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Research Article

Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances selenite-induced apoptosis

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Pages 332-339 | Received 04 Oct 2009, Published online: 21 Jan 2010

References

  • Rayman MP. The importance of selenium to human health. Lancet 2000;356:233–241.
  • Schrauzer GN. Nutritional selenium supplements: product types, quality, and safety. J Am Coll Nutr 2001;20:1–4.
  • Ip C. Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis. Cancer Res 1981;41:4386–4390.
  • Jung U, Zheng X, Yoon S, Chung S. Se-Methylselenocysteine induces apoptosis mediated by reactive oxygen species in HL-60 cells. Free Radic Biol Med 2001;31:479–489.
  • Stewart MS, Spallholz JE, Neldner KH, Pence BA. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med 1999;26:42–48.
  • Yang CF, Shen HM, Ong CN. Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis. Arch Biochem Biophys 2000;380:319–330.
  • Shen HM, Yang CF, Ding WX, Liu J, Ong CN. Superoxide radical-initiated apoptotic signaling pathway in selenite-treated HepG2 cells: mitochondria serve as the main target. Free Radic Biol Med 2001;30:9–21.
  • Ganther HE. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis 1999;20:1657–1666.
  • Koshland DE, Walsh K, LaPorte DC. Sensitivity of metabolic fluxes to covalent control. Curr Top Cell Regul 1985;27:13–22.
  • Kirsch M, de Groot H. NAD(P)H, a directly operating antioxidant? FASEB J 2001;15:1569–1574.
  • Nakamura H. Thioredoxin and its related molecules: update 2005. Antioxid Redox Signal 2005;7:823–828.
  • Jo SH, Son MK, Koh HJ, Lee SM, Song IH, Kim YO, Lee YS, Jeong KS, Kim WB, Park J-W, Song BJ, Huh TL. Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent iso-citrate dehydrogenase. J Biol Chem 2001;276:16168–16176.
  • Smyth GE, Colman RF. Cysteinyl peptides of pig heart NADP-dependent isocitrate dehydrogenase that are modified upon inactivation by N-ethylmaleimide. J Biol Chem 1991;266:14918–14925.
  • Fatania HR, al-Nassar KE, Thomas N. Chemical modification of rat liver cytosolic NADP(1)-linked isocitrate dehydrogenase by N-ethylmaleimide. Evidence for essential sulphydryl groups. FEBS Lett 1993;322:245–248.
  • Tauskela JS, Hewitt K, Kang LP, Comas T, Gendron T, Hakim A, Hogan M, Durkin J, Morley P. Evaluation of glutathione-sensitive fluorescent dyes in conical culture. Glia 2001;30:329–341.
  • Tak JK, Park J-W. The use of ebselen for radioprotection in cultured cells and mice. Free Radic Biol Med 2009;46:1177–1185.
  • Sundaresan M, Yu ZY, Ferrans CJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995;270:296–299.
  • Park HS, Park J-W. Fluorescent labeling of the leukocyte NADPH oxidase subunit p47phox: evidence for amphiphile-induced conformational changes. Arch Biochem Biophys 1998;360:165–172.
  • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494–498.
  • Lee JH, Kim SY, Kil IS, Park J-W. Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+dependent isocitrate dehydrogenase. J Biol Chem 2007;282:13385–13394.
  • Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today 1997;18:44–51.
  • Zhong W, Oberley TD. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Cancer Res 2001;61:7071–7078.
  • Lee SM, Huh TL, Park J-W. Inactivation of NADP+dependent isocitrate dehydrogenase by reactive oxygen species. Biochimie 2001;83:1057–1065.
  • Lee JH, Yang ES, Park JW. Inactivation of NADP+dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. J Biol Chem 2003;278:51360–51371.
  • Yang JH, Yang ES, Park J-W. Inactivation of NADP+dependent isocitrate dehydrogenase by lipid peroxidation products. Free Radic Res 2004;38:241–249.
  • Arai M, Imai H, Koumura T, Yoshida T, Emoto K, Umeda M, Chiba N, Nakagawa Y. Mitochondrial phospholipid hydroper-oxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem 1999;274:4924–4933.
  • Araki M, Nanri H, Ejima K, Murasato Y, Fujiwara T, Nakashima Y, Ikeda M. Antioxidant function of the mitochondrial protein SP-22 in the cardiovascular system. J Biol Chem 1999;274:2271–2278.
  • Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998;273:6297–6301.
  • Watabe S, Hasegawa H, Takimoto K, Yamamoto Y, Takahashi S. Possible function of SP-22, a substrate of mitochondrial ATP-dependent protease, as a radical scavenger. Biochem Biophys Res Commun 1995;213:1010–1016.
  • Knoops B, Clippe A, Bogard C, Arsalane K, Wattiez R, Hermans C, Duconseille E, Falmagne P, Bernard A. Cloning and characterization of AOEB166, a novel mammalian anti-oxidant enzyme of the peroxiredoxin family. J Biol Chem 1999;274:30451–30458.

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