Neuroleptics in the Elderly: Guidelines for Monitoring

References

• Ray WA, Federspiel CF, Schaffner W. A study of antipsychotic drug use in nursing homes: epidemiologic evidence suggesting misuse. Am J Public Health 1980; 70: 485–91
   PubMed Web of Science ®Google Scholar
• Wragg RE, Jeste DV. Neuroleptics and alternative treatments: management of behavioral symptoms and psychosis in Alzheimer's disease and related conditions. Psychiatr Clin North Am 1988; 11: 195–213
   PubMed Web of Science ®Google Scholar
• Zubenko GS, Rosen J, Sweet RA, Mulsant BH, Rifai AH. Impact of psychiatric hospitalization on behavioral complications of Alzheimer's disease. Am J Psychiatry 1992; 149: 1484–91
   Google Scholar
• Swearer JM, Drachman DA, O'Donnell BF, Mitchell AL. Troublesome and disruptive behaviors in dementia; relationships to diagnosis and disease severity. J Am Geriatr Soc 1988; 36: 784–90
   PubMed Web of Science ®Google Scholar
• Mulsant BH, Gershon S. Neuroleptics in the treatment of psychosis in late-life. A rational approach. Int J Geriatr Psychiatry 1993; 8: 979–92
   Web of Science ®Google Scholar
• Elon R, Pawlson LG. The impact of OBRA on medical practice within nursing facilities. J Am Geriatr Soc 1992; 40: 958–63
   PubMed Web of Science ®Google Scholar
• Garrard J, Makris L, Dunham T, Heston LL, Cooper S, Ratner ER, et al. Evaluation of neuroleptic drug use by nursing home elderly under proposed Medicare and Medicaid regulations. JAMA 1991; 265: 463–7
   PubMed Web of Science ®Google Scholar
• Rovner BW, Edelman BA, Cox MP, Shmuely Y. The impact of antipsychotic drug regulations on psychotropic prescribing practices in nursing homes. Am J Psychiatry 1992; 149: 1390–2
   PubMed Web of Science ®Google Scholar
• Shorr RI, Fought RL, Ray WA. Changes in antipsychotic drug use in nursing homes during implementation of the OBRA-87 regulations. JAMA 1994; 271: 358–62
   PubMed Web of Science ®Google Scholar
• Department of Health and Human Services. State operations manual; provider certification. Health Care Financing Administration. Transmittal 250. Department of Health and Human Services. 1992
   Google Scholar
• Salzman C. Treatment of agitation in the elderly. Psychopharmacology: the third generation of progress, HY Meltzer. Raven Press, New York 1987; 1167–76
   Google Scholar
• Schneider LS, Pollock VE, Lyness SA. A metaanalysis of controlled trials of neuroleptic treatment in dementia. J Am Geriatr Soc 1990; 38: 553–63
   PubMed Web of Science ®Google Scholar
• Teri L, Rabins P, Whitehouse P, Berg L, Reisberg B, Sunderland T, et al. Management of behavior disturbance in Alzheimer disease: current knowledge and future directions. Alzheimer Dis Assoc Disord 1992; 6: 77–88
   PubMed Web of Science ®Google Scholar
• Dysken MW, Johnson SB, Holden L, Vatassery G, Nygren J, Jelinski M, et al. Haloperidol concentrations in patients with Alzheimer's dementia. Am J Geriatr Psychiatry 1994; 2: 124–33
   Google Scholar
• Devanand DP, Sackeim HA, Mayeux R. Psychosis, behavioral disturbance, and the use of neuroleptics in dementia. Compr Psychiatry 1988; 29: 387–401
   PubMed Web of Science ®Google Scholar
