573
Views
112
CrossRef citations to date
0
Altmetric
Research Article

Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1

, , &
Pages 340-355 | Received 16 Sep 2009, Published online: 19 Feb 2010

References

  • Schiodt FV, Rochling FA, Casey DL, Lee WM. Acetaminophen toxicity in an urban county hospital. N Engl J Med 1997;337:1112–1117.
  • Ghosh A, Sil PC. Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepatonephro toxicity. J Biochem Mol Biol 2007;40:1039–1049.
  • Vermeulen NPE, Bessems JGM, Vandestraat R. Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention. Drug Metab Rev 1992;24: 367–407.
  • Ghosh A, Sil PC. Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-κB pathway: role of a novel plant protein. Chem Biol Interact 2009;177:96–106.
  • Huxtable RJ. Physiological actions of taurine. Physiol Rev 1992;72:101–163.
  • Ghosh J, Das J, Manna P, Sil PC. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol 2009;240:73–87.
  • Das J, Ghosh J, Manna P, Sinha M, Sil PC. Arsenic-induced oxidative cerebral disorders: protection by taurine. Drug Chem Toxicol 2009;32:93–102.
  • Das J, Ghosh J, Manna P, Sinha M, Sil PC. Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 2009;187:201–210.
  • Manna P, Sinha M, Sil PC. Amelioration of cadmium-induced cardiac impairment by taurine. Chem Biol Interact 2008; 174:88–97.
  • Manna P, Sinha M, Sil PC. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids 2009;36:417–428.
  • Hinson JA, Pike SL, Pumford NR, Mayeux PR. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 1998;11: 604–607.
  • Le J, Vilcek J. Tumor necrosis factor and interleukin 1: cytokines with multiple 646 overlapping biological activities. Lab Invest 1987;56:234–248.
  • Halliwell B. Free radicals and antioxidants: a personal view. Nutr Rev 1994;52:253–265.
  • Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJJ, Bucci TJ, Mehendale HM. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol Sci 2003;73: 220–234.
  • Henderson N, Pollock K, Frew J, Mackinnon A, Flavell R, Davis R, Sethi T, Simpson K. Critical role of c-jun (NH2) terminal kinase in paracetamol induced acute liver failure. Gut 2007;56:982–990.
  • Pearson G, Robinson F, Gibson TB, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001;22:153–183.
  • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of 650 ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326–1331.
  • Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res 2005;569:101–110.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–254.
  • Kornberg A. Lactic dehydrogenase of muscle. Colowick SP, Kaplan NO. Methods in enzymology. New York: Academic press; 1955. 441–443.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982;126:131–138.
  • Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990;186:407–421.
  • Lee CY. Glucose-6-phosphate dehydrogenase from mouse. Methods Enzymol 1982;89:252–257.
  • Sellins KS, Cohen JJ. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 1987;139:3199–3206.
  • Das J, Ghosh J, Manna P, Sil PC. Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes. Pathophysiology 2008;15:181–190.
  • Madesh M, Balasubramanian KA. A microlitre plate assay for superoxide using MTT reduction method. Ind J Biochem Biophys 1997;34:535–539.
  • Ito T, Asakura K, Tougou K, Fukuda T, Kubota R, Nonen S, Fujio Y, Azuma J. Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes. Mol Pharmacol 2007;72:173–181.
  • Ausubel FM, Brent R, Kingston RE, Moore DD, Siedman JG, Smith JA, Struhl K. Eds current protocols in molecular biology. Albright LM, Coen DM, Varki A. John Wiley and Sons, Inc; USA, 2003.
  • Ferreira MPLVO, Nunes MV, Mendes E, Remiilo F, Ferreirat IMA. Development of an HPLC-UV method for determination of taurine in infant formulae and breast milk. J Liq Chrom Rel Technol 1997;20:1269–1278.
  • Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999;19:2435–2444.
  • Malhi H, Gored GJ, Lemasters JJ. Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 2006;43:31–44.
  • Schnellman RG. Toxic responses of the kidney. Casarett, Doull. Toxicology: The basic science of poisons. 6th ed. New York: McGraw-Hill Medical Publishing Division; 2001. 491–514.
  • Michael SL, Mayeux PR, Bucci TJ, Warbritton AR, Irwin LK, Pumford NR, Hinson JA. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide 2001;5:432–441.
  • Gardner CR, Heck DE, Yang CS, Thomas PE, Zhang XJ, DeGeorge GL, Laskin JD, Laskin DL. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 1998;27:748–754.
  • Waters E, Wang J, Redmond H, Wu Q, Kay E, Bouchierhayes D. Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. Am J Physiol Gastrointest Liver Physiol 2001;280:1274–1279.
  • Moldeus P. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochem Pharmacol 1978; 27:2859–2863.
  • Whitehouse LW, Wong LT, Paul CJ, Pakuts A, Solomonraj G. Postabsorption antidotal effects of N- acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse. Can J Physiol Pharmacol 1985;63:431–437.
  • Salas VM, Corcoran GB. Calcium-dependent DNA damage and adenosine 39,59-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury. Hepatology 1997;251: 1432–1438.
  • Gregory M, Adamson GM, Harman AW. Oxidative stress in cultured hepatocytes exposed to acetaminophen. Biochem Pharmacol 1993;45:2289–2294.
  • Chen Y, Lin F, Liu P, Huang Y, Chiu J, Chang Y, Man K, Hong C, Ho Y, Lai M. Antioxidative and hepatoprotectve effects of magnolol on acetaminophen-induced liver damage in rats. Arch Pharm Res 2009;32:221–228.
  • Schaffer S, Azuma J, Takahashi K, Mozaffari M. Why is taurine cytoprotective? Adv Exp Med Biol 2003;526:307–321.
  • Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA. Taurine protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids 1998;15:53–76.
  • Bae M, Pie J, Song B. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH2-terminal protein kinase-related cell death pathway. Mol Pharmacol 2001;60: 847–856.
  • Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, Mukaida N. The pathogenic roles of tumor necrosis factor receptor p55 in paracetamol-induced liver injury in mice. J Leukoc Biol 2004;75:59–67.
  • Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2/M. Mol Cell Biol 1999;19:8469–8478.
  • Hassan H, Anwar K, Pirard PM, Crabtree M, Chow SC, Johnson VL, Lee PC, Hinton RH , Price SC, Kassa GEN. Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury roles of cytochrome c, Bax, Bid, and caspases. Toxicol Appl Pharmacol 2003;191:118–129.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.