. A longitudinal prospective study of characteristics and recovery. Arch Gen Psychiatry 1984; 41: 229–37
   PubMed Web of Science ®Google Scholar
• Kovacs M, Krol R, Voti L. Early onset psychopathology and the risk for teenage pregnancy among clinically referred girls. J Am Acad Child Adolesc Psychiatry 1994; 33: 106–13
   PubMed Web of Science ®Google Scholar
• Lewinsohn P, Rohde P, Seeley J, Hops H. Comorbidity of unipolar depression: I. Major depression with dysthymia. J Abnorm Psychol 1991; 100: 205–13
   PubMed Web of Science ®Google Scholar
• Lewinsohn P, Clarke G, Seeley J, Rohde P. Major depression in community adolescents. J Am Acad Child Adolesc Psychiatry 1994; 33: 809–18
   PubMed Web of Science ®Google Scholar
• Keller M, Shapiro R, Lavori P, Wolfe N. Recovery in major depressive disorder: analysis with life table and regression models. Arch Gen Psychiatry 1982; 39: 905–10
   PubMed Web of Science ®Google Scholar
• Rao U, Weissman MM, Martin JA, Hammond RW. Childhood depression and risk of suicide: a preliminary report of a longitudinal study. J Am Acad Child Adolesc Psychiatry 1993; 32: 44–50
   Google Scholar
• Marttunen MJ, Aro HM, Lonnqvist JK. Adolescent suicide: endpoint of long-term difficulties. J Am Acad Child Adolesc Psychiatry 1992; 31: 649–54
   PubMed Web of Science ®Google Scholar
• Kovacs M, Paulauskas S, Gatsonis C, Richards C. Depressive disorders in childhood. III. A longitudinal study of comorbidity with and risk for conduct disorders. J Affective Disord 1988; 15: 205–17
   PubMed Web of Science ®Google Scholar
• Keller MB, Beardslee WR, Dorer DJ, Lavori PW, Samuelson H, Herman GR. Impact of severity and chronicity of parental affective illness on adaptive functioning and psychopathology in children. Arch Gen Psychiatry 1986; 43: 930–7
   PubMed Web of Science ®Google Scholar
• Fleming JE, Offord DR, Boyle MH. Prevalence of childhood and adolescent depression in the community. Ontario Child Health Study. Br J Psychiatry 1989; 155: 647–54
   PubMed Web of Science ®Google Scholar
• Beardslee WR, Keller MB, Lavori PW, Klerman GK, Dorer DJ, Samuelson H. Psychiatric disorder in adolescent offspring of parents with affective disorder in a non-referred sample. J Affective Disord 1988; 15: 313–22
   PubMedGoogle Scholar
• Weissman MM, Prusoff BA, Gaumm GD, Merikangas KR, Leckman JF, Kidd KK. Psychopathology in the children (ages 6–18) of depressed and normal parents. J Am Acad Child Adolesc Psychiatry 1984; 23: 78–84
   Google Scholar
• Weissman MM, Gershon ES, Kidd KK. Psychiatric disorders in the relatives of probands with affective disorders: the Yale-NIMH collaborative family study. Arch Gen Psychiatry 1984; 41: 13–21
   PubMed Web of Science ®Google Scholar
• Weissman MM, Gammon GD, John K, Merikangas KR, Warner V, Prusoff BA. Children of depressed parents: increased psychopathology and early onset of major depression. Arch Gen Psychiatry 1987; 44: 847–53
   PubMed Web of Science ®Google Scholar
• Weissman MM, Fendrich M, Warner V, Wickramaratne P. Incidence of psychiatric disorder in offspring at high and low risk for depression. J Am Acad Child Adolesc Psychiatry 1992; 31: 640–8
   PubMed Web of Science ®Google Scholar
• Todd R, Reich W, Reich T. Prevalence of affective disorder in the child and adolescent offspring of a single kindred: a pilot study. J Am Acad Child Adolesc Psychiatry 1994; 33: 198–207
   Google Scholar
• Strober M, Carlson G. Bipolar illness in adolescents with major depression—clinical, genetic, and psychopharmacologic predictors in a three-to four-year prospective follow-up investigation. Arch Gen Psychiatry 1982; 39: 549–55
   PubMed Web of Science ®Google Scholar