• Pollock BG. Recent developments in drug metabolism of relevance to psychiatrists. Harvard Rev Psychiatry 1994; 2: 204–13
   PubMed Web of Science ®Google Scholar
• Devanand DP, Cooper T, Sackeim HA, Taurke E, Mayeux R. Low dose oral haloperidol and blood levels in Alzheimer's disease: a preliminary study. Psychopharmacol Bull 1992; 28: 169–73
   Google Scholar
• Katz IR, Simpson GM, Curlik SM, Parmelee PA, Muhly C. Pharmacologic treatment of major depression for elderly patients in residential care settings. J Clin Psychiatry 1990; 51: 41–7
   PubMed Web of Science ®Google Scholar
• Morriss RK, Rovner BW, Folstein MF, German PS. Delusions in newly admitted residents of nursing homes. Am J Psychiatry 1990; 147: 299–302
   Google Scholar
• Tariot PN, Podgorski CA, Blazina L, Leibovici A. Mental disorders in the nursing home: another perspective. Am J Psychiatry 1993; 150: 1063–9
   PubMed Web of Science ®Google Scholar
• Mulsant BH, Gershon S. Neuroleptics in the treatment of psychosis in late-life. A rational approach. Int J Geriatr Psychiatry 1993; 8: 979–92
   Web of Science ®Google Scholar
• Harris MJ, Jeste DV. Late-onset schizophrenia: an overview. Schizophr Bull 1988; 14: 39–55
   PubMed Web of Science ®Google Scholar
• Jeste DV, Harris MJ, Pearlson GD, Rabins P, Lesser I, Miller B, et al. Late-onset schizophrenia; studying clinical validity. Psychiatr Clin North Am 1988; 11: 1–13
   PubMed Web of Science ®Google Scholar
• Mulsant BH, Sweet RA, Perel JM, Zubenko GS, Reynolds CF, III. Pharmacotherapy of psychotic major depression [Abstract]. Proceedings of the American Psychiatric Association's 146th Annual Meeting, San Francisco, 1993, 223
   Google Scholar
• Devanand DP, Sackeim HA, Brown RP, Mayeux R. A pilot study of haloperidol treatment of psychosis and behavioral disturbance in Alzheimer's disease. Arch Neurol 1989; 46: 854–7
   PubMedGoogle Scholar
• Gottlieb GL, McAllister TW, Gur RC. Depot neuroleptics in the treatment of behavioral disorders in patients with Alzheimer's disease. J Am Geriatr Soc 1988; 36: 619–21
   Google Scholar
• Ganzini L, Heintz R, Hoffman WF, Keepers GA, Casey DE. Acute extrapyramidal syndromes in neuroleptic-treated elders: a pilot study. J Geriatr Psychiatry Neurol 1991; 4: 222–5
   Google Scholar
• Steele C, Lucas MJ, Tune L. Haloperidol versus thioridazine in the treatment of behavioral symptoms in senile dementia of the Alzheimer's type: preliminary findings. J Clin Psychiatry 1986; 47: 310–2
   Google Scholar
• Sweet RA, Mulsant BH, Pollock BG, Rosen J, Altieri LP. Neuroleptic-induced parkinsonism in major depression with psychotic features. Am J Geriatr Psychiatry 1995, [In press]
   Google Scholar
• Gelenberg AJ, Bellinghausen B, Wojcik JD, Falk WE, Sachs GS. A prospective survey of neuroleptic malignant syndrome in a short-term psychiatric hospital. Am J Psychiatry 1988; 145: 517–8
   PubMedGoogle Scholar
• Pope HG, Jr, Keck PE, Jr, McElroy SL. Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital. Am J Psychiatry 1986; 143: 1227–33
   PubMed Web of Science ®Google Scholar
• Ayd FJ. Early-onset neuroleptic-induced extrapyramidal reactions: a second survey, 1961–1981. Neuroleptics: neurochemical, behavioral, and clinical perspectives, JT Coyle, SJ Enna. Raven Press, New York 1983; 75–92