• Geller B, Fox LW, Clark KA. Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry 1994; 33: 461–8
   PubMedGoogle Scholar
• Puig-Antich J, Perel JM, Lupatkin W, Chambers WJ, Shea C, Tabrizi M, et al. Plasma levels of imipramine (IMI) and desmethylimipramine (DMI) and clinical response in prepubertal major depressive disorder. J Am Acad Child Psychiatry 1979; 18: 616–27
   PubMedGoogle Scholar
• Staton RD, Wilson H, Brumback RA. Cognitive improvement associated with tricyclic antidepressant treatment of childhood major depressive illness. Percept Mot Skills 1981; 53: 219–34
   PubMed Web of Science ®Google Scholar
• Preskorn SH, Weller EB, Weller RA. Depression in children: relationship between plasma imipramine levels and response. J Clin Psychiatry 1982; 43: 450–3
   Web of Science ®Google Scholar
• Weller EB, Weller RA, Preskorn SH, Glotzbach R. Steady-state plasma imipramine levels in prepubertal depressed children. Am J Psychiatry 1982; 139: 506–8
   Google Scholar
• Geller B, Perel JM, Knitter EF, Lycaki H, Farooki ZQ. Nortriptyline in major depressive disorder in children: response, steady-state plasma levels, predictive kinetics, and pharmacokinetics. Psychopharmacol Bull 1983; 19: 62–4
   Google Scholar
• Geller B, Cooper TB, Chestnut EC, Anker J, Schluchter MD. Preliminary data on relationships between nortriptyline plasma levels and response in depressed children. Am J Psychiatry 1986; 143: 1283–6
   PubMed Web of Science ®Google Scholar
• Ryan ND, Puig-Antich J, Cooper T, Rabinovich H, Ambrosini P, Davies M, et al. Imipramine in adolescent major depression: plasma level and clinical response. Acta Psychiatr Scand 1986; 73: 275–88
   PubMed Web of Science ®Google Scholar
• Ryan ND, Meyer V, Dachille S, Mazzie D, Puig-Antich J. Lithium antidepressant augmentation in TCA-refractory depression in adolescents. J Am Acad Child Adolesc Psychiatry 1988; 27: 371–6
   PubMed Web of Science ®Google Scholar
• Ryan ND, Puig-Antich J, Rabinovich H, Fried J, Ambrosini P, Meyer V, et al. MAOIs in adolescent major depression unresponsive to tricyclic antidepressants. J Am Acad Child Adolesc Psychiatry 1988; 27: 755–8
   PubMed Web of Science ®Google Scholar
• Joshi PT, Walkup JT, Capozzoli JA, Detrinis RB, Coyle JT. The use of fluoxetine in the treatment of major depressive disorder in children and adolescents [Abstract]. Scientific Proceedings of the 36th Annual Meeting of the Academy of Child and Adolescent Psychiatry, New York, 1989
   Google Scholar
• Strober M, Freeman R, Rigali J. The pharmacotherapy of depressive illness in adolescence: I. An open label trial of imipramine. Psychopharmacol Bull 1990; 26: 80–4
   Google Scholar
• Strober M, Freeman R, Rigali J, Schmidt S, Diamond R. The pharmacotherapy of depressive illness in adolescence: II. Effects of lithium augmentation in nonresponders to imipramine. J Am Acad Child Adolesc Psychiatry 1992; 31: 16–20
   PubMed Web of Science ®Google Scholar
• Boulos C, Kutcher S, Gardner D, Young E. An open naturalistic trial of fluoxetine in adolescents and young adults with treatment-resistant major depression. J Child Adolesc Psychopharmacol 1992; 2: 103–11
   Google Scholar
• Kashani JH, Shekim WO, Reid JC. Amitriptyline in children with major depressive disorder: a double-blind crossover pilot study. J Am Acad Child Psychiatry 1984; 23: 348–51
   Google Scholar
• Puig-Antich J, Perel JM, Lupatkin W, Chambers WJ, Tabrizi M, King J, et al. Imipramine in prepubertal major depressive disorders. Arch Gen Psychiatry 1987; 44: 81–9
   PubMed Web of Science ®Google Scholar
• Preskorn SH, Weller EB, Hughes CW, Weller RA, Bolte K. Depression in prepubertal children: dexamethasone nonsup-pression predicts differential response to imipramine vs. placebo. Psychopharmacol Bull 1987; 23: 128–33
   Google Scholar
• Geller B, Cooper TB, Graham DL, Fetner HH, Marsteller FA, Wells JM. Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder. J Am Acad Child Adolesc Psychiatry 1992; 31: 34–44
   Google Scholar
• Geller B, Cooper TB, Graham DL, Marsteller FA, Bryant D. Double-blind placebo-controlled study of nortriptyline in depressed adolescents using a “fixed plasma level” design. Psychopharmacol Bull 1990; 26: 85–90
   Google Scholar
• Simeon JG, Dinicola VF, Ferguson B, Copping W. Adolescent depression: a placebo-controlled fluoxetine treatment study and follow-up. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 791–5
   PubMed Web of Science ®Google Scholar
• Boulos C, Kutcher S, Marton P, Simeon J, Ferguson B, Roberts N. Response to desipramine treatment in adolescent major depression. Psychopharmacol Bull 1991; 27: 59–65
   Google Scholar
• Kutcher S, Boulos C, Ward B, Marton P, Simeon J, Ferguson H, et al. Response to desipramine treatment in adolescent depression: a fixed-dose, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 1994; 33: 686–94
   Google Scholar
• Strober M. The pharmacotherapy of depressive illness in adolescence: III. Diagnostic and conceptual issues in studies of tricyclic antidepressants. J Child Adolesc Psychopharmacol 1992; 2: 23–9
   Google Scholar
• Ryan ND. The pharmacologic treatment of child and adolescent depression. Psychiatry Clin North Am 1992; 15: 29–40
   Google Scholar
• Jensen PS, Ryan ND, Prien R. Psychopharmacology of child and adolescent major depression: present status and future directions. J Child Adolesc Psychopharmacol 1992; 2: 31–45
   Google Scholar
• Elliott GR. Dilemmas for clinicians and researchers using antidepressants to treat adolescents with depression. J Child Adolesc Psychopharmacol 1992; 2: 7–9
   Google Scholar
• Conners CK. Methodology of antidepressant drug trials for treating depression in adolescents. J Child Adolesc Psychopharmacol 1992; 2: 11–22
   PubMedGoogle Scholar
• Ambrosini PJ, Bianchi MD, Rabinovich H, Elia J. Antidepressant treatments in children and adolescents. I. Affective disorders. J Am Acad Child Adolesc Psychiatry 1993; 32: 1–6
   PubMed Web of Science ®Google Scholar
• Thase PR, Paykel ES. Predictors of drug response in depression. Arch Gen Psychiatry 1989; 46: 89–99
   Google Scholar
• Geller B, Fox LW, Cooper TB, Garrity K. Baseline and two- to three-year follow-up characteristics of placebo-washout responders from the nortriptyline study of depressed 6- to 12-year-olds. J Am Acad Child Adolesc Psychiatry 1992; 31: 622–8
   Google Scholar
• Kupfer DJ, Reynolds CF, III, Ulrich RF, Grochocinski VJ. Comparison of automated REM and slow-wave sleep analysis in young and middle-aged depressed subjects. Biol Psychiatry 1986; 21: 189–200
   Google Scholar
• Salamon G, Raynaud C, Regis J, Rumeau C. Magnetic resonance imaging of the pediatric brain: an anatomical atlas. Raven Press, New York 1990
   Google Scholar
• Biederman J, Baldessarini R, Wright V, Knee D, Harmatz J. A double-blind placebo controlled study of desipramine in the treatment of attention deficit disorder: I. Efficacy. J Am Acad Child Adolesc Psychiatry 1989; 28: 777–84
   PubMed Web of Science ®Google Scholar
• Donnelly M, Zametkin AJ, Rapoport JL, Ismond DR, Weingartner H, Lane E, et al. Treatment of childhood hyperactivity with desipramine: plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response. Clin Pharmacol Ther 1986; 39: 72–81
   PubMed Web of Science ®Google Scholar