   Google Scholar
• Simpson GM, Angus J W S. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand 1970; 212: 11–8
   Google Scholar
• Sweet RA, DeSensi EG, Zubenko GS. Reliability and applicability of movement disorder rating scales in the elderly. J Neuropsychiatry Clin Neurosci 1993; 5: 56–60
   Google Scholar
• Caligiuri MP. Portable device for quantifying parkinsonian wrist rigidity. Mov Disord 1994; 9: 57–63
   Google Scholar
• Caligiuri MP, Galasko DR. Quantifying drug-induced changes in parkinsonian rigidity using an instrumental measure of activated stiffness. Clin Neuropharmacol 1992; 15: 1–11
   Google Scholar
• Caligiuri MP, Bracha HS, Lohr JB. Asymmetry of neuroleptic-induced rigidity: development of quantitative methods and clinical correlates. Psychiatry Res 1989; 30: 275–84
   PubMed Web of Science ®Google Scholar
• Caligiuri MP, Lohr JB, Bracha S, Jeste DV. Clinical and instrumental assessment of neuroleptic-induced parkinsonism in patients with tardive dyskinesia. Biol Psychiatry 1991; 29: 139–48
   PubMed Web of Science ®Google Scholar
• Sweet RA, Pollock BG, Rosen J, Mulsant BH, Altieri LP, Perel JM. Early detection of neuroleptic-induced parkinsonism in elderly patients with dementia. J Geriatr Psychiatry Neurol 1994; 7: 251–4
   Google Scholar
• McEvoy JP, Hogarty GE, Steingard S. Optimal dose of neuroleptic in acute schizophrenia; a controlled study of the neuroleptic threshold and higher haloperidol dose. Arch Gen Psychiatry 1991; 48: 739–45
   PubMed Web of Science ®Google Scholar
• Simpson GM, Krakov L, Mattke D, St. Phard GS. A controlled comparison of the treatment of schizophrenic patients when treated according to the neuroleptic threshold or by clinical judgment. Acta Psychiatr Scand 1970; 212: 38–43
   Google Scholar
• The action of neuroleptic drugs, HJ Haase, P A J Janssen. Elsevier, New York 1985
   Google Scholar
• Stahl SM. Akathisia and tardive dyskinesia. Arch Gen Psychiatry 1985; 42: 915–7
   Google Scholar
• Munetz MR. Akathisia variants and tardive dyskinesia [Letter]. Arch Gen Psychiatry 1986; 43: 1015
   PubMed Web of Science ®Google Scholar
• Van Putten T, Marder SR. Toward a more reliable diagnosis of akathisia. Arch Gen Psychiatry 1986; 43: 1015–6
   Google Scholar
• Hermesh H, Shalev A, Munitz H. Contribution of adverse drug reaction to admission rates in an acute psychiatric ward. Acta Psychiatr Scand 1985; 72: 104–10
   PubMed Web of Science ®Google Scholar
• Sweet RA, Mulsant BH, Kunik ME, Rifai AH, Pasternak RE, Rosen J, et al. Phenomenology and prevalence of neuroleptic-induced akathisia in late life. Am J Geriatr Psychiatry 1993; 1: 136–42
   Google Scholar
• Barnes TR. A rating scale for drug-induced akathisia. Br J Psychiatry 1989; 154: 672–6
   PubMed Web of Science ®Google Scholar
• Braude WM, Barnes T R E, Gore SM. Clinical characteristics of akathisia: a systematic investigation of acute psychiatric inpatient admissions. Br J Psychiatry 1983; 143: 139–50
   PubMed Web of Science ®Google Scholar
• Barnes T R E, Braude WM. Akathisia variants and tardive dyskinesia. Arch Gen Psychiatry 1985; 42: 874–8
   PubMedGoogle Scholar