• Klein R, Koplewicz H, Kanner A. Imipramine treatment of children with separation anxiety disorder. J Am Acad Child Adolesc Psychiatry 1992; 31: 21–8
   PubMed Web of Science ®Google Scholar
• Rapoport JL, Mikkelsen EJ, Zavadil AP. Plasma imipramine and desmethylimipramine concentration and clinical response in childhood enuresis. Psychopharmacol Bull 1978; 14: 60–1
   Google Scholar
• Rapoport JL, Mikkelsen EJ, Zavadil A, Nee L, Gruenau C, Mendelson W, et al. Childhood enuresis. II. Psychopathology, tricyclic concentration in plasma, and antienuretic effect. Arch Gen Psychiatry 1980; 37: 1146–52
   PubMed Web of Science ®Google Scholar
• Wilder R, Berde C, Wolohan M, Vieyra M, Masek B, Micheli L. Reflex sympathetic dystrophy in children and adolescents: follow-up of a cohort of 70 patients and development of a treatment algorithm. J Bone Joint Surg [Am] 1992; 74: 910–9
   PubMed Web of Science ®Google Scholar
• Ryan ND, Puig-Antich J, Cooper TB, Rabinovich H, Ambrosini P, Fried J, et al. Relative safety of single versus divided dose imipramine in adolescent major depression. J Am Acad Child Adolesc Psychiatry 1987; 26: 400–6
   Google Scholar
• Geller B, Cooper TB, Schluchter MB, Warham JE, Carr LG. Child and adolescent nortriptyline single dose pharmacokinetic parameters: final report. J Clin Psychopharmacol 1987; 7: 321–3
   Google Scholar
• Preskorn SH, Jerkovich GS, Weller EB, Weller RA. Plasma levels of imipramine and metabolites in 68 hospitalized children. J Am Acad Child Adolesc Psychiatry 1989; 28: 373–5
   Google Scholar
• Biederman J, Steingard RJ. Psychopharmacology of children and adolescents: a primer for the clinician. World Health Organization, Washington, DC 1990
   Google Scholar
• Riddle MA, Nelson JC, Kleinman CS, Rasmussen A, Leckman JF, King RA, et al. Sudden death in children receiving Norpramin: a review of three reported cases and commentary. J Am Acad Child Adolesc Psychiatry 1991; 30: 104–8
   PubMed Web of Science ®Google Scholar
• Green WH. Child and adolescent clinical psychopharmacology. Williams and Wilkins, Baltimore 1991
   Google Scholar
• Riddle MA, Geller B, Ryan N. Another sudden death in a child treated with desipramine. J Am Acad Child Adolesc Psychiatry 1993; 32: 792–7
   PubMed Web of Science ®Google Scholar
• Ryan ND. Heterocyclic antidepressants in children and adolescents. J Child Adolesc Psychopharmacol 1990; 1: 21–31
   PubMedGoogle Scholar
• Weller EB, Weller RA. Mood disorders. Child and adolescent psychiatry, M Lewis. Williams and Wilkins, Baltimore 1991; 646–64
   Google Scholar
• Bunney WE, Jr. Psychopharmacology of the switch process in affective illness. Psychopharmacology: a generation of progress, MA Lipton, A Dimascio, KF Killam. Raven, New York 1978; 1249–59
   Google Scholar
• Geller B, Fox LW, Fletcher M. Effect of tricyclic antidepressants on switching to mania and on the onset of bipolarity in depressed 6- to 12-year-olds. J Am Acad Child Adolesc Psychiatry 1993; 32: 43–50
   PubMed Web of Science ®Google Scholar
• Angst J. Switch from depression to mania -a record study over decades between 1920 and 1982. Psychopathology 1985; 18: 140–54
   PubMed Web of Science ®Google Scholar
• Angst J. Switch from depression to mania, or from mania to depression: role of psychotropic drugs. Psychopharmacol Bull 1987; 23: 66–7
   Google Scholar
• Lewis JL, Winokur G. The induction of mania: a natural history study with controls. Psychopharmacol Bull 1987; 23: 74–8
   Google Scholar
• Solomon RL, Rich CL, Darko DF. Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression. J Affective Disord 1990; 18: 253–7
   PubMed Web of Science ®Google Scholar
• Nasrallah HA, Lyskowski J, Schroeder D. TCA-induced mania: differences between switchers and nonswitchers. Biol Psychiatry 1982; 17: 271–4
   PubMed Web of Science ®Google Scholar
• Akiskal HS, Mallya G. Criteria for the “soft” bipolar spectrum: treatment implications. Psychopharmacol Bull 1987; 23: 68–73
   PubMed Web of Science ®Google Scholar
• Boyer WF, Feighner JP. Pharmacokinetics and drug interactions. Selective serotonin re-uptake inhibitors. The clinical use of citalopram, fluoxetine, fluvox-amine, paroxetine, and sertraline, JP Feighner. John Wiley, New York 1991; 81–8
   Google Scholar
• Leonard BE. The comparative pharmacology of new antidepressants. J Clin Psychiatry 1993; 54(8, suppl)3–15
   Google Scholar
• Boyer WF, McFadden GA, Feighner JP. Clinical use of the selective serotonin re-uptake inhibitors. Selective serotonin re-uptake inhibitors. The clinical use of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, JP Feighner. John Wiley, New York 1991; 153–60
   Google Scholar
• DeVane CL. Pharmacokinetics of the selective serotonin reuptake inhibitors. J Clin Psychiatry 1992; 53(2, suppl)13–20
   Google Scholar
• Frommer EA. Treatment of childhood depression with antidepressants. BMJ 1967; 1: 729–32
   PubMed Web of Science ®Google Scholar
• Rosenbaum JF, Gelenberg AJ. Drug treatment of resistant depression. Treatment of psychiatric disorders. A task force report of the APA, TB Karasu. American Psychiatric Association, Washington, DC 1989
   Google Scholar
• Weilberg JB, Rosenbaum JF, Biederman J, Sachs GS, Pollack MH, Kelly K. Fluoxetine added to non-MAOI antidepressants converts nonresponders to responders: a preliminary report. J Clin Psychiatry 1989; 50: 447–9
   Google Scholar
• Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A preliminary open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Arch Gen Psychiatry 1991; 48: 303–7
   PubMed Web of Science ®Google Scholar
• Brent DA, Kolko DJ. Suicide and suicidal behavior in children and adolescents. Psychiatric disorders in children and adolescents, BD Garfinkel, GA Carlson, EB Weller. WB Saunders, Philadelphia 1990; 372–91
   Google Scholar
• Post RM, Susan R, Weiss B. Sensitization, kindling, and carbamazepine: an update on their implications for the course of affective illness. Pharmacopsychiatry 1992; 23: 41–3
   Google Scholar
• Post RM. Sensitization and kindling perspectives for the course of affective illness: toward a new treatment with the anticonvulsant carbamazepine. Pharmacopsychiatry 1990; 23: 3–17
   PubMed Web of Science ®Google Scholar
• Moreau D, Mufson L, Weissman MM, Klerman GL. Interpersonal psychotherapy for adolescent depression: description of modification and preliminary application. J Am Acad Child Adolesc Psychiatry 1991; 30: 642–51
   PubMed Web of Science ®Google Scholar
• Marton P, Connolly J, Kutcher S, Korenblum M. Cognitive social skills and social self-appraisal in depressed adolescents. J Am Acad Child Adolesc Psychiatry 1993; 32: 739–44
   PubMed Web of Science ®Google Scholar
• Beardslee WR, Salt P, Porterfield K, Rothberg PC, Van de Velde P, Swatling S, et al. Comparison of preventive interventions for families with parental affective disorder. J Am Acad Child Adolesc Psychiatry 1993; 32: 254–63
   PubMed Web of Science ®Google Scholar
• Cramer-Azima FJ. Group psychotherapy for children and adolescents. Child and adolescent psychiatry: a comprehensive textbook, M Lewis. Williams and Wilkins, Baltimore 1991; 842–9
   Google Scholar
• Nurcombe B. Malpractice. Child and adolescent psychiatry: a comprehensive textbook, M Lewis. Williams and Wilkins, Baltimore 1991; 1127–38
   Google Scholar