• Van Putten T, Marder SR. Behavioral toxicity of antipsychotic drugs. J Clin Psychiatry 1987; 48(9 suppl)13–8
   Google Scholar
• Guy W. Abnormal involuntary movement scale. ECDEU assessment manual for psychopharmacology, revised, W Guy. NIMH, Rockville, Maryland 1976; 534–7
   Google Scholar
• Schooler NR. Evaluation of drug-related movement disorders in the aged. Psychopharmacol Bull 1988; 24: 603–7
   PubMedGoogle Scholar
• Yassa R, Nastase C, Dupont D, Thibeau M. Tardive dyskinesia in elderly psychiatric patients: a 5-year study. Am J Psychiatry 1992; 149: 1206–11
   PubMed Web of Science ®Google Scholar
• Jeste DV, Caligiuri MP. Tardive dyskinesia. Schizophr Bull 1993; 19: 303–15
   PubMed Web of Science ®Google Scholar
• Kane JM, Woerner M, Borenstein M, Wegner J, Lieberman J. Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacol Bull 1986; 22: 254–8
   PubMedGoogle Scholar
• Saltz BL, Woerner MG, Kane JM, Lieberman JA, Alvir J M J, Bergmann KJ, et al. Prospective study of tardive dyskinesia incidence in the elderly. JAMA 1991; 266: 2402–6
   PubMed Web of Science ®Google Scholar
• Harris MJ, Panton D, Caligiuri MP, Krull AJ, Tran-Johnson TK, Jeste DV. High incidence of tardive dyskinesia in older outpatients on low doses of neuroleptics. Psychopharmacol Bull 1992; 28: 87–92
   PubMedGoogle Scholar
• Sweet RA, Mulsant BH, Gupta B, Rifai AH, Pasternak RE, Zubenko GS. Duration of neuroleptic treatment and prevalence of tardive dyskinesia in late life [Abstract]. Am J Geriatr Psychiatry 1994; 2: 267–8
   Google Scholar
• Morgenstern H, Glazer WM. Identifying risk factors for tardive dyskinesia among long-term outpatients maintained with neuroleptic medications. Arch Gen Psychiatry 1993; 50: 723–33
   PubMed Web of Science ®Google Scholar
• Toenniessen LM, Casey DE, McFarland BH. Tardive dyskinesia in the aged. Arch Gen Psychiatry 1985; 42: 278–84
   PubMedGoogle Scholar
• Tune L, Carr S, Hoag E, Cooper T. Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium. Am J Psychiatry 1992; 149: 1393–4
   PubMed Web of Science ®Google Scholar
• Semla TP, Palla K, Poddig B, Braunert DJ. Effect of the Omnibus Reconciliation Act 1987 on antipsychotic prescribing in nursing home residents. J Am Geriatr Soc 1994; 42: 648–52
   PubMed Web of Science ®Google Scholar
• Horwitz GJ. Discontinuation of antipsychotics in nursing home residents with dementia [Abstract]. Am J Geriatr Psychiatry 1994; 2: 264
   Google Scholar
• Thapa PB, Meador KG, Gideon P, Fought RL, Ray WA. Effects of antipsychotic withdrawal in elderly nursing home residents. J Am Geriatr Soc 1994; 42: 280–6
   PubMed Web of Science ®Google Scholar
• Lohr JB, Bracha HS. Association of psychosis and movement disorders in the elderly. Psychiatr Clin N Am 1988; 11: 61–81
   Google Scholar
• Pollock BG, Perel JM, Reynolds CF, III. Pharmacodynamic issues relevant to geriatric psychopharmacology. J Geriatr Psychiatry Neurol 1990; 3: 221–8
   PubMedGoogle Scholar
• Baldessarini RJ. Chemotherapy in psychiatry. Harvard University Press, Cambridge, Massachusetts 1985
   Google Scholar
• Davis JM. Antipsychotic drugs. Comprehensive textbook of psychiatry4th ed., HI Kaplan, BJ Sadock. Williams & Wilkins, Baltimore 1985; 1481–513
   Google Scholar